Method of controlling soybean rust fungus resistant to qoi fungicide

ABSTRACT

The present invention provides a method for controlling soybean rust fungus having an amino acid replacement of F129L in mitochondrial cytochrome b protein. A compound represented by formula (I) [wherein: Q represents a group represented by Q1 etc. (wherein “•” represents a position bonding to benzene ring); E represents C1-C6 chain hydrocarbon group, etc.; R 1  represents C1-C3 chain hydrocarbon group, etc.; n is 0, 1, 2 or 3; when n is 2 or 3, two or more of R 2  may be identical to or different from each other; and R 2  represents C1-C3 chain hydrocarbon group, etc.] can be used for controlling soybean rust fungus having an amino acid replacement of F129L in mitochondrial cytochrome b protein.

TECHNICAL FIELD

This application claims priority to and the benefit of Japanese PatentApplication Nos. 2020-015187 filed Jan. 31, 2020 and 2020-088494 filedMay 20, 2020, the entire contents of which are incorporated herein byreference.

The present invention relates to a method for controlling soybean rustfungus having an amino acid substitution of F129L on mitochondrialcytochrome b protein.

BACKGROUND ART

The spread of phytopathogenic fungi that shows acquired character beingresistant to agricultural fungicides becomes a major problem. Under suchcircumstances, FRAC (Fungicide Resistance Action Committee) has beenestablished as an organization that provides guidelines for acquiring aresistance to existing agricultural fungicides, and suppressing anddelaying the spread of the fungi having the resistance acquired. Avariety of information on phytopathogenic fungi that shows a resistanceto agricultural fungicides is available on the FRAC-provided website(http://www.frac.info/). It has been known that in the case of aphytopathogenic fungi, the main cause of acquiring a resistance is thata mutation of the phytopathogenic fungal gene encoding the target enzymeof the fungicide causes a partial substitution of amino acids in thetarget enzyme of the fungicides, which results in reducing the affinitybetween the fungicides and the target enzyme.

QoI fungicides are named as aliases a strobilurin fungicide, or amethoxyacrylate fungicide because of its characteristic structure. TheQoI fungicides are one group of agricultural fungicides that have beenwidely used to control phytopathogenic fungi including soybean rustfungus. QoI fungicides usually bind to the ubihydroquinone oxidationcenters of cytochrome bcl complex (electron transfer complex III) inmitochondria, and suppress a respiration of the phytopathogenic fungi,which results in killing the phytopathogenic fungi or stopping thegrowth of the same. The above-mentioned oxidation center is locatedoutside the mitochondrial inner membrane (see Non-patent document 1).

It has been revealed by model studies in the laboratory before QoIfungicides were actually used extensively as agricultural fungicidesthat phytopathogenic fungi are subjected to a selection pressure by QoIfungicide, which results in easily generating the fungi having aresistance to a QoI fungicide that has acquired a gene mutation thatcauses a specific single amino acid substitution such as G143A in thecytochrome b gene of the target enzyme cytochrome bcl complex (seeNon-patent documents 2 to 4).

Soybean rust fungus (scientific name: Phakopsora pachyrhizi) is aphytopathogenic fungus that causes damages to soybeans. Since QoIfungicides have been widely used for controlling soybean rust disease asagricultural fungicides, an emergence of soybean rust fungi showing aresistance to the QoI fungicides has been reported (see Non-patentdocument 5).

For soybean rust fungus, a strain which has acquired a gene mutationcausing a single amino acid substitution of F129L in the same cytochromeb gene becomes a problem as a resistant fungus against QoI fungicide.The efficacy of the QoI fungicides conventionally used against soybeanrust fungi, that is, pyribencarb, pyraclostrobin, azoxystrobin,picoxystrpbin, orysastrobin, dimoxystrobin, metominostrobin, and theothers, has been reduced to the level of practical problems against theresistant fungi (see Non-patent document 6).

CITATION LIST Non-Patent Document

-   Non-Patent Document 1: Sauter, “Modern Crop Protection Compounds”,    Volume 2, Wiley-VCH Verlag, 2007, p. 457-495: the 13.2 Chapter,    Strobilurins and other complex III inhibitors;-   Non-Patent Document 2: “Journal of Biological Chemistry”, 1989,    Volume 264, no. 24, p. 14543-14548-   Non-Patent Document 3: “Genetics”, 1991, Volume 127, p. 335-343-   Non-Patent Document 4: “Current Genetics”, 2000, Volume 3, p.    148-155-   Non-Patent Document 5: “Pest Management Science”, 2014, Volume 70,    no. 3, p. 379-388-   Non-Patent Document 6: “Pesq. agropec. bras.” (Brasilia), 2016,    Volume 51, no. 5, p. 407-421

SUMMARY OF THE INVENTION Problems to be Solved by Invention

On the basis of these facts, the present invention aims to provide amethod for controlling soybean rust fungus having an amino acidsubstitution of F129L on mitochondrial cytochrome b protein.

Means to Solve Problems

The present invention is as follows.

[1] A method for controlling a soybean rust fungus having an amino acidsubstitution of F129L on mitochondrial cytochrome b protein, whichcomprises applying an effective amount of a compound represented byformula (I):

[wherein,

-   -   a combination of Q and E represents        a combination wherein    -   Q represents a group represented by Q1, or a group represented        by Q2,    -   E represents a C1-C6 chain hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group A, a C3-C6 cycloalkyl group which may be optionally        substituted with one or more substituents selected from Group B,        R⁴R⁵C═C(R⁶)—, R¹⁵—CR¹⁶R³⁶—O—N═C(R⁷)—, R⁸R⁹C═N—O—CH₂—,        R¹²O—N═C(R⁷)—C(R⁹)═N—O—CH₂—, R¹²C(O)—C(R⁹)═N—O—CH₂—,        R¹²C(═N—O—R⁷)—C(R⁹)═N—O—CH₂—, R³⁴R³⁵C═N—N═C(R¹⁰)—,        R¹²R⁹N—N═C(R⁷)—, R¹²SC(R⁷)═N—, R¹²SC(SR⁷)═N—, R¹²N═C(R⁷)—S—CH₂—,        R¹²N═C(SR⁷)—S—CH₂—, R¹²O—N═C(R⁷)—S—CH₂—, R¹²O—N═C(SR⁷)—S—CH₂—,        R¹²R⁹N—C(S)—O—CH₂—, or R¹⁴O—; or        a combination wherein    -   Q represents a group represented by Q3, a group represented by        Q4, a group represented by Q5, a group represented by Q6, a        group represented by Q7, or a group represented by Q8,    -   E represents a C1-C6 chain hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group A, a C3-C6 cycloalkyl group, a C5-C6 cycloalkenyl        group {the C3-C6 cycloalkyl group, and the C5-C6 cycloalkenyl        group may be optionally substituted with one or more        substituents selected from Group B}, a C6-C10 aryl group, a        five- to ten-membered aromatic heterocyclic group {the C6-C10        aryl group and the five- to ten-membered aromatic heterocyclic        group may be optionally substituted with one or more        substituents selected from Group D}, R⁴R⁵C═C(R⁶)—,        R¹³O—N═C(R⁷)—, R⁸R⁹C═N—O—CH₂—, R¹²O—N═C(R⁷)—C(R⁹)═N—O—CH₂—,        R¹²C(O)—C(R⁹)═N—O—CH₂—, R¹²C(═N—O—R⁷)—C(R⁹)═N—O—CH₂—,        R³⁴R³⁵C═N—N═C(R¹⁰)—, R¹²R⁹N—N═C(R⁷)—, R¹²SC(R⁷)═N—,        R¹²SC(SR⁷)═N—, R¹²N═C(R⁷)—S—CH₂—, R¹²N═C(SR⁷)—S—CH₂—,        R¹²O—N═C(R⁷)—S—CH₂—, R¹²O—N═C(SR⁷)—S—CH₂—, R¹²R⁹N—C(S)—O—CH₂—,        R¹⁹O—, R²⁰—C≡C—, or R¹⁸—N═C(R⁷)—,    -   each of the group represented by Q1, the group represented by        Q2, the group represented by Q3, the group represented by Q4,        the group represented by Q5, the group represented by Q6, the        group represented by Q7, and the group represented by Q8        represents the following group respectively (where • represents        a binding site to a benzene ring),

-   -   L¹, L² and L³ are identical to or different from each other and        represent an oxygen atom or NH,    -   Z¹ represents a single bond, CH₂, an oxygen atom or NCH₃,    -   Z² represents a methyl group which is substituted with one or        more fluorine atoms,    -   Z³ represents CH or a nitrogen atom,    -   R¹ represents a C1-C3 chain hydrocarbon group, a C1-C3 alkoxy        group {the C1-C3 chain hydrocarbon group, and the C1-C3 alkoxy        group may be optionally substituted with one or more halogen        atoms}, a cyclopropyl group, a halogen atom, or a hydrogen atom,    -   n is 0, 1, 2 or 3,    -   when n is 2 or 3, a plural of R² may be identical to or        different from each other,    -   R² represents a C1-C3 chain hydrocarbon group which may be        optionally substituted with one or more halogen atoms, or a        C1-C3 alkoxy group {the C1-C3 chain hydrocarbon group, and the        C1-C3 alkoxy group may be optionally substituted with one or        more halogen atoms}, a cyclopropyl group, or a halogen atom,    -   R³ represents a C1-C3 alkoxy group which may be optionally        substituted with one or more halogen atoms, or a C1-C3 chain        hydrocarbon group which may be optionally substituted with one        or more halogen atoms,    -   R⁴ and R⁶ are identical to or different from each other and        represent a C1-C3 chain hydrocarbon group which may be        optionally substituted with one or more halogen atoms, a        cyclopropyl group, a halogen atom, a cyano group, or a hydrogen        atom,    -   R⁵ represents a C1-C6 chain hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group A, a C3-C6 cycloalkyl group which may be optionally        substituted with one or more substituents selected from Group B,        a C6-C10 aryl group, a five- to ten-membered aromatic        heterocyclic group {the C6-C10 aryl group and the five- to        ten-membered aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        D}, a halogen atom, a cyano group, or a hydrogen atom,    -   R⁸, R¹², R¹³, R¹⁵, R¹⁸, R²⁰, and R³⁴ are identical to or        different from each other and represent a C1-C6 chain        hydrocarbon group which may be optionally substituted with one        or more substituents selected from Group A, a C3-C10 alicyclic        hydrocarbon group which may be optionally substituted with one        or more substituents selected from Group E, a C6-C10 aryl group,        or a five- to ten-membered aromatic heterocyclic group {the        C6-C10 aryl group and the five- to ten-membered aromatic        heterocyclic group may be optionally substituted with one or        more substituents selected from Group D},    -   R⁷, R⁹, R¹⁰ and R³⁵ are identical to or different from each        other and represent a C1-C3 chain hydrocarbon group which may be        optionally substituted with one or more halogen atoms, a        cyclopropyl group, or a hydrogen atom,    -   R⁴ and R⁵ may combine together with a carbon atom to which they        are attached to form a C3-C10 alicyclic hydrocarbon group or a        three- to ten-membered non-aromatic heterocyclic group {the        C3-C10 alicyclic hydrocarbon group and the three- to        ten-membered non-aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        E},    -   R⁸ and R⁹ may combine together with a carbon atom to which they        are attached to form a C3-C10 alicyclic hydrocarbon group or a        three- to ten-membered non-aromatic heterocyclic group {the        C3-C10 alicyclic hydrocarbon group and the three- to        ten-membered non-aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        E},    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form a C3-C10 alicyclic hydrocarbon group        or a three- to ten-membered non-aromatic heterocyclic group {the        C3-C10 alicyclic hydrocarbon group and the three- to        ten-membered non-aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        E},    -   R¹⁴ represents a C6-C10 aryl group, a five- to ten-membered        aromatic heterocyclic group {the C6-C10 aryl group and the five-        to ten-membered aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        D}, R¹⁷R⁷NC(S)—, R¹⁷O—C(O)—, or R¹⁷C(O)—,    -   R¹⁵ represents a C6-C10 aryl group, or a five- to ten-membered        aromatic heterocyclic group {the C6-C10 aryl group and the five-        to ten-membered aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        C},    -   R¹⁶ represents a C1-C3 chain hydrocarbon group which may be        optionally substituted with one or more halogen atoms, or a        cyclopropyl group,    -   R¹⁷ represents a C1-C6 chain hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group A, a C3-C6 cycloalkyl group which may be optionally        substituted with one or more substituents selected from Group B,        a C6-C10 aryl group, or a five- to ten-membered aromatic        heterocyclic group {the C6-C10 aryl group and the five- to        ten-membered aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        C},    -   R¹⁹ represents a C6-C10 aryl group, a five- to ten-membered        aromatic heterocyclic group {the C6-C10 aryl group and the five-        to ten-membered aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        D}, a methyl group which is substituted with one or more        substituents selected from Group F, a C2-C6 chain hydrocarbon        group which may be optionally substituted with one or more        substituents selected from Group F, a C3-C4 cycloalkyl group        which may be optionally substituted with one or more        substituents selected from Group B, R¹⁷R⁷NC(S)—, R¹⁷O—C(O)—,        R¹⁷C(O)—, or R¹⁷R⁷NC(O)—,    -   R³⁶ represents a C1-C3 chain hydrocarbon group which may be        optionally substituted with one or more halogen atoms, a        cyclopropyl group, or a hydrogen atom,    -   Group A is a group consisting of a C3-C6 cycloalkyl group {the        C3-C6 cycloalkyl group may be optionally substituted with one or        more substituents selected from Group B}, a C1-C4 alkoxy group,        a C1-C4 alkylthio group {the C1-C4 alkoxy group and the C1-C4        alkylthio group may be optionally substituted with one or more        substituents selected from Group F}, a halogen atom, a cyano        group, a nitro group, a hydroxy group, an oxo group, a thioxo        group, a phenoxy group, a C6-C10 aryl group, and a five- to        ten-membered aromatic heterocyclic group {the phenoxy group, the        C6-C10 aryl group and the five- to ten-membered aromatic        heterocyclic group may be optionally substituted with one or        more substituents selected from Group D},    -   Group B is a group consisting of a C1-C3 chain hydrocarbon group        which may be optionally substituted with one or more halogen        atoms, a halogen atom, and a cyano group.    -   Group C is a group consisting of a C1-C6 chain hydrocarbon        group, a C1-C6 alkoxy group, a C1-C6 alkylthio group {the C1-C6        chain hydrocarbon group, the C1-C6 alkoxy group and the C1-C6        alkylthio group may be optionally substituted with one or more        substituents selected from Group F}, a C3-C6 cycloalkyl group        {the C3-C6 cycloalkyl group may be optionally substituted with        one or more substituents selected from Group B}, a halogen atom,        a cyano group, a nitro group, and a hydroxy group,    -   Group D is a group consisting of a C1-C6 chain hydrocarbon group        which may be optionally substituted with one or more        substituents selected from Group F, a C3-C6 cycloalkyl group        which may be optionally substituted with one or more        substituents selected from Group B, a C1-C6 alkylthio group        which may be optionally substituted with one or more        substituents selected from Group F, OR¹¹, C(O)R¹¹, C(O)OR¹¹,        NR¹¹R⁷, C(R⁷)═N—OR¹¹, a phenyl group, a naphthyl group, a five-        to six-membered aromatic heterocyclic group {the phenyl group,        the naphthyl group, and the five- to six-membered aromatic        heterocyclic group may be optionally substituted with one or        more substituents selected from Group C}, a halogen atom, a        cyano group, and a nitro group,    -   R¹¹ represents a C1-C6 chain hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group A, a C3-C6 cycloalkyl group which may be optionally        substituted with one or more substituents selected from Group B,        a phenyl group, a naphthyl group, a five- to six-membered        aromatic heterocyclic group {the phenyl group, the naphthyl        group, and the five- to six-membered aromatic heterocyclic group        may be optionally substituted with one or more substituents        selected from Group C}, or a hydrogen atom,    -   Group E is a group consisting of an oxo group, a thioxo group, a        C1-C3 chain hydrocarbon group, a C1-C3 alkoxy group {the C1-C3        chain hydrocarbon group and the C1-C3 alkoxy group may be        optionally substituted with one or more halogen atoms}, a        halogen atom, and a cyano group,    -   Group F is a group consisting of a C3-C4 cycloalkyl group, a        halogen atom, and a C1-C3 alkoxy group](hereinafter, referred to        as “Present compound N”), or its N oxide or an agriculturally        acceptable salt thereof (hereinafter, Compound represented by        formula (I), or its N oxide or agriculturally acceptable salts        are referred to as “Present compound”).

[2] The method according to [1] wherein the compound represented byformula (I), or its N oxide or an agriculturally acceptable salt thereofrepresents a compound wherein

-   -   Q represents a group represented by Q1, a group represented by        Q2, a group represented by Q3, a group represented by Q4, a        group represented by Q5, a group represented by Q6, a group        represented by Q7, or a group represented by Q8,    -   E represents R⁴R⁵C═C(R⁶)—, R¹⁵—CR¹⁶R³⁶—O—N═C(R⁷)—,        R⁸R⁹C═N—O—CH₂—, R³⁴R³⁵C═N—N═C(R¹⁰)—, or R¹⁴O—,    -   R⁴ and R⁶ are identical to or different from each other and        represent a C1-C3 alkyl group, a halogen atom, or a hydrogen        atom,    -   R⁵ represents a C1-C6 chain hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group J, a C3-C6 cycloalkyl group which may be optionally        substituted with one or more halogen atoms, or a phenyl group        which may be optionally substituted with one or more        substituents selected from Group G,    -   R⁷, R⁹ and R³⁵ are identical to or different from each other and        represent a C1-C3 alkyl group, or a hydrogen atom,    -   R⁸ and R³⁴ are identical to or different from each other and        represent a phenyl group, an indanyl group, a tetrahydronaphthyl        group, or a five- to six-aromatic heterocyclic group {the phenyl        group, the indanyl group, the tetrahydronaphthyl group, and the        five- to six-aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        G},    -   R⁴ and R⁵ may combine together with a carbon atom to which they        are attached to form a C3-C10 alicyclic hydrocarbon group, or a        three- to ten-membered non-aromatic heterocyclic group {the        C3-C10 alicyclic hydrocarbon group and the three- to        ten-membered non-aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        E},    -   R⁸ and R⁹ may combine together with a carbon atom to which they        are attached to form a C3-C10 alicyclic hydrocarbon group or a        three- to ten-membered non-aromatic heterocyclic group {the        C3-C10 alicyclic hydrocarbon group and the three- to        ten-membered non-aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        E},    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form a C3-C10 alicyclic hydrocarbon group        or a three- to ten-membered non-aromatic heterocyclic group {the        C3-C10 alicyclic hydrocarbon group and the three- to        ten-membered non-aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        E},    -   R¹⁴ and R¹⁵ are identical to or different from each other and        represent a phenyl group, or a five- to six-membered aromatic        heterocyclic group {the a phenyl group and the five- to        six-membered aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        G},    -   R¹⁶ represents a C1-C3 alkyl group, and    -   R³⁶ represents a hydrogen atom,    -   Group G is a group consisting of a C1-C3 chain hydrocarbon        group, a C1-C3 alkoxy group {the C1-C3 chain hydrocarbon group        and the C1-C3 alkoxy group may be optionally substituted with        one or more halogen atoms}, a halogen atom, and a cyano group,    -   Group J is a group consisting of a halogen atom and a        cyclopropyl group,        or its N oxide or agriculturally acceptable salt thereof.

[3] The method according to [2] wherein the compound represented byformula (I), or its N oxide or an agriculturally acceptable salt thereofrepresents a compound wherein

-   -   E represents R¹⁵—CR¹⁶R³⁶—O—N═C(R⁷)—, R⁸R⁹C═N—O—CH₂—, or R¹⁴O—,    -   R⁷ and R⁸ are identical to or different from each other and        represent a C1-C3 alkyl group or a hydrogen atom,    -   R⁸, R¹⁴ and R¹⁵ are identical to or different from each other        and represent a phenyl group which may be optionally substituted        with one or more substituents selected from Group G,    -   R¹⁶ represents a C1-C3 alkyl group, and    -   R³⁶ represents a hydrogen atom,        or its N oxide or agriculturally acceptable salt thereof.

[4] The method according to [1] wherein the compound respected byformula (I) is a compound wherein

-   -   E represents R¹⁴O—,    -   R¹⁴ represents a thiazolyl group which may be optionally        substituted with one or more substituents selected from Group H,        or a thienyl group which may be optionally substituted with one        or more halogen atoms,    -   Group H is a group consisting of a C1-C3 chain hydrocarbon group        which may be optionally substituted with one or more        substituents selected from Group F, a C3-C6 cycloalkyl group, a        phenyl group {the C3-C6 cycloalkyl group and the phenyl group        may be optionally substituted with one or more halogen atoms},        and a halogen atom.

[5] The method according to any one of [1] to [4] wherein the compoundrepresented by formula (I), or its N oxide or an agriculturallyacceptable salt thereof represents a compound wherein

-   -   Q represents a group represented by Q1 or a group represented by        Q2,    -   R¹ represents a methyl group, or a halogen atom, and    -   n is 0,        or its N oxide or agriculturally acceptable salt thereof.

[6] The method according to any one of [1] to [4] wherein the compoundrepresented by formula (I), or its N oxide or an agriculturallyacceptable salt thereof represents a compound wherein

-   -   Q represents a group represented by Q1,    -   R¹ represents a methyl group, and    -   n is 0,        or its N oxide or agriculturally acceptable salt thereof.

[7] Use of the compound represented by formula (I) according to any oneof [1] to [6], or its N oxide or an agriculturally acceptable saltthereof, for controlling soybean rust fungus having an amino acidsubstitution of F129L on mitochondrial cytochrome b protein.

[8] A compound represented by formula (II):

[wherein

-   -   R¹ represents a methyl group,    -   Q represents a group represented by Q1 or a group represented by        Q2 (where • represents a binding site to a benzene ring),

-   -   L¹ represents an oxygen atom or NH,    -   E represents R³⁴R³⁵C═N—N═C(R¹⁰)—, R⁸R⁹C═N—O—CH₂—,        R¹⁵—CH(R¹⁶)—O—N═C(R⁷)—, or R¹⁹O—,    -   R³⁴ represents a C1-C6 chain hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group J, a C3-C10 alicyclic hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group E, a phenyl group, or a five- to six-membered        aromatic heterocyclic group {the phenyl group and the five- to        six-membered aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        G},    -   R⁹ and R³⁵ are identical to or different from each other and        represent a C1-C3 alkyl group, or a hydrogen atom,    -   R⁷, R¹⁰ and R¹⁶ are identical to or different from each other        and represent a C1-C3 alkyl group,    -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group G},    -   R⁸ and R⁹ may combine together with a carbon atom to which they        are attached to form a C3-C10 alicyclic hydrocarbon group or a        three- to ten-membered non-aromatic heterocyclic group {the        C3-C10 alicyclic hydrocarbon group and the three- to        ten-membered non-aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        E},    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form a C3-C10 alicyclic hydrocarbon group        or a three- to ten-membered non-aromatic heterocyclic group {the        C3-C10 alicyclic hydrocarbon group and the three- to        ten-membered non-aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        E},    -   R¹⁵ represents a phenyl group, or a five- to six-membered        aromatic heterocyclic group {the phenyl group and the five- to        six-membered aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        G},    -   R¹⁹ represents a phenyl group which is substituted at its        2-position with substituent(s) selected from Group L, a phenyl        group which is substituted at its 3-position with substituent(s)        selected from Group M, a phenyl group which is substituted at        its 4-position with substituent(s) selected from Group N, a        phenyl group which is substituted with two or more substituents        selected from Group P (where the two or more substituents        selected from Group P may be identical to or different from each        other), a pyridyl group which may be optionally substituted with        substituent(s) selected from Group P, a pyrazolyl group which        may be optionally substituted with substituent(s) selected from        Group G, or a pyrimidinyl group which may be optionally        substituted with substituent(s) selected from Group Q,    -   Group E is a group consisting of an oxo group, a thioxo group, a        C1-C3 chain hydrocarbon group, a C1-C3 alkoxy group {the C1-C3        chain hydrocarbon group and the C1-C3 alkoxy group may be        optionally substituted with one or more halogen atoms}, a        halogen atom, and a cyano group,    -   Group G is a group consisting of a C1-C3 chain hydrocarbon        group, a C1-C3 alkoxy group {the C1-C3 chain hydrocarbon group        and the C1-C3 alkoxy group may be optionally substituted with        one or more halogen atoms}, a halogen atom, and a cyano group,    -   Group J is a group consisting of a halogen atom and a        cyclopropyl group,    -   Group L is a group consisting of a C2-C4 chain hydrocarbon        group, a C1-C4 alkoxy group {the C2-C4 chain hydrocarbon group        and the C1-C4 alkoxy group may be optionally substituted with        one or more halogen atoms}, a cyclopropyl group, a halogen atom,        and a cyano group,    -   Group M is a group consisting of a C2-C3 chain hydrocarbon        group, a C2-C3 alkoxy group {the C2-C3 chain hydrocarbon group        and the C2-C3 alkoxy group may be optionally substituted with        one or more halogen atoms}, a trifluoromethyl group, a        cyclopropyl group, and a chlorine atom,    -   Group N is a group consisting of a C1-C3 alkyl group which is        substituted with one or more fluorine atoms, a methoxy group, a        cyclopropyl group, a halogen atom, and a cyano group,    -   Group P is a group consisting of a C2-C3 chain hydrocarbon        group, a C1-C3 alkoxy group {the C2-C3 chain hydrocarbon group        and the C1-C3 alkoxy group may be optionally substituted with        one or more halogen atoms}, a halogen atom, and a cyano group,    -   Group Q is a group consisting of a C1-C3 chain hydrocarbon group        which may be optionally substituted with one or more halogen        atoms, a C1-C3 alkoxy group, a halogen atom, and a cyano group]        (hereinafter, referred to as “Present compound C”), or its N        oxide or agriculturally acceptable salt thereof.

[9] The compound according to [8] wherein

-   -   E represents R¹⁹O—,    -   R¹⁹ represents a phenyl group which is substituted at its        2-position with substituent(s) selected from Group V, a phenyl        group which is substituted at its 4-position with substituent(s)        selected from Group V, a 3-chlorophenyl group, a phenyl group        which is substituted with two or more halogen atoms, or a        pyridyl group which may be optionally substituted with one or        more halogen atoms,    -   Group V is a group consisting of a halogen atom and a methoxy        group,        or its N oxide or agriculturally acceptable salt thereof.

[10] An agricultural composition which comprises the compound accordingto [8] or [9] or its N-oxide compound or an agriculturally acceptablesalt thereof and an inert carrier.

[11] The agricultural composition according to [10] which comprises oneor more ingredients selected from the group consisting of the followingGroups (a), (b), (c) and (d):

-   -   Group (a): a group consisting of insecticidal ingredients,        miticidal ingredients, and nematicidal ingredients;    -   Group (b): fungicidal ingredients:    -   Group (c): plant growth modulating ingredients; and    -   Group (d): repellent ingredients.

[12] A method for controlling a soybean rust fungus having an amino acidsubstitution of F129L on mitochondrial cytochrome b protein, whichcomprises applying an effective amount of a compound represented byformula (III):

[wherein

-   -   E³ represents R³⁹OCH₂—, R⁴⁰CH₂O—, R⁴¹S—, R⁴²SCH₂—, R⁴³CH₂S—, or        R⁴⁶O—,    -   Q represents a group represented by Q1, a group represented by        Q2, a group represented by Q3, a group represented by Q4, a        group represented by Q5, a group represented by Q6, a group        represented by Q7, or a group represented by Q8,    -   each of the group represented by Q1, the group represented by        Q2, the group represented by Q3, the group represented by Q4,        the group represented by Q5, the group represented by Q6, the        group represented by Q7, and the group represented by Q8        represents the following group respectively (where • represents        a binding site to a benzene ring),

-   -   L¹, L² and L³ are identical to or different from each other and        represent an oxygen atom, or NH,    -   Z¹ represents a single bond, CH₂, an oxygen atom or NCH₃,    -   Z² represents a methyl group which is substituted with one or        more fluorine atoms,    -   Z³ represents CH or a nitrogen atom,    -   R¹ represents a C1-C3 chain hydrocarbon group, a C1-C3 alkoxy        group {the C1-C3 chain hydrocarbon group, and the C1-C3 alkoxy        group may be optionally substituted with one or more halogen        atoms}, a cyclopropyl group, a halogen atom, or a hydrogen atom,    -   n is 0, 1, 2, or 3,    -   when n is 2 or 3, a plural of R² may be identical to or        different from each other,    -   R² represents a C1-C3 chain hydrocarbon group, a C1-C3 alkoxy        group {the C1-C3 chain hydrocarbon group, and the C1-C3 alkoxy        group may be optionally substituted with one or more halogen        atoms}, a cyclopropyl group, or a halogen atom,    -   R³⁹ represents a five- to ten-membered aromatic heterocyclic        group which may be optionally substituted with one or more        substituents selected from Group R,    -   R⁴⁰ represents a C6-C10 aryl group, or a five- to ten-membered        aromatic heterocyclic group {the C6-C10 aryl group, and the        five- to ten-membered aromatic heterocyclic group may be        optionally substituted with one or more substituents selected        from Group R},    -   R⁴¹ represents a C1-C6 chain hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group S, a C6-C10 aryl group, a five- to ten-membered        aromatic heterocyclic group {the C6-C10 aryl group, and the        five- to ten-membered aromatic heterocyclic group may be        optionally substituted with one or more substituents selected        from Group R}, or a C3-C6 cycloalkyl group which may be        optionally substituted with one or more substituents selected        from Group T,    -   R⁴² represents a C6-C10 aryl group, or a five- to ten-membered        aromatic heterocyclic group {the C6-C10 aryl group, and the        five- to ten-membered aromatic heterocyclic group may be        optionally substituted with one or more substituents selected        from Group R},    -   R⁴³ represents a C6-C10 aryl group, or a five- to ten-membered        aromatic heterocyclic group {the C6-C10 aryl group, and the        five- to ten-membered aromatic heterocyclic group may be        optionally substituted with one or more substituents selected        from Group R},    -   R⁴⁶ represents a C5-C6 cycloalkyl group which may be optionally        substituted with one or more substituents selected from Group T,    -   Group R is a group consisting of a C1-C6 chain hydrocarbon        group, a C1-C6 alkoxy group, a C1-C6 alkylthio group {the C1-C6        chain hydrocarbon group, the C1-C6 alkoxy group, and the C1-C6        alkylthio group may be optionally substituted with one or more        substituents selected from Group S}, a C3-C6 cycloalkyl group        which may be optionally substituted with one or more        substituents selected from Group T, a phenyl group, a five- to        six-membered aromatic heterocyclic group {the phenyl group, and        the five- to six-membered aromatic heterocyclic group may be        optionally substituted with one or more substituents selected        from Group U}, a halogen atom, a cyano group, and a nitro group,    -   Group S is a group consisting of a C3-C4 cycloalkyl group, a        halogen atom, and a C1-C3 alkoxy group,    -   Group T is a group consisting of a C1-C3 chain hydrocarbon group        which may be optionally substituted with one or more halogen        atoms, a halogen atom, and a cyano group,    -   Group U is a group consisting of a C1-C6 chain hydrocarbon        group, a C1-C6 alkoxy group, a C1-C6 alkylthio group {the C1-C6        chain hydrocarbon group, the C1-C6 alkoxy group, and the C1-C6        alkylthio group may be optionally substituted with one or more        substituents selected from Group S}, a C3-C6 cycloalkyl group        which may be optionally substituted with one or more        substituents selected from Group T, a halogen atom, a cyano        group, and a nitro group.](hereinafter, referred to as “Present        compound D”), or its N oxide or agriculturally acceptable salt        thereof.

[13] The method according to [12] wherein the compound represented byformula (III) is a compound wherein

-   -   E³ represents R³⁹OCH₂—, R⁴⁰CH₂O—, R⁴¹S—, R⁴²SCH₂—, or R⁴³CH₂S—,    -   R⁴¹ represents a C1-C6 chain hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group S, a C6-C10 aryl group, or a five- to ten-membered        aromatic heterocyclic group {the C6-C10 aryl group, and the        five- to ten-membered aromatic heterocyclic group may be        optionally substituted with one or more substituents selected        from Group R.}.

[14] Use of the compound represented by formula (III) according to [12]or [13], or its N oxide or an agriculturally acceptable salt thereof,for controlling soybean rust fungus having an amino acid substitution ofF129L on mitochondrial cytochrome b protein.

[15] A composition for controlling a plant disease, which comprises acompound represented by the following formula (IV) (hereinafter,referred to as “Present compound A”) and one or more of compoundsselected from Group (B) (hereinafter, referred to as “Present compoundB”) (hereinafter, a composition is referred to as “Present compositionof the present invention”),

-   -   a compound represented by formula (IV):

[wherein

-   -   E⁴ represents a phenyl group, a 2-methylphenyl group, a        3-methylphenyl group, a 4-methylphenyl group, a 3-fluorophenyl        group, a 3-methoxyphenyl group, a 3-(trifluoromethoxy)phenyl        group, a 3-phenoxyphenyl group, a 3-thienyl group, a 2-thiazolyl        group, a 4-(trifluoromethyl)thizol-2-yl group, a        5-chlorothiazol-2-yl group, a 5-bromothiazol-2-yl group, a        5-(trifluoromethyl)thiazol-2-yl group, a        5-cyclopropylthiazol-2-yl group, a 5-ethynylthiazol-2-yl group,        or a (5-cyclopropylethynyl)thiazol-2-yl group,    -   a combination of A⁴ and L⁴ represents a combination wherein    -   A⁴ represents CH, and L⁴ represents an oxygen atom; or        a combination wherein    -   A⁴ represents a nitrogen atom, and L⁴ represents NH.] Group (B)        is a group consisting of the following sub-groups (B-1), (B-2),        (B-3) and (B-4),    -   Sub-group (B-1) is a mitochondrial electron transport chain        complex III inhibitor, which consists of coumoxystrobin,        enoxastrobin, flufenoxystrobin, picoxystrobin, pyraoxystrobin,        pyraclostrobin, mandestrobin, pyrametostrobin, triclopyricarb,        trifloxystrobin, dimoxystrobin, fenaminstrobin, metominostrobin,        orysastrobin, fluoxastrobin, fenamidone, pyribencarb,        metyltetraprole, cyazofamid, amisulbrom, fenpicoxamid, and        florylpicoxamid,    -   Sub-group (B-2) is a mitochondrial electron transport chain        complex II inhibitor, which consists of bixafen, fluxapyroxad,        benzovindiflupyr, fluindapyr, pydiflumetofen,        3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide,        a compound represented by the following formula (1), a compound        represented by the following formula (2), and a compound        represented by the following formula (3),

-   -   Sub-group (B-3) is a sterol biosynthesis inhibitor, which        consists of prothioconazole and mefentrifluconazole,    -   Sub-group (B-4) is a group consisting of        3-(2-methylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate,        3-(4-fluoro-2-methylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate,        3-(4-methoxy-2-methylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate,        3-(2,4-dimethylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate,        3-(2-methylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate,        3-(4-fluoro-2-methylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate,        3-(4-methoxy-2-methylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate,        3-(2,4-dimethylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate,        3-(2-methylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate,        3-(4-fluoro-2-methylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate,        3-(4-methoxy-2-methylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate, and        3-(2,4-dimethylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate.

[16] The composition for controlling a plant disease according to [15],wherein the compound represented by formula (IV) is a compound wherein

-   -   E⁴ represents a phenyl group, a 2-methylphenyl group, a        3-methylphenyl group, a 4-methylphenyl group, a 3-fluorophenyl        group, a 3-methoxyphenyl group, a 3-(trifluoromethoxy)phenyl        group, or a 3-phenoxyphenyl group, and    -   Group (B) is a group consisting of the sub-group (B-1), the        sub-group (B-2), and the sub-group (B-3).

[17] The composition for controlling a plant disease according to [16]wherein the compound represented by formula (IV) is

a compound wherein

-   -   A⁴ represents CH, L⁴ represents an oxygen atom, E⁴ represents a        phenyl group, a 2-methylphenyl group, a 3-methylphenyl group, a        4-methylphenyl group, a 3-fluorophenyl group, a 3-methoxyphenyl        group, a 3-(trifluoromethoxy)phenyl group, or a 3-phenoxyphenyl        group, or        a compound wherein    -   A⁴ represents a nitrogen atom, L⁴ represents NH, and E⁴        represents a 2-methylphenyl group, or a 3-fluorophenyl group.

[18] The composition for controlling a plant disease according to [16]or [17] wherein in the Group (B),

-   -   the sub-group (B-1) is a group consisting of pyraclostrobin,        picoxystrobin, metyltetraprole, fenpicoxamid, and        florylpicoxamid, and    -   the sub-group (B-2) is a group consisting of fluxapyroxad,        benzovindiflupyr, fluindapyr, pydiflumetofen,        3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide,        the compound represented by formula (1), the compound        represented by formula (2), and the compound represented by        formula (3),

-   -   the sub-group (3) is a group consisting of prothioconazole and        mefentrifluconazole.

[19] The composition for controlling a plant disease according to anyone of [15] to [18] wherein the weight ratio of the compound representedby formula (IV) to one or more compounds selected from Group (B) iswithin a range of 1:0.01 to 1:100.

[20] The composition for controlling a plant disease according to anyone of [15] to [18] wherein a weight ratio of the compound representedby formula (IV) to one of more compounds selected from Group (B) iswithin a range of 1:0.1 to 1:10.

[21] A method for controlling a plant disease which comprises applyingan effective amount of the composition for controlling a plant diseaseaccording to any one of [15] to [20] to a plant or soil where a plant iscultivated.

[22] Use of any one of the composition for controlling a plant diseaseaccording to any one of [15] to [20].

Effect of Invention

The present invention can control soybean rust fungus having an aminoacid substitution of F129L on mitochondrial cytochrome b protein.

MODE FOR CARRYING OUT THE INVENTION

The substituent(s) as described herein is/are explained.

The term “halogen atom” represents fluorine atom, chlorine atom, bromineatom, or iodine atom.

When the substituent has two or more halogen atoms, these halogen atomsmay be identical to or different from each other.

The expression of “CX-CY” as used herein represents that the number ofcarbon atom is from X to Y. For example, the expression of “C1-C6”represents that the number of carbon atom is from 1 to 6.

The term “chain hydrocarbon group” represents an alkyl group, an alkenylgroup, or an alkynyl group.

Examples of the “alkyl group” include methyl group, ethyl group, propylgroup, isopropyl group, 1,1-dimethylpropyl group, 1,2-dimethylpropylgroup, 1-ethylpropyl group, butyl group, sec-butyl group, tert-butylgroup, pentyl group, and hexyl group.

Examples of the “alkenyl group” include vinyl group, 1-propenyl group,2-propenyl group, 1-methyl-1-propenyl group, 1-methyl-2-propenyl group,1,2-dimethyl-1-propenyl group, 1-ethyl-2-propenyl group, 3-butenylgroup, 4-pentenyl group, and 5-hexenyl group.

Examples of the “alkynyl group” include ethynyl group, 1-propynyl group,2-propynyl group, 1-methyl-2-propynyl group, 1,1-dimethyl-2-propynylgroup, 1-ethyl-2-propynyl group, 2-butynyl group, 4-pentynyl group, and5-hexynyl group.

Examples of the “alkoxy group” include methoxy group, ethoxy group,propoxy group, isopropoxy group, butoxy group, tert-butoxy group,pentyloxy group, and hexyloxy group.

Examples of the “alkylthio group” includes methylthio group, ethylthiogroup, propylthio group, isopropylthio group, butylthio group,pentylthio group, and hexylthio group.

Examples of the “alicyclic hydrocarbon group” include cycloalkyl groupand cycloalkenyl group.

Examples of the “cycloalkyl group” include cyclopropyl group, cyclobutylgroup, cyclopentyl group, cyclohexyl group, bicyclo[6.5.0]nonyl group,and bicyclo[6.6.0]decyl group.

Examples of the “cycloalkenyl group” include cyclopentenyl group, andcyclohexenyl group. Also the cycloalkenyl group may be fused by abenzene ring, and includes, for example, indanyl group andtetrahydronaphthyl group.

Examples of the “aryl group” include phenyl group, and naphthyl group.

Examples of the “aromatic heterocyclic group” include five-memberedaromatic heterocyclic group such as pyrrolyl group, furanyl group,thienyl group, pyrazolyl group, imidazolyl group, triazolyl group,tetrazolyl group, oxazolyl group, isoxazolyl group, thiazolyl group,isothiazolyl group, oxadiazolyl group, and thiadiazolyl group and so on;six-membered aromatic heterocyclic group such as pyridyl group,pyridazinyl group, pyrimidinyl group, pyrazinyl group, triazinyl group,and tetrazinyl group and so on; nine-membered aromatic heterocyclicgroup such as indazolyl group, indolidinyl group, imidazopyridyl groupand so on; and ten-membered aromatic heterocyclic group such as quinolylgroup, isoquinolyl group, quinazolinyl group, naphthylidinyl group, andbenzopyranyl group and so on.

Examples of the “non-aromatic heterocyclic group” include aziridinylgroup, oxiranyl group, thiranyl group, azetidinyl group, oxetanyl group,thietanyl group, pyrrolidinyl group, tetrahydrofuranyl group,tetrahydrothienyl group, pyrazolynyl group, pyrazolidinyl group,imidazolinyl group, imidazolidinyl group, oxazolinyl group, thiazolinylgroup, oxazolidinyl group, thiazolidinyl group, isoxazolinyl group,isoxazolidinyl group, isothiazolynyl group, isothiazolidinyl group,dioxolanyl group, dioxanyl group, piperidyl group, piperazinyl group,morpholinyl group, thiomorpholinyl group, pyranyl group, dihydropyranylgroup, tetrahydropyranyl group, azepanyl group, oxepanyl group,thiepanyl group, dihydrobenzofuranyl group, 1,3-benzodioxolyl group, anda dihydrobenzopyranyl group.

The term(s) as described herein is/are explained.

The term of “soybean rust fungus having an amino acid substitution ofF129L on mitochondrial cytochrome b protein” represents soybean rustfungus (scientific name: Phakopsora pachyrhizi) which shows a resistanceagainst QoI fungicide by having a mutation in the mitochondrialcytochrome b gene encoding mitochondrial cytochrome protein and as aresult of the mutation, causing amino acid substitution of F129L.

The present compound N, the present compound C, the present compound D,and the present compound A may be existed as one or more stereoisomers.Examples of the stereoisomer include enantiomer, diastereoisomer,atropisomer, and geometric isomer. Each stereoisomer, and stereoisomermixture(s) in an arbitrary ratio of the present compound N, the presentcompound C, the present compound D, and the present compound A areincluded.

Examples of the geometric isomer include the following structures.

Examples of the agriculturally acceptable salt thereof include acidaddition salts such as hydrochloride salts, sulfates, nitrates,phosphates, sulfonates, acetates, and benzoates.

Examples of the embodiment of the present compound N include thefollowing compounds.

[Embodiment 1] The present compound N wherein E represents R²⁰—C≡C—, R²⁰represents a C1-C6 chain hydrocarbon group which may be optionallysubstituted with one or more substituents selected from Group F, or aC3-C6 cycloalkyl group which may be optionally substituted with one ormore halogen atoms.

[Embodiment 2] The present compound N wherein E represents R²⁰—C≡C—, R²⁰represents a C1-C6 chain hydrocarbon group which may be optionallysubstituted with one or more halogen atoms, or a C3-C4 cycloalkyl groupwhich may be optionally substituted with one or more halogen atoms.

[Embodiment 3] The present compound N wherein E represents R²⁰—C≡C—, R²⁰represents a C1-C6 chain hydrocarbon group, or a C3-C4 cycloalkyl group.

[Embodiment 4] The present compound N wherein E represents R²⁰—C≡C—, R²⁰represents a C1-C6 chain hydrocarbon group, or a cyclopropyl group.

[Embodiment 5] The present compound N wherein E represents a phenylgroup which may be optionally substituted with one or more substituentsselected from Group D.

[Embodiment 6] The present compound N wherein E represents a phenylgroup which may be optionally substituted with one or more substituentsselected from Group J1, and

-   -   Group J1 is a group consisting of a C1-C3 alkyl group, a C1-C3        alkoxy group {the C1-C3 alkyl group and the C1-C3 alkoxy group        may be optionally substituted with one or more halogen atoms}, a        halogen atom, a cyano group, and C(R⁷)═N—OR¹¹.

[Embodiment 7] The present compound N wherein E represents a grouprepresented by formula (V)

[wherein

-   -   R²⁴ and R²⁸ are identical to or different from each other and        represent a halogen atom, or a hydrogen atom,    -   R²⁵ and R²⁷ are identical to or different from each other and        represent a C1-C3 alkyl group which may be optionally        substituted with one or more halogen atoms, a C1-C3 alkoxy group        which may be optionally substituted with one or more halogen        atoms, C(O) R^(11X), C(R^(7X))═N—OR^(11X), a halogen atom, a        cyano group, or a hydrogen atom,    -   R^(7x) and R^(11x) are identical to or different from each other        and represent a C1-C3 alkyl group, and    -   R²⁶ represents a C1-C3 alkyl group which may be optionally        substituted with one or more halogen atoms, a C1-C3 alkoxy group        which may be optionally substituted with one or more halogen        atoms, a halogen atom, or a hydrogen atom.

[Embodiment 8] The present compound according to Embodiment 7 whereinR²⁴, R²⁶ and R²⁸ are identical to or different from each other andrepresent a fluorine atom or a hydrogen atom,

-   -   R²⁵ and R²⁷ are identical to or different from each other and        represent C(R^(7X))═N—OR^(11X), a halogen atom, a cyano group,        or a hydrogen atom.

[Embodiment 9] The present compound N wherein E represents a five- tosix-membered aromatic heterocyclic group which may be optionallysubstituted with one or more substituents selected from Group D.

[Embodiment 10] The present compound N wherein E represents a pyridylgroup which may be optionally substituted with one or more substituentsselected from Group J2, or a pyrimidinyl group which may be optionallysubstituted with one or more substituents selected from Group K,

-   -   Group J2 is a group consisting of a C1-C3 alkyl group, a C1-C3        alkoxy group {the C1-C3 alkyl group and the C1-C3 alkoxy group        may be optionally substituted with one or more halogen atoms}, a        halogen atom, and C(R^(7X))═N—OR^(11Y),    -   R^(11Y) represents a C1-C6 chain hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group F, and    -   Group K is a group consisting of a C1-C3 alkyl group which may        be optionally substituted with one or more halogen atoms, a        phenoxy group which may be optionally substituted with one or        more substituents selected from Group G, and a halogen atom.

[Embodiment 11] The present compound N wherein E represents a pyridylgroup which may be optionally substituted with one or more substituentsselected from Group J3, or a pyrimidinyl group which may be optionallysubstituted with one or more substituents selected from Group K1,

-   -   Group J3 is a group consisting of a C1-C3 alkyl group, a C1-C3        alkoxy group {the C1-C3 alkyl group and the C1-C3 alkoxy group        may be optionally substituted with one or more halogen atoms},        and a halogen atom,    -   Group K1 is a group consisting of a C1-C3 alkyl group which may        be optionally substituted with one or more halogen atoms, a        phenoxy group which may be optionally substituted with one or        more substituents selected from Group G, and a halogen atom,    -   Group G1 is a group consisting of a cyano group and a halogen        atom.

[Embodiment 12] The present compound N wherein E represents a thienylgroup, a furanyl group, a thiadiazolyl group, or a pyrazolyl group {thethienyl group, the furanyl group, the thiadiazolyl group, and thepyrazolyl group may be optionally substituted with one or moresubstituents selected from Group J4},

-   -   Group J4 is a group consisting of a C1-C6 chain hydrocarbon        group which may be optionally substituted with one or more        substituents selected from Group F, and a C1-C6 alkoxy group        which may be optionally substituted with one or more halogen        atoms, and a halogen atom.

[Embodiment 13] The present compound N wherein E represents a thienylgroup, a furanyl group, a thiadiazolyl group, or a pyrazolyl group {thethienyl group, the furanyl group, the thiadiazolyl group, and thepyrazolyl group may be optionally substituted with one or moresubstituents selected from Group J5}, and

-   -   Group J5 is a group consisting of a C1-C6 chain hydrocarbon        group which may be optionally substituted with one or more        substituents selected from Group F, and a halogen atom.

[Embodiment 14] The present compound N wherein E represents a grouprepresented by formula (IV-1), a group represented by formula (IV-2), agroup represented by formula (IV-3), a group represented by formula(IV-4), a group represented by formula (IV-5), a group represented byformula (IV-6), or a group represented by formula (IV-7),

-   -   R³⁶ and R³⁷ are identical to or different from each other and        represent a C1-C3 chain hydrocarbon group which may be        optionally substituted with one or more halogen atoms, a halogen        atom, or a hydrogen atom,    -   R³⁸ represents a C1-C3 chain hydrocarbon group which may be        optionally substituted with one or more halogen atoms, or a        hydrogen atom, and    -   A represents a phenyl group, or a pyridyl group {the phenyl        group and the pyridyl group may be optionally substituted with        one or more substituents selected from Group G}.

[Embodiment 15] The present compound N wherein E represents a grouprepresented by formula (IV-1), a group represented by formula (IV-2), ora group represented by formula (IV-3), and A represents a phenyl groupwhich may be optionally substituted with one or more halogen atoms.

[Embodiment 16] The present compound N wherein E represents a pyridylgroup which may be optionally substituted with one or more substituentsselected from Group J2, a pyrimidinyl group which may be optionallysubstituted with one or more substituents selected from Group K, athienyl group, a furanyl group, a thiadiazolyl group, a pyrazolyl group{the thienyl group, the furanyl group, the thiadiazolyl group, and thepyrazolyl group may be optionally substituted with one or moresubstituents selected from Group J4}, a group represented by formula(IV-1), a group represented by formula (IV-2), a group represented byformula (IV-3), a group represented by formula (IV-4), a grouprepresented by formula (IV-5), a group represented by formula (IV-6), ora group represented by formula (IV-7). [Embodiment 17] The presentcompound N wherein E represents a pyridyl group which may be optionallysubstituted with one or more substituents selected from Group J3, apyrimidinyl group which may be optionally substituted with one or moresubstituents selected from Group K1, a thienyl group, a furanyl group, athiadiazolyl group, a pyrazolyl group {the thienyl group, the furanylgroup, the thiadiazolyl group, and the pyrazolyl group may be optionallysubstituted with one or more substituents selected from Group J5}, agroup represented by formula (IV-1), a group represented by formula(IV-2), or a group represented by formula (IV-3), and A represents aphenyl group which may be optionally substituted with one or morehalogen atoms.

[Embodiment 18] The present compound N wherein E representsR¹³O—N═C(R⁷)—, R⁷ represents a C1-C3 alkyl group, or a hydrogen atom,R¹³ represents a C1-C6 chain hydrocarbon group which may be optionallysubstituted with one or more substituents selected from Group F, a C3-C6cycloalkyl group which may be optionally substituted with one or morehalogen atoms, a phenyl group, a five- to six-membered aromaticheterocyclic group {the phenyl group and the five- to six-memberedaromatic heterocyclic group may be optionally substituted with one ormore substituents selected from Group G}, or R¹⁸—CH₂—, R¹⁸ represents aphenyl group, or a five- to six-membered aromatic heterocyclic group{the phenyl group and the five- to six-membered aromatic heterocyclicgroup may be optionally substituted with one or more substituentsselected from Group G}.

[Embodiment 19] The present compound N wherein E representsR¹⁵—CH₂—O—N═C(R⁷)—, R⁷ represents a C1-C3 alkyl group, or a hydrogenatom, R¹⁵ represents a C1-C6 chain hydrocarbon group which may beoptionally substituted with one or more substituents selected from GroupF, a C3-C4 cycloalkyl group which may be optionally substituted with oneor more halogen atoms, or R¹⁸—CH₂—, and R¹⁸ represents a phenyl groupwhich may be optionally substituted with one or more substituentsselected from Group G.

[Embodiment 20] The present compound N wherein E representsR¹⁵—CH₂—O—N═C(R⁷)—, R⁷ represents a methyl group, or a hydrogen atom,R¹⁵ represents a C1-C4 alkyl group which may be optionally substitutedwith one or more substituents selected from Group F, a C1-C4 alkyl groupwhich may be optionally substituted with one or more substituentsselected from Group F, a C3-C4 cycloalkyl group, or R¹⁸—CH₂—, and R¹⁸represents a phenyl group {the phenyl group may be optionallysubstituted with one or more substituents selected from a C1-C3 alkylgroup which may be optionally substituted with one or more halogen atomsand a halogen atom}.

[Embodiment 21] The present compound N wherein E represents R¹⁹O—, andR¹⁹ represents a C2-C6 chain hydrocarbon group which may be optionallysubstituted with one or more substituents selected from Group F, a C3-C4cycloalkyl group which may be optionally substituted with one or morehalogen atoms, or R¹⁷R⁷NC(O)—.

[Embodiment 22] The present compound N wherein E represents R¹⁹O—, andR¹⁹ represents a C2-C6 chain hydrocarbon group which may be optionallysubstituted with one or more halogen atoms.

[Embodiment 23] The present compound N wherein E represents R¹⁹O—, andR¹⁹ represents a C2-C6 chain hydrocarbon group.

[Embodiment 24] The present compound N wherein E represents, and R¹⁹represents a C2-C6 alkyl group.

[Embodiment 25] The present compound N wherein E represents a C5-C6cycloalkenyl group which may be optionally substituted with one or moresubstituents selected from Group B.

[Embodiment 26] The present compound N wherein E represents a C5-C6cycloalkenyl group which may be optionally substituted with one or morehalogen atoms.

[Embodiment 27] The present compound N wherein E represents a C5-C6cycloalkenyl group.

[Embodiment 28] The present compound N wherein E represents a phenylgroup which may be optionally substituted with one or more substituentsselected from Group D, or a five- to six-membered aromatic heterocyclicgroup which may be optionally substituted with one or more substituentsselected from Group D.

[Embodiment 29] The present compound N wherein E represents a phenylgroup which may be optionally substituted with one or more substituentsselected from Group J1, a pyridyl group which may be optionallysubstituted with one or more substituents selected from Group J2, apyrimidinyl group which may be optionally substituted with one or moresubstituents selected from Group K, a thienyl group, a furanyl group, athiadiazolyl group, a pyrazolyl group {the a thienyl group, the furanylgroup, the thiadiazolyl group, and the pyrazolyl group may be optionallysubstituted with one or more substituents selected from Group J4}, agroup represented by formula (IV-1), a group represented by formula(IV-2), a group represented by formula (IV-3), a group represented byformula (IV-4), a group represented by formula (IV-5), a grouprepresented by formula (IV-6), or a group represented by formula (IV-7).

[Embodiment 30] The present compound N wherein E represents a phenylgroup which may be optionally substituted with one or more substituentsselected from Group J1, a pyridyl group which may be optionallysubstituted with one or more substituents selected from Group J3, apyrimidinyl group which may be optionally substituted with one or moresubstituents selected from Group K1, a thienyl group, a furanyl group, athiadiazolyl group, a pyrazolyl group {the a thienyl group, the furanylgroup, the thiadiazolyl group, and the pyrazolyl group may be optionallysubstituted with one or more substituents selected from Group J5}, agroup represented by formula (IV-1), a group represented by formula(IV-2), or a group represented by formula (IV-3), and A represents aphenyl group which may be optionally substituted with one or morehalogen atoms.

[Embodiment 31] The present compound N wherein E represents a grouprepresented by formula (V), a pyridyl group which may be optionallysubstituted with one or more substituents selected from Group J3, apyrimidinyl group which may be optionally substituted with one or moresubstituents selected from Group K1, a thienyl group, a furanyl group, athiadiazolyl group, a pyrazolyl group {the thienyl group, the furanylgroup, the thiadiazolyl group, and the pyrazolyl group may be optionallysubstituted with one or more substituents selected from Group J5}, agroup represented by formula (IV-1), a group represented by formula(IV-2), or a group represented by formula (IV-3), and A represents aphenyl group which may be optionally substituted with one or morehalogen atoms.

[Embodiment 32] The present compound N wherein R²⁴, R²⁶ and R²⁸ areidentical to or different from each other and represent a fluorine atom,or a hydrogen atom, and R²⁵ and R²⁷ are identical to or different fromeach other and represent C(R^(7X))═N—OR^(11X), a halogen atom, a cyanogroup, or a hydrogen atom.

[Embodiment 33] The present compound N wherein E represents a phenylgroup which may be optionally substituted with one or more substituentsselected from Group D, a five- to six-membered aromatic heterocyclicgroup which may be optionally substituted with one or more substituentsselected from Group D, or R²⁰—C≡C—, and R²⁰ represents a C1-C6 chainhydrocarbon group which may be optionally substituted with one or moresubstituents selected from Group, or a C3-C6 cycloalkyl group which maybe optionally substituted with one or more halogen atoms.

[Embodiment 34] The present compound N wherein E represents a phenylgroup which may be optionally substituted with one or more substituentsselected from Group J1, a five- to six-membered aromatic heterocyclicgroup which may be optionally substituted with one or more substituentsselected from Group I, or R²⁰—C≡C—, and R²⁰ represents a C1-C6 chainhydrocarbon group, or C3-C4 cycloalkyl group.

[Embodiment 35] The present compound N wherein E represents a phenylgroup which may be optionally substituted with one or more substituentsselected from Group J1, a pyridyl group which may be optionallysubstituted with one or more substituents selected from Group J2, apyrimidinyl group which may be optionally substituted with one or moresubstituents selected from Group K, a thienyl group, a furanyl group, athiadiazolyl group, a pyrazolyl group {the a thienyl group, the furanylgroup, the thiadiazolyl group, and the pyrazolyl group may be optionallysubstituted with one or more substituents selected from Group J4}, agroup represented by formula (IV-1), a group represented by formula(IV-2), a group represented by formula (IV-3), a group represented byformula (IV-4), a group represented by formula (IV-5), a grouprepresented by formula (IV-6), a group represented by formula (IV-7), orR²⁰—C≡C—, and R²⁰ represents a C1-C6 chain hydrocarbon group, or a C3-C4cycloalkyl group.

[Embodiment 36] The present compound N wherein E represents a phenylgroup which may be optionally substituted with one or more substituentsselected from Group J1, a pyridyl group which may be optionallysubstituted with one or more substituents selected from Group J3, apyrimidinyl group which may be optionally substituted with one or moresubstituents selected from Group K1, a thienyl group, a furanyl group, athiadiazolyl group, a pyrazolyl group {the a thienyl group, the furanylgroup, the thiadiazolyl group, and the pyrazolyl group may be optionallysubstituted with one or more substituents selected from Group J5}, agroup represented by formula (IV-1), a group represented by formula(IV-2), a group represented by formula (IV-3), or R²⁰—C≡C—, R²⁰represents a C1-C6 alkyl group, or a cyclopropyl group, and A representsa phenyl group which may be optionally substituted with one or morehalogen atoms.

[Embodiment 37] The present compound N wherein E represents a grouprepresented by formula (V), a pyridyl group which may be optionallysubstituted with one or more substituents selected from Group J3, apyrimidinyl group which may be optionally substituted with one or moresubstituents selected from Group K1, a thienyl group, a furanyl group, athiadiazolyl group, a pyrazolyl group {the thienyl group, the furanylgroup, the thiadiazolyl group, and the pyrazolyl group may be optionallysubstituted with one or more substituents selected from Group J5}, agroup represented by formula (IV-1), a group represented by formula(IV-2), a group represented by formula (IV-3), or R²⁰—C≡C—, R²⁰represents a C1-C6 alkyl group, or a cyclopropyl group, and A representsa phenyl group which may be optionally substituted with one or morehalogen atoms.

[Embodiment 38] The compound according to [Embodiment 37] wherein R²⁴,R²⁶ and R²⁸ are identical to or different from each other and representa fluorine atom or a hydrogen atom, and R²⁵ and R²⁷ are identical to ordifferent from each other and represent C(R^(7X))═N—OR^(11X), a halogenatom, a cyano group, or a hydrogen atom.

[Embodiment 39] The present compound N wherein E represents a phenylgroup which may be optionally substituted with one or more substituentsselected from Group D, a five- to six-membered aromatic heterocyclicgroup which may be optionally substituted with one or more substituentsselected from Group D, a C5-C6 cycloalkenyl group which may beoptionally substituted with one or more substituents selected from GroupD, or R²⁰—C≡C—, and R²⁰ represents a C1-C6 chain hydrocarbon group whichmay be optionally substituted with one or more substituents selectedfrom Group F, or a C3-C6 cycloalkyl group which may be optionallysubstituted with one or more halogen atoms.

[Embodiment 40] The present compound N wherein E represents a phenylgroup which may be optionally substituted with one or more substituentsselected from Group J1, a pyridyl group which may be optionallysubstituted with one or more substituents selected from Group J2, apyrimidinyl group which may be optionally substituted with one or moresubstituents selected from Group K, a thienyl group, a furanyl group, athiadiazolyl group, a pyrazolyl group {the thienyl group, the furanylgroup, the thiadiazolyl group, and the pyrazolyl group may be optionallysubstituted with one or more substituents selected from Group J4}, agroup represented by formula (IV-1), a group represented by formula(IV-2), a group represented by formula (IV-3), a group represented byformula (IV-4), a group represented by formula (IV-5), a grouprepresented by formula (IV-6), a group represented by formula (IV-7), aC5-C6 cycloalkenyl group, or R²⁰—C≡C—, and R²⁰ represents a C1-C6 chainhydrocarbon group, or a C3-C4 cycloalkyl group.

[Embodiment 41] The present compound N wherein E represents a phenylgroup which may be optionally substituted with one or more substituentsselected from Group J1, a pyridyl group which may be optionallysubstituted with one or more substituents selected from Group J3, apyrimidinyl group which may be optionally substituted with one or moresubstituents selected from Group K1, a thienyl group, a furanyl group, athiadiazolyl group, a pyrazolyl group {the thienyl group, the furanylgroup, the thiadiazolyl group, and the pyrazolyl group may be optionallysubstituted with one or more substituents selected from Group J5}, agroup represented by formula (IV-1), a group represented by formula(IV-2), a group represented by formula (IV-3), a C5-C6 cycloalkenylgroup, or R²⁰—C≡C—, R²⁰ represents a C1-C6 alkyl group, or a cyclopropylgroup, and A represents a phenyl group which may be optionallysubstituted with one or more halogen atoms.

[Embodiment 42] The present compound N wherein E represents a grouprepresented by formula (V), a pyridyl group which may be optionallysubstituted with one or more substituents selected from Group J3, apyrimidinyl group which may be optionally substituted with one or moresubstituents selected from Group K1, a thienyl group, a furanyl group, athiadiazolyl group, a pyrazolyl group {the thienyl group, the furanylgroup, the thiadiazolyl group, and the pyrazolyl group may be optionallysubstituted with one or more substituents selected from Group J5}, agroup represented by formula (IV-1), a group represented by formula(IV-2), a group represented by formula (IV-3), a C5-C6 cycloalkenylgroup, or R²⁰—C≡C—, R²⁰ represents a C1-C6 alkyl group, or a cyclopropylgroup, and A represents a phenyl group which may be optionallysubstituted with one or more halogen atoms.

[Embodiment 43] The compound according to [Embodiment 42] wherein R²⁴,R²⁵, and R²⁶ are identical to or different from each other and representa fluorine atom or a hydrogen atom, R²⁵ and R²⁷ are identical to ordifferent from each other and represent C(R^(7X))═N—OR^(11X), a halogenatom, a cyano group, or a hydrogen atom.

[Embodiment 44] The present compound N wherein E represents a C1-C6alkyl group which may be optionally substituted with one or more halogenatoms, a cyclopropyl group which may be optionally substituted with oneor more substituents selected from Group B, or R⁴R⁵C═C(R⁶)—, R⁴ and R⁶are identical to or different from each other and represent a C1-C3alkyl group, a halogen atom, or a hydrogen atom, and R⁵ represents aC1-C6 chain hydrocarbon group which may be optionally substituted withone or more substituents selected from Group J, or a C3-C6 cycloalkylgroup which may be optionally substituted with one or more halogenatoms.

[Embodiment 45] The present compound N wherein E representsR⁴R⁵C═C(R⁶)—, R⁴ and R⁶ represent a hydrogen atom, R⁵ represents a C1-C6chain hydrocarbon group which may be optionally substituted with one ormore substituents selected from Group J, or a C3-C6 cycloalkyl groupwhich may be optionally substituted with one or more halogen atoms.

[Embodiment 46] The present compound N wherein E representsR⁴R⁵C═C(R⁶)—, R⁴ and R⁶ represent a hydrogen atom, R⁵ represents a C1-C6chain hydrocarbon group, or a C3-C4 cycloalkyl group.

[Embodiment 47] The present compound N wherein E represents a R¹⁹O—, andR¹⁹ represents a phenyl group, or a five- to six-membered aromaticheterocyclic group {the phenyl group, and the five- to six-memberedaromatic heterocyclic group may be optionally substituted with one ormore substituents selected from Group G}.

[Embodiment 48] The present compound N wherein E represents R¹⁹O—, andR¹⁹ represents a phenyl group which may be optionally substituted withone or more substituents selected from Group G.

[Embodiment 49] The present compound N wherein E represents R¹⁹O—, andR¹⁹ represents a phenyl group which is substituted with one or moresubstituents selected from a halogen atom and a methyl group {with theproviso that a 2-methyl phenyl group, a 3-methylphenyl group, a4-methylphenyl group, a 3,5-dimethylphenyl group, a 3-fluorophenylgroup, a 3-bromophenyl group, and a 3-iodophenyl group are excluded}.

[Embodiment 50] The present compound N wherein E represents R¹⁹O—, andR¹⁹ represents a phenyl group which is substituted with one or morechlorine atoms.

[Embodiment 51] The present compound N wherein E represents R¹⁹O—, andR¹⁹ represents a phenyl group which is substituted with one or morefluorine atoms {with the proviso that a 3-fluorophenyl group isexcluded}.

[Embodiment 52] The present compound N wherein E represents R¹⁹O—, andR¹⁹ represents a phenyl group which is substituted at its 2-positionwith a halogen atom, a phenyl group which is substituted at its4-position with a halogen atom, a phenyl group which is substituted withtwo or more halogen atoms, or a 3-chlorophenyl group.

[Embodiment 53] The present compound N wherein E represents R¹⁹O—, andR¹⁹ represents a phenyl group which is substituted at its 2-positionwith a halogen atom.

[Embodiment 54] The present compound N wherein E represents R¹⁹O—, andR¹⁹ represents a phenyl group which is substituted at its 4-positionwith a halogen atom.

[Embodiment 55] The present compound N wherein E represents R¹⁹O—, andR¹⁹ represents a phenyl group which is substituted at its 2- or4-position with a halogen atom.

[Embodiment 56] The present compound N wherein E represents R¹⁹O—, andR¹⁹ represents a phenyl group which is substituted at its 2-positionwith substituent(s) selected from Group L.

[Embodiment 57] The present compound N wherein E represents R¹⁹O—, andR¹⁹ represents a phenyl group which is substituted at its 3-positionwith substituent(s) selected from Group M.

[Embodiment 58] The present compound N wherein E represents R¹⁹O—, andR¹⁹ represents a phenyl group which is substituted at its 4-positionwith substituent(s) selected from Group N.

[Embodiment 59] The present compound N wherein E represents R¹⁹O—, andR¹⁹ represents a phenyl group which is substituted at its 2- or4-position with substituent(s) selected from Group O,

-   -   Group O is a group consisting of a C2-C4 chain hydrocarbon group        which may be optionally substituted with one or more halogen        atoms, a methoxy group, a cyclopropyl group, a halogen atom, and        a cyano group.

[Embodiment 60] The present compound N wherein E represents R¹⁹O—, andR¹⁹ represents a phenyl group which is substituted with two or moresubstituents selected from Group P.

[Embodiment 61] The present compound N wherein E represents R¹⁹O—, andR¹⁹ represents a phenyl group which is substituted at its 2-positionwith substituent(s) selected from Group L, a phenyl group which issubstituted at its 3-position with substituent(s) selected from Group M,a phenyl group which is substituted at its 4-position withsubstituent(s) selected from Group N, or a phenyl group which issubstituted with two or more substituents selected from Group P.

[Embodiment 62] The present compound N wherein E represents R¹⁹O—, andR¹⁹ represents a pyridyl group which may be optionally withsubstituent(s) selected from Group P, a pyrazolyl group which may beoptionally substituted with substituent(s) selected from Group G, or apyrimidinyl group which may be optionally substituted withsubstituent(s) selected from Group Q.

[Embodiment 63] The present compound N wherein E represents R¹⁹O—, andR¹⁹ represents a phenyl group which is substituted at its 2-positionwith substituent(s) selected from Group L a phenyl group which issubstituted at its 3-position with substituent(s) selected from Group M,a phenyl group which is substituted at its 4-position withsubstituent(s) selected from Group N, a phenyl group which issubstituted with two or more substituents selected from Group P, apyridyl group which may be optionally with substituent(s) selected fromGroup P, a pyrazolyl group which may be optionally substituted withsubstituent(s) selected from Group G, or a pyrimidinyl group which maybe optionally substituted with substituent(s) selected from Group Q.

[Embodiment 64] The present compound N wherein E representsR¹⁵—CH(R¹⁶)—O—N═C(R⁷)—, and R⁷ represents a C1-C3 alkyl group, R¹⁵represents a phenyl group, or a five- to six-membered aromaticheterocyclic group {the phenyl group and the five- to six-memberedaromatic heterocyclic group may be optionally substituted with one ormore substituents selected from Group G}, and R¹⁶ represents a C1-C3alkyl group.

[Embodiment 65] The present compound N wherein E representsR¹⁵—CH(R¹⁶)—O—N═C(R⁷)—, R⁷ represents a C1-C3 alkyl group, R¹⁵represents a phenyl group which may be optionally substituted with oneor more substituents selected from Group G, and R¹⁶ represents a C1-C3alkyl group.

[Embodiment 66] The present compound N wherein E representsR¹⁵—CH(R¹⁶)—O—N═C(R⁷)—, R⁷ represents a methyl group, R⁵ represents aphenyl group {the phenyl group may be optionally substituted with one ormore substituents selected from a C1-C3 alkyl group which may beoptionally substituted with halogen atom and halogen atom}, and R¹⁶represents a methyl group.

[Embodiment 67] The present compound N wherein E representsR¹⁵—CH(R¹⁶)—O—N═C(R⁷)—, R⁷ represents a hydrogen atom, R¹⁵ represents aphenyl group may be optionally substituted with one or more substituentsselected from Group G6, and Group G6 is a group consisting of a C2-C3chain hydrocarbon group which may be optionally substituted with one ormore halogen atoms, a C1-C3 alkoxy group, a fluorine atom, or a cyanogroup, and R¹⁶ represents a C1-C3 alkyl group.

[Embodiment 68] The present compound N wherein E representsR¹⁵—CH(R¹⁶)—O—N═C(R⁷)—, and a combination of R⁷, R¹⁵ and R¹⁶ represents

-   -   a combination wherein R⁷ represents a C1-C3 alkyl group, or a        cyclopropyl group, R¹⁵ represents a phenyl group which may be        optionally substituted with one or more substituents selected        from Group G, R¹⁶ represents a C1-C3 alkyl group, or    -   a combination wherein R⁷ represents a hydrogen atom, R¹⁵        represents a phenyl group may be optionally substituted with one        or more substituents selected from Group G6, and R¹⁶ represents        a C1-C3 alkyl group.

[Embodiment 69] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R³⁴ represents a C1-C6 chain hydrocarbon groupwhich may be optionally substituted with one or more substituentsselected from Group J, a C3-C10 alicyclic hydrocarbon group which may beoptionally substituted with one or more substituents selected from GroupE, a phenyl group, or a five- to six-membered aromatic heterocyclicgroup {the phenyl group and the five- to six-membered aromaticheterocyclic group may be optionally substituted with one or moresubstituents selected from Group G}, R³⁵ represents a C1-C3 alkyl group,or a hydrogen atom,

-   -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form a C3-C10 alicyclic hydrocarbon group,        or a three- to ten-membered non-aromatic heterocyclic group {the        C3-C10 alicyclic hydrocarbon group and the three- to        ten-membered non-aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        E}.

[Embodiment 70] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—. R³⁴ represents a phenyl group, or a five- tosix-membered aromatic heterocyclic group {the phenyl group, and thefive- to six-membered aromatic heterocyclic group may be optionallysubstituted with one or more substituents selected from Group G},

-   -   R³⁵ represents a C1-C3 alkyl group, or a hydrogen atom,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G}.

[Embodiment 71] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, and R³⁴ and R³⁵ may combine together with a carbonatom to which they are attached to form an indan-1-ylidene group, a1,2,3,4-tetrahydronaphthalen-1-yline group, a2,3-dihydrobenzofuran-3-yline group, a3,4-dihydro-2H-1-benzofuran-4-ylidene group, a3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene group,the 1,2,3,4-tetrahydronaphthalen-1-yline group, the2,3-dihydrobenzofuran-3-yline group, and the3,4-dihydro-2H-1-benzofuran-4-ylidene group, the3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionallysubstituted with one or more substituents selected from Group G}.

[Embodiment 72] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R³⁴ represents a C1-C6 chain hydrocarbon groupwhich may be optionally substituted with one or more substituentsselected from Group J, a C3-C6 cycloalkyl group which may be optionallysubstituted with one or more halogen atoms, a phenyl group, or a five-to six-membered aromatic heterocyclic group {the phenyl group and thefive- to six-membered aromatic heterocyclic group may be optionallysubstituted with one or more substituents selected from Group G}, andR³⁵ represents a C1-C3 alkyl group, or a hydrogen atom.

[Embodiment 73] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R³⁴ represents a phenyl group which may beoptionally substituted with one or more substituents selected from GroupG, and R³⁵ represents a methyl group.

[Embodiment 74] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R³⁴ represents a phenyl group, a pyridyl group, apyrazolyl group, or a thiazolyl group {the phenyl group, the pyridylgroup, the pyrazolyl group, and the thiazolyl group may be optionallysubstituted with one or more substituents selected from Group G}, andR³⁵ represents a C1-C3 alkyl group, or

-   -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G}.

[Embodiment 75] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R³⁴ represents a phenyl group which may beoptionally substituted with one or more substituents selected from GroupG, and R³⁵ represents a C1-C3 alkyl group, or

-   -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, or a        3,4-dihydro-2H-1-benzofuran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G}.

[Embodiment 76] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R³⁴ represents a phenyl group which may beoptionally substituted with one or more substituents selected from GroupG, and R³⁵ represents a C1-C3 alkyl group, or

-   -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, or a        3,4-dihydro-2H-1-benzofuran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        J3}.

[Embodiment 77] The compound according to [Embodiment 69] wherein R¹⁰represents a C1-C3 alkyl group, or a hydrogen atom.

[Embodiment 78] The compound according to [Embodiment 70] wherein R¹⁰represents a C1-C3 alkyl group, or a hydrogen atom.

[Embodiment 79] The compound according to [Embodiment 71] wherein R¹⁰represents a C1-C3 alkyl group, or a hydrogen atom.

[Embodiment 80] The compound according to [Embodiment 72] wherein R¹⁰represents a C1-C3 alkyl group, or a hydrogen atom.

[Embodiment 81] The compound according to [Embodiment 73] wherein R¹⁰represents a C1-C3 alkyl group, or a hydrogen atom.

[Embodiment 82] The compound according to [Embodiment 69] wherein R¹⁰represents a C1-C3 alkyl group.

[Embodiment 83] The compound according to [Embodiment 70] wherein R¹⁰represents a C1-C3 alkyl group.

[Embodiment 84] The compound according to [Embodiment 71] wherein R¹⁰represents a C1-C3 alkyl group.

[Embodiment 85] The compound according to [Embodiment 72] wherein R¹⁰represents a C1-C3 alkyl group.

[Embodiment 86] The compound according to [Embodiment 73] wherein R¹⁰represents a C1-C3 alkyl group.

[Embodiment 87] The compound according to [Embodiment 74] wherein R¹⁰represents a C1-C3 alkyl group.

[Embodiment 88] The compound according to [Embodiment 75] wherein R¹⁰represents a C1-C3 alkyl group.

[Embodiment 89] The compound according to [Embodiment 76] wherein R¹⁰represents a C1-C3 alkyl group.

[Embodiment 90] The compound according to [Embodiment 69] wherein R¹⁰represents a methyl group.

[Embodiment 91] The compound according to [Embodiment 70] wherein R¹⁰represents a methyl group.

[Embodiment 92] The compound according to [Embodiment 71] wherein R¹⁰represents a methyl group.

[Embodiment 93] The compound according to [Embodiment 72] wherein R¹⁰represents a methyl group.

[Embodiment 94] The compound according to [Embodiment 73] wherein R¹⁰represents a methyl group.

[Embodiment 95] The compound according to [Embodiment 74] wherein R¹⁰represents a methyl group.

[Embodiment 96] The compound according to [Embodiment 75] wherein R¹⁰represents a methyl group.

[Embodiment 97] The compound according to [Embodiment 76] wherein R¹⁰represents a methyl group.

[Embodiment 98] The compound according to [Embodiment 70] wherein R¹⁰represents a hydrogen atom.

[Embodiment 99] The compound according to [Embodiment 71] wherein R¹⁰represents a hydrogen atom.

[Embodiment 100] The compound according to [Embodiment 72] wherein R¹⁰represents a hydrogen atom.

[Embodiment 101] The compound according to [Embodiment 73] wherein R¹⁰represents a hydrogen atom.

[Embodiment 102] The present compound N wherein E representsR⁸R⁹C═N—O—CH₂—, R⁸ and R⁹ may combine together with a carbon atom towhich they are attached to form a C3-C10 alicyclic hydrocarbon group, ora three- to ten-membered non-aromatic heterocyclic group {the C3-C10alicyclic hydrocarbon group and the three- to ten-membered non-aromaticheterocyclic group may be optionally substituted with one or moresubstituents selected from Group E}.

[Embodiment 103] The present compound N wherein E representsR⁸R⁹C═N—O—CH₂—,

-   -   R⁸ represents a C1-C6 chain hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group J, a C3-C10 alicyclic hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group E, a phenyl group, or a five- to six-membered        aromatic heterocyclic group {the phenyl group and the five- to        six-membered aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        G}, and    -   R⁹ represents a C1-C3 alkyl group, or a hydrogen atom.

[Embodiment 104] The present compound N wherein E representsR⁸R⁹C═N—O—CH₂—,

-   -   R⁸ represents a phenyl group which may be optionally substituted        with one or more substituents selected from Group G, and    -   R⁹ represents a methyl group.

[Embodiment 105] The present compound N wherein E representsR⁸R⁹C═N—O—CH₂—,

-   -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group G}, and    -   R⁹ represents a C1-C3 alkyl group, or a hydrogen atom,    -   R⁸ and R⁹ may combine together with a carbon atom to which they        are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G}.

[Embodiment 106] The present compound N wherein E representsR⁸R⁹C═N—O—CH₂—,

-   -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J3}, and    -   R⁹ represents a C1-C3 alkyl group.

[Embodiment 107] The present compound N wherein E representsR⁸R⁹C═N—O—CH₂—,

-   -   R⁸ represents an indanyl group, or a tetrahydronaphthyl group        {the indanyl group, and the tetrahydronaphthyl group may be        optionally substituted with one or more substituents selected        from Group J3}, and    -   R⁹ represents a C1-C3 alkyl group.

[Embodiment 108] The present compound N wherein E representsR⁸R⁹C═N—O—CH₂—,

-   -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group G}, and    -   R⁹ represents a C1-C3 alkyl group,    -   R⁸ and R⁹ may combine together with a carbon atom to which they        are attached to form a C3-C10 alicyclic hydrocarbon group, or a        three- to ten-membered non-aromatic heterocyclic group {the        C3-C10 alicyclic hydrocarbon group and the three- to        ten-membered non-aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        E}.

[Embodiment 109] The present compound N wherein E representsR⁸R⁹C═N—O—CH₂—, and

-   -   R⁸ and R⁹ may combine together with a carbon atom to which they        are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        J3}.

[Embodiment 110] The present compound N wherein E represents T-O—CH₂—,and

-   -   T represents a phenyl group, or a five- to six-membered aromatic        heterocyclic group {the phenyl group and the five- to        six-membered aromatic heterocyclic group which may be optionally        substituted with one or more substituents selected from Group        D1},    -   Group D1 is a group consisting of a C1-C6 chain hydrocarbon        group which may be optionally substituted with one or more        substituents selected from Group F, a C3-C6 cycloalkyl group        which may be optionally substituted with one or more        substituents selected from Group B, a C1-C3 alkoxy group which        may be optionally substituted with one or more halogen atoms, a        phenyl group, a five- to six-membered aromatic heterocyclic        group {the phenyl group and the five- to six-membered aromatic        heterocyclic group may be optionally substituted with one or        more substituents selected from Group G}, a halogen atom, and a        cyano group.

[Embodiment 111] The present compound N wherein E represents T-O—CH₂—,and

-   -   T represents a phenyl group, a pyridin-2-yl group {the phenyl        group and the pyridin-2-yl group may be optionally substituted        with one or more substituents selected from Group D2}, a        1-phenyl-1H-pyrazol-3-yl group, or a        1-methyl-3-phenyl-1H-pyrazol-5-yl group {the phenyl group in the        1-phenyl-1H-pyrazol-3-yl group and the        1-methyl-3-phenyl-1H-pyrazol-5-yl group are identical to or        different from each other and may be optionally substituted with        one or more substituents selected from Group D3, and the        pyrazolyl group in the 1-phenyl-1H-pyrazol-3-yl group and the        1-methyl-3-phenyl-1H-pyrazol-5-yl group are identical to or        different from each other and may be optionally substituted with        one or more substituents selected from Group D2},    -   Group D2 is a group consisting of a C1-C3 alkyl group which may        be optionally substituted with one or more halogen atoms and a        halogen atom,    -   Group D3 is a group consisting of a C1-C3 alkyl group which may        be optionally substituted with one or more halogen atoms, a        C1-C3 alkoxy group which may be optionally substituted with one        or more halogen atoms, a cyano group and a halogen atom.

[Embodiment 112] The present compound N wherein E representsR⁴R⁵C═C(R⁶)—, R¹⁵—CH(R¹⁶)—O—N═C(R⁷)—, or R¹⁹O—,

-   -   R⁴ and R⁶ represent a hydrogen atom, and R⁵ represents a C1-C6        chain hydrocarbon group, or a C3-C4 cycloalkyl group,    -   R⁷ represents a methyl group, or a hydrogen atom, R¹⁵ represents        a phenyl group which may be optionally substituted with one or        more substituents selected from Group G, and R¹⁶ represents a        methyl group, and    -   R¹⁹ represents a phenyl group which is substituted with one or        more fluorine atoms [with the proviso that a 3-fluorophenyl        group is excluded}.

[Embodiment 113] The present compound N wherein E representsR⁴R⁵C═C(R⁶)—, R¹⁵—CH(R¹⁶)—O—N═C(R⁷)—, R⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R⁴ and R⁶ represent a hydrogen atom, and R⁵ represents a C1-C6        chain hydrocarbon group, or C3-C4 cycloalkyl group,    -   R⁷ represents a methyl group, or a hydrogen atom, R¹⁵ represents        a phenyl group which may be optionally substituted with one or        more substituents selected from Group G, and R¹⁶ represents a        methyl group,    -   R⁸ represents a phenyl group which may be optionally substituted        with one or more substituents selected from Group G, and R⁹        represents a methyl group,    -   R¹⁹ represents a phenyl group which is substituted with one or        more fluorine atoms {with the proviso that a 3-fluorophenyl        group is excluded}.

[Embodiment 114] The present compound N wherein E representsR⁴R⁵C═C(R⁶)—, R¹⁵—CH(R¹⁶)—O—N═C(R⁷)—, R⁸R⁹C═N—O—CH₂—, T-O—CH₂— or R¹⁹O—,

-   -   R⁴ and R⁶ represent a hydrogen atom, and R⁵ represents a C1-C6        chain hydrocarbon group, or a C3-C4 cycloalkyl group,    -   R⁷ represents a methyl group, or a hydrogen atom, R¹⁵ represents        a phenyl group which may be optionally substituted with one or        more substituents selected from Group G, and R¹⁶ represents a        methyl group,    -   R⁸ represents a phenyl group which may be optionally substituted        with one or more substituents selected from Group G, and R⁹        represents a methyl group,    -   R¹⁹ represents a phenyl group which is substituted with one or        more fluorine atoms [with the proviso that a 3-fluorophenyl        group is excluded},    -   T represents a phenyl group, a pyridin-2-yl group {the phenyl        group and the pyridin-2-yl group may be optionally substituted        with one or more substituents selected from Group D2}, a        1-phenyl-1H-pyrazol-3-yl group, or a        1-methyl-3-phenyl-1H-pyrazol-5-yl group {the phenyl group in the        1-phenyl-1H-pyrazol-3-yl group and the        1-methyl-3-phenyl-1H-pyrazol-5-yl group are identical to or        different from each other and may be optionally substituted with        one or more substituents selected from Group D3, and the        pyrazolyl group in the 1-phenyl-1H-pyrazol-3-yl group and the        1-methyl-3-phenyl-1H-pyrazol-5-yl group are identical to or        different from each other and may be optionally substituted with        one or more substituents selected from Group D2}.

[Embodiment 115] The present compound N wherein E representsR⁴R⁵C═C(R⁶)—, R¹⁵—CH(R¹⁶)—O—N═C(R⁷)—, R⁸R⁹C═N—O—CH₂—, T-O—CH₂—,R³⁴R³⁵C═N—N═C(R¹⁰)—, or R¹⁹O—,

-   -   R⁴ and R⁶ represent a hydrogen atom, R⁵ represents a C1-C6 chain        hydrocarbon group, or a C3-C4 cycloalkyl group,    -   R⁷ represents a methyl group, or a hydrogen atom, R¹⁵ represents        a phenyl group which may be optionally substituted with one or        more substituents selected from Group G, and R¹⁶ represents a        methyl group,    -   R⁸ represents a phenyl group which may be optionally substituted        with one or more substituents selected from Group G, R⁹        represents a methyl group,    -   R¹⁹ represents a phenyl group which is substituted with one or        more fluorine atoms {with the proviso that a 3-fluorophenyl        group is excluded},    -   T represents a phenyl group a pyridin-2-yl group {the phenyl        group, and the pyridin-2-yl group may be optionally substituted        with one or more substituents selected from Group D2}, a        1-phenyl-1H-pyrazol-3-yl group, or a        1-methyl-3-phenyl-1H-pyrazol-5-yl group {the phenyl group in the        1-phenyl-1H-pyrazol-3-yl group and the        1-methyl-3-phenyl-1H-pyrazol-5-yl group are identical to or        different from each other and may be optionally substituted with        one or more substituents selected from Group D3, and the        pyrazolyl group in the 1-phenyl-1H-pyrazol-3-yl group and the        1-methyl-3-phenyl-1H-pyrazol-5-yl group are identical to or        different from each other and may be optionally substituted with        one or more substituents selected from Group D2},    -   R³⁴ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,    -   R³⁵ represents a C1-C3 alkyl group, or a hydrogen atom,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, a        1-oxo-3,4-dihydro-2H-1-benzopyran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        1,1-dioxo-3,4-dihydro-2H-1-benzopyran-4-ylidene group {the        indan-1-ylidene group, the 1,2,3,4-tetrahydronaphthalen-1-yline        group, the 2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, the        1-oxo-3,4-dihydro-2H-1-benzopyran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        1,1-dioxo-3,4-dihydro-2H-1-benzopyran-4-ylidene group may be        optionally substituted with one or more substituents selected        from Group G},    -   R¹⁰ represents a C1-C3 alkyl group, or a hydrogen atom.

[Embodiment 116] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R⁸R⁹C═N—O—CH₂—, R¹⁵—CH(R¹⁶)—O—N═C(R⁷)—, or R¹⁹O—,

-   -   R³⁴ represents a C1-C6 chain hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group J, a C3-C10 alicyclic hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group E, a phenyl group, or a five- to six-membered        aromatic heterocyclic group {the phenyl group and the five- to        six-membered aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        G},    -   R⁹ and R³⁵ are identical to or different from each other and        represent a C1-C3 alkyl group, or a hydrogen atom,    -   R⁷, R¹⁰ and R¹⁶ are identical to or different from each other        and represent a C1-C3 alkyl group,    -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group G},    -   R⁸ and R⁹ may combine together with a nitrogen atom to which        they are attached to form a C3-C10 alicyclic hydrocarbon group,        or a three- to ten-membered non-aromatic heterocyclic group {the        C3-C10 alicyclic hydrocarbon group and the three- to        ten-membered non-aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        E},    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form a C3-C10 alicyclic hydrocarbon group,        or a three- to ten-membered non-aromatic heterocyclic group {the        C3-C10 alicyclic hydrocarbon group, and the three- to        ten-membered non-aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        E},    -   R¹⁵ represents a phenyl group, or a five- to six-membered        aromatic heterocyclic group {the phenyl group and the five- to        six-membered aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        G},    -   R¹⁹ represents a phenyl group which is substituted at its        2-position with substituent(s) selected from Group L a phenyl        group which is substituted at its 3-position with substituent(s)        selected from Group M, a phenyl group which is substituted at        its 4-position with substituent(s) selected from Group N, a        phenyl group which is substituted with two or more substituents        selected from Group P (the two or more substituents selected        from Group P may be identical to or different from each other),        a pyridyl group which may be optionally with substituent(s)        selected from Group P, A pyrazolyl group which may be optionally        substituted with substituent(s) selected from Group G, or a        pyrimidinyl group which may be optionally substituted with        substituent(s) selected from Group Q.

[Embodiment 117] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R³⁴ represents a C1-C6 chain hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group J, a C3-C10 alicyclic hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group E, a phenyl group, or a five- to six-membered        aromatic heterocyclic group {the phenyl group and the five- to        six-membered aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        G},    -   R⁹ and R³⁵ are identical to or different from each other and        represent a C1-C3 alkyl group, or a hydrogen atom,    -   R¹⁰ represents a C1-C3 alkyl group,    -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group G},    -   R⁸ and R⁹ may combine together with a nitrogen atom to which        they are attached to form a C3-C10 alicyclic hydrocarbon group,        or a three- to ten-membered non-aromatic heterocyclic group{the        C3-C10 alicyclic hydrocarbon group and the three- to        ten-membered non-aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        E},    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form a C3-C10 alicyclic hydrocarbon group,        or a three- to ten-membered non-aromatic heterocyclic group {the        C3-C10 alicyclic hydrocarbon group and the three- to        ten-membered non-aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        E},    -   R¹⁹ represents a phenyl group which is substituted at its        2-position with substituent(s) selected from Group L, a phenyl        group which is substituted at its 3-position with substituent(s)        selected from Group M, a phenyl group which is substituted at        its 4-position with substituent(s) selected from Group N, a        phenyl group which is substituted with two or more substituents        selected from Group P (the two or more substituents selected        from Group P may be identical to or different from each other),        a pyridyl group which may be optionally with substituent(s)        selected from Group P, a pyrazolyl group which may be optionally        substituted with substituent(s) selected from Group G, or a        pyrimidinyl group which may be optionally substituted with        substituent(s) selected from Group Q.

[Embodiment 118] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, or R¹⁹O—,

-   -   R³⁴ represents a C1-C6 chain hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group J, a C3-C10 alicyclic hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group E, a phenyl group, or a five- to six-membered        aromatic heterocyclic group {the phenyl group and the five- to        six-membered aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        G},    -   R³⁵ represents a C1-C3 alkyl group, or a hydrogen atom,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form, C3-C10 alicyclic hydrocarbon group,        or a three- to ten-membered non-aromatic heterocyclic group{the        C3-C10 alicyclic hydrocarbon group and the three- to        ten-membered non-aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        E},    -   R¹⁰ represents a C1-C3 alkyl group,    -   R¹⁹ represents a phenyl group which is substituted at its        2-position with substituent(s) selected from Group L, a phenyl        group which is substituted at its 3-position with substituent(s)        selected from Group M, a phenyl group which is substituted at        its 4-position with substituent(s) selected from Group N, a        phenyl group which is substituted with two or more substituents        selected from Group P (the two or more substituents selected        from Group P may be identical to or different from each other),        a pyridyl group which may be optionally with substituent(s)        selected from Group P, a pyrazolyl group which may be optionally        substituted with substituent(s) selected from Group G, or a        pyrimidinyl group which may be optionally substituted with        substituent(s) selected from Group Q.

[Embodiment 119] The present compound N wherein E representsR⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group G}, and R⁹ represents a C1-C3 alkyl group, or    -   R⁸ and R⁹ may combine together with a nitrogen atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G},    -   R¹⁹ represents a phenyl group which is substituted at its        2-position with substituent(s) selected from Group L a phenyl        group which is substituted at its 3-position with substituent(s)        selected from Group M, a phenyl group which is substituted at        its 4-position with substituent(s) selected from Group N, a        phenyl group which is substituted with two or more substituents        selected from Group P (the two or more substituents selected        from Group P may be identical to or different from each other),        a pyridyl group which may be optionally with substituent(s)        selected from Group P, a pyrazolyl group which may be optionally        substituted with substituent (s) selected from Group G, or a        pyrimidinyl group which may be optionally substituted with        substituent(s) selected from Group Q.

[Embodiment 120] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, or R⁸R⁹C═N—O—CH₂—,

-   -   R³⁴ represents a C1-C6 chain hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group J, a C3-C6 cycloalkyl group which may be optionally        substituted with one or more halogen atoms, a phenyl group, or a        five- to six-membered aromatic heterocyclic group {the phenyl        group and the five- to six-membered aromatic heterocyclic group        may be optionally substituted with one or more substituents        selected from Group G},    -   R³⁵ represents a C1-C3 alkyl group, or a hydrogen atom,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form a C3-C10 alicyclic hydrocarbon group,        or a three- to ten-membered non-aromatic heterocyclic group {the        C3-C10 alicyclic hydrocarbon group and the three- to        ten-membered non-aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        E},    -   R¹⁰ represents a C1-C3 alkyl group,    -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group G}, and R⁹ represents a C1-C3 alkyl group, or    -   R⁸ and R⁹ may combine together with a nitrogen atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G}.

[Embodiment 121] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R¹⁵—CH(R¹⁶)—O—N═C(R⁷)—, or R¹⁹O—,

-   -   R³⁴ represents a C1-C6 chain hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group J, a C3-C6 cycloalkyl group which may be optionally        substituted with one or more halogen atoms, a phenyl group, or a        five- to six-membered aromatic heterocyclic group {the phenyl        group and the five- to six-membered aromatic heterocyclic group        may be optionally substituted with one or more substituents        selected from Group G},    -   R³⁵ represents a C1-C3 alkyl group, or a hydrogen atom,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form a C3-C10 alicyclic hydrocarbon group,        or a three- to ten-membered non-aromatic heterocyclic group {the        C3-C10 alicyclic hydrocarbon group and the three- to        ten-membered non-aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        E},    -   R¹⁰ represents a C1-C3 alkyl group,    -   R⁷ represents a C1-C3 alkyl group,    -   R¹⁵ represents a phenyl group, or a five- to six-membered        aromatic heterocyclic group {the phenyl group and the five- to        six-membered aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        G},    -   R¹⁶ represents a C1-C3 alkyl group,    -   R¹⁹ represents a phenyl group which is substituted at its        2-position with substituent(s) selected from Group L, a phenyl        group which is substituted at its 3-position with substituent(s)        selected from Group M, a phenyl group which is substituted at        its 4-position with substituent(s) selected from Group N, a        phenyl group which is substituted with two or more substituents        selected from Group P (the two or more substituents selected        from Group P may be identical to or different from each other),        a pyridyl group which may be optionally with substituent(s)        selected from Group P, a pyrazolyl group which may be optionally        substituted with substituent(s) selected from Group G, or a        pyrimidinyl group which may be optionally substituted with        substituent(s) selected from Group Q.

[Embodiment 122] The present compound N wherein E representsR⁸R⁹C═N—O—CH₂—, R¹⁵—CH(R¹⁶)—O—N═C(R⁷)—, or R¹⁹O—,

-   -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group G}, and R⁹ represents a C1-C3 alkyl group,    -   R⁸ and R⁹ may combine together with a nitrogen atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G},    -   R⁷ represents a C1-C3 alkyl group,    -   R¹⁵ represents a phenyl group, or a five- to six-membered        aromatic heterocyclic group {the phenyl group and the five- to        six-membered aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        G},    -   R¹⁶ represents a C1-C3 alkyl group,    -   R¹⁹ represents a phenyl group which is substituted at its        2-position with substituent(s) selected from Group L, a phenyl        group which is substituted at its 3-position with substituent(s)        selected from Group M, a phenyl group which is substituted at        its 4-position with substituent(s) selected from Group N, a        phenyl group which is substituted with two or more substituents        selected from Group P (the two or more substituents selected        from Group P may be identical to or different from each other),        a pyridyl group which may be optionally with substituent(s)        selected from Group P, a pyrazolyl group which may be optionally        substituted with substituent(s) selected from Group G, or a        pyrimidinyl group which may be optionally substituted with        substituent(s) selected from Group Q.

[Embodiment 123] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R¹⁵—CH(R¹⁶)—O—N═C(R⁷)—, or R⁸R⁹C═N—O—CH₂—

-   -   R³⁴ represents a C1-C6 chain hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group J, a C3-C6 cycloalkyl group which may be optionally        substituted with one or more halogen atoms, a phenyl group, or a        five- to six-membered aromatic heterocyclic group {the phenyl        group and the five- to six-membered aromatic heterocyclic group        may be optionally substituted with one or more substituents        selected from Group G}, and    -   R³⁵ represents a C1-C3 alkyl group, or a hydrogen atom,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form a C3-C10 alicyclic hydrocarbon group,        or a three- to ten-membered non-aromatic heterocyclic group {the        C3-C10 alicyclic hydrocarbon group and the three- to        ten-membered non-aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        E},    -   R¹⁰ represents a C1-C3 alkyl group,    -   R⁷ represents a C1-C3 alkyl group, R¹⁵ represents a phenyl group        which may be optionally substituted with one or more        substituents selected from Group G, R¹⁶ represents a C1-C3 alkyl        group,    -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group G}, R⁹ represents a C1-C3 alkyl group, or    -   R⁸ and R⁹ may combine together with a nitrogen atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G}.

[Embodiment 124] The present compound N wherein E representsR¹⁵—CH(R⁶)—O—N═C(R⁷)—, or R¹⁹O—,

-   -   R⁷ represents a C1-C3 alkyl group,    -   R³⁵ represents a phenyl group, or a five- to six-membered        aromatic heterocyclic group {the phenyl group and the five- to        six-membered aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        G},    -   R¹⁶ represents a C1-C3 alkyl group,    -   R¹⁹ represents a phenyl group which is substituted at its        2-position with substituent(s) selected from Group L, a phenyl        group which is substituted at its 3-position with substituent(s)        selected from Group M, a phenyl group which is substituted at        its 4-position with substituent(s) selected from Group N, a        phenyl group which is substituted with two or more substituents        selected from Group P (the two or more substituents selected        from Group P may be identical to or different from each other),        a pyridyl group which may be optionally with substituent(s)        selected from Group P, a pyrazolyl group which may be optionally        substituted with substituent(s) selected from Group G, or a        pyrimidinyl group which may be optionally substituted with        substituent(s) selected from Group Q.

[Embodiment 125] The present compound N wherein E representsR⁸R⁹C═N—O—CH₂—, or R¹⁵—CH(R¹⁶)—O—N═C(R⁷)—,

-   -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group G}, and R⁹ represents a C1-C3 alkyl group,    -   R⁸ and R⁹ may combine together with a nitrogen atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G},    -   R⁷ represents a C1-C3 alkyl group,    -   R¹⁵ represents a phenyl group, or a five- to six-membered        aromatic heterocyclic group {the phenyl group and the five- to        six-membered aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        G}, and    -   R¹⁶ represents a C1-C3 alkyl group.

[Embodiment 126] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, or R¹⁵—CH(R¹⁶)—O—N═C(R⁷)—,

-   -   R³⁴ represents a C1-C6 chain hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group J, a C3-C6 cycloalkyl group which may be optionally        substituted with one or more halogen atoms, a phenyl group, or a        five- to six-membered aromatic heterocyclic group {the phenyl        group, and the five- to six-membered aromatic heterocyclic group        may be optionally substituted with one or more substituents        selected from Group G}, and    -   R³⁵ represents a C1-C3 alkyl group, or a hydrogen atom, or    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form a C3-C10 alicyclic hydrocarbon group,        or a three- to ten-membered non-aromatic heterocyclic group {the        C3-C10 alicyclic hydrocarbon group and the three- to        ten-membered non-aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        E},    -   R¹⁰ represents a C1-C3 alkyl group,    -   R⁷ represents a C1-C3 alkyl group,    -   R¹⁵ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,        and    -   R¹⁶ represents a C1-C3 alkyl group.

[Embodiment 127] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R⁸R⁹C═N—O—CH₂—, R¹⁵—CH(R¹⁶)—O—N═C(R⁷)—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group, a pyridyl group, a pyrazolyl        group, or a thiazolyl group {the phenyl group, the pyridyl        group, the pyrazolyl group, and the thiazolyl group may be        optionally substituted with one or more substituents selected        from Group G}, and R³⁵ represents a C1-C3 alkyl group,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G},    -   R¹⁰ represents a C1-C3 alkyl group,    -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J3}, R⁹ represents a C1-C3 alkyl group,    -   R⁷ represents a C1-C3 alkyl group,    -   R¹⁵ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,    -   R¹⁶ represents a C1-C3 alkyl group,    -   R¹⁹ represents a phenyl group which is substituted at its 2- or        4-position with a halogen atom.

[Embodiment 128] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group, a pyridyl group, a pyrazolyl        group, or a thiazolyl group {the phenyl group, the pyridyl        group, the pyrazolyl group, and the thiazolyl group may be        optionally substituted with one or more substituents selected        from Group G}, and R³⁵ represents a C1-C3 alkyl group, or    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G},    -   R¹⁰ represents a C1-C3 alkyl group,    -   R¹⁹ represents a phenyl group which is substituted at its 2- or        4-position with a halogen atom.

[Embodiment 129] The present compound N wherein E representsR⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J3}, R⁹ represents a C1-C3 alkyl group, and    -   R¹⁹ represents a phenyl group which is substituted at its 2- or        4-position with a halogen atom.

[Embodiment 130] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, or R⁸R⁹C═N—O—CH₂—,

-   -   R³⁴ represents a phenyl group, a pyridyl group, a pyrazolyl        group, or a thiazolyl group {the phenyl group, the pyridyl        group, the pyrazolyl group, and the thiazolyl group may be        optionally substituted with one or more substituents selected        from Group G}, and R³⁵ represents a C1-C3 alkyl group, and    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G},    -   R¹⁰ represents a C1-C3 alkyl group,    -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J3}, and R⁹ represents a C1-C3 alkyl group.

[Embodiment 131] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group, a pyridyl group, a pyrazolyl        group, or a thiazolyl group {the phenyl group, the pyridyl        group, the pyrazolyl group, and the thiazolyl group may be        optionally substituted with one or more substituents selected        from Group G}, and R³⁵ represents a C1-C3 alkyl group,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G},    -   R¹⁰ represents a C1-C3 alkyl group,    -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J3}, and R⁹ represents C1-C3 alkyl group,    -   R⁹ represents a phenyl group which is substituted at its        2-position with a halogen atom, a phenyl group which is        substituted at its 4-position with a halogen atom, a phenyl        group which is substituted with two or more halogen atoms, or a        3-chlorophenyl group.

[Embodiment 132] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group, a pyridyl group, a pyrazolyl        group, or a thiazolyl group {the phenyl group, the pyridyl        group, the pyrazolyl group, and the thiazolyl group may be        optionally substituted with one or more substituents selected        from Group G}, and R³⁵ represents a C1-C3 alkyl group,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G},    -   R¹⁰ represents a C1-C3 alkyl group, and    -   R⁹ represents a phenyl group which is substituted at its 2- or        4-position with a halogen atom.

[Embodiment 133] The present compound N wherein E representsR⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J3}, R⁹ represents C1-C3 alkyl group,    -   R¹⁹ represents a phenyl group which is substituted at its        2-position with a halogen atom, a phenyl group which is        substituted at its 4-position with a halogen atom, a phenyl        group which is substituted with two or more halogen atoms, or a        3-chlorophenyl group.

[Embodiment 134] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group, a pyridyl group, a pyrazolyl        group, or a thiazolyl group {the phenyl group, the pyridyl        group, the pyrazolyl group, and the thiazolyl group may be        optionally substituted with one or more substituents selected        from Group G}, and R³⁵ represents a C1-C3 alkyl group, or    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G},    -   R¹⁰ represents a C1-C3 alkyl group,    -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J3}, R⁹ represents C1-C3 alkyl group, and    -   R¹⁹ represents a phenyl group which is substituted at its 2- or        4-position with substituent(s) selected from Group O.

[Embodiment 135] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group, a pyridyl group, a pyrazolyl        group, or a thiazolyl group {the phenyl group, the pyridyl        group, the pyrazolyl group, and the thiazolyl group may be        optionally substituted with one or more substituents selected        from Group G}, and R³⁵ represents a C1-C3 alkyl group, or    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G},    -   R¹⁰ represents a C1-C3 alkyl group, and    -   R⁹ represents a phenyl group which is substituted at its 2- or        4-position with substituent(s) selected from Group O.

[Embodiment 136] The present compound N wherein E representsR⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J3}, and R⁹ represents C1-C3 alkyl group, or    -   R⁹ represents a phenyl group which is substituted at its 2- or        4-position with substituent(s) selected from Group O.

[Embodiment 137] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group, a pyridyl group, a pyrazolyl        group, or a thiazolyl group {the phenyl group, the pyridyl        group, the pyrazolyl group, and the thiazolyl group may be        optionally substituted with one or more substituents selected        from Group G}, and R³⁵ represents a C1-C3 alkyl group,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G},    -   R¹⁰ represents a C1-C3 alkyl group,    -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J3}, R⁹ represents a C1-C3 alkyl group, and    -   R¹⁹ represents a phenyl group which is substituted with one or        more chlorine atoms.

[Embodiment 138] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group, a pyridyl group, a pyrazolyl        group, or a thiazolyl group {the phenyl group, the pyridyl        group, the pyrazolyl group, and the thiazolyl group may be        optionally substituted with one or more substituents selected        from Group G}, and R³⁵ represents a C1-C3 alkyl group, or    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G},    -   R¹⁰ represents a C1-C3 alkyl group,    -   R⁹ represents a phenyl group which is substituted with one or        more chlorine atoms.

[Embodiment 139] The present compound N wherein E representsR⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J3}, R⁹ represents a C1-C3 alkyl group, and    -   R¹⁹ represents a phenyl group which is substituted with one or        more chlorine atoms.

[Embodiment 140] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,        R³⁵ represents a C1-C3 alkyl group,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, or a        3,4-dihydro-2H-1-benzofuran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        J3},    -   R¹⁰ represents a C1-C3 alkyl group,    -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J3}, R⁹ represents C1-C3 alkyl group, and    -   R¹⁹ represents a phenyl group which is substituted at its 2- or        4-position with a halogen atom.

[Embodiment 141] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,        and R³⁵ represents a C1-C3 alkyl group,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, or a        3,4-dihydro-2H-1-benzofuran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        J3},    -   R¹⁰ represents a C1-C3 alkyl group, and    -   R¹⁹ represents a phenyl group which is substituted at its 2- or        4-position with a halogen atom.

[Embodiment 142] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, or R⁸R^(9C)═N—O—CH₂—,

-   -   R³⁴ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,        and R³⁵ represents a C1-C3 alkyl group,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, or a        3,4-dihydro-2H-1-benzofuran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        J3},    -   R¹⁰ represents a C1-C3 alkyl group,    -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J3}, and R⁹ represents a C1-C3 alkyl group.

[Embodiment 143] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R⁸R^(9C)═N—O—CH₂—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,        R³⁵ represents a C1-C3 alkyl group,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, or a        3,4-dihydro-2H-1-benzofuran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        J3},    -   R¹⁰ represents a C1-C3 alkyl group,    -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J31, R⁹ represents a C1-C3 alkyl group, and    -   R¹⁹ represents a phenyl group which is substituted at its        2-position with a halogen atom, a phenyl group which is        substituted at its 4-position with a halogen atom, a phenyl        group which is substituted with two or more halogen atoms, or a        3-chlorophenyl group.

[Embodiment 144] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,        R³⁵ represents a C1-C3 alkyl group,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, or a        3,4-dihydro-2H-1-benzofuran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        J3},    -   R¹⁰ represents a C1-C3 alkyl group, and    -   R¹⁹ represents a phenyl group which is substituted at its 2- or        4-position with a halogen atom.

[Embodiment 145] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,        and R³⁵ represents a C1-C3 alkyl group, or    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, or a        3,4-dihydro-2H-1-benzofuran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        J3},    -   R¹⁰ represents a C1-C3 alkyl group,    -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J3}, R⁹ represents C1-C3 alkyl group, and    -   R¹⁹ represents a phenyl group which is substituted at its 2- or        4-position with substituent(s) selected from Group O.

[Embodiment 146] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,        R³⁵ represents a C1-C3 alkyl group,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, or a        3,4-dihydro-2H-1-benzofuran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        J3},    -   R¹⁰ represents a C1-C3 alkyl group, and    -   R¹⁹ represents a phenyl group which is substituted at its 2- or        4-position with substituent(s) selected from Group O.

[Embodiment 147] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,        and R³⁵ represents a C1-C3 alkyl group, or    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, or a        3,4-dihydro-2H-1-benzofuran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        J3},    -   R¹⁰ represents a C1-C3 alkyl group,    -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J3}, R⁹ represents C1-C3 alkyl group, and    -   R¹⁹ represents a phenyl group which is substituted with one or        more chlorine atoms.

[Embodiment 148] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,        and R³⁵ represents a C1-C3 alkyl group, or    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, or a        3,4-dihydro-2H-1-benzofuran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        J3},    -   R¹⁰ represents a C1-C3 alkyl group, and    -   R¹⁹ represents a phenyl group which is substituted with one or        more chlorine atoms.

[Embodiment 149] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,    -   R⁹, R¹⁰ and R³⁵ are identical to or different from each other        and represent a C1-C3 alkyl group, or    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, or a        3,4-dihydro-2H-1-benzofuran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        J3},    -   R⁸ represents an indanyl group, or a tetrahydronaphthyl group        {the indanyl group, and the tetrahydronaphthyl group may be        optionally substituted with one or more substituents selected        from Group J3}, and    -   R¹⁹ represents a phenyl group which is substituted at its        2-position with substituent(s) selected from Group L, a phenyl        group which is substituted at its 3-position with substituent(s)        selected from Group M, a phenyl group which is substituted at        its 4-position with substituent(s) selected from Group N, or a        phenyl group which is substituted with two or more substituents        selected from Group P (the two or more substituents selected        from Group P may be identical to or different from each other).

[Embodiment 150] The present compound N wherein E representsR⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R⁸ represents an indanyl group, or a tetrahydronaphthyl group        {the indanyl group, and the tetrahydronaphthyl group may be        optionally substituted with one or more substituents selected        from Group J3},    -   R⁹ represents a C1-C3 alkyl group, and    -   R¹⁹ represents a phenyl group {the phenyl group is substituted        at its 2-position with substituent(s) selected from Group L, is        substituted at its 3-position with substituent(s) selected from        Group M, is substituted at its 4-position with substituent(s)        selected from Group N, or is substituted with two or more        substituents selected from Group P},

[Embodiment 151] The present compound N wherein E representsR⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R¹⁰ and R³⁵ are identical to or different from each other and        represent a C1-C3 alkyl group,    -   R³⁴ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, or a        3,4-dihydro-2H-1-benzofuran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        J3},    -   R¹⁹ represents a phenyl group which is substituted at its        2-position with substituent(s) selected from Group L, a phenyl        group which is substituted at its 3-position with substituent(s)        selected from Group M, a phenyl group which is substituted at        its 4-position with substituent(s) selected from Group N, or a        phenyl group which is substituted with two or more substituents        selected from Group P (the two or more substituents selected        from Group P may be identical to or different from each other).

[Embodiment 152] The present compound N wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, or R⁸R⁹C═N—O—CH₂—,

-   -   R³⁴ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,    -   R⁹, R¹⁰, a and R³⁵ represent are identical to or different from        each other and represent a C1-C3 alkyl group,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, or a        3,4-dihydro-2H-1-benzofuran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        J3}, and    -   R⁸ represents an indanyl group, or a tetrahydronaphthyl group        {the indanyl group, and the tetrahydronaphthyl group may be        optionally substituted with one or more substituents selected        from Group J3}.

[Embodiment 192] The present compound N wherein E representsR¹⁵—CR¹⁶R³⁶—O—N═C(R⁷)—, R⁸R⁹C═N—O—CH₂—, or R¹⁴O—, R⁷ and R⁸ areidentical to or different from each other and represent a C1-C3 alkylgroup, or a hydrogen atom, R⁸ and R¹⁵ are identical to or different fromeach other and represent a phenyl group which may be optionallysubstituted with one or more substituents selected from Group G, R¹⁴represents a phenyl group which may be optionally substituted with oneor more substituents selected from Group G, a thiazolyl group which maybe optionally substituted with one or more substituents selected fromGroup H, or a thienyl group which may be optionally substituted with oneor more halogen atoms, and R³⁶ represents a hydrogen atom.

[Embodiment 193] The present compound N wherein E represents R¹⁴O—, R¹⁴represents a phenyl group which may be optionally substituted with oneor more substituents selected from Group G, a thiazolyl group which maybe optionally substituted with one or more substituents selected fromGroup H, or a thienyl group which may be optionally substituted with oneor more halogen atoms.

[Embodiment 194] The present compound N wherein E represents R¹⁴O—, R¹⁴represents a phenyl group which may be optionally substituted with oneor more substituents selected from Group G, a thiazolyl group which maybe optionally substituted with one or more substituents selected fromGroup H2, or a thienyl group which may be optionally substituted withone or more halogen atoms,

-   -   Group H2 is a group consisting of a C1-C3 chain hydrocarbon        group, a phenyl group {the C1-C3 chain hydrocarbon group, and        the phenyl group may be optionally substituted with one or more        halogen atoms}, a cyclopropyl group, and a halogen atom.

[Embodiment 195] The present compound N wherein E represents R¹⁴O—, R¹⁴represents a phenyl group, or a five- to six-membered aromaticheterocyclic group {the phenyl group, and the five- to six-memberedaromatic heterocyclic group may be optionally substituted with one ormore substituents selected from Group G}.

[Embodiment 196] The present compound N wherein E represents R¹⁴O—, andR¹⁴ represents a phenyl group which may be optionally substituted withone or more substituents selected from Group G.

[Embodiment 197] The present compound N wherein E represents R¹⁴O—, andR¹⁴ represents a thiazolyl group which may be optionally substitutedwith one or more substituents selected from Group H.

[Embodiment 198] The present compound N wherein E represents R¹⁴O—, andR¹⁴ represents a phenyl group, a 2-methyl phenyl group, a 3-methylphenylgroup, a 4-methylphenyl group, a 3-fluorophenyl group, a 3-methoxyphenylgroup, a 3-(trifluoromethoxy)phenyl group, a 3-phenoxyphenyl group, a3-thienyl group, a 2-thiazolyl group, a 4-(trifluoromethyl)thizol-2-ylgroup, a 5-chlorothiazol-2-yl group, a 5-bromothiazol-2-yl group, a5-(trifluoromethyl)thiazol-2-yl group, a 5-cyclopropylthiazol-2-ylgroup, a 5-ethynylthiazol-2-yl group, or a(5-cyclopropylethynyl)thiazol-2-yl group.

[Embodiment 199] The present compound N wherein E represents R¹⁴O—, andR¹⁴ represents a phenyl group, a 2-methyl phenyl group, a 3-methylphenylgroup, a 4-methylphenyl group, a 3-fluorophenyl group, a 3-methoxyphenylgroup, a 3-(trifluoromethoxy)phenyl group, or a 3-phenoxyphenyl group.

[Embodiment 200] The present compound N wherein E represents R¹⁴O—, andR¹⁴ represents a 3-thienyl group, a 2-thiazolyl group, a4-(trifluoromethyl)thizol-2-yl group, a 5-chlorothiazol-2-yl group, a5-bromothiazol-2-yl group, a 5-(trifluoromethyl)thiazol-2-yl group, a5-cyclopropylthiazol-2-yl group, a 5-ethynylthiazol-2-yl group, or a(5-cyclopropylethynyl)thiazol-2-yl group.

[Embodiment 201] The present compound N wherein E represents R¹⁴O—, andR¹⁴ represents a 2-thiazolyl group, a 4-(trifluoromethyl)thizol-2-ylgroup, a 5-chlorothiazol-2-yl group, a 5-bromothiazol-2-yl group, a5-(trifluoromethyl)thiazol-2-yl group, a 5-cyclopropylthiazol-2-ylgroup, a 5-ethynylthiazol-2-yl group, or a(5-cyclopropylethynyl)thiazol-2-yl group.

[Embodiment 202] The present compound N wherein E represents a C1-C6alkyl group which may be optionally substituted with one or moresubstituents selected from Group A2, a C3-C6 cycloalkyl group which maybe optionally substituted with one or more substituents selected fromGroup B2, R⁴R⁵C═C(R⁶)—, R¹⁵—CR¹⁶R³⁶—O—N═C(R⁷)—, R⁸R⁹C═N—O—CH₂—,R³⁴R³⁵C═N—N═C(R¹⁰)—, R¹²O—N═C(SR⁷)—S—CH₂—, or R¹⁴O—, R⁴, R⁶, and R¹⁶represent a hydrogen atom, R⁵ represents a C1-C6 chain hydrocarbon groupwhich may be optionally substituted with one or more substituentsselected from Group A2, a C3-C6 cycloalkyl group which may be optionallysubstituted with one or more substituents selected from Group B2, aphenyl group, or a five- to six-membered aromatic heterocyclic group{the phenyl group, and the five- to six-membered aromatic heterocyclicgroup may be optionally substituted with one or more substituentsselected from Group G}, R⁷, R⁹, and R¹⁰ are identical to or differentfrom each other and represent a methyl group, or a hydrogen atom, R⁸represents a phenyl group which may be optionally substituted with oneor more substituents selected from Group G, R¹² represents a C1-C6 chainhydrocarbon group which may be optionally substituted with one or moresubstituents selected from Group A2, R¹⁴ represents a phenyl group, or afive- to ten-membered aromatic heterocyclic group {the phenyl group andthe five- to ten-membered aromatic heterocyclic group may be optionallysubstituted with one or more substituents selected from Group D4}, R¹⁵represents a phenyl group which may be optionally substituted with oneor more substituents selected from Group G, and R³⁶ represents ahydrogen atom,

-   -   Group A2 is a group consisting of a C3-C6 cycloalkyl group, a        halogen atom, a phenoxy group, a phenyl group, and a five- to        six-membered aromatic heterocyclic group {the a phenoxy group,        the phenyl group, and the five- to six-membered aromatic        heterocyclic group may be optionally substituted with one or        more substituents selected from Group G},    -   Group B2 is a group consisting of a C1-C3 alkyl group and a        C3-C6 cycloalkyl group,    -   Group D4 is a group consisting of a C1-C6 chain hydrocarbon        group which may be optionally substituted with one or more        substituents selected from Group F, a C3-C6 cycloalkyl group        which may be optionally substituted with one or more        substituents selected from Group B, a C1-C6 alkoxy group which        may be optionally substituted with one or more substituents        selected from Group F, a phenoxy group, a phenyl group, a five-        to six-membered aromatic heterocyclic group {the a phenoxy        group, the phenyl group, and the five- to six-membered aromatic        heterocyclic group may be optionally substituted with one or        more substituents selected from Group G}, and a halogen atom.

[Embodiment 203] The present compound N wherein E represents a C1-C6alkyl group which may be optionally substituted with one or moresubstituents selected from Group A3, a cyclopropyl group, R⁴R⁵C═C(R⁶)—,R¹⁵—CR¹⁶R³⁶—O—N═C(R⁷)—, R⁸R⁹C═N—O—CH₂—, R³⁴R³⁵C═N—N═C(R¹⁰)—,R¹²O—N═C(SR⁷)—S—CH₂—, or R¹⁴O—, R⁴, R⁶, and R³⁶ represent a hydrogenatom, R⁵ represents a C1-C6 chain hydrocarbon group which may beoptionally substituted with one or more phenyl groups, a phenyl groupwhich may be optionally substituted with one or more halogen atoms, or acyclopropyl group, R⁷, R⁹, and R¹⁶ are identical to or different fromeach other and represent a methyl group, or a hydrogen atom, R⁸represents a phenyl group which may be optionally substituted with oneor more trifluoromethyl groups, R¹² represents a C1-C6 chain hydrocarbongroup, R¹⁵ represents a phenyl group, R¹⁴ represents a phenyl group, anaphthyl group, a pyridyl group, a pyrimidinyl group, a thienyl group, athiazolyl group, thiadiazolyl group, a benzothiazolyl group, abenzoxazolyl group {the phenyl group, the a naphthyl group, the pyridylgroup, the pyrimidinyl group, the thienyl group, the thiazolyl group,the thiadiazolyl group, the benzothiazolyl group, and the benzoxazolylgroup may be optionally substituted with one or more substituentsselected from Group G}, or a pyrazolyl group {the pyrazolyl group may beoptionally substituted with a phenyl group which may be optionallysubstituted with one or more halogen atoms},

-   -   Group A3 is a group consisting of a halogen atom, a cyclopropyl        group, a phenoxy group, a phenyl group, and a pyrazolyl group        {the phenyl group, and the pyrazolyl group may be optionally        substituted with one or more substituents selected from Group        G2},    -   Group G2 is a group consisting of a C1-C3 alkyl group and a        halogen atom.

[Embodiment 204] The present compound N wherein E representsR⁴R⁵C═C(R⁶)—, R¹⁵—CR¹⁶R³⁶—O—N═C(R⁷)—, R⁸R⁹C═N—O—CH₂—,R³⁴R³⁵C═N—N═C(R¹⁰)—, or R¹⁴O—, R⁴, R⁶, R⁷, and R³⁶ represent a hydrogenatom, R⁵ represents a C1-C6 chain hydrocarbon group 1-C6 chainhydrocarbon group which may be optionally substituted with one or morehalogen atoms, a C3-C6 cycloalkyl group which may be optionallysubstituted with one or more halogen atoms, or a phenyl group which maybe optionally substituted with one or more substituents selected fromGroup G, R⁹, R¹⁶, and R³⁵ are identical to or different from each otherand represent a C1-C3 alkyl group, R⁸ and R¹⁵ are identical to ordifferent from each other and represent a phenyl group which may beoptionally substituted with one or more substituents selected from GroupG, R³⁴ represents a phenyl group, an indanyl group, or a five- tosix-aromatic heterocyclic group {the phenyl group, the indanyl group,and the five- to six-aromatic heterocyclic group may be optionallysubstituted with one or more substituents selected from Group G}, R³⁴and R³⁵ may combine together with a carbon atom to which they areattached to form an indan-1-ylidene group, or a3,4-dihydro-2H-1-benzofuran-4-ylidene group {the indan-1-ylidene group,and the 3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionallysubstituted with one or more halogen atoms}, R¹⁴ represents a phenylgroup, a naphthyl group, or a five- to six-membered aromaticheterocyclic group {the phenyl group, the naphthyl group, and the five-to six-membered aromatic heterocyclic group may be optionallysubstituted with one or more substituents selected from Group D4}.

[Embodiment 205] The present compound N wherein E representsR⁴R⁵C═C(R⁶)—, R¹⁵—CR¹⁶R³⁶—O—N═C(R⁷)—, R⁸R⁹C═N—O—CH₂—,R³⁴R³⁵C═N—N═C(R¹⁰)—, or R¹⁴O—, R⁴, R⁶, R⁷, and R³⁶ represent a hydrogenatom, R⁵ represents a C1-C6 chain hydrocarbon group which may beoptionally substituted with one or more halogen atoms, a C3-C6cycloalkyl group, or a phenyl group, R⁹, R¹⁶ and R³⁵ represent a methylgroup, R⁸ and R¹⁵ are identical to or different from each other andrepresent a phenyl group which may be optionally substituted with one ormore trifluoromethyl groups, R³⁴ represents a phenyl group, an indanylgroup, a pyridyl group, or a thiazolyl group {the phenyl group, theindanyl group, the pyridyl group, and the thiazolyl group may beoptionally substituted with a C1-C3 alkyl group which may be optionallysubstituted with one or more halogen atoms}, R³⁴ and R³⁵ may combinetogether with a carbon atom to which they are attached to form anindan-1-ylidene group, or a 3,4-dihydro-2H-1-benzofuran-4-ylidene group{the indan-1-ylidene group, and the3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionallysubstituted with one or more halogen atoms}, R¹⁴ represents a phenylgroup, a naphthyl group, a pyridyl group, a pyrimidinyl group, a thienylgroup, a thiazolyl group, a thiadiazolyl group, a benzothiazolyl group,a benzoxazolyl group {the phenyl group, the naphthyl group, the pyridylgroup, the pyrimidinyl group, the thienyl group, the thiazolyl group,the thiadiazolyl group, the benzothiazolyl group, and the benzoxazolylgroup may be optionally substituted with one or more substituentsselected from Group G}, or a pyrazolyl group {the pyrazolyl group may beoptionally substituted with a phenyl group which may be optionallysubstituted with one or more halogen atoms}.

[Embodiment 206] The present compound N wherein E represents R¹⁴O—, andR¹⁴ represents a phenyl group which may be optionally substituted withone or more substituents selected from a halogen atom and a methyl group(with the proviso that a 2-methyl phenyl group, a 3-methylphenyl group,a 4-methylphenyl group, a 3,5-dimethylphenyl group, a 3-fluorophenylgroup, a 3-bromophenyl group, and a 3-iodophenyl group are excluded).

[Embodiment 207] The present compound N wherein E represents R¹⁴O—, andR¹⁴ represents a phenyl group which is substituted with one or morechlorine atoms.

[Embodiment 208] The present compound N wherein E represents R¹⁴O—, andR¹⁴ represents a phenyl group which is substituted with one or morefluorine atoms {with the proviso that a 3-fluorophenyl group isexcluded}.

[Embodiment 209] The present compound N wherein E represents R¹⁴O—, andR¹⁴ represents a phenyl group which is substituted at its 2-positionwith a halogen atom, a phenyl group which is substituted at its4-position with a halogen atom, a phenyl group which is substituted withtwo or more halogen atoms, or a 3-chlorophenyl group.

[Embodiment 210] The present compound N wherein E represents R¹⁴O—, andR¹⁴ represents a phenyl group which is substituted at its 2-positionwith a halogen atom.

[Embodiment 211] The present compound N wherein E represents R¹⁴O—, andR¹⁴ represents a phenyl group which is substituted at its 4-positionwith a halogen atom.

[Embodiment 212] The present compound N wherein E represents R¹⁴O—, andR¹⁴ represents a phenyl group which is substituted at its 2- or4-position with a halogen atom.

[Embodiment 213] The present compound N wherein E represents R¹⁴O—, andR¹⁴ represents a phenyl group which is substituted at its 2-positionwith substituent(s) selected from Group L.

[Embodiment 214] The present compound N wherein E represents R¹⁴O—, andR¹⁴ represents a phenyl group which is substituted at its 3-positionwith substituent(s) selected from Group M.

[Embodiment 215] The present compound N wherein E represents R¹⁴O—, andR¹⁴ represents a phenyl group which is substituted at its 4-positionwith substituent(s) selected from Group N.

[Embodiment 216] The present compound N wherein E represents R¹⁴O—, andR¹⁴ represents a phenyl group which is substituted at its 2- or4-position with substituent(s) selected from Group O.

[Embodiment 217] The present compound N wherein E represents R¹⁴O—, andR¹⁴ represents a phenyl group which is substituted with two or moresubstituents selected from Group P.

[Embodiment 218] The present compound N wherein E represents R¹⁴O—, andR¹⁴ represents a phenyl group which is substituted at its 2-positionwith substituent(s) selected from Group L, a phenyl group which issubstituted at its 3-position with substituent(s) selected from Group M,a phenyl group which is substituted at its 4-position withsubstituent(s) selected from Group N, or a phenyl group which issubstituted with two or more substituents selected from Group P.

[Embodiment 219] The present compound N wherein E represents R¹⁴O—, andR¹⁴ represents a pyridyl group which may be optionally withsubstituent(s) selected from Group P, a pyrazolyl group which may beoptionally substituted with substituent(s) selected from Group G, or apyrimidinyl group which may be optionally substituted withsubstituent(s) selected from Group Q.

[Embodiment 220] The present compound N wherein E represents R¹⁴O—, andR¹⁴ represents a phenyl group which is substituted at its 2-positionwith substituent(s) selected from Group L, a phenyl group which issubstituted at its 3-position with substituent(s) selected from Group M,a phenyl group which is substituted at its 4-position withsubstituent(s) selected from Group N, a phenyl group which issubstituted with two or more substituents selected from Group P, apyridyl group which may be optionally with substituent(s) selected fromGroup P, a pyrazolyl group which may be optionally substituted withsubstituent(s) selected from Group G, or a pyrimidinyl group which maybe optionally substituted with substituent(s) selected from Group Q.

[Embodiment 153] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to

[Embodiment 220], or the present compound N wherein R¹ represents aC1-C3 chain hydrocarbon group which may be optionally substituted withone or more halogen atoms, or a halogen atom, and n is 0.

[Embodiment 154] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a methyl group, and n is 0.

[Embodiment 155] The compound according to any one of [Embodiment 44] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a C1-C3 chain hydrocarbon group whichmay be optionally substituted with one or more halogen atoms, or ahalogen atom, n is 0, and Q represents a group represented by Q1.

[Embodiment 156] The compound according to any one of [Embodiment 44] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a methyl group, n is 0, and Qrepresents a group represented by Q1.

[Embodiment 157] The compound according to any one of [Embodiment 44] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a C1-C3 chain hydrocarbon group whichmay be optionally substituted with one or more halogen atoms, or ahalogen atom, n is 0, and Q represents a group represented by Q2.

[Embodiment 158] The compound according to any one of [Embodiment 44] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a methyl group, n is 0, and Qrepresents a group represented by Q2.

[Embodiment 159] The compound according to any one of [Embodiment 44] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a C1-C3 chain hydrocarbon group whichmay be optionally substituted with one or more halogen atoms, or ahalogen atom, n is 0, and Q represents a group represented by Q1 or agroup represented by Q2.

[Embodiment 160] The compound according to any one of [Embodiment 44] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a methyl group, n is 0, and Qrepresents a group represented by Q1 or a group represented by Q2.

[Embodiment 161] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a C1-C3 chain hydrocarbon group whichmay be optionally substituted with one or more halogen atoms, or ahalogen atom, n is 0, and Q represents a group represented by Q3.

[Embodiment 162] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a methyl group, n is 0, and Qrepresents a group represented by Q3.

[Embodiment 163] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a C1-C3 chain hydrocarbon group whichmay be optionally substituted with one or more halogen atoms, or ahalogen atom, n is 0, and Q represents a group represented by Q4.

[Embodiment 164] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a methyl group, n is 0, and Qrepresents a group represented by Q4.

[Embodiment 165] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a C1-C3 chain hydrocarbon group whichmay be optionally substituted with one or more halogen atoms, or ahalogen atom, n is 0, and Q represents a group represented by Q5.

[Embodiment 166] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a methyl group, n is 0, and Qrepresents a group represented by Q5.

[Embodiment 167] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a C1-C3 chain hydrocarbon group whichmay be optionally substituted with one or more halogen atoms, or ahalogen atom, n is 0, and Q represents a group represented by Q6.

[Embodiment 168] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a methyl group, n is 0, and Qrepresents a group represented by Q6.

[Embodiment 169] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a C1-C3 chain hydrocarbon group whichmay be optionally substituted with one or more halogen atoms, or ahalogen atom, n is 0, and Q represents a group represented by Q7.

[Embodiment 170] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a methyl group, n is 0, and Qrepresents a group represented by Q7.

[Embodiment 171] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a C1-C3 chain hydrocarbon group whichmay be optionally substituted with one or more halogen atoms, or ahalogen atom, n is 0, and Q represents a group represented by Q8.

[Embodiment 172] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a methyl group, n is 0, and Qrepresents a group represented by Q8.

[Embodiment 173] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a methyl group, n is 0, Q represents agroup represented by Q8, Z¹ represents an oxygen atom, Z² represents amethyl group which is substituted with one or more fluorine atoms, Z³represents CH, and L³ represents an oxygen atom.

[Embodiment 174] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a methyl group, n is 0, Q represents agroup represented by Q8, Z¹ represents an oxygen atom, Z² represents amethyl group which is substituted with one or more fluorine atoms, Z³represents a nitrogen atom, and L³ represents an oxygen atom.

[Embodiment 175] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a methyl group, n is 0, Q represents agroup represented by Q8, Z¹ represents an oxygen atom, Z² represents amethyl group which is substituted with one or more fluorine atoms, Z³represents a nitrogen atom, and L³ represents NH.

[Embodiment 176] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a methyl group, n is 0, Q represents agroup represented by Q8, Z¹ represents CH₂, Z² represents a methyl groupwhich is substituted with one or more fluorine atoms, Z³ represents CH,and L³ represents an oxygen atom.

[Embodiment 177] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a methyl group, n is 0, Q represents agroup represented by Q8, Z¹ represents CH₂, Z² represents a methyl groupwhich is substituted with one or more fluorine atoms, Z³ represents anitrogen atom, and L³ represents an oxygen atom.

[Embodiment 178] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a methyl group, n is 0, Q represents agroup represented by Q8, Z¹ represents CH₂, Z² represents a methyl groupwhich is substituted with one or more fluorine atoms, Z³ represents anitrogen atom, and L³ represents NH.

[Embodiment 179] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a hydrogen group, n is 0, Q representsa group represented by Q8, Z¹ represents NCH₃, Z² represents a methylgroup which is substituted with one or more fluorine atoms, Z³represents CH, and L³ represents NH.

[Embodiment 180] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a hydrogen atom, n is 0, Q represents agroup represented by Q8, Z¹ represents NCH₃, Z² represents a methylgroup which is substituted with one or more fluorine atoms, Z³represents a nitrogen atom, and L³ represents an oxygen atom.

[Embodiment 181] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a hydrogen atom, n is 0, Q represents agroup represented by Q8, Z¹ represents NCH₃, Z² represents a methylgroup which is substituted with one or more fluorine atoms, Z³represents a nitrogen atom, and L³ represents NH.

[Embodiment 182] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a methyl group, n is 0, Q represents agroup represented by Q8, Z¹ represents a single bond, Z² represents amethyl group which is substituted with one or more fluorine atoms, Z³represents CH, and L³ represents an oxygen atom.

[Embodiment 183] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a methyl group, n is 0, Q represents agroup represented by Q8, Z¹ represents a single bond, Z² represents amethyl group which is substituted with one or more fluorine atoms, Z³represents a nitrogen atom, and L³ represents an oxygen atom.

[Embodiment 184] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a methyl group, n is 0, Q represents agroup represented by Q8, Z¹ represents a single bond, Z² represents amethyl group which is substituted with one or more fluorine atoms, Z³represents a nitrogen atom, and L³ represents NH.

[Embodiment 185] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a hydrogen atom, n is 1, and R²represents a methyl group, or a halogen atom.

[Embodiment 186] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a hydrogen atom, n is 1, and R²represents a methyl group.

[Embodiment 187] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a hydrogen atom, n is 1, and R²represents a chlorine atom.

[Embodiment 188] The compound according to any one of [Embodiment 1] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a hydrogen atom, n is 1, R² representsa methyl group, or a halogen atom, and Q represents a group representedby Q1.

[Embodiment 189] The compound according to any one of [Embodiment 44] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a hydrogen atom, n is 1, R² representsa methyl group, and Q represents a group represented by Q1.

[Embodiment 190] The compound according to any one of [Embodiment 44] to[Embodiment 152], [Embodiment 192] to [Embodiment 220], or the presentcompound N wherein R¹ represents a hydrogen atom, n is 1, R² representsa hydrogen atom, and Q represents a group represented by Q1.

[Embodiment 191] The compound according to [Embodiment 116] wherein R¹represents a methyl group, n is 0, Q represents a group represented byQ1 or a group represented by Q2, and L¹ represents an oxygen atom or NH.

Examples of the embodiment of the present compound C include thefollowing compounds.

[Embodiment C1] The present compound C wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R⁸R⁹C═N—O—CH₂—, or R¹⁹O—.

[Embodiment C2] The present compound C wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, or R¹⁶O—.

[Embodiment C3] The present compound C wherein E representsR⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R⁹ represents a C1-C3 alkyl group, and    -   R⁸ and R⁹ may combine together with a nitrogen atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G}.

[Embodiment C4] The present compound C wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, or R⁸R⁹C═N—O—CH₂—,

-   -   R³⁴ represents a C1-C6 chain hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group J, a C3-C6 cycloalkyl group which may be optionally        substituted with one or more halogen atoms, a phenyl group, or a        five- to six-membered aromatic heterocyclic group {the phenyl        group, and the five- to six-membered aromatic heterocyclic group        may be optionally substituted with one or more substituents        selected from Group G},    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form a C3-C10 alicyclic hydrocarbon group,        or a three- to ten-membered non-aromatic heterocyclic group {the        C3-C10 alicyclic hydrocarbon group, and the three- to        ten-membered non-aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        E},    -   R⁹ represents a C1-C3 alkyl group, and    -   R⁸ and R⁹ may combine together with a nitrogen atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G}.

[Embodiment C5] The present compound C wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R¹⁵—CH(R¹⁶)—O—N═C(R⁷)—, or R¹⁹O—,

-   -   R³⁴ represents a C1-C6 chain hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group J, a C3-C6 cycloalkyl group, a phenyl group which may        be optionally substituted with one or more halogen atoms, or a        five- to six-membered aromatic heterocyclic group {the phenyl        group, and the five- to six-membered aromatic heterocyclic group        may be optionally substituted with one or more substituents        selected from Group G},    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form a C3-C10 alicyclic hydrocarbon group,        or a three- to ten-membered non-aromatic heterocyclic group {the        C3-C10 alicyclic hydrocarbon group, and the three- to        ten-membered non-aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        E}.

[Embodiment C6] The present compound C wherein E representsR⁸R⁹C═N—O—CH₂—, R¹⁵—CH(R¹⁶)—O—N═C(R⁷)—, or R¹⁹O—,

-   -   R⁹ represents a C1-C3 alkyl group, and    -   R⁸ and R⁹ may combine together with a nitrogen atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G}.

[Embodiment C7] The present compound C wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R¹⁵—CH(R¹⁶)—O—N═C(R⁷)—, or R⁸R⁹C═N—O—CH₂—,

-   -   R³⁴ represents a C1-C6 chain hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group J, a C3-C6 cycloalkyl group, a phenyl group which may        be optionally substituted with one or more halogen atoms, or a        five- to six-membered aromatic heterocyclic group {the phenyl        group, and the five- to six-membered aromatic heterocyclic group        may be optionally substituted with one or more substituents        selected from Group G},    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form a C3-C10 alicyclic hydrocarbon group,        or a three- to ten-membered non-aromatic heterocyclic group {the        C3-C10 alicyclic hydrocarbon group, and the three- to        ten-membered non-aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        E},    -   R¹⁵ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,    -   R⁹ represents a C1-C3 alkyl group,    -   R⁸ and R⁹ may combine together with a nitrogen atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G}.

[Embodiment C8] The present compound C wherein E representsR¹⁵—CH(R¹⁶)—O—N═C(R⁷)—, or R¹⁹O—.

[Embodiment C9] The present compound C wherein E representsR⁸R⁹C═N—O—CH₂—, or R¹⁵—CH(R¹⁶)—O—N═C(R⁷)—,

-   -   R⁹ represents a C1-C3 alkyl group, and    -   R⁸ and R⁹ may combine together with a nitrogen atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G}.

[Embodiment C10] The present compound C wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, or R¹⁵—CH(R¹⁶)—O—N═C(R⁷)—,

-   -   R³⁴ represents a C1-C6 chain hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group J, a C3-C6 cycloalkyl group which may be optionally        substituted with one or more halogen atoms, a phenyl group, or a        five- to six-membered aromatic heterocyclic group {the phenyl        group, and the five- to six-membered aromatic heterocyclic group        may be optionally substituted with one or more substituents        selected from Group G},    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form a C3-C10 alicyclic hydrocarbon group,        or a three- to ten-membered non-aromatic heterocyclic group {the        C3-C10 alicyclic hydrocarbon group, and the three- to        ten-membered non-aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        E}, and    -   R¹⁵ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group.

[Embodiment C11] The present compound C wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R⁸R⁹C═N—O—CH₂—, R¹⁵—CH(R¹⁶)—O—N═C(R⁷)—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group, a pyridyl group, a pyrazolyl        group, or a thiazolyl group {the phenyl group, the pyridyl        group, the pyrazolyl group, and the thiazolyl group may be        optionally substituted with one or more substituents selected        from Group G}, and R³⁵ represents a C1-C3 alkyl group,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G},    -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J3}, R⁹ represents a C1-C3 alkyl group,    -   R¹⁵ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,        and    -   R¹⁹ represents a phenyl group which is substituted at its 2- or        4-position with a halogen atom.

[Embodiment C12] The present compound C wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group, a pyridyl group, a pyrazolyl        group, or a thiazolyl group {the phenyl group, the pyridyl        group, the pyrazolyl group, and the thiazolyl group may be        optionally substituted with one or more substituents selected        from Group G}, and R³⁵ represents a C1-C3 alkyl group,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G},    -   R¹⁹ represents a phenyl group which is substituted at its 2- or        4-position with a halogen atom.

[Embodiment C13] The present compound C wherein E representsR⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J3}, R⁹ represents a C1-C3 alkyl group, and    -   R¹⁹ represents a phenyl group which is substituted at its 2- or        4-position with a halogen atom.

[Embodiment C14] The present compound C wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, or R⁸R⁹C═N—O—CH₂—,

-   -   R³⁴ represents a phenyl group, a pyridyl group, a pyrazolyl        group, or a thiazolyl group {the phenyl group, the pyridyl        group, the pyrazolyl group, and the thiazolyl group may be        optionally substituted with one or more substituents selected        from Group G}, and R³⁵ represents a C1-C3 alkyl group,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G},    -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J3}, and R⁹ represents a C1-C3 alkyl group.

[Embodiment C15] The present compound C wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group, a pyridyl group, a pyrazolyl        group, or a thiazolyl group {the phenyl group, the pyridyl        group, the pyrazolyl group, and the thiazolyl group may be        optionally substituted with one or more substituents selected        from Group G}, and R³⁵ represents a C1-C3 alkyl group,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G},    -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J31, R⁹ represents a C1-C3 alkyl group, and    -   R¹⁹ represents a phenyl group which is substituted at its        2-position with a halogen atom, a phenyl group which is        substituted at its 4-position with a halogen atom, a phenyl        group which is substituted with two or more halogen atoms, or a        3-chlorophenyl group.

[Embodiment C16] The present compound C wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group, a pyridyl group, a pyrazolyl        group, or a thiazolyl group {the phenyl group, the pyridyl        group, the pyrazolyl group, and the thiazolyl group may be        optionally substituted with one or more substituents selected        from Group G}, and R³⁵ represents a C1-C3 alkyl group,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G}, and    -   R¹⁹ represents a phenyl group which is substituted at its 2- or        4-position with a halogen atom.

[Embodiment C17] The present compound C wherein E representsR⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J3}, R⁹ represents a C1-C3 alkyl group,    -   R¹⁹ represents a phenyl group which is substituted at its        2-position with substituent(s), a phenyl group which is        substituted at its 4-position with a halogen atom, a phenyl        group which is substituted with two or more halogen atoms, or a        3-chlorophenyl group.

[Embodiment C18] The present compound C wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group, a pyridyl group, a pyrazolyl        group, or a thiazolyl group {the phenyl group, the pyridyl        group, the pyrazolyl group, and the thiazolyl group may be        optionally substituted with one or more substituents selected        from Group G}, and R³⁵ represents a C1-C3 alkyl group,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G},    -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J3}, R⁹ represents a C1-C3 alkyl group, and    -   R¹⁹ represents a phenyl group which is substituted at its 2- or        4-position with substituent(s) selected from Group O.

[Embodiment C19] The present compound C wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group, a pyridyl group, a pyrazolyl        group, or a thiazolyl group {the phenyl group, the pyridyl        group, the pyrazolyl group, and the thiazolyl group may be        optionally substituted with one or more substituents selected        from Group G}, and R³⁵ represents a C1-C3 alkyl group,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G}, and    -   R¹⁹ represents a phenyl group which is substituted at its 2- or        4-position with substituent(s) selected from Group O.

[Embodiment C20] The present compound C wherein E representsR⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J3}, R⁹ represents a C1-C3 alkyl group, and    -   R¹⁹ represents a phenyl group which is substituted at its 2- or        4-position with substituent(s) selected from Group O.

[Embodiment C21] The present compound C wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group, a pyridyl group, a pyrazolyl        group, or a thiazolyl group {the phenyl group, the pyridyl        group, the pyrazolyl group, and the thiazolyl group may be        optionally substituted with one or more substituents selected        from Group G}, and R³⁵ represents a C1-C3 alkyl group,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G},    -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J3}, R⁹ represents a C1-C3 alkyl group, and    -   R¹⁹ represents a phenyl group which is substituted with one or        more chlorine atoms.

[Embodiment C22] The present compound C wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group, a pyridyl group, a pyrazolyl        group, or a thiazolyl group {the phenyl group, the pyridyl        group, the pyrazolyl group, and the thiazolyl group may be        optionally substituted with one or more substituents selected        from Group G}, and R³⁵ represents a C1-C3 alkyl group,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, a        3,4-dihydro-2H-1-benzofuran-4-ylidene group, a        3,4-dihydro-2H-1-benzopyran-4-ylidene group, or a        3,4-dihydro-2H-1-benzopyran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group, the        3,4-dihydro-2H-1-benzopyran-4-ylidene group, and the        3,4-dihydro-2H-1-benzopyran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        G}, and    -   R¹⁹ represents a phenyl group which is substituted with one or        more chlorine atoms.

[Embodiment C23] The present compound C wherein E representsR⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J3}, R⁹ represents a C1-C3 alkyl group, and    -   R¹⁹ represents a phenyl group which is substituted with one or        more chlorine atoms.

[Embodiment C24] The present compound C wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,        R³⁵ represents a C1-C3 alkyl group,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, or a        3,4-dihydro-2H-1-benzofuran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        J3},    -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J3}, R⁹ represents C1-C3 alkyl group, and    -   R¹⁹ represents a phenyl group which is substituted at its 2- or        4-position with a halogen atom.

[Embodiment C25] The present compound C wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,        R³⁵ represents a C1-C3 alkyl group, or    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, or a        3,4-dihydro-2H-1-benzofuran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        J3}, and    -   R¹⁹ represents a phenyl group which is substituted at its 2- or        4-position with a halogen atom.

[Embodiment C26] The present compound C wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, or R⁸R⁹C═N—O—CH₂—,

-   -   R³⁴ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,        R³⁵ represents a C1-C3 alkyl group,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, or a        3,4-dihydro-2H-1-benzofuran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        J3},    -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J3}, and R⁹ represents a C1-C3 alkyl group.

[Embodiment C27] The present compound C wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,        R³⁵ represents a C1-C3 alkyl group,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, or a        3,4-dihydro-2H-1-benzofuran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        J3},    -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J3}, R⁹ represents a C1-C3 alkyl group, and    -   R¹⁹ represents a phenyl group which is substituted at its        2-position with a halogen atom, a phenyl group which is        substituted at its 4-position with a halogen atom, a phenyl        group which is substituted with two or more halogen atoms, or a        3-chlorophenyl group.

[Embodiment C28] The present compound C wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,        R³⁵ represents a C1-C3 alkyl group,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, or a        3,4-dihydro-2H-1-benzofuran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        J3}, and    -   R¹⁹ represents a phenyl group which is substituted at its 2- or        4-position with a halogen atom.

[Embodiment C29] The present compound C wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,        and R³⁵ represents a C1-C3 alkyl group, or    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, or a        3,4-dihydro-2H-1-benzofuran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        J3},    -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J3}, R⁹ represents a C1-C3 alkyl group, and    -   R¹⁹ represents a phenyl group which is substituted at its 2- or        4-position with substituent(s) selected from Group O.

[Embodiment C30] The present compound C wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,        R³⁵ represents a C1-C3 alkyl group,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, or a        3,4-dihydro-2H-1-benzofuran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        J3}, and    -   R¹⁹ represents a phenyl group which is substituted at its 2- or        4-position with substituent(s) selected from Group O.

[Embodiment C31] The present compound C wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R⁸R⁹C═N—O—CH₂—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,        and R³⁵ represents a C1-C3 alkyl group, or    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, or a        3,4-dihydro-2H-1-benzofuran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        J3},    -   R⁸ represents an indanyl group, a tetrahydronaphthyl group, a        dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group J3}, R⁹ represents a C1-C3 alkyl group, and    -   R¹⁹ represents a phenyl group which is substituted with one or        more chlorine atoms.

[Embodiment C32] The present compound C wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,        and R³⁵ represents a C1-C3 alkyl group, or    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, or a        3,4-dihydro-2H-1-benzofuran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        J3}, and    -   R¹⁹ represents a phenyl group which is substituted with one or        more chlorine atoms.

[Embodiment C33] The present compound C wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R⁸R⁹C═N—O—CH²—, or R¹⁹O—,

-   -   R³⁴ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,    -   R⁹ and R³⁵ are identical to or different from each other and        represent, C1-C3 alkyl group,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, or a        3,4-dihydro-2H-1-benzofuran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        J3},    -   R⁸ represents an indanyl group, or a tetrahydronaphthyl group        {the indanyl group, and the tetrahydronaphthyl group may be        optionally substituted with one or more substituents selected        from Group J3}, and    -   R¹⁹ represents a phenyl group which is substituted at its        2-position with substituent(s) selected from Group L a phenyl        group which is substituted at its 3-position with substituent(s)        selected from Group M, a phenyl group which is substituted at        its 4-position with substituent(s) selected from Group N, or a        phenyl group which is substituted with two or more substituents        selected from Group P (the two or more substituents selected        from Group P may be identical to or different from each other).

[Embodiment C34] The present compound C wherein E representsR⁸R⁹C═N—O—CH²—, or R¹⁹O—,

-   -   R⁸ represents an indanyl group, or a tetrahydronaphthyl group        {the indanyl group, and the tetrahydronaphthyl group may be        optionally substituted with one or more substituents selected        from Group J3},    -   R⁹ represents a C1-C3 alkyl group, and    -   R¹⁹ represents a phenyl group {the phenyl group is substituted        at its 2-position with substituent(s) selected from Group L, is        substituted at its 3-position with substituent(s) selected from        Group M, is substituted at its 4-position with substituent(s)        selected from Group N, or is substituted with two or more        substituent(s) selected from Group P.

[Embodiment C35] The present compound C wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, R⁸R⁹C═N—O—CH²—, or R¹⁹O—,

-   -   R³⁵ represents a C1-C3 alkyl group, and    -   R³⁴ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,        or    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, or a        3,4-dihydro-2H-1-benzofuran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        J3}, and    -   R¹⁹ represents a phenyl group which is substituted at its        2-position with substituent(s) selected from Group L, a phenyl        group which is substituted at its 3-position with substituent(s)        selected from Group M, a phenyl group which is substituted at        its 4-position with substituent(s) selected from Group N, or a        phenyl group which is substituted with two or more substituents        selected from Group P (the two or more substituents selected        from Group P may be identical to or different from each other).

[Embodiment C36] The present compound C wherein E representsR³⁴R³⁵C═N—N═C(R¹⁰)—, or R⁸R⁹C═N—O—CH²—,

-   -   R³⁴ represents a phenyl group which may be optionally        substituted with one or more substituents selected from Group G,    -   R⁹ and R³⁵ are identical to or different from each other and        represent a C1-C3 alkyl group,    -   R³⁴ and R³⁵ may combine together with a carbon atom to which        they are attached to form an indan-1-ylidene group, a        1,2,3,4-tetrahydronaphthalen-1-yline group, a        2,3-dihydrobenzofuran-3-yline group, or a        3,4-dihydro-2H-1-benzofuran-4-ylidene group {the indan-1-ylidene        group, the 1,2,3,4-tetrahydronaphthalen-1-yline group, the        2,3-dihydrobenzofuran-3-yline group, and the        3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionally        substituted with one or more substituents selected from Group        J3}, and    -   R⁸ represents an indanyl group, or a tetrahydronaphthyl group        {the indanyl group, and the tetrahydronaphthyl group may be        optionally substituted with one or more substituents selected        from Group J3}.

[Embodiment C37] The present compound C wherein E represents R¹⁹O—, R¹⁹represents a phenyl group which is substituted at its 2-position with ahalogen atom, a phenyl group which is substituted at its 4-position witha halogen atom, a 3-chlorophenyl group, a phenyl group which issubstituted with two or more halogen atoms, or a pyridyl group which maybe optionally substituted with one or more halogen atoms.

[Embodiment C38] The present compound C wherein E represents R¹⁹O—, R¹⁹represents a 2-fluorophenyl group, a 4-fluorophenyl group, a3-chlorophenyl group, a phenyl group which is substituted with two ormore fluorine atoms, or a pyridyl group which may be optionallysubstituted with one or more fluorine atoms.

[Embodiment C39] The compound according to any one of [Embodiment C1] to[Embodiment C38] or the present compound C wherein Q represents a grouprepresented by Q1.

[Embodiment C40] The compound according to any one of [Embodiment C1] to[Embodiment C38] or the present compound C wherein Q represents a grouprepresented by Q2.

[Embodiment C41] A compound represented by formula (IIa):

[wherein

-   -   Q^(a) represents a group represented by Q1, or a group        represented by Q2,    -   E^(a) represents R^(34a)R^(35a)C═N—N═C(R^(10a))—,        R^(8a)R^(9a)C═N—O—CH₂—, R^(15a)—CH(R^(16a))—O—N═C(R^(7a))—, or        R^(14a)O—,    -   R^(34a) represents a C1-C6 chain hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group J, a C3-C10 alicyclic hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group E, a phenyl group, or a five- to six-membered        aromatic heterocyclic group {the phenyl group, and the five- to        six-membered aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        G},    -   R^(9a) and R^(35a) are identical to or different from each other        and represent a C1-C3 alkyl group, or a hydrogen atom,    -   R^(7a), R^(10a), and R^(16a) are identical to or different from        each other and represent a C1-C3 alkyl group,    -   R^(8a) represents an indanyl group, a tetrahydronaphthyl group,        a dihydrobenzofuranyl group, or a dihydrobenzopyranyl group {the        indanyl group, the tetrahydronaphthyl group, the        dihydrobenzofuranyl group, and the dihydrobenzopyranyl group may        be optionally substituted with one or more substituents selected        from Group G},    -   R^(8a) and R^(9a) may combine together a carbon atom to which        they are attached to form a C3-C10 alicyclic hydrocarbon group,        or a three- to ten-membered non-aromatic heterocyclic group {the        C3-C10 alicyclic hydrocarbon group, and the three- to        ten-membered non-aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        E},    -   R^(34a) and R^(35a) may combine together with a carbon atom to        which they are attached to form a C3-C10 alicyclic hydrocarbon        group, or a three- to ten-membered non-aromatic heterocyclic        group {the C3-C10 alicyclic hydrocarbon group, and the three- to        ten-membered non-aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        E},    -   R^(15a) represents a phenyl group, or a five- to six-membered        aromatic heterocyclic group {the phenyl group, and the five- to        six-membered aromatic heterocyclic group may be optionally        substituted with one or more substituents selected from Group        G},    -   R^(14a) represents a phenyl group which is substituted at its        2-position with substituent(s) selected from Group L, a phenyl        group which is substituted at its 3-position with substituent(s)        selected from Group M, a phenyl group which is substituted at        its 4-position with substituent(s) selected from Group N, a        phenyl group which is substituted with two or more substituents        selected from Group P (the two or more substituents selected        from Group P may be identical to or different from each other),        a pyridyl group which may be optionally with substituent(s)        selected from Group P, a pyrazolyl group which may be optionally        substituted with substituent(s) selected from Group G, or a        pyrimidinyl group which may be optionally substituted with        substituent(s) selected from Group Q.]    -   or its N oxide or agriculturally acceptable salt thereof.

[Embodiment C42] The compound according to [Embodiment C41] whereinE^(a) represents R^(14a)O—, R^(14a) represents a phenyl group which issubstituted at its 2-position with substituent(s) selected from Group V,a phenyl group which is substituted at its 4-position withsubstituent(s) selected from Group V, a 3-chlorophenyl group, a phenylgroup which is substituted with two or more halogen atoms, or a pyridylgroup which may be optionally substituted with one or more halogenatoms.

[Embodiment C43] The compound according to [Embodiment C41] whereinE^(a) represents R^(34a)R^(35a)C═N—N═C(R^(10a))—, or R^(14a)O—.

[Embodiment C44] The compound according to [Embodiment C41] whereinE^(a) represents R^(15a)—CH(R^(16a))—O—N═C(R^(7a))—, or R^(14a)O—.

[Embodiment C45] The compound according to [Embodiment C41] whereinE^(a) represents R^(34a)R^(35a)C═N—N═C(R^(10a))—,R^(15a)—CH(R^(6a))—O—N═C(R^(7a))—, or R^(14a)O—.

[Embodiment C46] The compound according to [Embodiment C41] whereinE^(a) represents R^(14a)O—, and R^(14a) represents a phenyl group whichis substituted at its 2-position with a halogen atom, a phenyl groupwhich is substituted at its 4-position with a halogen atom, a3-chlorophenyl group, a phenyl group which is substituted with two ormore halogen atoms, or a pyridyl group which may be optionallysubstituted with one or more halogen atoms.

[Embodiment C47] The compound according to [Embodiment C41] whereinE^(a) represents R^(14a)O—, and R^(14a) represents a 2-fluorophenylgroup, a 4-fluorophenyl group, a 3-chlorophenyl group, a phenyl groupwhich is substituted with two or more fluorine atoms, or a pyridyl groupwhich is substituted with two or more fluorine atoms.

[Embodiment C48] The compound according to [Embodiment C41] whereinE^(a) represents R^(34a)R^(35a)C═N—N═C(R^(10a))—,R^(15a)—CH(R^(16a))—O—N═C(R^(7a))—, or R^(14a)O—, R^(34a) represents aphenyl group, or a five- to six-membered aromatic heterocyclic group{the phenyl group, and the five- to six-membered aromatic heterocyclicgroup may be optionally substituted with one or more substituentsselected from Group G}, R^(35a) represents a C1-C3 alkyl group, or ahydrogen atom, R⁷?, R^(10a), and R^(16a) are identical to or differentfrom each other and represent a C1-C3 alkyl group, R^(34a) and R^(35a)combine together with a carbon atom to which they are attached to forman indan-1-ylidene group, or a 3,4-dihydro-2H-1-benzofuran-4-ylidenegroup {the indan-1-ylidene group, and the3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionallysubstituted with one or more substituents selected from Group J3},R^(15a) represents a phenyl group which may be optionally substitutedwith one or more substituents selected from Group G, R^(14a) representsa phenyl group which is substituted at its 2-position withsubstituent(s) selected from Group L2, a phenyl group which issubstituted at its 3-position with substituent(s) selected from GroupM2, a phenyl group which is substituted at its 4-position withsubstituent(s) selected from Group L², a phenyl group which issubstituted with two or more halogen atoms, or a pyridyl group which issubstituted with substituent(s) selected from Group L2,

-   -   Group L2 is a group consisting of a C1-C3 alkoxy group and a        halogen atom,    -   Group M2 is a group consisting of a C1-C3 alkyl group which is        substituted with one or more halogen atoms, and a chlorine atom.

[Embodiment C49] The compound according to [Embodiment C41] whereinE^(a) represents R^(34a)R^(35a)C═N—N═C(R^(10a))—,R^(15a)—CH(R^(16a))—O—N═C(R^(7a))—, or R^(14a)O—, R^(34a) represents aphenyl group, a pyridyl group, a thiazolyl group, or a pyrazolyl group{the phenyl group, the pyridyl group, the thiazolyl group, and thepyrazolyl group may be optionally substituted with one or moresubstituents selected from Group G}, R^(35a) represents methyl group, ora hydrogen atom, R^(7a), R^(10a), and R^(16a) represent a methyl group,R^(34a) and R^(35a) may combine together with a carbon atom to whichthey are attached to form an indan-1-ylidene group, or a3,4-dihydro-2H-1-benzofuran-4-ylidene group {the indan-1-ylidene group,and the 3,4-dihydro-2H-1-benzofuran-4-ylidene group may be optionallysubstituted with one or more substituents selected from Group J3},R^(15a) represents a phenyl group which may be optionally substitutedwith one or more substituents selected from Group G, R^(14a) representsa phenyl group which is substituted at its 2-position withsubstituent(s) selected from Group L2, a phenyl group which issubstituted at its 3-position with substituent(s) selected from GroupM2, a phenyl group which is substituted at its 4-position withsubstituent(s) selected from Group L2, a phenyl group which issubstituted with two or more halogen atoms, or a pyridyl group which maybe optionally substituted with substituent(s) selected from Group L2.

[Embodiment C50] The compound according to [Embodiment C41] whereinE^(a) represents R^(14a)O—, R^(14a) represents a phenyl group which issubstituted at its 2-position with substituent(s) selected from GroupL3, a phenyl group which is substituted at its 3-position withsubstituent(s) selected from Group M3, a phenyl group which issubstituted at its 4-position with substituent(s) selected from GroupL³, a phenyl group which is substituted with two or more fluorine atoms,or a pyridyl group which may be optionally substituted withsubstituent(s) selected from Group L3,

-   -   Group L3 is a group consisting of a methoxy group, a fluorine        atom, and a chlorine atom,    -   Group M3 is a group consisting of a trifluoromethyl group and a        chlorine atom.

[Embodiment C51] The compound according to [Embodiment C41] whereinR^(14a) represents a phenyl group which may be optionally substitutedwith one or more substituents selected from a halogen atom and a methylgroup [with the proviso that a 2-methyl phenyl group, a 3-methylphenylgroup, a 4-methylphenyl group, a 3,5-dimethylphenyl group, a3-fluorophenyl group, a 3-bromophenyl group, and a 3-iodophenyl groupare excluded}.

[Embodiment C52] The compound according to [Embodiment C41] whereinE^(a) represents R^(14a)O—, and R^(14a) represents a phenyl group whichis substituted with one or more chlorine atoms.

[Embodiment C53] The compound according to [Embodiment C41] whereinE^(a) represents R^(14a)O—, and R^(14a) represents a phenyl group whichis substituted with one or more fluorine atoms [with the proviso that a3-fluorophenyl group is excluded}.

[Embodiment C54] The compound according to [Embodiment C41] whereinE^(a) represents R^(14a)O—, and R^(14a) represents a phenyl group whichis substituted at its 2-position with a halogen atom, a phenyl groupwhich is substituted at its 4-position with a halogen atom, a phenylgroup which is substituted with two or more halogen atoms, or a3-chlorophenyl group.

[Embodiment C55] The compound according to [Embodiment C41] whereinE^(a) represents R^(14a)O—, and R^(14a) represents a phenyl group whichis substituted at its 2-position with a halogen atom.

[Embodiment C56] The compound according to [Embodiment C41] whereinE^(a) represents R^(14a)O—, and R^(14a) represents a phenyl group whichis substituted at its 4-position with a halogen atom.

[Embodiment C57] The compound according to [Embodiment C41] whereinE^(a) represents R^(14a)O—, and R^(14a) represents a phenyl group whichis substituted at its 2- or 4-position with a halogen atom.

[Embodiment C58] The compound according to [Embodiment C41] whereinE^(a) represents R^(14a)O—, and R^(14a) represents a phenyl group whichis substituted at its 2-position with substituent(s) selected from GroupL.

[Embodiment C59] The compound according to [Embodiment C41] whereinE^(a) represents R^(14a)O—, and R^(14a) represents a phenyl group whichis substituted at its 3-position with substituent(s) selected from GroupM.

[Embodiment C60] The compound according to [Embodiment C41] whereinE^(a) represents R^(14a)O—, and R^(14a) represents a phenyl group whichis substituted at its 4-position with substituent(s) selected from GroupN.

[Embodiment C61] The compound according to [Embodiment C41] whereinE^(a) represents R^(14a)O—, and R^(14a) represents a phenyl group whichis substituted at its 2- or 4-position with substituent(s) selected fromGroup O.

[Embodiment C62] The compound according to [Embodiment C41] whereinE^(a) represents R^(14a)O—, and R^(14a) represents a phenyl group whichis substituted with two or more substituents selected from Group P.

[Embodiment C63] The compound according to [Embodiment C41] whereinE^(a) represents R^(14a)O—, and R^(14a) represents a phenyl group whichis substituted at its 2-position with substituent(s) selected from GroupL, a phenyl group which is substituted at its 3-position withsubstituent(s) selected from Group M, a phenyl group which issubstituted at its 4-position with substituent(s) selected from Group N,or a phenyl group which is substituted with two or more substituentsselected from Group P.

[Embodiment C64] The compound according to [Embodiment C41] whereinE^(a) represents R^(14a)O—, and R^(14a) represents a pyridyl group whichmay be optionally with substituent(s) selected from Group P, a pyrazolylgroup which may be optionally substituted with substituent(s) selectedfrom Group G, or a pyrimidinyl group which may be optionally substitutedwith substituent(s) selected from Group Q.

[Embodiment C65] The compound according to [Embodiment C41] whereinE^(a) represents R^(14a)O—, and R^(14a) represents a phenyl group whichis substituted at its 2-position with substituent(s) selected from GroupL, a phenyl group which is substituted at its 3-position withsubstituent(s) selected from Group M, a phenyl group which issubstituted at its 4-position with substituent(s) selected from Group N,a phenyl group which is substituted with two or more substituentsselected from Group P, a pyridyl group which may be optionally withsubstituent(s) selected from Group P, a pyrazolyl group which may beoptionally substituted with substituent(s) selected from Group G, or apyrimidinyl group which may be optionally substituted withsubstituent(s) selected from Group Q.

[Embodiment C66] The compound according to any one of [Embodiment C41]to [Embodiment C65] or the present compound C wherein Q^(a) represents agroup represented by Q1.

[Embodiment C67] The compound according to any one of [Embodiment C41]to [Embodiment C65] or the present compound C wherein Q^(a) represents agroup represented by Q2.

Examples of the embodiment of the present compound D include thefollowing compounds.

[Embodiment D1] The present compound D wherein E³ represents R³⁹OCH₂—,or R⁴⁰CH₂O—.

[Embodiment D2] The present compound D wherein E³ represents R³⁹OCH₂—.

[Embodiment D3] The present compound D wherein E³ represents R⁴⁰CH₂O—.

[Embodiment D4] The present compound D1 wherein R³⁹ represents a five-to six-membered aromatic heterocyclic group which may be optionallysubstituted with one or more substituents selected from Group R, and R⁴⁰represents a phenyl group which may be optionally substituted with oneor more substituents selected from Group R.

[Embodiment D5] The present compound D1 wherein R³⁹ represents apyrazolyl group, or a pyridyl group {the pyrazolyl group, and thepyridyl group may be optionally substituted with one or moresubstituents selected from Group W}, and R⁴⁰ represents a phenyl groupwhich may be optionally substituted with one or more substituentsselected from Group W,

-   -   Group W is a group consisting of a methyl group, a phenyl group        {the methyl group, and the phenyl group may be optionally        substituted with one or more halogen atoms}, and a halogen atom.

[Embodiment D6] The present compound D2 wherein R³⁹ represents apyrazolyl group which may be optionally substituted with one or moreR⁴⁴, or a pyridyl group which may be optionally substituted with one ormore R⁴⁵, R⁴⁴ represents a phenyl group which may be optionallysubstituted with one or more halogen atoms, and R⁴⁵ represents a methylgroup which may be optionally substituted with one or more halogenatoms.

[Embodiment D7] The present compound D3 wherein R⁴⁰ represents a phenylgroup which may be optionally substituted with one or more substituentsselected from Group Z,

-   -   Group Z is a group consisting of a methyl group which may be        optionally substituted with one or more halogen atoms, and a        halogen atom.

[Embodiment D14] The present compound D wherein E³ represents R⁴⁶O—.

[Embodiment D15] The present compound D wherein E³ represents R⁴¹S—.

[Embodiment D16] The present compound D wherein E³ represents R³⁹OCH₂—,R⁴⁰CH₂O—, R⁴¹S—, or R⁴⁶O—.

[Embodiment D17] The present compound D wherein E³ represents R³⁹OCH₂—,R⁴⁰CH₂O—, or R⁴⁶O—.

[Embodiment D18] The present compound D14 wherein R⁴⁶ represents a C5-C6cycloalkyl group.

[Embodiment D19] The present compound D15 wherein R⁴¹ represents aphenyl group which may be optionally substituted with one or morehalogen atoms.

[Embodiment D20] The present compound D16 wherein R³⁹ represents apyrazolyl group which may be optionally substituted with one or more R⁴,a pyridyl group which may be optionally substituted with one or moreR⁴⁵, or a phenyl group, R⁴⁴ represents a phenyl group which may beoptionally substituted with one or more halogen atoms, R⁴⁵ represents amethyl group which may be optionally substituted with one or morehalogen atoms, R⁴⁰ represents a phenyl group which may be optionallysubstituted with one or more substituents selected from Group Z, R⁴¹represents a phenyl group which may be optionally substituted with oneor more halogen atoms, and R⁴⁶ represents a C5-C6 a cycloalkyl group.

[Embodiment D21] The present compound D17 wherein R³⁹ represents apyrazolyl group which may be optionally substituted with one or moreR⁴⁴, a pyridyl group which may be optionally substituted with one ormore R⁴⁵, or a phenyl group, R⁴⁴ represents a phenyl group which may beoptionally substituted with one or more halogen atoms, R⁴⁵ representsmethyl group which may be optionally substituted with one or morehalogen atoms, R⁴⁰ represents a phenyl group which may be optionallysubstituted with one or more substituents selected from Group Z, and R⁴⁶represents a C5-C6 a cycloalkyl group.

[Embodiment D8] The compound according to any one of [Embodiment D1] to[Embodiment D7], [Embodiment D14] to [Embodiment D21], or the presentcompound D wherein n is 0, R¹ represents a methyl group, Q represents agroup represented by Q1, or a group represented by Q2, and L¹ representsan oxygen atom or NH.

[Embodiment D9] The compound according to any one of [Embodiment D1] to[Embodiment D7], [Embodiment D14] to [Embodiment D21], or the presentcompound D wherein n is 0, R¹ represents a methyl group, and Qrepresents a group represented by Q1.

[Embodiment D10] The compound according to any one of [Embodiment D1] to[Embodiment D7], [Embodiment D14] to [Embodiment D21], or the presentcompound D wherein n is 0, R¹ represents a methyl group, and Qrepresents a group represented by Q2.

[Embodiment D11] The compound according to any one of [Embodiment D1] to[Embodiment D7], [Embodiment D14] to [Embodiment D21], or the presentcompound D wherein n is 1, R¹ represents a hydrogen atom, and Qrepresents a group represented by Q1, or a group represented by Q2.

[Embodiment D12] The compound according to any one of [Embodiment D1] to[Embodiment D7], [Embodiment D14] to [Embodiment D21], or the presentcompound D wherein n is 1, R¹ represents a hydrogen atom, and Qrepresents a group represented by Q1.

[Embodiment D13] The compound according to any one of [Embodiment D1] to[Embodiment D7], [Embodiment D14] to [Embodiment D21], or the presentcompound D wherein n is 1, R¹ represents a hydrogen atom, and Qrepresents a group represented by Q2.

Next, the process for preparing the compounds disclosed herein(including the present compound C, the present compound D and thepresent compound A) are explained.

Process A

A compound represented by formula (A1) (hereinafter, referred to as“Compound (A1)”) can be prepared by reacting a compound represented byformula (B1) (hereinafter, referred to as “Compound (B1)”) with acompound represented by formula (M1) (hereinafter, referred to as“Compound (M1)”) in the presence of a palladium catalyst and a base.

[wherein

-   -   a combination of Q and E′ represents a combination wherein Q        represents a group represented by Q1, or a group represented by        Q2, E′ represents a C1-C6 chain hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group A, a cyclopropyl group which may be optionally        substituted with one or more substituents selected from Group B,        or R⁴R⁵C═C(R⁶)—; or a combination wherein Q represents a group        represented by Q3, a group represented by Q4, a group        represented by Q5, a group represented by Q6, a group        represented by Q7, or a group represented by Q8; and E¹        represents a C1-C6 chain hydrocarbon group which may be        optionally substituted with one or more substituents selected        from Group A, a cyclopropyl group which may be optionally        substituted with one or more substituents selected from Group B,        a C6-C10 aryl group which may be optionally substituted with one        or more substituents selected from Group D, or a five- to        ten-membered aromatic heterocyclic group which may be optionally        substituted with one or more substituents selected from Group D,        M1 represents B(OH)₂, or a        4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl group; X⁵¹        represents a leaving group such as chlorine atom, bromine atom,        iodine atom, or triflyloxy group; and the other symbols are the        same as defined above.]

The reaction is usually carried out in a solvent. Examples of thesolvent to be used in the reaction include hydrocarbons such as hexane,toluene, and xylene (hereinafter, collectively referred to ashydrocarbons); ethers such as methyl tert-butyl ether (hereinafter,referred to as MTBE), tetrahydrofuran (hereinafter, referred to as THF),dimethoxyethane (hereinafter, collectively referred to as ethers);halogenated hydrocarbons such as chloroform and chlorobenzene(hereinafter, collectively referred to as halogenated hydrocarbons);amides such as dimethylformamide (hereinafter, referred to as DMF) andN-methyl pyrrolidone (hereinafter, collectively referred to as amides);esters such as methyl acetate and ethyl acetate (hereinafter,collectively referred to as esters); nitriles such as acetonitrile andpropionitrile (hereinafter, collectively referred to as nitriles);water; and mixed solvents of these two or more solvents.

Example of the palladium catalysts includes[1,1′-bis(diphenylphoshino)ferrocene]palladium (II) dichloride.

Examples of the base include organic bases such as triethylamine andpyridine (hereinafter, collectively referred to as organic bases);alkali metal carbonates such as sodium carbonates and potassiumcarbonates (hereinafter, collectively referred to as alkali metalcarbonates); alkali metal hydrocarbonates such as sodium hydrocarbonateand potassium hydrocarbonate (hereinafter, collectively referred to asalkali metal hydrocarbonates); sodium fluoride, and tripotassiumphosphate.

In the reaction, the compound (M1) is usually used within a range of 1to 10 molar ratio(s), the palladium catalyst is usually used within arange of 0.01 to 1 molar ratio(s), and the base is usually used within arange of 1 to 10 molar ratio(s), as opposed to 1 mole of the compound(B1).

The reaction temperature is usually within a range of 0 to 150° C. Thereaction period of the reaction is usually within a range of 0.1 to 120hours.

When the reaction is completed, water is added to reaction mixtures, andthe reaction mixtures are extracted with organic solvent(s), and theorganic layers are worked up (such as concentration and drying) toisolate the compound (A1).

The compound (B1) and the compound (M1) are known compounds, or can beprepared according to a known method.

Process B

The compound (A1) can be prepared by reacting a compound represented byformula (B2) (hereinafter, referred to as “Compound (B2)”) with acompound represented by formula (M2) (hereinafter, referred to as“Compound (M2)”) in the presence of a palladium catalyst and a base.

[wherein the symbols are the same as defined above.]

The reaction can be carried out by using the compound (M2) in place ofthe compound (M1) and using the compound (B2) in place of the compound(M2) according to the process A.

The compound (B2) and the compound (M2) are known compounds, or can beprepared according to a known method.

Process C

A compound represented by formula (A2) (hereinafter, referred to as“Compound (A2)”) can be prepared by reacting a compound represented byformula (B36) (hereinafter, referred to as “Compound (B36)”) with acompound represented by formula (M3) (hereinafter, referred to as“Compound (M3)”) in the presence of a metal catalyst and a base.

[wherein, Q^(x) represents a group represented by Q3, a grouprepresented by Q4, a group represented by Q5, a group represented by Q6,a group represented by Q7, or a group represented by Q8, and the othersymbols are the same as defined above.]

The reaction is usually carried out in a solvent. Examples of thesolvents to be used in the reaction include hydrocarbons, ethers,halogenated hydrocarbons, amides, esters, nitriles, and mixed solventsof these two or more solvents.

Examples of the metal catalyst to be used in the reaction includebis(triphenylphosphine)palladium(II) dichloride (hereinafter, referredto as PdCl₂(PPh₃)₂) and a copper (I) iodide.

The base to be used in the reaction includes the organic bases.

In the reaction, the compound (M3) is usually used within a range of 1to 10 molar ratio(s), the metal catalyst is usually used within a rangeof 0.01 to 1 molar ratio(s), and the base is usually used within a rangeof 1 to 10 molar ratio(s), as opposed to 1 mole of the compound (B36).

The reaction temperature is usually within a range of 0 to 150° C. Thereaction period of the reaction is usually within a range of 0.1 to 120hours.

When the reaction is completed, water is added to the reaction mixtures,and the organic layers are worked up (such as concentration and drying)to isolate the compound (A2).

The compound (B36) and the compound (M3) are known compounds, or can beprepared according to a known method.

Process D

A compound represented by formula (A3) (hereinafter, referred to as“Compound (A3)”) can be prepared by reacting a compound represented byformula (B3) (hereinafter, referred to as “Compound (B3)”) with acompound represented by formula (M4) (hereinafter, referred to as“Compound (M4)”) or salts thereof.

[wherein

-   -   a combination of Q and R⁵¹ represents a combination wherein Q        represents a group represented by Q1, or a group represented by        Q2, and R⁵¹ represents R¹⁵—CH(R¹⁶)—; or a combination wherein Q        represents a group represented by Q3, a group represented by Q4,        a group represented by Q5, a group represented by Q6, a group        represented by Q7, or a group represented by Q8, and R⁵¹        represents R¹³; and the other symbols are the same as defined        above.]

Examples of the salts of the compound (M4) include hydrochloride saltsand sulfates.

The reaction is usually carried out in a solvent. Examples of thesolvents to be used in the reaction include hydrocarbons, ethers,halogenated hydrocarbons, amides, esters, nitriles, alcohols (such asmethanol, and ethanol), and mixed solvents of these two or moresolvents.

A base may be used in the reaction as needed.

Examples of the bases to be used in the reaction include organic bases,alkali metal carbonates, alkali metal hydrocarbonates, sodium hydrideand tripotassium phosphate.

When a base is used in the reaction, the base is usually within a rangeof 1 to 10 molar ratio(s), as opposed to 1 mole of the compound (B3).

In the reaction, the compound (M4) is usually used within a range of 1to 10 molar ratio(s) as opposed to 1 mole of the compound (B3).

The reaction temperature is usually within a range of 0 to 150° C. Thereaction period of the reaction is usually within a range of 0.1 to 120hours.

When the reaction is completed, water is added to the reaction mixtures,and the resulting mixtures are extracted with organic solvent(s), andthe organic layers are worked up (such as concentration and drying) toisolate the compound (A3).

Also the compound (A3) can be prepared according a method described inWO 1999/043949 A1, WO 2000/041999 A1, or WO 2000/007999 A1.

The compound (B3) and the compound (M4) are known compounds, or can beprepared according to a known method.

Process E

A compound represented by formula (A4) (hereinafter, referred to as“Compound (A4)”) can be prepared by reacting the compound (B3) with acompound represented by formula (M5) (hereinafter, referred to as“Compound (M5)”) or salts thereof.

[wherein,

-   -   a combination of Q and R⁵² represents a combination wherein Q        represents a group represented by Q1, or a group represented by        Q2, R⁵² represents R³⁴R³⁵C═N—, or R¹²R⁹N—; or a combination        wherein Q represents a group represented by Q3, a group        represented by Q4, a group represented by Q5, a group        represented by Q6, a group represented by Q7, or a group        represented by Q8, and R⁵² represents R³⁴R³⁵C═N—, R¹²R⁹N—, or        R¹⁸; and the other symbols are the same as defined above.]

Examples of the salts of the compound (M5) include hydrochloride saltsand sulfates.

The reaction can be carried out by using the compound (M5) in place ofthe compound (M4) according to the process D.

The compound (M5) are known compounds, or can be prepared according to aknown method.

Process F

The compound (A3) can be prepared by reacting a compound represented byformula (B4) (hereinafter, referred to as “Compound (B4)”) with acompound represented by formula (M6) (hereinafter, referred to as“Compound (M6)”) in the presence of a base.

[wherein the symbols are the same as defined above.]

The reaction is usually carried out in a solvent. Examples of thesolvents to be used in the reaction include hydrocarbons, ethers,halogenated hydrocarbons, amides, esters, nitriles, and mixed solventsof these two or more solvents.

Examples of the bases include organic bases, alkali metal carbonates,alkali metal hydrocarbonates, sodium hydride and tripotassium phosphate.

A metal catalyst and/or a ligand may be used in the reaction as needed.

Examples of the metal catalyst include copper catalysts (such as copper(I) iodide, copper (I) bromide, copper (I) chloride, copper (I) oxide,trifluoromethane sulfonate copper (I) benzene complex,tetrakis(acetonitrile) copper (I) hexafluorophoshate, and 2-thiophenecarboxylate copper (I)); nickel catalysts (such asbis(cyclooctadine)nickel (0), and nickel (II) chloride). When the metalcatalyst is used in the reaction, the metal catalyst is usually usedwithin a range of 0.01 to 1 molar ratio(s) as opposed to 1 mole of thecompound (B4).

Examples of the ligand include triphenylphosphine, Xantphos,2,2′-bis(diphenylphosphino)-1,1′-binaphthyl,1,1′-bis(diphenylphosphino)ferrocene,2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl,2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl,1,2-bis(diphenylphosphino)ethane, 2,2′-bipyridine, 2-aminoethanol,8-hydroxyquinoline, 1,10-phenanthroline, trans-1,2-cyclohexanediamine,trans-N,N′-dimethylcyclohexane-1,2-diamine, N,N′-dimethyletylenediamine,and N,N-dimethylglycine hydrochloride salt.

When the ligand is used in the reaction, the ligand is usually usedwithin a range of 0.1 to 1 molar ratio(s) as opposed to 1 mole of thecompound (B4).

In the reaction, the compound (M6) is usually used within a range of 1to 10 molar ratio(s), and the base is usually used within a range of 1to 10 molar ratio(s), as opposed to 1 mole of the compound (B4).

The reaction temperature is usually within a range of −20 to 150° C. Thereaction period of the reaction is usually within a range of 0.1 to 48hours.

When the reaction is completed, water is added to the reaction mixtures,and the resulting mixtures are extracted with organic solvent(s), andthe organic layers are worked up (such as concentration and drying) toisolate the compound (A3).

The compound (M6) is known compound, or can be prepared according to aknown method.

Process G

A compound represented by formula (A5) (hereinafter, referred to as“Compound (A5)”) can be reacting a compound represented by formula (B5)(hereinafter, referred to as “Compound (B5)”) with a compoundrepresented by formula (M7) (hereinafter, referred to as “Compound(M7)”) in the presence of a base.

[wherein,

-   -   E² represents R⁸R⁹C═N—O—, R¹²O—N═C(R⁷)—C(R⁹)═N—O—,        R¹²C(O)—C(R⁹)═N—O—, R¹²C(═N—O—R⁷)—C(R⁹)═N—O—, R¹²N═C(R⁷)—S—,        R¹²N═C(SR⁷)—S—, R¹²O—N═C(R⁷)—S—, or R¹²O—N═C(SR⁷)—S—; and the        other symbols are the same as defined above.]

The reaction is usually carried out in a solvent. Examples of thesolvents to be used in the reaction include hydrocarbons, ethers,halogenated hydrocarbons, amides, esters, nitriles, and mixed solventsof these two or more solvents.

Examples of the bases include organic bases, alkali metal carbonates,alkali metal hydrocarbonates, sodium hydride and tripotassium phosphate.

In the reaction, the compound (M7) is usually used within a range of 1to 10 molar ratio(s), and the base is usually used within a range of 1to 10 molar ratio(s), as opposed to 1 mole of the compound (B5).

The reaction temperature is usually within a range of −20 to 150° C. Thereaction period of the reaction is usually within a range of 0.1 to 48hours.

When the reaction is completed, water is added to the reaction mixtures,and the resulting mixtures are extracted with organic solvent(s), andthe organic layers are worked up (such as concentration and drying) toisolate the compound (A5).

Also the compound (A5) can be prepared according a method described inWO 1990/07493 A1, WO 1995/18789 A1 and so no.

The compound (M7) is a known compound, or can be prepared according to aknown method.

Process H

A compound represented by formula (AG) (hereinafter, referred to as“Compound (A6)”) can be prepared by reacting a compound represented byformula (B45) (hereinafter, referred to as “Compound (B45)”) with acompound represented by formula (M8) (hereinafter, referred to as“Compound (M8)”) in the presence of phosphines and azodiesters.

[wherein R⁵³ represents a methyl group which is substituted with one ormore substituents selected from Group F, a C2-C6 chain hydrocarbon groupwhich may be optionally substituted with one or more substituentsselected from Group F, or a C3-C4 cycloalkyl group which may beoptionally substituted with one or more substituents selected from GroupB; and the other symbols are the same as defined above.]

The reaction is usually carried out in a solvent. Examples of thesolvents to be used in the reaction include hydrocarbons, ethers,halogenated hydrocarbons, amides, esters, nitriles, and mixed solventsof these two or more solvents.

Examples of the phosphines include triphenylphosphine andtrimethylphisphine.

Examples of azodiesters include diethyl azodicarboxylate, diisopropylazodicarboxylate and bis(2-methoxyethyl)azodicarboxylate.

In the reaction, the compound (M8) is usually used within a range of 1to 10 molar ratio(s), and the phosphines is usually used within a rangeof 1 to 10 molar ratio(s), and the azodiesters is usually used within arange of 1 to 10 molar ratio(s), as opposed to 1 mole of the compound(B45)

The reaction temperature is usually within a range of 0 to 150° C. Thereaction period of the reaction is usually within a range of 0.1 to 48hours.

When the reaction is completed, water is added to the reaction mixtures,and the resulting mixtures are extracted with organic solvent(s), andthe organic layers are worked up (such as concentration and drying) toisolate the compound (A6).

The compound (M8) is a known compound, or can be prepared according to aknown method.

Process I

A compound represented by formula (A7) (hereinafter, referred to as“Compound (A7)”) can be prepared by reacting a compound represented byformula (B6) (hereinafter, referred to as “Compound (B6)”) with acompound represented by formula (M9) (hereinafter, referred to as“Compound (M9)”) in the presence of a base.

[wherein

-   -   a combination of Q and R⁵⁴ represents a combination wherein Q        represents a group represented by Q1, or a group represented by        Q2, R⁵⁴ represents a C6-C10 aryl group which may be optionally        substituted with one or more substituents selected from Group D,        or a five- to ten-membered aromatic heterocyclic group which may        be optionally substituted with one or more substituents selected        from Group D; or a combination wherein Q represents a group        represented by Q3 to Q8, and R⁵⁴ represents a C6-C10 aryl group        which may be optionally substituted with one or more        substituents selected from Group D, a five- to ten-membered        aromatic heterocyclic group which may be optionally substituted        with one or more substituents selected from Group D, a methyl        group which is substituted with one or more substituents        selected from Group F, a C2-C6 chain hydrocarbon group which may        be optionally substituted with one or more substituents selected        from Group F, or a C3-C4 cycloalkyl group which may be        optionally substituted with one or more substituents selected        from Group B; and the other symbols are the same as defined        above.]

The reaction is usually carried out in a solvent. Examples of thesolvents to be used in the reaction include hydrocarbons, ethers,halogenated hydrocarbons, amides, esters, nitriles, and mixed solventsof these two or more solvents.

Examples of the bases include organic bases, alkali metal carbonates,alkali metal hydrocarbonates, sodium hydride, and tripotassiumphosphate.

A metal catalyst and/or a ligand may be used in the reaction as needed.

Examples of the metal catalyst include copper catalysts (such as copper(I) iodide, copper (I) bromide, copper (I) chloride, copper (I) oxide,trifluoromethane sulfonate copper (I) benzene complex,tetrakis(acetonitrile) copper (I) hexafluorophoshate, and 2-thiophenecarboxylate copper (I)); nickel catalysts (such asbis(cyclooctadine)nickel (0), and nickel (II) chloride). When the metalcatalyst is used in the reaction, the metal catalyst is usually usedwithin a range of 0.01 to 1 molar ratio(s) as opposed to 1 mole of thecompound (B6).

Examples of the ligand include triphenylphosphine, Xantphos,2,2′-bis(diphenylphosphino)-1,1′-binaphthyl,1,1′-bis(diphenylphosphino)ferrocene,2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl,2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl,1,2-bis(diphenylphosphino)ethane, 2,2′-bipyridine, 2-aminoethanol,8-hydroxyquinoline, 1,10-phenanthroline, trans-1,2-cyclohexanediamine,trans-N,N′-dimethylcyclohexane-1,2-diamine, N,N′-dimethyletylenediamine,and N,N-dimethylglycine hydrochloride salt.

When the ligand is used in the reaction, the ligand is usually usedwithin a range of 0.01 to 1 molar ratio(s), as opposed to 1 mole of thecompound (B6).

In the reaction, the compound (M9) is usually used within a range of 1to 10 molar ratio(s), and the base is usually used within a range of 1to 10 molar ratio(s), as opposed to 1 mole of the compound (B6).

The reaction temperature is usually within a range of −20 to 150° C. Thereaction period of the reaction is usually within a range of 0.1 to 48hours.

When the reaction is completed, water is added to the reaction mixtures,and the resulting mixtures are extracted with organic solvent(s), andthe organic layers are worked up (such as concentration and drying) toisolate the compound (A7).

The compound (M9) is a known compound, or can be prepared according to aknown method.

Process J

The compound (A7) can be prepared by reacting the compound (B1) with acompound represented by formula (M10) (hereinafter, referred to as“Compound (M10)”) in the presence of a base.

[wherein the symbols are the same as defined above.]

The reaction is usually carried out in a solvent. Examples of thesolvents to be used in the reaction include hydrocarbons, ethers,halogenated hydrocarbons, amides, esters, nitriles, and mixed solventsof these two or more solvents.

Examples of the base include organic bases, alkali metal carbonates,alkali metal hydrocarbonates, sodium hydride and tripotassium phosphate.

A metal catalyst and/or a ligand may be used in the reaction as needed.

Examples of the metal catalyst include copper catalysts (such as copper(I) iodide, copper (I) bromide, copper (I) chloride, copper (I) oxide,trifluoromethane sulfonate copper (I) benzene complex,tetrakis(acetonitrile) copper (I) hexafluorophoshate, and 2-thiophenecarboxylate copper (I)); nickel catalysts (such asbis(cyclooctadine)nickel (0), and nickel (II) chloride). When the metalcatalyst is used in the reaction, the metal catalyst is usually usedwithin a range of 0.01 to 1 molar ratio(s) as opposed to 1 mole of thecompound (B1).

Examples of the ligand include triphenylphosphine, Xantphos,2,2′-bis(diphenylphosphino)-1,1′-binaphthyl,1,1′-bis(diphenylphosphino)ferrocene,2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl,2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl,1,2-bis(diphenylphosphino)ethane, 2,2′-bipyridine, 2-aminoethanol,8-hydroxyquinoline, 1,10-phenanthroline, trans-1,2-cyclohexanediamine,trans-N,N′-dimethylcyclohexane-1,2-diamine, N,N′-dimethyletylenediamine,and N,N-dimethylglycine hydrochloride salt.

When the ligand is used in the reaction, the ligand is usually usedwithin a range of 0.01 to 1 molar ratio(s), as opposed to 1 mole of thecompound (B1).

In the reaction, the compound (M10) is usually used within a range of 1to 10 molar ratio(s), and the base is usually used within a range of 1to 10 molar ratio(s), as opposed to 1 mole of the compound (B1).

The reaction temperature is usually within a range of −20 to 150° C. Thereaction period of the reaction is usually within a range of 0.1 to 48hours.

When the reaction is completed, water is added to the reaction mixtures,and the resulting mixtures are extracted with organic solvent(s), andthe organic layers are worked up (such as concentration and drying) toisolate the compound (A7).

The compound (M10) is a known compound, or can be prepared according toa known method.

Process K

A compound represented by formula (A8) (hereinafter, referred to as“Compound (A8)”) can be prepared by reacting the compound (B6) with acompound represented by formula (M11) (hereinafter, referred to as“Compound (M11)”) in the presence of a base.

[wherein a combination of Q and R⁵⁵ represents a combination wherein Qrepresents a group represented by Q1, or a group represented by Q2, andR⁵⁵ represents R¹⁷R⁷NC(S)—, R¹⁷O—C(O)—, or R¹⁷C(O)—; or a combinationwherein Q represents a group represented by Q3, a group represented byQ4, a group represented by Q5, a group represented by Q6, a grouprepresented by Q7, or a group represented by Q8, R⁵⁵ representsR¹⁷R⁷NC(S)—, R¹⁷O—C(O)—, R¹⁷C(O)—, or R¹⁷R⁷NC(O)—; and the other symbolsare the same as defined above.]

The reaction is usually carried out in a solvent. Examples of thesolvents to be used in the reaction include hydrocarbons, ethers,halogenated hydrocarbons, amides, esters, nitriles, and mixed solventsof these two or more solvents.

Examples of the bases include organic bases, alkali metal carbonates,alkali metal hydrocarbonates, sodium hydride, and tripotassiumphosphate.

In the reaction, the compound (M11) is usually used within a range of 1to 10 molar ratio(s), and the base is usually used within a range of 1to 10 molar ratio(s), as opposed to 1 mole of the compound (B6).

The reaction temperature is usually within a range of −78 to 100° C. Thereaction period of the reaction is usually within a range of 0.1 to 48hours.

When the reaction is completed, water is added to the reaction mixtures,and the resulting mixtures are extracted with organic solvent(s), andthe organic layers are worked up (such as concentration and drying) toisolate the compound (A8).

The compound (M11) is a known compound, or can be prepared according toa known method.

Process L

A compound represented by formula (A9) (hereinafter, referred to as“Compound (A9)”) can be prepared by a step where a compound representedby formula (B7) (hereinafter, referred to as “Compound (B7)”) and acompound represented by formula (M12) (hereinafter, referred to as“Compound (M12)”) are reacted in the presence of a base to obtain acompound represented by (B8) (hereinafter, referred to as “Compound(B8)”) (hereinafter, referred to as Step (L-1)) and a step where thecompound (B8) and a compound represented by formula (M13) (hereinafter,referred to as “Compound (M13)”) in the presence of a base (hereinafter,referred to as Step (L-2))

[wherein R⁵⁶ represents a C1-C4 alkyl group, X⁵² represents an iodineatom, a methoxysulfonyloxy group, a mesyloxy group, or a tosyl group;and the other symbols are the same defined above.]

A step (L-1) is usually carried out is a solvent. Examples of thesolvent to be used in the reaction include ethers, amides, and mixedsolvents of these two or more solvents.

Examples of the base to be used in the reaction include sodium hydrideand alkali metal hydrides.

In the reaction, the compound (M12) is usually used within a range of 1to 10 molar ratio(s), and the base is usually used within a range of 0.5to 5 molar ratio(s), as opposed to 1 mole of the compound (B7).

The reaction period of the reaction is usually within a range of 5minutes to 72 hours. The reaction temperature is usually within a rangeof −20 to 100° C.

When the reaction is completed, water is added to the reaction mixtures,and the resulting mixtures are extracted with organic solvent(s), andthe organic layers are worked up (such as concentration and drying) toisolate the compound (B8).

The compound (B7) and the compound (M12) are commercially availablecompounds, or can be prepared according to a known method.

A step (L-2) is usually carried out is a solvent. Examples of thesolvent to be used in the reaction include hydrocarbons, ethers,halogenated hydrocarbons, amides, esters, nitriles and mixed solvents ofthese two or more solvents.

Examples of the base to be used in the reaction include organic bases,alkali metal carbonates, alkali metal hydrocarbonates, sodium hydride,and mixed solvents of these two or more solvents.

In the reaction, the compound (M13) is usually used within a range of 1to 10 molar ratio(s), and the base is usually used within a range of 1to 20 molar ratio(s), as opposed to 1 mole of the compound (B8).

The reaction temperature is usually within a range of −20 to 100° C. Thereaction period of the reaction is usually within a range of 0.1 to 48hours.

When the reaction is completed, water is added to the reaction mixtures,and the resulting mixtures are extracted with organic solvent(s), andthe organic layers are worked up (such as concentration and drying) toisolate the compound (A9).

Process M

A compound represented by formula (A10) (hereinafter, referred to as“Compound (A10)”) can be prepared by a step where a compound representedby formula (B43) (hereinafter, referred to as “Compound (B43)”) and acompound represented by formula (M14) (hereinafter, referred to as“Compound (M14)”) are reacted in the presence of a base to obtain acompound represented by formula (B9) (hereinafter, referred to as“Compound (B9)”) (hereinafter, referred to Step (M-1)) and a step wherea compound (B9) and a compound (M13) are reacted in the presence of abase (hereinafter, referred to as Step (M-2)) in the presence of a base.

[wherein L represents an oxygen atom or NH, R⁵⁷ represents a t-butylgroup, or an isopentyl group; and the other symbols are the same asdefined above.]

A step (M-1) is usually carried out is a solvent. Examples of thesolvent to be used in the reaction include ethers, amides, alcohols, andmixed solvents of these two or more solvents.

Examples of the base to be used in the reaction include sodium hydrideand alkali metal alkoxides (such as sodium methoxide, sodium ethoxide,and potassium t-butoxide)

In the reaction, the compound (M14) is usually used within a range of 1to 10 molar ratio(s), and the base is usually used within a range of 1to 5 molar ratio(s), as opposed to 1 mole of the compound (B43).

The reaction period of the reaction is usually within a range of 5minutes to 72 hours. The reaction temperature is usually within a rangeof −20 to 100° C.

When the reaction is completed, water is added to the reaction mixtures,and the resulting mixtures are extracted with organic solvent(s), andthe organic layers are worked up (such as concentration and drying) toisolate the compound (B9).

The compound (B43) and the compound (M14) are commercially availablecompounds, or can be prepared according to a known method.

A step (M-2) can be carried out by using the compound (B9) in place ofthe compound (B8) according to the step (L-2) of the Process L.

The compound (M13) are known compounds, or can be prepared according toa known method.

Process N

A compound represented by formula (A12) (hereinafter, referred to as“Compound (A12)”) can be prepared by reacting a compound represented byformula (A11) (hereinafter, referred to as “Compound (A11)”) with methylamine.

[wherein a combination of Z⁵¹, Z⁵² and Z⁵³ represents a combinationwhere Z⁵¹ represents a nitrogen atom, Z⁵² represents an oxygen atom, andZ⁵³ represents a methyl group, a combination where Z⁵¹ represents anitrogen atom or CH, Z⁵² represents Z¹, and Z⁵³ represents Z², or acombination where Z⁵¹ represents a nitrogen atom, Z⁵² represents asingle bond, and Z⁵³ represents a methyl group; and the other symbolsare the same as defined above.]

The reaction is usually carried out in a solvent. Examples of thesolvents to be used in the reaction include alcohols, hydrocarbons,ethers, halogenated hydrocarbons, amides, esters, nitriles and mixedsolvents of these two or more solvents.

A base may be used in the reaction as needed. Examples of the base to beused in the reaction include organic bases; alkali metal carbonates;alkali metal hydroxides (such as sodium hydroxide, and potassiumhydroxide) (hereinafter, referred to as “alkali metal hydroxides”) andsodium hydride. When a base is used in the reaction, the base is usuallyused within a range of 0.1 to 10 molar ratio(s), as opposed to 1 mole ofthe compound (A11).

In the reaction, methylamine is usually used within a range of 1 to 100molar ratio(s) as opposed to 1 mole of the compound (A11).

The reaction temperature is usually within a range of −20 to 150° C. Thereaction period of the reaction is usually within a range of 0.1 to 120hours.

When the reaction is completed, water is added to the reaction mixtures,and the resulting mixtures are extracted with organic solvent(s), andthe organic layers are worked up (such as concentration and drying) toisolate the compound (A12).

Process O

A compound represented by formula (A14) (hereinafter, referred to as“Compound (A14)”) can be prepared by a step where a compound representedby formula (A13) (hereinafter, referred to as “Compound (A13)”) andhydroxyl amine are reacted in the presence of a base to obtain acompound represented by formula (B26) (hereinafter, referred to as“Compound (B26)”) (hereinafter, referred to as Step (O-1)”) and a stepwhere the compound (B26) and a compound represented by formula (M18)(hereinafter, referred to as “Compound (M18)”) are reacted in thepresence of a base (hereinafter, referred to as Step (O-2)”).

[wherein X⁵³ represents a chlorine atom, bromine atom, or iodine atom,and the other symbols are the same as defined above.]

The step (O-1) can be carried out by using hydroxylamine in place ofmethylamine according to the process N.

The step (O-2) is usually carried out in a solvent. Examples of thesolvents to be used in the reaction include hydrocarbons, ethers,halogenated hydrocarbons, amides, esters, nitriles, water and mixedsolvents of these two or more solvents.

Examples of the base include organic bases, alkali metal carbonates,alkali metal hydrocarbonates, sodium hydride and tripotassium phosphate.

In the reaction, the compound (M18) is usually used within a range of 1to 10 molar ratio(s), and the base is usually used within a range of 1to 10 molar ratio(s), as opposed to 1 mole of the compound (B26).

The reaction temperature is usually within a range of −20 to 150° C. Thereaction period of the reaction is usually within a range of 0.1 to 48hours.

When the reaction is completed, water is added to the reaction mixtures,and the resulting mixtures are extracted with organic solvent(s), andthe organic layers are worked up (such as concentration and drying) toisolate the compound (A14).

The compound (M18) is a known compound, or can be prepared according toa known method.

Process P

A compound represented by formula (A15) (hereinafter, referred to as“Compound (A15)”) can be prepared by a step where a compound representedby formula (B27) (hereinafter, referred to as “Compound (B27)”) and anisocyanate agent are reacted to obtain a compound represented by formula(B28) (hereinafter, referred to as “Compound (B28)”) (hereinafter,referred to as Step (P-1)), a step wherein the compound (B28) and anazide agent are reacted to obtain a compound represented by formula(B29) (hereinafter, referred to as “Compound (B29)”) (hereinafter,referred to as Step (P-2)), and a step where the compound (B29) and thecompound (M13) are reacted in the presence of a base (hereinafter,referred to as “Compound (P-3)”).

[wherein the symbols are the same as defined above]

The step (P-1) is usually carried out in a solvent. Examples of thesolvents to be used in the reaction include alcohols, hydrocarbons,ethers, halogenated hydrocarbons, amides, esters, nitriles, and mixedsolvents of these two or more solvents.

Examples of the isocyanate agent include phosgene, diphosgene,triphosgene, thiophosgene, N,N-carbodiimidazole, andN,N-thiocarbonyldiimidazole. These isocyanate agent is usually usedwithin a range of 1 to 10 molar ratio(s) as opposed to 1 mole ofCompound (B27).

A base may be used in the reaction as needed. Examples of the base to beused in the reaction include organic bases, alkali metal carbonates,alkali metal hydroxides, and sodium hydride. These bases are usualy usedwithin a range of 0.05 to 5 molar ratio(s) as opposed to 1 mole of thecompound (B27).

The reaction temperature is usually within a range of −20 to 150° C. Thereaction period of the reaction is usually within a range of 0.1 to 48hours.

When the reaction is completed, water is added to the reaction mixtures,and the resulting mixtures are extracted with organic solvent(s), andthe organic layers are worked up (such as concentration and drying) toisolate the compound (B28).

The compound (B27) is a commercially available compound, or can beprepared according to a known method.

The step (P-2) is usually carried out in a solvent. Examples of thesolvent include alcohols, hydrocarbons, ethers, halogenatedhydrocarbons, amides, esters, nitriles and mixed solvents of these twoor more solvents.

Examples of the azide agent to be used in the reaction include inorganicazides (such as sodium azide, barium azide, and lithium azide); andorganic azides (such as trimethylsilyl azide, and diphenylphosphorylazide). The azide agent is usually used within a range of 1 to 10 molarratio(s) as opposed to 1 mole of the compound (B28).

A Lewis acid may be used in the reaction as needed. Examples of theLewis acid to be used in the reaction include aluminium (III) chlorideand zinc chloride. The Lewis acid is usually used within a range of 0.05to 5 molar ratio(s), as opposed to 1 mole of the compound (B28).

The reaction temperature is usually within a range of −20 to 150° C. Thereaction period of the reaction is usually within a range of 0.1 to 48hours.

When the reaction is completed, water is added to the reaction mixtures,and the resulting mixtures are extracted with organic solvent(s), andthe organic layers are worked up (such as concentration and drying) toisolate the compound (B29).

The step (P-3) is usually carried out in a solvent. Examples of thesolvent include alcohols, hydrocarbons, ethers, halogenatedhydrocarbons, amides, esters, nitriles and mixed solvents of these twoor more solvents.

Examples of the base to be used in the reaction include organic bases,alkali metal carbonates, alkali metal hydrocarbonates, sodium hydride,and mixed solvents of these two or more solvents.

In the reaction, the compound (M13) are usually used within a range of 1to 10 molar ratio(s), and the base is usually used within a range of 1to 10 molar ratio(s), as opposed to 1 mole of the compound (B29).

The reaction temperature is usually within a range of −20 to 150° C. Thereaction period of the reaction is usually within a range of 0.1 to 48hours.

When the reaction is completed, water is added to the reaction mixtures,and the resulting mixtures are extracted with organic solvent(s), andthe organic layers are worked up (such as concentration and drying) toisolate the compound (A15).

Process Q

A compound represented by formula (A16) (hereinafter, referred to as“Compound (A16)”) can be prepared by a step where a compound representedby formula (B44) (hereinafter, referred to as “Compound (B44)”) andhydrazine are reacted to obtain a compound represented by formula (B30)(hereinafter, referred to as “Compound (B30)”) (hereinafter, referred toas “Step (Q-1)”), a step where the compound (B30) and a compoundrepresented by formula (M16) (hereinafter, referred to as “Compound(M16)”) are reacted to obtain a compound represented by formula (B31)(hereinafter, referred to as “Compound (B31)”) (hereinafter, referred toas “Step (Q-2)”), and a step where the compound (B31) and a phosgene arereacted in the presence of a base (hereinafter, referred to as “Step(Q-3)”).

[wherein

-   -   X⁵⁴ represents a chlorine atom, bromine atom, or iodine atom;        and the other symbols are the same as defined above.]

The step (Q-1) is usually carried out in a solvent. Examples of thesolvent include alcohols, hydrocarbons, ethers, halogenatedhydrocarbons, amides, esters, nitriles, water, and mixed solvents ofthese two or more solvents.

The hydrazine to be used in the reaction can be in the form of hydrazinemonohydrate, hydrazine hydrochloride salt, hydrazine sulfate, anhydroushydrazine.

In the reaction, hydrazine is used within a range of 1 to 100 molarratio(s) as opposed to 1 mole of the compound (B29)

The reaction temperature is usually within a range of −20 to 150° C. Thereaction period of the reaction is usually within a range of 0.1 to 48hours.

When the reaction is completed, water is added to the reaction mixtures,and the resulting mixtures are extracted with organic solvent(s), andthe organic layers are worked up (such as concentration and drying) toisolate the compound (B30).

The compound (B44) is a commercially available compound, or can beprepared according to a known method.

The step (Q-2) is usually carried out in a solvent. Examples of thesolvent include alcohols, hydrocarbons, ethers, halogenatedhydrocarbons, amides, esters, nitriles, and mixed solvents of these twoor more solvents.

In the reaction, the compound (M14) is used within a range of 1 to 10molar ratio(s) as opposed to 1 mole of the compound (B30).

A base may be used in the reaction as needed. Examples of the base to beused in the reaction include organic bases, alkali metal carbonates,alkali metal hydroxides, and sodium hydride. When a base is used in thereaction, the base is usually used within a range of 0.05 to 5 molarratio(s) as opposed to 1 mole of the compound (B30).

The reaction temperature is usually within a range of −20 to 150° C. Thereaction period of the reaction is usually within a range of 0.1 to 48hours.

When the reaction is completed, water is added to the reaction mixtures,and the resulting mixtures are extracted with organic solvent(s), andthe organic layers are worked up (such as concentration and drying) toisolate the compound (B31).

The compound (M16) is a known compound, or can be prepared according toa known method.

The step (Q-3) can be carried out by using the compound (B31) in placeof the compound (B28) according to the step (P-2) of the process P.

Also the compound (A16) can be prepared according to the methoddescribed in JP 2006-151865 A1 or JP 2006-160620 A1.

Process R

The present compound wherein Q represents a group represented by Q7, ora group represented by Q8 can be prepared according to a methoddescribed in WO 99/67209 A1, JP 2000-103773 A1, or JP H11-286472 A1.

Process S

A N-oxide of the compound represented by formula (I) can be prepared byreacting a compound represented by formula (I) and an oxidizing agent.The reaction can be carried out by a method described in US patentpublication No. 2018/0009778 A1 or WO 2016/121970 A1.

Process T

A compound represented by formula (A17) (hereinafter, referred to as“Compound (A17)”) can be prepared by reacting a compound represented byformula (A1-T) (hereinafter, referred to as “Compound (A1-T)”) with areducing agent in the presence of a catalyst.

[wherein the symbols are the same as defined above.]

The reaction is usually carried out in a solvent. Examples of thesolvent to be used in the reaction include hydrocarbons, ethers,halogenated hydrocarbons, amides, esters, nitriles, alcohols, and mixedsolvents of these two or more solvents.

Examples of the catalyst to be used in the reaction includepalladium/carbon, and palladium hydroxide.

Examples of the reducing agent to be used in the reaction includehydrogen, ammonium formate, and hydrazine.

In the reaction, the reducing agent is usually used within a range of 1to 1000 molar ratio(s), and the catalyst is usually used within a rangeof 0.01 to 10 molar ratio(s), as opposed to 1 mole of the compound(A1-T).

The reaction temperature is usually within a range of −78 to 100° C. Thereaction period of the reaction is usually within a range of 0.1 to 48hours.

When the reaction is completed, water is added to the reaction mixtures,and the resulting mixtures are extracted with organic solvent(s), andthe organic layers are worked up (such as concentration and drying) toisolate the compound (A17).

Process U

A compound represented by formula (A18) (hereinafter, referred to as“Compound (A18)”) can be prepared by reacting a compound represented byformula (B50) (hereinafter, referred to as “Compound (B50)”) with acompound represented by formula (M19) (hereinafter, referred to as“Compound (M19)”) in the presence of a catalyst and a base.

[wherein a combination of A1 and L⁶ represents a combination where A1represents CH, and L⁶ represents an oxygen atom; a combination where A1represents a nitrogen atom, and L⁶ represents an oxygen atom or NH; andthe other symbols are the same as defined above.]

The reaction is usually carried out in a solvent. Examples of thesolvent to be used in the reaction include hydrocarbons, ethers,halogenated hydrocarbons, amides, esters, nitriles, water, and mixedsolvents of these two or more solvents.

Examples of the catalyst to be used in the reaction include a palladiumcatalysts (such as tris(dibenzylideneacetone)dipalladium (0),tetrakis(triphenylphosphine)palladium (0), and[1,1′-bis(diphenylphosphino)ferrocene] palladium (II) dichloride)

Examples of the base to be used in the reaction include organic bases;alkali metal carbonates; alkali metal hydrocarbonates; alkali metalphosphates (such as tripotassium phosphate); and acetates (such assodium acetate).

A ligand may be used in the reaction as needed. Examples of the ligandto be used in the reaction include triphenylphosphine, Xantphos,2,2′-bis(diphenylphosphino)-1,1′-binaphthyl,1,1′-bis(diphenylphosphino)ferrocene,2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl,2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl, and1,2-bis(diphenylphosphino)ethane.

When a ligand is used in the reaction, the ligand is usually used withina range of 0.01 to 1 molar ratio(s) as opposed to 1 mole of the compound(B50).

In the reaction, the compound (M19) is usually used within a range of0.1 to 10 molar ratio(s), the catalyst is usually used within a range of0.01 to 1 molar ratio(s), and the base is usually used within a range of1 to 10 molar ration(s), as opposed to 1 mole of the compound (B50).

The reaction period of the reaction is usually within a range of 5minutes to 72 hours. The reaction temperature is usually within a rangeof −20 to 150° C.

When the reaction is completed, water is added to the reaction mixtures,and the resulting mixtures are extracted with organic solvent(s), andthe organic layers are worked up (such as concentration and drying) toisolate the compound (A18).

The compound (M19) is a known compound, or can be prepared according toa known method.

Reference Process 1

A compound represented by formula (B12) (hereinafter, referred to as“Compound (B12)”) can be prepared by a step where a compound representedby formula (B10) (hereinafter, referred to as “Compound (B10)”) and acompound represented by formula (M12) (hereinafter, referred to as“Compound (M12)”) are reacted in the presence of a base to obtain acompound represented by formula (B11) (hereinafter, referred to as“Compound (B11)”) (hereinafter, referred to as “Step (1-1)”), and a stepwhere the compound (B11) and the compound (M13) are reacted in thepresence of a base (hereinafter, referred to as “Step (1-2)”).

[wherein the symbols are the same as defined above.]

The step (1-1) can be carried out by using the compound (B10) in placeof the compound (B7) according to the step (L-1) of the Process L.

The step (1-2) can be carried out by using the compound (B11) in placeof the compound (B8) according to the step (L-2) of the Process L.

Reference Process 2

A compound represented by formula (B15) (hereinafter, referred to as“Compound (B15)”) can be prepared by a step where a compound representedby formula (B13) (hereinafter, referred to as “Compound (B13)”) and acompound represented by formula (M14) (hereinafter, referred to as“Compound (M14)”) are reacted in the presence of a base to obtain acompound represented by formula (B14) (hereinafter, referred to as“Compound (B14)”) (hereinafter, referred to as “Step (2-1)”), and a stepwhere the compound (B14) and the compound (M13) are reacted in thepresence of a base (hereinafter, referred to as “Step (2-2)”).

[wherein the symbols are the same as defined above.]

The step (2-1) can be carried out by using the compound (B14) in placeof the compound (B43) according to the step (M-1) of the process M.

The step (2-2) can be carried out by using the compound (B14) in placeof the compound (B9) according to the step (M-2) of the process M.

Reference Process 3

A compound represented by formula (B16) (hereinafter, referred to as“Compound (B16)”) can be prepared reacting the compound (B1) withbis(pinacolato)diboron in the presence of a base and a palladiumcatalyst.

[wherein the symbols are the same defined above.]

The reaction is usually carried out in a solvent. Examples of thesolvent to be used in the reaction include hydrocarbons, ethers,halogenated hydrocarbons, amides, esters, sulfoxides (such asdimethylsulfoxide (hereinafter, referred to as DMSO)) (hereinafter,referred to as sulfoxides), nitriles and mixed solvents of these two ormore solvents.

Examples of the base to be used in the reaction include organic bases,alkali metal carbonates, alkali metal hydrocarbonates and tripotassiumphosphate.

Examples of the palladium catalyst include[1,1′-bis(diphenylphosphino)ferrocene]palladium (II) dichloride.

In the reaction, bis(pinacolato)diboron is usually used within a rangeof 1 to 5 molar ratio(s), the base is usually used within a range of 1to 5 molar ratio(s), and the palladium catalyst is usually used within arange of 0.01 to 0.5 molar ratios, as opposed to 1 mole of the compound(B1).

The reaction temperature is usually within a range of 0 to 150° C. Thereaction period of the reaction is usually within a range of 0.1 to 48hours.

When the reaction is completed, water is added to the reaction mixtures,and the resulting mixtures are extracted with organic solvent(s), andthe organic layers are worked up (such as concentration and drying) toisolate the compound (B16).

Reference Process 4

The compound (B6) can be prepared by oxidizing the compound (B16).

[wherein the symbols are the same as defined above.]

The reaction is usually carried out in a solvent. Examples of thesolvent to be used in the reaction include hydrocarbons, ethers,halogenated hydrocarbons, amides, esters, nitriles, alcohols, water, andmixed solvents of these two or more solvents.

Examples of the oxidizing agent to be used in the reaction include metachloroperbenzoic acid, and aqueous hydrogen peroxide solution.

When the aqueous hydrogen peroxide solution is used as an oxidizingagent, a base may be added as needed.

Examples of the base include alkali metal hydroxides.

When a base is used in the reaction, the base is usually used within arange of 0.1 to 5 molar ratios as opposed to 1 mole of the compound(B16).

In the reaction, the oxidizing agent is usually used within a range of 1to 5 molar ratio(s) as opposed to 1 mole of the compound (B16).

The reaction temperature is usually within a range of −20 to 120° C. Thereaction period of the reaction is usually within a range of 0.1 to 48hours.

When the reaction is completed, water and a reducing agent (such assodium thiosulfate) are added to the reaction mixture, and the resultingmixture was extracted with organic solvent(s), and the organic layersare worked up (for example, drying and concentration) to isolate thecompound (B6).

Reference Process 5

A compound represented by formula (B17) (hereinafter, referred to as“Compound (B17)”) can be prepared by reacting the compound (B1) with acompound represented by formula (M15) (hereinafter, referred to as“Compound (M15)”).

[wherein R⁵¹ represents a methyl group, or ethyl group, and the othersymbols are the same as defined above.]

The reaction can be carried out according to the method described in,for example, WO 2016/123253 A1.

Reference Process 6

The compound (B4) can be prepared by reacting the compound (B3) withhydroxylamine or salts thereof.

[wherein the symbols are the same as defined above.]

Examples of the salts of hydroxylamine include hydrochloride salts andsulfates.

The reaction can be carried out by using hydroxylamine in place of thecompound (M4) according to the process D.

Reference Process 7

A compound represented by formula (B19) (hereinafter, referred to as“Compound (B19)”) can be prepared by reacting a compound represented byformula (B18) (hereinafter, referred to as “Compound (B18)”) with carbontetrachloride, carbon tetrabromide, or iodine in the presence oftriphenylphosphine.

[wherein the symbols are the same as defined above.]

The reaction can be carried out according to the method described in J.Org. Synth., 1974, 54, 63.

Reference Process 8

The compound (B18) can be prepared by a step where the compound (B1) andN-formylsaccharine in the presence of a palladium catalyst, a ligand,triethylsilane, and a base to obtain a compound represented by formula(B20) (hereinafter, referred to as “Compound (B20)”) (hereinafter,referred to as “Step (8-1)”) and a step where the compound (B20) andsodium borohydride are reacted (hereinafter, referred to as “Step(8-2)”).

[wherein the symbols are the same as defined above.]

The step (8-1) can be carried out according to a method described inAngew. Chem. Int. Ed., 2013, 52, 8611-8615.

The step (8-2) can be carried out according to a method described inChemistry-A European Journal, 2019, 25 (15), 3950-3956.

Reference Process 9

A compound represented by formula (B23) (hereinafter, referred to as“Compound (B23)”) can be prepared by as step where a compoundrepresented by formula (B21) (hereinafter, referred to as “Compound(B21)”) and triphosgene are reacted to obtain a compound represented byformula (B22) (hereinafter, referred to as “Compound (B22)”)(hereinafter, referred to as “Step (9-1)”) and a step where the compound(B22) and N,N-dimethyl hydrazine are reacted (hereinafter, referred toas “Step (9-2)”).

[wherein the symbols are the same as defined above.]

The step (9-1) is usually carried out in a solvent. Examples of thesolvents to be used in the reaction include hydrocarbons, halogenatedhydrocarbons, ethers and mixed solvents of these two or more solvents.

In the reaction, triphosgene is usually used within a range of 0.3 to 5molar ratios as opposed to 1 mole of the compound (B21).

The reaction period of the reaction is usually within a range of 5minutes to 72 hours. The reaction temperature is usually within a rangeof 0 to 150° C.

When the reaction is completed, the reaction mixture is worked up (forexample, concentration) to obtain the compound (B22).

The compound (B21) is a commercially available compound, or can beprepared according to a known method.

The step (9-2) is usually carried out in a solvent. Examples of thesolvent to be used in the reaction include hydrocarbons, ethers, amidesand mixed solvents of these two or more solvents.

In the reaction, N,N-dimethylhydrazine is usually used within a range of0.8 to 5 molar ratios as opposed to 1 mole of the compound (B22).

The reaction period of the reaction is usually within a range of 5minutes to 72 hours. The reaction temperature is usually within a rangeof −20 to 100° C.

When the reaction is completed, the precipitated out-solids arecollected by a filtration, or water is added to the reaction mixture,and the resulting mixture was extracted with organic solvent(s), and theorganic layers are worked up (for example, drying and concentration) toobtain the compound (B23).

Reference Process 10

A compound represented by formula (B25) (hereinafter, referred to as“Compound (B25)”) can be prepared by a step where the compound (B23) andtriphosgene are reacted to obtain a compound represented by formula(B24) (hereinafter, referred to as “Compound (B24)”) (hereinafter,referred to as “Step (10-1)”) and a step where the compound (B24) and acompound represented by formula (M17) (hereinafter, referred to as“Compound (M17)”) are reacted in the presence of a base (hereinafter,referred to “Step (10-2)”).

[wherein R⁵⁹ represents a C1-C3 alkyl group which may be optionallysubstituted with one or more halogen atoms; and the other symbols arethe same as defined above.]

The step (10-1) is usually carried out in a solvent. Examples of thesolvents to be used in the reaction include hydrocarbons, ethers,halogenated hydrocarbons and mixed solvents of these two or moresolvents.

In the reaction, triphosgene is usually carried out within a range of 1to 10 molar ratio(s) as opposed to 1 mole of the compound (B23).

The reaction period of the reaction is usually within a range of 5minutes to 72 hours. The reaction temperature is usually within a rangeof 0 to 150° C.

When the reaction is completed, water is added to the reaction mixtures,and the resulting mixtures are extracted with organic solvent(s), andthe organic layers are worked up (such as concentration and drying) toisolate the compound (B24).

The step (10-2) is usually carried out in a solvent. Examples of thesolvent to be used in the reaction include hydrocarbons, ethers,halogenated hydrocarbons, amides, esters, nitriles and mixed solvents ofthese two or more solvents.

Examples of the base to be used in the reaction include organic bases,alkali metal carbonates, alkali metal hydrocarbonates, sodium hydride,and mixed bases of these two or more bases.

In the reaction, the compound (M17) is usually used within a range of 1to 10 molar ratio(s), and the base is usually used within a range of 1to 20 molar ratio(s), as opposed to 1 mole of the compound (B24).

The reaction temperature is usually within a range of −20 to 100° C. Thereaction period of the reaction is usually within a range of 0.1 to 48hours.

When the reaction is completed, water is added to the reaction mixtures,and the resulting mixtures are extracted with organic solvent(s), andthe organic layers are worked up (such as concentration and drying) toisolate the compound (B25).

Reference Process 11

A compound represented by formula (B35) (hereinafter, referred to as“Compound (B35)”) can be prepared by a step where a compound representedby formula (B33) (hereinafter, referred to as “Compound (B33)”) andhydroxylamine are reacted in the presence of a base to obtain a compoundrepresented by formula (B34) (hereinafter, referred to as “Compound(B34)”) (hereinafter, referred to as “Step (11-1)”) and a step where thecompound (B34) and a compound represented by formula (M18) (hereinafter,referred to as “Compound (M17)”) are reacted in the presence of a base(hereinafter, referred to “Step (11-2)”).

[wherein the symbols are the same as defined above.]

The step (11-1) and the step (11-2) can be carried out according to theProcess O.

The compound (B33) is a known compound, or can be prepared according toa known method.

Reference Process 12

A compound represented by formula (B39) (hereinafter, referred to as“Compound (B39)”) can be prepared by a step where the compound (B22) andan azide agent are reacted to obtain a compound represented by formula(B38) (hereinafter, referred to as “Compound (B38)”) (hereinafter,referred to as “Step (12-1)”) and a step where the compound (B38) andthe compound (M13) are reacted in the presence of a base (hereinafter,referred to “Step (12-2)”).

[wherein the symbols are the same as defined above.]

The step (12-1) and the step (12-2) can be carried out according to theProcess P.

Reference Process 13

A compound represented by formula (B42) (hereinafter, referred to as“Compound (B42)”) can be prepared by a step where a compound representedby formula (B40) (hereinafter, referred to as “Compound (B40)”) and thecompound (M16) are reacted to obtain a compound represented by formula(B41) (hereinafter, referred to as “Compound (B41)”) (hereinafter,referred to as “Step (13-1)”) and a step where the compound (B41) and aphosgene are reacted in the presence of a base (hereinafter, referred to“Step (13-2)”).

[wherein the symbols are the same as defined above.]

The step (B13-1) and the step (13-2) can be carried out according to theProcess Q.

The compound (B40) is a known compound, or can be prepared according toa known method.

Reference Process 14

A compound represented by formula (B47) (hereinafter, referred to as“Compound (B47)”) can be prepared by reacting a compound represented byformula (B46) (hereinafter, referred to as “Compound (B46)”) in thepresence of a hydrazine.

[wherein the symbols are the same as defined above.]

The reaction can be carried out according to a method described inTetrahedron Letters, 2011, 52, 1553.

The compound (B46) is a known compound, or can be prepared according toa known method.

Reference Process 15

A compound represented by formula (B49) (hereinafter, referred to as“Compound (B49)”) can be prepared by reacting a compound represented byformula (B48) (hereinafter, referred to as “Compound (B48)”) with thecompound (M19) in the presence of a catalyst and a base.

[wherein, X⁵⁵ represents a leaving group (such as a chlorine atom,bromine atom, iodine atom, and triflyloxy group), B(OH)₂, or4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl group; and the other symbolsare the same as defined above.]

The reaction can be carried out according to the Process U.

The compound (B48) is known compounds, or can be prepared according to aknown method.

Reference Process 16

The compound (B50) can be prepared by reacting the compound (B44) withbis(pinacolato)diboron in the presence of a base and a palladiumcatalyst.

[wherein the symbols are the same as defined above.]

The reaction can be carried out according to the Reference Process 3.

Process a

A compound represented by formula (a1) can be prepared by reacting thecompound (B6) with a compound represented by formula (m1) (hereinafter,referred to as “Compound (m1)”) in the presence of a base.

[wherein the symbols are the same as defined above.]

The reaction can be carried out by using the compound (m1) in place ofthe compound (M11) according to the Process K.

The compound (m1) is a known compound, or can be prepared according to aknown method.

Process b1

A compound represented by formula (a2) can be prepared by reacting thecompound (B19) with a compound represented by formula (m2) (hereinafter,referred to as “Compound (m2)”) in the presence of a base.

[wherein the symbols are the same as defined above.]

The reaction can be carried out by using the compound (B19) in place ofthe compound (M11) and using the compound (m2) in place of the compound(B6) according to the Process K.

The compound (m2) is a known compound, or can be prepared according to aknown method.

Process b2

A compound represented by formula (a3) can be prepared by reacting thecompound (B19) with a compound represented by formula (m3) (hereinafter,referred to as “Compound (m3)” in the presence of a base.

[wherein the symbols are the same as defined above.]

The reaction can be carried out by using the compound (B19) in place ofthe compound (M11) and using the compound (m3) in place of the compound(B6) according to the Process K.

The compound (m3) is a known compound, or can be prepared according to aknown method.

Process k

A compound represented by formula (a8) can be prepared by reacting acompound represented by formula (b6) (hereinafter, referred to as“Compound (b6)”) with a compound represented by formula (m11)(hereinafter, referred to as “Compound (m11)”) in the presence of abase.

[wherein R^(55X) represents R⁴¹ or R⁴³CH₂—, and the other symbols arethe same as defined above.]

The reaction can be carried out by using the compound (b6) in place ofthe compound (B6) and using the compound (m11) in place of the compound(M11) according to the Process K.

The compound (m11) is a known compound, or can be prepared according toa known method.

Process 1

A compound represented by formula (a9) can be prepared by a step where acompound represented by formula (b7) (hereinafter, referred to as“Compound (b7)”) and the compound (M12) are reacted in the presence of abase to obtain a compound represented by formula (b8) (hereinafter,referred to as “Compound (b8)”) (hereinafter, referred to as “Step(1-1)”) and a step where the compound (b8) and the compound (M13) arereacted in the presence of a base (hereinafter, referred to “Step(1-2)”).

[wherein the symbols are the same defined above.]

The step (1-1) can be carried out by using the compound (b7) in place ofthe compound (B7) and using the compound (m12) in place of the compound(M12) according to the step (1-1) of the process L.

The step (1-2) can be carried out by using the compound (b8) in place ofthe compound (B8) and using the compound (m13) in place of the compound(M13) according to the step (1-2) of the Process L.

The compound (b7) is a known compound, or can be prepared according to aknown method.

Process m

A compound represented by formula (a10) can be prepared by a step wherea compound represented by formula (b43) (hereinafter, referred to as“Compound (b43)”) and the compound (M14) are reacted in the presence ofa base to obtain a compound represented by formula (b9) (hereinafter,referred to as “Compound (b9)”) (hereinafter, referred to as “Step(m-1)”) and a step where the compound (b9) and the compound (M13) arereacted in the presence of a base (hereinafter, referred to “Step(m-2)”).

[wherein the symbols are the same as defined above.]

The step (m-1) can be carried out by using the compound (b43) in placeof the compound (B43) according to the step (M-1) of the Process M.

The step (m-2) can be carried out by using the compound (b9) in place ofthe compound (B9) according to the step (M-2) of the Process M.

The compound (b43) is a commercially available compound, or can beprepared according to a known method.

Process n

A compound represented by formula (a12) can be prepared by reacting acompound represented by formula (a11) (hereinafter, referred to as“Compound (a11)”) with methyl amine.

[wherein the symbols are the same as defined above.]

The reaction can be carried out by using the compound (a11) in place ofthe compound (A11) according to the Process N.

Process o

A compound represented by formula (a14) can be prepared by a step wherea compound represented by formula (a13) (hereinafter, referred to as“Compound (a13)”) and hydroxyl amine are reacted in the presence of abase to obtain a compound represented by formula (b26) (hereinafter,referred to as “Compound (b26)”) (hereinafter, referred to as “Step(o-1)”) and a step where the compound (b26) and the compound (M18) arereacted in the presence of a base (hereinafter, referred to “Step(o-2)”).

[wherein the symbols are the same as defined above.]

The step (o-1) can be carried out by using the compound (a13) in placeof the compound (A13) according to the step (o-1) of the Process O.

The step (o-2) can be carried out by using the compound (b26) in placeof the compound (B26) according to the step (o-2) of the Process O.

Process p

A compound represented by formula (a15) can be prepared by a step wherea compound represented by formula (b27) (hereinafter, referred to as“Compound (b27)”) and an isocyanate agent are reacted to obtain acompound represented by formula (b28) (hereinafter, referred to as“Compound (b28)”) (hereinafter, referred to as “Step (p-1)”), a stepwhere the compound (b28) and an azide compound are reacted to obtain acompound represented by formula (b29) (hereinafter, referred to as“Compound (b29)”) (hereinafter, referred to “Step (p-2)”), and a stepwhere the compound (b29) and the compound (M13) are reacted in thepresence of a base (hereinafter, referred to “Step (p-3)”).

[wherein the symbols are the same as defined above.]

The step (p-1) can be carried out by using the compound (b27) in placeof the compound (B27) according to the step (P-1) of the Process P.

The step (p-2) can be carried out by using the compound (b28) in placeof the compound (B28) according to the step (P-2) of the Process P.

The step (p-3) can be carried out by using the compound (b29) in placeof the compound (B29) according to the step (P-3) of the Process P.

The compound (b27) is a commercially available compound, or can beprepared according to a known method.

Process q

A compound represented by formula (a16) (hereinafter, referred to as“Compound (b16)”) can be prepared by a step where a compound representedby formula (b44) (hereinafter, referred to as “Compound (b44)”) andhydrazine are reacted to obtain a compound represented by formula (b30)(hereinafter, referred to as “Compound (b30)”) (hereinafter, referred toas “Step (q-1)”), a step where the compound (b30) and the compound (M16)are reacted to obtain a compound represented by formula (b31)(hereinafter, referred to as “Compound (b31)”) (hereinafter, referred to“Step (q-2)”), and a step where the compound (b31) and a phosgene arereacted in the presence of a base (hereinafter, referred to “Step(q-3)”).

[wherein the symbols are the same as defined above.]

The step (q-1) can be carried out by using the compound (b44) in placeof the compound (B44) according to the step (Q-1) of the Process Q.

The step (q-2) can be carried out by using the compound (b30) in placeof the compound (B30) according to the step (Q-2) of the Process Q.

The step (q-3) can be carried out by using the compound (b31) in placeof the compound (B31) according to the step (Q-3) of the Process Q.

The compound (b44) is a commercially available compound, or can beprepared according to a known method.

Also the compound (a16) can be prepared according to a method describedin JP 2006-151865 A1 or JP 2006-160620 A1.

Process s

A N-oxide of the compound represented by formula (III) can be preparedby reacting a compound represented by formula (III) with an oxidizingagent. The reaction can be carried out according to a method describedin US patent publication No. 2018/0009778 A1 or WO2016/121970 A1.

Process t

A compound represented by formula (a17) (hereinafter, referred to as“Compound (a17)”) can be prepared by reacting a compound represented byformula (b32) (hereinafter, referred to as “Compound (b32)”) with acompound represented by formula (m19) (hereinafter, referred to as“Compound (bm19)”) in the presence of a phosphines and an azodiester

[wherein, a combination of Lai and R^(56X) represents a combinationwhere Lai represents an oxygen atom, R^(56X) represents a C5-C6 acycloalkyl group which may be optionally substituted with one or moresubstituents selected from Group T, a combination where L^(a1)represents a sulfur atom, R^(56x) represents a C3-C6 cycloalkyl groupwhich may be optionally substituted with one or more substituentsselected from Group T; and the other symbols are the same as definedabove.]

The reaction is usually carried out in a solvent. Examples of thesolvent to be used in the reaction include hydrocarbons, ethers,halogenated hydrocarbons, amides, esters, nitriles, and mixed solventsof these two or more solvents.

Examples of the phosphines include triphenylphosphine andtrimethylphosphine.

Examples of the azodiesters include diethyl azodicarboxylate,diisopropyl azodicarboxylate, and bis(2-methoxyethyl) azodicarboxylate.

In the reaction, the compound (m19) is usually used within a range of 1to 10 molar ratio(s), the phosphines is usually used within a range of 1to 10 molar ratio(s), and the azodiester is usually used within a rangeof 1 to 10 molar ratio(s), as opposed to 1 mole of the compound (b32).

The reaction temperature is usually within a range of 0 to 150° C. Thereaction period of the reaction is usually within a range of 0.1 to 48hours.

When the reaction is completed, water is added to the reaction mixtures,and the resulting mixtures are extracted with organic solvent(s), andthe organic layers are worked up (such as concentration and drying) toisolate the compound (a17).

The compound (m19) is a known compound, or can be prepared according toa known method.

Reference Process 1a

The compound (b6) can be prepared by reacting the compound (B6) with asulfurizing agent.

[wherein the symbols are the same as defined above.]

The reaction can be carried out according to a method described in USpatent Publication No. 2014/135359 A1.

The present compound C may be mixed or combined with one or moreingredients selected from a group consisting of the following Group (a),Group (b), Group (c), and Group (d), (hereinafter, referred to as“Present ingredient”).

The above-mentioned mixing or combining represents a use of the presentcompound C and the Present ingredient at same time, separately or atcertain intervals.

When the present compound C and the present ingredient are used at thesame time, the compound of the present invention and the Presentingredient may be contained in separate formulations respectively, ormay be contained in the same one formulation.

One aspect of the present invention is a composition comprising one ormore ingredients selected from Group (a), Group (b), Group (c) and Group(d) as well as the present compound C (hereinafter, referred to asComposition A).

Group (a) is a group consisting of each active ingredient asAcetylcholinesterase inhibitors (for example, carbamate insecticides, ororganophosphorus insecticides), GABA-gated chloride channel blockers(for example, phenylpyrazole insecticides), Sodium channel modulators(for example, pyrethroid insecticides), Nicotinic acetylcholine receptorcompetitive modulators (for example, neonicotinoid insecticides),Nicotinic acetylcholine receptor allosteric modulators, Glutamatergicchlorine ion channel allosteric modulators (for example, macrolideinsecticides), Juvenile hormone mimic, Multisite inhibitors, chordotonalorgan TRPV channel modulators, Mites growth inhibitors, Mitochondria ATPbiosynthetic enzyme inhibitors, Uncouplers of oxidative phosphorylation,Nicotinic acetylcholine receptor channel blocker (for example,Nereistoxin insecticides), Chitin synthesis inhibitors, Moltinginhibitors, Ecdysone receptor agonist, Octopamine receptor agonist,Inhibitors of Mitochondrial electron transport system complex I, II, IIIand IV, Voltage-dependent sodium channel blockers, Acetyl CoAcarboxylase inhibitor, Ryanodine receptor modulator (for example,Diamide insecticides), Chordotonal organ modulators, Microbialpesticides; and

-   -   the other insecticidal, miticidal or nematicidal active        ingredients.

These ingredients are classified as a class based on the actionmechanism of IRAC.

Group (b) is a group consisting of

-   -   Nucleic acid synthesis inhibitors (for example, Phenylamide        fungicides, or Acylamino acid fungicides), cell division and        cytoskeleton inhibitors (for example, MBC fungicides),        Respiratory inhibitors (for example, QoI fungicides or Qil        fungicides), Amino acid synthesis and protein synthesis        inhibitors (for example, anilinopyridine fungicides), Signal        transduction inhibitors, Lipid synthesis and membrane synthesis        inhibitors, sterol biosynthesis inhibitors (for example, DMI        fungicides such as triazole), cell wall synthesis inhibitors,        Melanin synthesis inhibitors, Plant defense inducers, Other        action point contact active fungicides, Microbial fungicides,        and the other fungicidal ingredients. These are classified as a        class based on the action mechanism of FRAC.

Group (c) is a plant growth modulating ingredient group (includingMycorrhizal fungi, and Root nodule bacteria).

Group (d) is a repellent ingredient group consisting of a bird repellantingredient and an insect repellant ingredient.

Examples of the combination of the Present ingredient and the presentcompound C are described below. For example, alanycarb+SX represents acombination of alanycarb and SX. The symbol of “SX” represents any oneof the compound of the present invention selected from the CompoundClass SX944 to the Compound Class SX1453. Also, all of thebelow-mentioned present active ingredient are known ingredients, and arecommercially available or may be produced by the known method. If thepresent ingredient is a bacterium, it is available from the bacterialauthority depository. The numerical number in bracket represents a CASRN (Register Trademark).

Combinations of the present ingredient of the above Group (a) and thepresent compound C:

-   -   abamectin+SX, acephate+SX, acequinocyl+SX, acetamiprid+SX,        acetoprole+SX, acrinathrin+SX, acynonapyr+SX, afidopyropen+SX,        afoxolaner+SX, alanycarb+SX, aldicarb+SX, allethrin+SX,        alpha-cypermethrin+SX, alpha-endosulfan+SX, aluminium        phosphide+SX, amitraz+SX, azadirachtin+SX, azamethiphos+SX,        azinphos-ethyl+SX, azinphos-methyl+SX, azocyclotin+SX, bark of        Celastrus angulatus+SX, bendiocarb+SX, benfluthrin+SX,        benfuracarb+SX, bensultap+SX, benzoximate+SX, benzpyrimoxan+SX,        beta-cyfluthrin+SX, beta-cypermethrin+SX, bifenazate+SX,        bifenthrin+SX, bioallethrin+SX, bioresmethrin+SX,        bistrifluron+SX, borax+SX, boric acid+SX, broflanilide+SX,        bromopropylate+SX, buprofezin+SX, butocarboxim+SX,        butoxycarboxim+SX, cadusafos+SX, calcium phosphide+SX,        carbaryl+SX, carbofuran+SX, carbosulfan+SX, cartap        hydrochloride+SX, cartap+SX, chinomethionat+SX,        chlorantraniliprole+SX, chlordane+SX, chlorethoxyfos+SX,        chlorfenapyr+SX, chlorfenvinphos+SX, chlorfluazuron+SX,        chlormephos+SX, chloropicrin+SX, chlorpyrifos+SX,        chlorpyrifos-methyl+SX, chromafenozide+SX, clofentezine+SX,        clothianidin+SX, concanamycin A+SX, coumaphos+SX, cryolite+SX,        cyanophos+SX, cyantraniliprole+SX, cyclaniliprole+SX,        cyclobutrifluram+SX, cycloprothrin+SX, cycloxaprid+SX,        cyenopyrafen+SX, cyetpyrafen+SX, cyflumetofen+SX, cyfluthrin+SX,        cyhalodiamide+SX, cyhalothrin+SX, cyhexatin+SX, cypermethrin+SX,        cyphenothrin+SX, cyromazine+SX, dazomet+SX, deltamethrin+SX,        demeton-S-methyl+SX, diafenthiuron+SX, diazinon+SX,        dichlorvos+SX, dicloromezotiaz+SX, dicofol+SX, dicrotophos+SX,        diflovidazin+SX, diflubenzuron+SX, dimefluthrin+SX,        dimethoate+SX, dimethylvinphos+SX, dimpropyridaz+SX,        dinotefuran+SX, disodium octaborate+SX, disulfoton+SX,        DNOC(2-methyl-4,6-dinitrophenol)+SX, doramectin+SX, dried leaves        of Dryopteris filix-mas+SX, emamectin-benzoate+SX,        empenthrin+SX, endosulfan+SX, EPN(O-ethyl O-(4-nitrophenyl)        phenylphosphonothioate)+SX, epsilon-metofluthrin+SX,        epsilon-momfluorothrin+SX, esfenvalerate+SX, ethiofencarb+SX,        ethion+SX, ethiprole+SX, ethoprophos+SX, etofenprox+SX,        etoxazole+SX, extract of Artemisia absinthium+SX, extract of        Cassia nigricans+SX, extract of clitoria ternatea+SX, extract of        Symphytum officinale+SX, extracts or simulated blend of        Chenopodium ambrosioides+SX, extract of Tanacetum vulgare+SX,        extract of Urtica dioica+SX, extract of Viscum album+SX,        famphur+SX, fenamiphos+SX, fenazaquin+SX, fenbutatin oxide+SX,        fenitrothion+SX, fenobucarb+SX, fenoxycarb+SX, fenpropathrin+SX,        fenpyroximate+SX, fenthion+SX, fenvalerate+SX, fipronil+SX,        flometoquin+SX, flonicamid+SX, fluacrypyrim+SX,        fluazaindolizine+SX, fluazuron+SX, flubendiamide+SX,        flucycloxuron+SX, flucythrinate+SX, fluensulfone+SX,        flufenoprox+SX, flufenoxuron+SX, flufiprole+SX, flumethrin+SX,        flupentiofenox+SX, flupyradifurone+SX, flupyrimin+SX,        fluralaner+SX, fluvalinate+SX, fluxametamide+SX, formetanate+SX,        fosthiazate+SX, furamethrin+SX, furathiocarb+SX,        gamma-cyhalothrin+SX, GS-omega/kappa HXTX-Hvla peptide+SX,        halfenprox+SX, halofenozide+SX, heptafluthrin+SX,        heptenophos+SX, hexaflumuron+SX, hexythiazox+SX, potassium salt        of hop beta acid+SX, hydramethylnon+SX, hydroprene+SX,        imicyafos+SX, imidacloprid+SX, imidaclothiz+SX, imiprothrin+SX,        indoxacarb+SX, isocycloseram+SX, isofenphos+SX, isoprocarb+SX,        isopropyl-O-(methoxyaminothiophosphoryl) salicylate+SX,        isoxathion+SX, ivermectin+SX, kadethrin+SX, kappa-tefluthrin+SX,        kappa-bifenthrin+SX, kinoprene+SX, lambda-cyhalothrin+SX,        lenoremycin+SX, lepimectin+SX, lime sulfur+SX, lotilaner+SX,        lufenuron+SX, machine oil+SX, malathion+SX, mecarbam+SX,        meperfluthrin+SX, metaflumizone+SX, metam+SX, methamidophos+SX,        methidathion+SX, methiocarb+SX, methomyl+SX, methoprene+SX,        methoxychlor+SX, methoxyfenozide+SX, methyl bromide+SX,        metofluthrin+SX, metolcarb+SX, metoxadiazone+SX, mevinphos+SX,        milbemectin+SX, milbemycin oxime+SX, momfluorothrin+SX,        monocrotophos+SX, moxidectin+SX, naled+SX, neem oil+SX,        nicotine+SX, nicotine-sulfate+SX, nitenpyram+SX, novaluron+SX,        noviflumuron+SX, oil of the seeds of Chenopodium        anthelminticum+SX, omethoate+SX, oxamyl+SX, oxazosulfyl+SX,        oxydemeton-methyl+SX, parathion+SX, parathion-methyl+SX,        permethrin+SX, phenothrin+SX, phenthoate+SX, phorate+SX,        phosalone+SX, phosmet+SX, phosphamidon+SX, phosphine+SX,        phoxim+SX, pirimicarb+SX, pirimiphos-methyl+SX, prallethrin+SX,        profenofos+SX, profluthrin+SX, propargite+SX, propetamphos+SX,        propoxur+SX, propylene glycol alginate+SX, prothiofos+SX,        pyflubumide+SX, pymetrozine+SX, pyraclofos+SX, pyrethrins+SX,        pyridaben+SX, pyridalyl+SX, pyridaphenthion+SX,        pyrifluquinazone+SX, pyrimidifen+SX, pyriminostrobin+SX,        pyriprole+SX, pyriproxyfen+SX, quinalphos+SX, resmethrin+SX,        rotenone+SX, ryanodine+SX, sarolaner+SX, selamectin+SX,        sigma-cypermethrin+SX, silafluofen+SX, sodium borate+SX, sodium        metaborate+SX, spinetoram+SX, spinosad+SX, spirodiclofen+SX,        spiromesifen+SX, spiropidion+SX, spirotetramat+SX,        sulfluramid+SX, sulfotep+SX, sulfoxaflor+SX, sulfur+SX, sulfuryl        fluoride+SX, tartar emetic+SX, tau-fluvalinate+SX,        tebufenozide+SX, tebufenpyrad+SX, tebupirimfos+SX,        teflubenzuron+SX, tefluthrin+SX, temephos+SX, terbufos+SX,        terpene constituents of the extract of Chenopodium ambrosioides        near ambrosioides+SX, tetrachlorantraniliprole+SX,        tetrachlorvinphos+SX, tetradifon+SX, tetramethrin+SX,        tetramethylfluthrin+SX, tetraniliprole+SX,        theta-cypermethrin+SX, thiacloprid+SX, thiamethoxam+SX,        thiocyclam+SX, thiodicarb+SX, thiofanox+SX, thiometon+SX,        thiosultap-disodium+SX, thiosultap-monosodium+SX, tioxazafen+SX,        tolfenpyrad+SX, tralomethrin+SX, transfluthrin+SX,        triazamate+SX, triazophos+SX, trichlorfon+SX,        triflumezopyrim+SX, triflumuron+SX, trimethacarb+SX,        tyclopyrazoflor+SX, vamidothion+SX, wood extract of Quassia        amara+SX, XMC (3,5-dimethylphenyl N-methylcarbamate)+SX,        xylylcarb+SX, zeta-cypermethrin+SX, zinc phosphide+SX,        4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methyl-N-(1-oxothietan-3-yl)benzamide        (1241050-20-3)+SX,        3-methoxy-N-(5-{5-(trifluoromethyl)-5-[3-(trifluoromethyl)phenyl]-4,5-dihydro-1,2-oxazol-3-yl}indan-1-yl)propanamide        (1118626-57-5)+SX,        4-chloro-5-[2,2-difluoro-2-(3,4,5-trifluorophenyl)ethoxy]-2-methylphenyl        2,2,2-trifluoroethyl sulfoxide (1632218-00-8)+SX,        4-fluoro-5-[2,2-difluoro-2-(3,4,5-trifluorophenyl)ethoxy]-2-methylphenyl        2,2,2-trifluoroethyl sulfoxide (1632217-98-1)+SX,        2-({2-fluoro-4-methyl-5-[(2,2,2-trifluoroethyl)sulfinyl]phenyl}imino)-3-(2,2,2-trifluoroethyl)-1,3-thiazolidin-4-one        (1445683-71-5)+SX,        (3R)-3-(2-chlorothiazol-5-yl)-8-methyl-7-oxo-6-phenyl-2,3-dihydrothiazolo[3,2-a]pyrimidin-4-ium-5-olate        (2249718-27-0)+SX, BT crop protein Cry1Ab+SX, BT crop protein        Cry1Ac+SX, BT crop protein Cry1Fa+SX, BT crop protein        Cry1A.105+SX, BT crop protein Cry2Ab+SX, BT crop protein        Vip3A+SX, BT crop protein Cry3A+SX, BT crop protein Cry3Ab+SX,        BT crop protein Cry3Bb+SX, BT crop protein Cry34Ab1/Cry35Ab1+SX,        Adoxophyes orana granulosis virus strain BV-0001+SX, Anticarsia        gemmatalis mNPV+SX, Autographa californica mNPV+SX, Cydia        pomonella GV strain V15+SX, Cydia pomonella GV strain V22+SX,        Cryptophlebia leucotreta GV+SX, Dendrolimus punctatus        cypovirus+SX, Helicoverpa armigera NPV strain BV-0003+SX,        Helicoverpa zea NPV+SX, Lymantria dispar NPV+SX, Mamestra        brassicae NPV+SX, Mamestra configurata NPV+SX, Neodiprion        abietis NPV+SX, Neodiprion lecontei NPV+SX, Neodiprion sertifer        NPV+SX, Nosema locustae+SX, Orgyia pseudotsugata NPV+SX, Pieris        rapae GV+SX, Plodia interpunctella GV+SX, Spodoptera exigua        mNPV+SX, Spodoptera littoralis mNPV+SX, Spodoptera litura        NPV+SX, Arthrobotrys dactyloides+SX, Bacillus firmus strain        GB-126+SX, Bacillus firmus strain 1-1582+SX, Bacillus        megaterium+SX, Bacillus sp. strain AQ175+SX, Bacillus sp. strain        AQ177+SX, Bacillus sp. strain AQ178+SX, Bacillus sphaericus        strain 2362+SX, Bacillus sphaericus strain ABTS1743+SX, Bacillus        sphaericus Serotype strain H5a5b+SX, Bacillus thuringiensis        strain AQ52+SX, Bacillus thuringiensis strain BD #32+SX,        Bacillus thuringiensis strain CR-371+SX, Bacillus thuringiensis        subsp. Aizawai strain ABTS-1857+SX, Bacillus thuringiensis        subsp. Aizawai strain AM65-52+SX, Bacillus thuringiensis subsp.        Aizawai strain GC-91+SX, Bacillus thuringiensis subsp. Aizawai        Serotype strain H-7+SX, Bacillus thuringiensis subsp. Kurstaki        strain ABTS351+SX, Bacillus thuringiensis subsp. Kurstaki strain        BMP123+SX, Bacillus thuringiensis subsp. Kurstaki strain        EG234+SX, Bacillus thuringiensis subsp. Kurstaki strain        EG7841+SX, Bacillus thuringiensis subsp. Kurstaki strain        EVB113-19+SX, Bacillus thuringiensis subsp. Kurstaki strain        F810+SX, Bacillus thuringiensis subsp. Kurstaki strain HD-1+SX,        Bacillus thuringiensis subsp. Kurstaki strain PB54+SX, Bacillus        thuringiensis subsp. Kurstaki strain SA-11+SX, Bacillus        thuringiensis subsp. Kurstaki strain SA-12+SX, Bacillus        thuringiensis subsp. Tenebriosis strain NB176+SX, Bacillus        thuringiensis subsp. Thuringiensis strain MPPL002+SX, Bacillus        thuringiensis subsp. morrisoni+SX, Bacillus thuringiensis var.        colmeri+SX, Bacillus thuringiensis var. darmstadiensis strain        24-91+SX, Bacillus thuringiensis var. dendrolimus+SX, Bacillus        thuringiensis var. galleriae+SX, Bacillus thuringiensis var.        israelensis strain BMP144+SX, Bacillus thuringiensis var.        israelensis serotype strain H-14+SX, Bacillus thuringiensis var.        japonensis strain buibui+SX, Bacillus thuringiensis var. san        diego strain M-7+SX, Bacillus thuringiensis var. 7216+SX,        Bacillus thuringiensis var. aegypti+SX, Bacillus thuringiensis        var. T36+SX, Beauveria bassiana strain ANT-03+SX, Beauveria        bassiana strain ATCC74040+SX, Beauveria bassiana strain GHA+SX,        Beauveria brongniartii+SX, Burkholderia rinojensis strain        A396+SX, Chromobacterium subtsugae strain PRAA4-1T+SX,        Dactyllela ellipsospora+SX, Dectylaria thaumasia+SX, Hirsutella        minnesotensis+SX, Hirsutella rhossiliensis+SX, Hirsutella        thompsonii+SX, Lagenidium giganteum+SX, Lecanicillium lecanii        strain KV01+SX, Lecanicillium lecanii conidia of strain        DAOM198499+SX, Lecanicillium lecanii conidia of strain        DAOM216596+SX, Lecanicillium muscarium strain Ve6+SX,        Metarhizium anisopliae strain F52+SX, Metarhizium anisopliae        var. acridum+SX, Metarhizium anisopliae var. anisopliae BIPESCO        5/F52+SX, Metarhizium flavoviride+SX, Monacrosporium        phymatopagum+SX, Paecilomyces fumosoroseus Apopka strain 97+SX,        Paecilomyces lilacinus strain 251+SX, Paecilomyces tenuipes        strain T1+SX, Paenibacillus popilliae+SX, Pasteuria nishizawae        strain Pn1+SX, Pasteuria penetrans+SX, Pasteuria usgae+SX,        Pasteuria thoynei+SX, Serratia entomophila+SX, Verticillium        chlamydosporium+SX, Verticillium lecani strain NCIM1312+SX,        2-chloro-N-cyclopropyl-5-{l-[2,6-dichloro-4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl]-1H-pyrazol-4-yl}-N-methylpyridine-3-carboxamide        (1771741-86-6)+SX,        N-{4-chloro-3-[(1-cyanocyclopropyl)carbamoyl]phenyl}-1-methyl-4-(methanesulfonyl)-3-(1,1,2,2,2-pentafluoroethyl)-1H-pyrazole-3-carboxamide        (1400768-21-9)+SX,        11-(4-chloro-2,6-dimethylphenyl)-12-hydroxy-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one        (907187-07-9)+SX,        3-(4′-fluoro-2,4-dimethyl[1,1′-biphenyl]-3-yl)-4-hydroxy-8-oxa-1-azaspiro[4.5]dec-3-en-2-one        (1031385-91-7)+SX,        N-[3-chloro-1-(pyridin-3-yl)-1H-pyrazol-4-yl]-2-(methanesulfonyl)propanamide        (2396747-83-2)+SX,        2-isopropyl-5-[(3,4,4-trifluoro-3-buten-1-yl)sulfonyl]-1,3,4-thiadiazole        (2058052-95-0)+SX,        1,4-dimethyl-2-[2-(3-pyridinyl)-2H-indazol-5-yl]-1,2,4-triazolidine-3,5-dione        (2171099-09-3)+SX, cyproflanilide+SX,        N-({2-fluoro-4-[(2S,3S)-2-hydroxy-3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]phenyl}methyl)cyclopropanecarboxamide+SX.

Combinations of the present ingredient of the above Group (b) and thepresent compound C:

-   -   acibenzolar-S-methyl+SX, aldimorph+SX, ametoctradin+SX,        aminopyrifen+SX, amisulbrom+SX, anilazine+SX, azaconazole+SX,        azoxystrobin+SX, basic copper sulfate+SX, benalaxyl+SX,        benalaxyl-M+SX, benodanil+SX, benomyl+SX, benthiavalicarb+SX,        benthiavalicarb-isopropyl+SX, benzovindiflupyr+SX,        binapacryl+SX, biphenyl+SX, bitertanol+SX, bixafen+SX,        blasticidin-S+SX, Bordeaux mixture+SX, boscalid+SX,        bromothalonil+SX, bromuconazole+SX, bupirimate+SX, captafol+SX,        captan+SX, carbendazim+SX, carboxin+SX, carpropamid+SX,        chinomethionat+SX, chitin+SX, chloroneb+SX, chlorothalonil+SX,        chlozolinate+SX, colletochlorin B+SX, copper(II) acetate+SX,        copper(II) hydroxide+SX, copper oxychloride+SX, copper(II)        sulfate+SX, coumoxystrobin+SX, cyazofamid+SX, cyflufenamid+SX,        cymoxanil+SX, cyproconazole+SX, cyprodinil+SX,        dichlobentiazox+SX, dichlofluanid+SX, diclocymet+SX,        diclomezine+SX, dicloran+SX, diethofencarb+SX,        difenoconazole+SX, diflumetorim+SX, dimethachlone+SX,        dimethirimol+SX, dimethomorph+SX, dimoxystrobin+SX,        diniconazole+SX, diniconazole-M+SX, dinocap+SX, dipotassium        hydrogenphosphite+SX, dipymetitrone+SX, dithianon+SX,        dodecylbenzenesulphonic acid bisethylenediamine copper(II)        salt+SX, dodemorph+SX, dodine+SX, edifenphos+SX,        enoxastrobin+SX, epoxiconazole+SX, etaconazole+SX, ethaboxam+SX,        ethirimol+SX, etridiazole+SX, extract from Melaleuca        alternifolia+SX, extract from Reynoutria sachalinensis+SX,        extract from the cotyledons of lupine plantlets (“BLAD”)+SX,        extract of Allium sativum+SX, extract of Equisetum arvense+SX,        extract of Tropaeolum majus+SX, famoxadone+SX, fenamidone+SX,        fenaminstrobin+SX, fenarimol+SX, fenbuconazole+SX, fenfuram+SX,        fenhexamid+SX, fenoxanil+SX, fenpiclonil+SX, fenpicoxamid+SX,        fenpropidin+SX, fenpropimorph+SX, fenpyrazamine+SX, fentin        acetate+SX, fentin chloride+SX, fentin hydroxide+SX, ferbam+SX,        ferimzone+SX, florylpicoxamid+SX, fluazinam+SX, flubeneteram+SX,        fludioxonil+SX, flufenoxystrobin+SX, fluindapyr+SX, flumorph+SX,        fluopicolide+SX, fluopyram+SX, fluopimomide+SX, fluoroimide+SX,        fluoxapiprolin+SX, fluoxastrobin+SX, fluquinconazole+SX,        flusilazole+SX, flusulfamide+SX, flutianil+SX, flutolanil+SX,        flutriafol+SX, fluxapyroxad+SX, folpet+SX, fosetyl+SX,        fosetyl-aluminium+SX, fuberidazole+SX, furalaxyl+SX,        furametpyr+SX, guazatine+SX, hexaconazole+SX, hymexazole+SX,        imazalil+SX, imibenconazole+SX, iminoctadine+SX, iminoctadine        triacetate+SX, inpyrfluxam+SX, iodocarb+SX, ipconazole+SX,        ipfentrifluconazole+SX, ipflufenoquin+SX, iprobenfos+SX,        iprodione+SX, iprovalicarb+SX, isofetamid+SX, isoflucypram+SX,        isoprothiolane+SX, isopyrazam+SX, isotianil+SX, kasugamycin+SX,        kresoxim-methyl+SX, laminarin+SX, leaves and bark of Quercus+SX,        mancozeb+SX, mandestrobin+SX, mandipropamid+SX, maneb+SX,        mefentrifluconazole+SX, mepanipyrim+SX, mepronil+SX,        meptyldinocap+SX, metalaxyl+SX, metalaxyl-M+SX, metconazole+SX,        methasulfocarb+SX, metiram+SX, metominostrobin+SX,        metrafenone+SX, metyltetraprole+SX, mineral oils+SX,        myclobutanil+SX, naftifine+SX, nuarimol+SX, octhilinone+SX,        ofurace+SX, orysastrobin+SX, oxadixyl+SX, oxathiapiprolin+SX,        oxine-copper+SX, oxolinic acid+SX, oxpoconazole+SX, oxpoconazole        fumarate+SX, oxycarboxin+SX, oxytetracycline+SX, pefurazoate+SX,        penconazole+SX, pencycuron+SX, penflufen+SX, penthiopyrad+SX,        phenamacril+SX, phosphorous acid+SX, phthalide+SX,        picarbutrazox+SX, picoxystrobin+SX, piperalin+SX, polyoxins+SX,        potassium hydrogencarbonate+SX, potassium        dihydrogenphosphite+SX, probenazole+SX, prochloraz+SX,        procymidone+SX, propamidine+SX, propamocarb+SX,        propiconazole+SX, propineb+SX, proquinazid+SX, prothiocarb+SX,        prothioconazole+SX, pydiflumetofen+SX, pyraclostrobin+SX,        pyrametostrobin+SX, pyraoxystrobin+SX, pyrapropoyne+SX,        pyraziflumid+SX, pyrazophos+SX, pyribencarb+SX, pyributicarb+SX,        pyridachlometyl+SX, pyrifenox+SX, pyrimethanil+SX, pyrimorph+SX,        pyriofenone+SX, pyrisoxazole+SX, pyroquilon+SX, Quillaja        extract+SX, quinconazole+SX, quinofumelin+SX, quinoxyfen+SX,        quintozene+SX, Saponins of Chenopodium quinoa+SX, sedaxane+SX,        silthiofam+SX, simeconazole+SX, sodium hydrogencarbonate+SX,        spiroxamine+SX, streptomycin+SX, sulfur+SX, tebuconazole+SX,        tebufloquin+SX, teclofthalam+SX, tecnazene+SX, terbinafine+SX,        tetraconazole+SX, thiabendazole+SX, thifluzamide+SX,        thiophanate+SX, thiophanate-methyl+SX, thiram+SX, thymol+SX,        tiadinil+SX, tolclofos-methyl+SX, tolfenpyrad+SX, tolprocarb+SX,        tolylfluanid+SX, triadimefon+SX, triadimenol+SX, triazoxide+SX,        triclopyricarb+SX, tricyclazole+SX, tridemorph+SX,        trifloxystrobin+SX, triflumizole+SX, triforine+SX,        triticonazole+SX, validamycin+SX, valifenalate+SX,        vinclozolin+SX, yellow mustard powder+SX, zinc thiazole+SX,        zineb+SX, ziram+SX, zoxamide+SX,        N′-[4-({3-[(4-chlorophenyl)methyl]-1,2,4-thiadiazol-5-yl}oxy)-2,5-dimethylphenyl]-N-ethyl-N-methylmethanimidamide        (1202781-91-6)+SX,        N′-{4-[(4,5-dichlorothiazol-2-yl)oxy]-2,5-dimethylphenyl}-N-ethyl-N-methylmethanimidamide        (929908-57-6)+SX,        N′-(2,5-dimethyl-4-phenoxyphenyl)-N-ethyl-N-methylmethanimidamide        (1052688-31-9)+SX,        N′-[5-choro-4-(2-fluorophenoxy)-2-methylphenyl)-N-ethyl-N-methylmethanimidamide        (2055589-28-9)+SX,        N′-[2-choro-4-(2-fluorophenoxy)-5-methylphenyl)-N-ethyl-N-methylmethanimidamide        (2055756-21-1)+SX,        N′-[4-(1-hydroxy-1-phenyl-2,2,2-trifluoroethyl)-2-methyl-5-methoxyphenyl)-N-isopropyl-N-methylmethanimidamide        (2101814-55-3)+SX,        N′-[5-bromo-6-(1-methyl-2-propoxyethoxy)-2-methylpyridin-3-yl)-N-ethyl-N-methylmethanimidamide        (1817828-69-5)+SX,        4-(2-bromo-4-fluorophenyl)-N-(2-chloro-6-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine        (1362477-26-6)+SX,        2-[6-(3-fluoro-4-methoxyphenyl)-5-methylpyridin-2-yl]quinazoline        (1257056-97-5)+SX,        5-fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidin-2(1H)-one        (1616664-98-2)+SX, ethyl (2Z)-3-amino-2-cyano-3-phenylacrylate        (39491-78-6)+SX,        N-[(2-chlorothiazol-5-yl)methyl]-N-ethyl-6-methoxy-3-nitropyridin-2-amine        (1446247-98-8)+SX,        5-(4-chlorobenzyl)-2-(chloromethyl)-2-methyl-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentan-1-ol        (1394057-11-4)+SX, (1R, 2S,        5S)-5-(4-chlorobenzyl)-2-(chloromethyl)-2-methyl-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentan-1-ol        (1801930-06-2)+SX, (1S, 2R,        5R)-5-(4-chlorobenzyl)-2-(chloromethyl)-2-methyl-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentan-1-ol        (1801930-07-3)+SX,        2-(chloromethyl)-5-(4-fluorobenzyl)-2-methyl-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentan-1-ol        (1394057-13-6)+SX, (1R, 2S,        5S)-2-(chloromethyl)-5-(4-fluorobenzyl)-2-methyl-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentan-1-ol        (1801930-08-4)+SX, (1S, 2R,        5R)-2-(chloromethyl)-5-(4-fluorobenzyl)-2-methyl-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentan-1-ol        (1801930-09-5)+SX, methyl        3-[(4-chlorophenyl)methyl]-2-hydroxy-1-methyl-2-(1H-1,2,4-triazol-1-ylmethyl)cyclopentan-1-carboxylate        (1791398-02-1)+SX,        1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-[1-(4-bromo-2,6-difluorophenoxy)cyclopropyl]ethanol        (2019215-86-0)+SX,        1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-[1-(4-chloro-2,6-difluorophenoxy)cyclopropyl]ethanol        (2019215-84-8)+SX,        1-[2-(1-chlorocyclopropyl)-3-(2-fluorophenyl)-2-hydroxypropyl]-1H-imidazole-5-carbonitrile        (2018316-13-5)+SX,        1-[2-(1-chlorocyclopropyl)-3-(2,3-difluorophenyl)-2-hydroxypropyl]-1H-imidazole-5-carbonitrile        (2018317-25-2)+SX,        4-({6-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]pyridin-3-yl}oxy)benzonitrile        (2046300-61-0)+SX,        2-[6-(4-bromophenoxy)-2-(trifluoromethyl)pyridin-3-yl]-1-(1H-1,2,4-triazol-1-yl)propan-2-ol        (2082661-43-4)+SX,        2-[6-(4-chlorophenoxy)-2-(trifluoromethyl)pyridin-3-yl]-1-(1H-1,2,4-triazol-1-yl)propan-2-ol        (2082660-27-1)+SX, methyl        ({2-methyl-5-[1-(4-methoxy-2-methylphenyl)-1H-pyrazol-3-yl]phenyl}methyl)carbamate        (1605879-98-8)+SX,        2-(difluoromethyl)-N-[1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl]pyridine-3-carboxamide        (1616239-21-4)+SX,        2-(difluoromethyl)-N-[3-ethyl-1,1-dimethyl-2,3-dihydro-1H-inden-4-yl]pyridine-3-carboxamide        (1847460-02-9)+SX,        2-(difluoromethyl)-N-[3-propyl-1,1-dimethyl-2,3-dihydro-1H-inden-4-yl]pyridine-3-carboxamide        (1847460-05-2)+SX,        (2E,3Z)-5-{[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy}-2-(methoxyimino)-N,3-dimethylpent-3-enamide        (1445331-27-0)+SX,        (2E,3Z)-5-{[1-(2,4-dichlorophenyl)-1H-pyrazol-3-yl]oxy}-2-(methoxyimino)-N,3-dimethylpent-3-enamide        (1445331-54-3)+SX,        5-chloro-4-({2-[6-(4-chlorophenoxy)pyridin-3-yl]ethyl}amino)-6-methylpyrimidine        (1605340-92-8)+SX,        N-(1-benzyl-1,3-dimethylbutyl)-8-fluoroquinoline-3-carboxamide        (2132414-04-9)+SX,        N-(1-benzyl-3,3,3-trifluoro-1-methylpropyl)-8-fluoroquinoline-3-carboxamide        (2132414-00-5)+SX,        4,4-dimethyl-2-({4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)isoxazolidin-3-one        (2098918-25-1)+SX,        5,5-dimethyl-2-({4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)isoxazolidin-3-one        (2098918-26-2)+SX,        N-acetyl-2-(ethanesulfonyl)-N-[2-(methoxycarbonyl)-4-(trifluoromethoxy)        phenyl]-4-(trifluoromethyl) benzamide (2043675-28-9)+SX,        Agrobacterium radiobactor strain K1026+SX, Agrobacterium        radiobactor strain K84+SX, Bacillus amyloliquefaciens (Aveo        (trademark) EZ Nematicide)+SX, Bacillus amyloliquefaciens strain        AT332+SX, Bacillus amyloliquefaciens strain B3+SX, Bacillus        amyloliquefaciens strain D747+SX, Bacillus amyloliquefaciens        strain DB101+SX, Bacillus amyloliquefaciens strain DB102+SX,        Bacillus amyloliquefaciens strain GB03+SX, Bacillus        amyloliquefaciens strain FZB24+SX, Bacillus amyloliquefaciens        strain FZB42+SX, Bacillus amyloliquefaciens strain IN937a+SX,        Bacillus amyloliquefaciens strain MBI600+SX, Bacillus        amyloliquefaciens strain QST713+SX, Bacillus amyloliquefaciens        isolate strain B246+SX, Bacillus amyloliquefaciens strain        F727+SX, Bacillus amyloliquefaciens subsp. plantarum strain        D747+SX, Bacillus licheniformis strain HB-2+SX, Bacillus        licheniformis strain SB3086+SX, Bacillus pumilus strain        AQ717+SX, Bacillus pumilus strain BUF-33+SX, Bacillus pumilus        strain GB34+SX, Bacillus pumilus strain QST2808+SX, Bacillus        simplex strain CGF2856+SX, Bacillus subtilis strain AQ153+SX,        Bacillus subtilis strain AQ743+SX, Bacillus subtilis strain        BU1814+SX, Bacillus subtilis strain D747+SX, Bacillus subtilis        strain DB101+SX, Bacillus subtilis strain FZB24+SX, Bacillus        subtilis strain GB03+SX, Bacillus subtilis strain HAI0404+SX,        Bacillus subtilis strain IAB/BS03+SX, Bacillus subtilis strain        MBI600+SX, Bacillus subtilis strain QST30002/AQ30002+SX,        Bacillus subtilis strain QST30004/AQ30004+SX, Bacillus subtilis        strain QST713+SX, Bacillus subtilis strain QST714+SX, Bacillus        subtilis var. Amyloliquefaciens strain FZB24+SX, Bacillus        subtilis strain Y1336+SX, Burkholderia cepacia+SX, Burkholderia        cepacia type Wisconsin strain J82+SX, Burkholderia cepacia type        Wisconsin strain M54+SX, Candida oleophila strain O+SX, Candida        saitoana+SX, Chaetomium cupreum+SX, Clonostachys rosea+SX,        Coniothyrium minitans strain CGMCC8325+SX, Coniothyrium minitans        strain CON/M/91-8+SX, Cryptococcus albidus+SX, Erwinia        carotovora subsp. carotovora strain CGE234M403+SX, Fusarium        oxysporum strain Fo47+SX, Gliocladium catenulatum strain        J1446+SX, Paenibacillus polymyxa strain AC-1+SX, Paenibacillus        polymyxa strain BS-0105+SX, Pantoea agglomerans strain E325+SX,        Phlebiopsis gigantea strain VRA1992+SX, Pseudomonas aureofaciens        strain TX-1+SX, Pseudomonas chlororaphis strain 63-28+SX,        Pseudomonas chlororaphis strain AFS009+SX, Pseudomonas        chlororaphis strain MA342+SX, Pseudomonas fluorescens strain        1629RS+SX, Pseudomonas fluorescens strain A506+SX, Pseudomonas        fluorescens strain CL145A+SX, Pseudomonas fluorescens strain        G7090+SX, Pseudomonas sp. strain CAB-02+SX, Pseudomonas syringae        strain 742RS+SX, Pseudomonas syringae strain MA-4+SX, Pseudozyma        flocculosa strain PF-A22UL+SX, Pseudomonas rhodesiae strain        HAI-0804+SX, Pythium oligandrum strain DV74+SX, Pythium        oligandrum strain M1+SX, Streptomyces griseoviridis strain        K61+SX, Streptomyces lydicus strain WYCD108US+SX, Streptomyces        lydicus strain WYEC108+SX, Talaromyces flavus strain        SAY-Y-94-01+SX, Talaromyces flavus strain V117b+SX, Trichoderma        asperellum strain ICC012+SX, Trichoderma asperellum SKT-1+SX,        Trichoderma asperellum strain T25+SX, Trichoderma asperellum        strain T34+SX, Trichoderma asperellum strain TV1+SX, Trichoderma        atroviride strain CNCM 1-1237+SX, Trichoderma atroviride strain        LC52+SX, Trichoderma atroviride strain IMI 206040+SX,        Trichoderma atroviride strain SC1+SX, Trichoderma atroviride        strain SKT-1+SX, Trichoderma atroviride strain T11+SX,        Trichoderma gamsii strain ICC080+SX, Trichoderma harzianum        strain 21+SX, Trichoderma harzianum strain DB104+SX, Trichoderma        harzianum strain DSM 14944+SX, Trichoderma harzianum strain        ESALQ-1303+SX, Trichoderma harzianum strain ESALQ-1306+SX,        Trichoderma harzianum strain IIHR-Th-2+SX, Trichoderma harzianum        strain ITEM908+SX, Trichoderma harzianum strain kd+SX,        Trichoderma harzianum strain MO1+SX, Trichoderma harzianum        strain SF+SX, Trichoderma harzianum strain T22+SX, Trichoderma        harzianum strain T39+SX, Trichoderma harzianum strain T78+SX,        Trichoderma harzianum strain TH35+SX, Trichoderma polysporum        strain IMI206039+SX, trichoderma stromaticum+SX, Trichoderma        virens strain G-41+SX, Trichoderma virens strain GL-21+SX,        Trichoderma viride+SX, Variovorax paradoxus strain CGF4526+SX,        Harpin protein+SX,        N-acetyl-2-(ethanesulfonyl)-N-[2-(methoxycarbonyl)-4-(trifluoromethoxy)phenyl]-4-(trifluoromethyl)benzamide        (2043675-28-9)+SX, (2S,3S)-3-(2-methylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate        (2376210-00-1)+SX, (2S,3S)-3-(4-fluoro-2-methylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate+SX,        (2S,3S)-3-(4-methoxy-2-methylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate+SX,        (2S,3S)-3-(2,4-dimethylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate        (2376209-13-9)+SX, (2S,3S)-3-(2-methylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)-L-alaninate        (2376210-02-3)+SX, (2S,3S)-3-(4-fluoro-2-methylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)-L-alaninate+SX,        (2S,3S)-3-(4-methoxy-2-methylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)-L-alaninate        (2376209-40-2)+SX, (2S,3S)-3-(2,4-dimethylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)-L-alaninate        (2376209-15-1)+SX,        N′-(2-choro-4-phenoxy-5-methylphenyl)-N-ethyl-N-methylmethanimidamide        (2062599-39-5)+SX, (2S,3S)-3-(2-methylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate+SX,        (2S,3S)-3-(4-fluoro-2-methylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate+SX,        (2S,3S)-3-(4-methoxy-2-methylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate+SX,        (2S,3S)-3-(2,4-dimethylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate+SX,        (2S,3S)-3-(4-fluoro-2-methylphenyl)-4-methylpentan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate+SX,        (2S,3S)-3-(2-fluoro-4-methylphenyl)-4-methylpentan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate+SX,        (2S,3S)-3-(2,4-difluorophenyl)-4-methylpentan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate+SX,        (2S,3S)-3-(2,4-dimethylphenyl)-4-methylpentan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate+SX,        (2S,3S)-3-(4-fluoro-2-methoxylphenyl)-4-methylpentan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate+SX,        (2S,3S)-3-(4-fluoro-2-methylphenyl)-4-methylpentan-2-yl        N-{[3-(acetoxymethoxy)-4-methoxypyridin-2-yl]carbonyl}-L-alaninate+SX,        (2S,3S)-3-(2-fluoro-4-methylphenyl)-4-methylpentan-2-yl        N-{[3-(acetoxymethoxy)-4-methoxypyridin-2-yl]carbonyl}-L-alaninate+SX,        (2S,3S)-3-(2,4-difluorophenyl)-4-methylpentan-2-yl        N-{[3-(acetoxymethoxy)-4-methoxypyridin-2-yl]carbonyl}-L-alaninate+SX,        (2S,3S)-3-(2,4-dimethylphenyl)-4-methylpentan-2-yl        N-{[3-(acetoxymethoxy)-4-methoxypyridin-2-yl]carbonyl}-L-alaninate+SX,        (2S,3S)-3-(4-fluoro-2-methoxylphenyl)-4-methylpentan-2-yl        N-{[3-(acetoxymethoxy)-4-methoxypyridin-2-yl]carbonyl}-L-alaninate+SX,        (2S,3S)-3-(4-fluoro-2-methylphenyl)-4-methylpentan-2-yl        N-({3-[(isobutyryloxy)methoxy]-4-methoxypyridin-2-yl}carbonyl)-L-alaninate+SX,        (2S,3S)-3-(2-fluoro-4-methylphenyl)-4-methylpentan-2-yl        N-({3-[(isobutyryloxy)methoxy]-4-methoxypyridin-2-yl}carbonyl)-L-alaninate+SX,        (2S,3S)-3-(2,4-difluorophenyl)-4-methylpentan-2-yl        N-({3-[(isobutyryloxy)methoxy]-4-methoxypyridin-2-yl}carbonyl)-L-alaninate+SX,        (2S,3S)-3-(2,4-dimethylphenyl)-4-methylpentan-2-yl        N-({3-[(isobutyryloxy)methoxy]-4-methoxypyridin-2-yl}carbonyl)-L-alaninate+SX,        (2S,3S)-3-(4-fluoro-2-methoxylphenyl)-4-methylpentan-2-yl        N-({3-[(isobutyryloxy)methoxy]-4-methoxypyridin-2-yl}carbonyl)-L-alaninate+SX,        (2S,3S)-3-(4-fluoro-2-methylphenyl)-4-methylpentan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate+SX,        (2S,3S)-3-(2-fluoro-4-methylphenyl)-4-methylpentan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate+SX,        (2S,3S)-3-(2,4-difluorophenyl)-4-methylpentan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate+SX,        (2S,3S)-3-(2,4-dimethylphenyl)-4-methylpentan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate+SX,        (2S,3S)-3-(4-fluoro-2-methoxylphenyl)-4-methylpentan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate+SX,        3-(4-bromo-7-fluoroindol-1-yl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate+SX,        3-(7-bromoindol-1-yl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate+SX,        3-(7-bromo-4-fluoroindol-1-yl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate+SX,        3-(3,5-dichloropyridin-2-yl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate+SX,        3-(3,5-dichloropyridin-2-yl)butan-2-yl        N-{[3-(acetoxymethoxy)-4-methoxypyridin-2-yl]carbonyl}-L-alaninate+SX,        (1S)-1-[1-(naphthalen-1-yl)cyclopropyl]ethyl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate+SX,        (1S)-1-[1-(naphthalen-1-yl)cyclopropyl]ethyl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate+SX,        (1S)-1-[1-(naphthalen-1-yl)cyclopropyl]ethyl        N-{[3-(acetoxymethoxy)-4-methoxypyridin-2-yl]carbonyl}-L-alaninate+SX,        chloroinconazide+SX,        N-ethyl-2-methyl-N-({4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)propanamide+SX,        N,2-dimethoxy-N-({4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)propanamide+SX,        N-methoxy-N-({4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)cyclopropanecarboxamide+SX,        N-methoxy-N′-methyl-N-({4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)urea+SX,        N′-ethyl-N-methoxy-N-({4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)urea+SX,        N,N′-dimethoxy-N-({4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)urea+SX,        N-(2-fluorophenyl)-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide+SX,        N-[2-(difluoromethoxy)phenyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide+SX,        N-[2-(difluoromethoxy)-4-fluorophenyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide+SX.

Combinations of the present ingredient of the above Group (c) and thepresent compound C:

-   -   1-methylcyclopropene+SX, 1,3-diphenylurea+SX,        2,3,5-triiodobenzoic acid+SX, IAA ((1H-indol-3-yl) acetic        acid)+SX, IBA (4-(1H-indol-3-yl)butyric acid)+SX, MCPA        (2-(4-chloro-2-methylphenoxy)acetic acid)+SX, MCPB        (4-(4-chloro-2-methylphenoxy)butyric acid)+SX, 4-CPA        (4-chlorophenoxyacetic acid)+SX, 5-aminolevulinic acid        hydrochloride+SX, 6-benzylaminopurine+SX, abscisic acid+SX, AVG        (aminoethoxyvinylglycine)+SX, ancymidol+SX, butralin+SX, calcium        carbonate+SX, calcium chloride+SX, calcium formate+SX, calcium        peroxide+SX, calcium polysulfide+SX, calcium sulfate+SX,        chlormequat-chloride+SX, chlorpropham+SX, choline chloride+SX,        cloprop+SX, cyanamide+SX, cyclanilide+SX, daminozide+SX,        decan-1-ol+SX, dichlorprop+SX, dikegulac+SX, dimethipin+SX,        diquat+SX, ethephon+SX, ethychlozate+SX, flumetralin+SX,        flurprimidol+SX, forchlorfenuron+SX, formononetin+SX,        Gibberellin A+SX, Gibberellin A3+SX, inabenfide+SX, Kinetin+SX,        lipochitooligosaccharide SP104+SX, maleic hydrazide+SX,        mefluidide+SX, mepiquat-chloride+SX, oxidized glutathione+SX,        pacrobutrazol+SX, pendimethalin+SX, prohexandione-calcium+SX,        prohydrojasmon+SX, pyraflufen-ethyl+SX, sintofen+SX, sodium        1-naphthaleneacetate+SX, sodium cyanate+SX, streptmycin+SX,        thidiazuron+SX, triapenthenol+SX, Tribufos+SX,        trinexapac-ethyl+SX, uniconazole-P+SX,        2-(naphthalen-1-yl)acetamide+SX,        [4-oxo-4-(2-phenylethyl)amino]butyric acid+SX, methyl        5-(trifluoromethyl)-benzo[b]thiophen-2-carboxylate+SX,        3-[(6-chloro-4-phenylquinazolin-2-yl)amino]propan-1-ol+SX,        Claroideoglomus etunicatum+SX, Claroideoglomus claroideum+SX,        Funneliformis mosseae+SX, Gigaspora margarita+SX, Gigaspora        rosea+SX, Glomus aggregatum+SX, Glomus deserticola+SX, Glomus        monosporum+SX, Paraglomus brasillianum+SX, Rhizophagus        clarus+SX, Rhizophagus intraradices RTI-801+SX, Rhizophagus        irregularis DAOM 197198+SX, Azorhizobium caulinodans+SX,        Azospirillum amazonense+SX, Azospirillum brasilense XOH+SX,        Azospirillum brasilense Ab-V5+SX, Azospirillum brasilense        Ab-V6+SX, Azospirillum caulinodans+SX, Azospirillum        halopraeferens+SX, Azospirillum irakense+SX, Azospirillum        lipoferum+SX, Bradyrhizobium elkanii SEMIA 587+SX,        Bradyrhizobium elkanii SEMIA 5019+SX, Bradyrhizobium japonicum        TA-11+SX, Bradyrhizobium japonicum USDA 110+SX, Bradyrhizobium        liaoningense+SX, Bradyrhizobium lupini+SX, Delftia acidovorans        RAY209+SX, Mesorhizobium ciceri+SX, Mesorhizobium huakii+SX,        Mesorhizobium loti+SX, Rhizobium etli+SX, Rhizobium galegae+SX,        Rhizobium leguminosarum bv. Phaseoli+SX, Rhizobium leguminosarum        bv. Trifolii+SX, Rhizobium leguminosarum bv. Viciae+SX,        Rhizobium trifolii+SX, Rhizobium tropici+SX, Sinorhizobium        fredii+SX, Sinorhizobium meliloti+SX, Zucchini Yellow Mosaik        Virus weak strain+SX.

Combinations of the present ingredient of the above Group (d) and thepresent compound C:

-   -   anthraquinone+SX, deet+SX, icaridin+SX.

The ratio of the present compound C to the Present ingredient includes,but not limited thereto, as a ratio by weight (the compound of thepresent invention:the Present ingredient) 1,000:1 to 1:1,000, 500:1 to1:500, 100:1 to 1:100, 50:1, 20:1, 10:1, 9:1, 8:1, 7:1, 6:1, 5:1, 4:1,3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10. 1:20, and1:50, and the others.

The present compound, the present compound C, the present compound D, orthe composition A is usually mixed with solid carrier(s), liquidcarrier(s), oil(s), and/or surfactant(s), and if necessary, added by theother auxiliary agents for formulation, to formulate into emulsifiableconcentrates, oil solutions, dust formulations, granules, wettablepowders, wettable dispersible granules, flowables, dry flowables,microcapsules and the others. In these formulations, the presentcompound, the present compound C, the present compound D, or thecomposition A is contained in usually 0.1 to 99% by weight, preferably0.2 to 90%.

Examples of the solid carrier include fine powders or granules of clays(for example, kaolin clay, diatomaceous earth, bentonite, or acid whiteclay), dry silica, wet silica, hydrated silica, talcs, ceramics, otherinorganic minerals (for example, sericite, quartz, sulfur, activecarbon, or calcium carbonate); as well as synthetic resins (for example,polyester resins such as polypropylene, polyacrylonitrile, polymethylmethacrylate or polyethylene terephthalate; nylon resins (for example,nylon-6, nylon-11, or nylon-66); polyamide resins; polyvinyl chloride,polyvinylidene chloride, vinyl chloride-propylene copolymers, and theothers).

Examples of the liquid carriers include water; alcohols (for example,methanol, ethanol, isopropyl alcohol, butanol, hexanol, benzyl alcohol,ethylene glycol, propylene glycol, or phenoxy ethanol); ketones (forexample, acetone, methyl ethyl ketone, or cyclohexanone); aromatichydrocarbons (for example, toluene, xylene, ethyl benzene, dodecylbenzene, phenyl xylyl ethane, or methylnaphthalene); aliphatichydrocarbons (for example, hexane, cyclohexane, kerosene, or light oil);esters (for example, ethyl acetate, butyl acetate, isopropyl myristate,ethyl oleate, diisopropyl adipate, diisobutyl adipate, or propyleneglycol monomethyl ether acetate); nitriles (for example, acetonitrile,or isobutyronitrile); ethers (for example, diisopropyl ether,1,4-dioxane, 1,2-dimethoxyethane, diethyleneglycol dimethyl ether,diethylene glycol monomethyl ether, propylene glycol monomethyl ether,dipropylene glycol monomethyl ether, or 3-methoxy-3-methyl-1-butanol);amides (for example, DMF, or N,N-dimethylacetamide); sulfoxides (forexample, dimethyl sulfoxide); propylene carbonate; and vegetable oils(for example, soybean oil or cottonseed oil).

Examples of the surfactants include nonionic surfactants such aspolyoxyethylenated alkyl ethers, polyoxyethylenated alkyl aryl ethers,and polyethylene glycol fatty acid esters; and anionic surfactants suchas alkyl sulfonates, alkylbenzene sulfonates and alkyl sulfates.Specific examples thereof include Nimbus (registered trademark), Assist(registered trademark), Aureo (registered trademark), Iharol (registeredtrademark), Silwet L-77 (registered trademark), BreakThru (registeredtrademark), SundanceII (registered trademark), Induce (registeredtrademark), Penetrator (registered trademark), AgriDex (registeredtrademark), Lutensol A8 (registered trademark), NP-7 (registeredtrademark), Triton (registered trademark), Nufilm (registeredtrademark), Emulgator NP7 (registered trademark), Emulad (registeredtrademark), TRITON X 45 (registered trademark), AGRAL 90 (registeredtrademark), AGROTIN (registered trademark), ARPON (registeredtrademark), EnSpray N (registered trademark), and BANOLE (registeredtrademark), and the others.

Examples of the other auxiliary agents for formulation include a binder,a dispersant, a colorant and a stabilizer. Specific examples includecasein, gelatin, polysaccharides (for example, starch, gum arabic,cellulose derivatives and alginic acid), lignin derivatives, bentonite,water-soluble synthetic polymers (for example, polyvinyl alcohol,polyvinyl pyrrolidone and polyacrylic acids), acidic isopropylphosphate, 2,6-di-tert-butyl-4-methylphenol, and a mixture of2-tert-butyl-4-methoxyphenol and 3-tert-butyl-4-methoxyphenol.

Examples of an application of the present compound, the present compoundC, the present compound D or the composition A include a spreading tostems and leaves of soybeans, an application to seeds, and anapplication to soil for cultivating soybeans.

The application dose of the present compound, the present compound C, orthe present compound D may be varied depending on a climate condition, aformulation form, an application period, an application method, anapplication site, plant diseases to be controlled, plant to be applied,and the others. In the cases where these compounds are spread to stemsand leaves of soybean or are applied to soil for cultivating soybeans,the application dose thereof is within a range of usually 1 to 500 g,preferably 2 to 200 g per 1,000 m². In the cases where these compoundsare applied to seeds, the application dose thereof is within a range of0.01 to 100 g, preferably 0.01 to 50 g per 1 Kg of seeds. Theapplication dose of the composition A is within a range of usually 1 to500 g per 1,000 m² in the case where it is spread to stems and leaves ofsoybean or are applied to soil for cultivating soybeans. In the caseswhere it is applied to seeds, the application dose thereof is within arange of usually 0.001 to 100 g per 1 Kg of seeds. The emulsifiableconcentrate, the wettable powder, the suspension etc., is usuallyapplied by diluting them with water. In these cases, the concentrationof the present compound, the present compound C, the present compound D,or the composition A after the dilution is within a range of usually0.0005 to 2% by weight, preferably 0.005 to 2% by weight. The dustformulation or the granular formulation, etc., is usually applied asitself without diluting them.

Seeds are treated with the present compound C or the composition A toobtain seeds carrying the present compound C or the composition A. Theseeds carrying the present compound C or the composition A means seedsin the state where the present compound C or the composition A isadhered to a surface of the seeds. Also, the present compound C or thecomposition A which are may be adhered on the surface of the seeds maybe permeated from the surface to the interior of the plant.

Also, when the composition A is adhered on the surface of the seeds, alayer consisting of single active ingredient may be multiply overlapped,a plural of the active ingredients may be mixed to form a single layer,a layer consisting of the single active ingredient and a layerconsisting of the plural of the active ingredients may be multiplyoverlapped, or a layer consisting of the plural of the activeingredients may be multiply overlapped. In the seeds used for the seedtreatment, any materials other than the present compound C or thecomposition A may be adhered before or after being treated with thepresent compound C or the composition A.

Examples of the application to seeds (or seed treatments) include anapplication of the present compound C or the composition A to seeds, andspecific examples thereof include spraying treatment in which asuspension of the present compound C or the composition A is sprayedonto seed surface in the form of mist; smearing treatment in which thepresent compound C or the composition A is coated a surface of seeds; asoaking treatment in which the seeds are soaked into the solution of thepresent compound C or the composition A for a certain time; and a methodfor coating the seeds with a carrier containing the present compound Cor the composition A (film coating treatment, pellet coating treatment).

When the composition A is applied to seeds, the composition A may bealso applied to seeds as a single formulation, or the composition A maybe applied to seeds as a divided plural of formulations by a pluralityof times. Examples of the method in which the composition A is appliedas a divided plural of formulations by a plurality of times include, forexmaple, a method in which the formulations comprising as an activecomponent the present compound C only are applied, and seeds are airdried, followed by applying the formulations comprising the presentingredient: and a method in which the formulations comprising as anactive component the present compound C and the present ingredients areapplied, and seeds are air dried, followed by applying the formulationscomprising the present ingredients other than the already-appliedpresent ingredients, are included.

The above-mentioned soybean may be a plant which can be produced bynatural mating, a soybean which can be generated by mutation, a F1hybrid soybean, and a transgenic soybean (also referred to asgenetically modified soybean). In general, these soybeans havecharacteristics that are tolerance to herbicides, accumulation of toxicsubstances against pests (which is also referred to as pest resistance),suppression of sensitivity to diseases (which is also referred to asdisease resistance), increase of yield potential, improvement oftolerance to biological and abiotic stress factors, modification ofquality of products (for example, increase or decrease of the content ofingredient(s), change of composition, or improvement of storability andprocessability), and the like. Techniques for producing theabove-mentioned soybeans include, for example, traditional breedimprovement techniques; genetic recombination technologies; genomebreeding technologies; new breeding techniques; and genome editingtechniques.

Examples of the soybeans which are imparted with herbicide toleranceinclude auxin type herbicidal compounds such as 2,4-D, dicamba; soybeanshaving tolerance to glufosinate, soybeans having tolerance toglyphosate, soybeans having tolerance to isoxaflutole, soybeans havingtolerance to 4-hydroxyphenylpyruvate dioxygenase inhibitory herbicides(such mesotrione); soybeans having tolerance to imidazolinone typeherbicides; acetolactate synthase (ALS) inhibitory herbicides (such assulfonylurea herbicide inhibitors); and soybeans having tolerance toprotoporphyrinogen oxidase inhibitory herbicides (such as flumioxazin),and the others.

The soybeans which are imparted with herbicide tolerance by geneticrecombination technologies can be produced by introducing foreign genes(such as genes derived from other organisms such as microorganisms). Forexample, a tolerance to 2,4-D is introduced by “aad-12” which is a genederived from Delftia acidovorans; a tolerance to Dicamba is introducedby “dmo” which is a gene derived from Stenotrophomonas maltophiliastrain DI-6; a tolerance to glufosinate is introduced by “bar” which isa gene derived from Streptomyces hygroscopicus or “pat” which is a genederived from Streptomyes viridochromogenes; a tolerance to glyphosate isintroduced by “2mepsps” which is a gene derived from Zea mays, “CP4epsps” which is a gene derived from Agrobacterium tumefaciens strainCP4, or “gat4601” which is a gene derived from Bacillus licheniformis; atolerance to isoxaflutole is introduced by “hppdPF W336” which is a genederived from Pseudomonas fluorescens strain A32; a tolerance tomesotrione is introduced by “avhppd-03” which is a gene derived from Oat(Avena sativa); a tolerance to imidazolinone herbicides is introduced by“csr1-2” which is a gene derived from Arabidopsis thaliana; a toleranceto sulfonylurea herbicides is introduced by “gm-hra” which is a genederived from Glycine max.

Examples of soybeans which are imparted with herbicides by traditionalbreed improvement techniques or genome breeding technologies includesoybean having tolerance to sulfonylurea ALS inhibitory herbicides (suchas thifensulfuron methyl) (“STS (registered trademark) soybean”).

Examples of soybeans which are imparted with herbicides by a newbreeding technique include the plants in which glyphosate tolerance isimparted to nontransgenic soybean by using Roundup Ready (Registeredtrademark) having glyphosate tolerance as a rootstock (see, WeedTechnology 27: 412-416 2013).

Examples of soybeans which are imparted with pest tolerance includesoybean having tolerance to Lepidoptera pests (such as Pseuoplusiaincludes, Helicoverpa zea, Spodoptera frugiperda), soybean havingtolerance to Hemiptera (such as Aphis glycines), and soybean havingtolerance to Nematode (such as Heterodera glycines, Meloidogyneincognita).

The soybeans which are imparted with pest tolerance by geneticrecombination technologies can be produced by introducing foreign genes(such as genes encoding 5-endotoxin which is insecticidal proteinderived from Bacillus thuringiensis For example, a tolerance toLepidoptera pests is introduced by “cry1Ac” which is a gene derived fromBacillus thuringiensis subsp. Kurstaki strain HD73, “cry1F” which is agene derived from Bacillus thuringiensis var. aizawai, “cry1A.105” whichis a gene derived from Bacillus thuringiensis subsp. kumamotoensis, or“cry2Ab2” which is a gene derived from Bacillus thuringiensis subsp.kumamotoensis.

Examples of soybeans which are imparted with pest tolerance bytraditional breed improvement techniques or genome breeding technologiesinclude soybean having as a resistance gene against aphid a resistancegene Rag1 (Tolerance Aphid Gene 1) or a gene Rag1 (Tolerance AphidGene 1) and also showing resistance to aphids (see J. Econ. Entomol.,2015, 108, 326.); soybean showing resistance to Heterodera glycines (seePhytopathology, 2016, 106, 1444.); and soybean showing resistance toSpodoptera litura (that is, “Fukuminori”).

Examples of soybeans which are imparted with disease resistance includesoybean which is imparted with a resistance to soybean rust disease bytraditional breed improvement techniques or genetic recombinationtechnologies. Examples of commonly used resistance genes include, notlimited thereto, Rpp1, Rpp2, Rpp3, Rpp4, Rpp5, and Rpp6. These genes maybe introduced alone into a soybean, or may be introduced in anycombinations of a plural of these genes into soybean. These genes aredescribed in the following scientific documents: Crop Science, 2007, 47,837.; Theoretical and Applied Genetics, 2008, 117, 57.; Theoretical andApplied Genetics, 117, 545.; Crop Science, 2009, 49, 783.; Theoreticaland Applied Genetics, 2009, 119, 271.; Theoretical and Applied Genetics,2010, 121, 1023.; Theoretical and Applied Genetics, 2012, 125, 133.

Examples of the soybeans which are imparted with disease resistance bygenome breeding technologies include soybean showing resistance tosoybean stem disease due to Phytophthora sojae by destructing RXLReffector gene (Avr4/6) using CRISPR-Cas9 (see, Mol. Plant. Pathol.,2016, 17, 127.).

Also, soybeans which is imparted with a resistance to soybean diseasesother than soybean rust disease (for example, frogeye leaf spot, brownring spot disease, stem disease, sudden death syndrome) are alsoincluded.

Examples of soybeans in which a quality of product is modified bygenetic recombination technologies include soybean “Plenish (Trademark)”or “Treus (Trademark)” in which partial gene of 6)-6 desaturase(gm-fad2-1) derived from Glycine max which is the fatty acid desaturaseenzyme, is introduced and an expression of the same genes are thensuppressed, and the oleic acid contents is enriched; soybean “VistiveGold (Trademark)”) in which the contents of saturated fatty acid isreduced by introducing genes that produce double-stranded RNA ofacyl-acyl carrier protein-thioesterase gene (fatb1-A) derived fromGlycine max and genes that produce double-stranded RNA of 5-12desaturase (fad2-1A) derived from Glycine max; genetically modifiedsoybean in which the contents of stearidonic acid as one of W3 fattyacid is enriched by introducing δ-6 desaturase gene (Pj. D6D) derivedfrom Primula juliae and δ-12 desaturase gene (Nc. Fad3) derived fromNeurospora crassa; soybean in which the oil contents is altered; soybeanin which the allergen contents is reduced (see U.S. Pat. No. 6,864,362);spybeans in which the lysine contents are increased (see Bio/Technology,1995, 13, 577.); soybean in which the composition of methionine,leucine, isoleucine, and valine is modified; soybean in which thecontents of a sulfur-containing amino acid is increased (see WO1997/041239 A1); soybean in which the contents of phenolic compound isincreased (see US publication No. 2008/235829); soybean in which thecontents of vitamin E is increased (see WO 2004/058934 A1).

Examples of soybeans in which a quality of product is modified bygenetic recombination technologies include soybean in which the contentsof allergen is reduced (that is, “Yumeminori”).

Examples of the plants in which the traits related to plant growth andyields are altered include soybean in which the plant growth is enhancedby introducing a gene derived from thale cress encoding transcriptionfactor which regulates daily periodicity (“bbx32”), and thereby a highyields are expected.

Examples of soybeans having other characteristics include soybean inwhich an uptake of phosphorus is improved; soybean which is impartedwith fertility traits; soybean which is imparted with tolerance todrought; soybean which is imparted with tolerance to low temperature;soybean which is imparted with tolerance to high salinity; soybean inwhich iron chlorosis is altered; and soybean in which chloridesensitivity is altered.

Examples of the above-mentioned soybeans encompass also soybeans inwhich two or more characteristics selected from the above-mentionedherbicide tolerance, pest resistance, disease resistance, abiotic stresstolerance, traits relating to growth or yield, traits relating tonutrient intake, traits relating to product quality, or fertility traitsare imparted. Examples of these soybeans include soybean having atolerance to glyphosate; soybean having a tolerance to glyphosate;soybean having tolerance to glufosinate; soybean having a resistance tofrogeye leaf spot, Sudden Death Syndrome, southern stem canker,Phytophthora root rot, southern root-knot nematode, Sclerotinia whitemold, brown stem rot, or soybean cyst nematode; soybean in which ironchlorosis is improved; and soybean in which chloride sensitivity isaltered (that is, “Credenz (registered trademark) soybean”).

Hereinafter, the soybeans that is commercially available or has beendeveloped are listed below. Hereafter, they are described as [EventName, Event code, Tread name]. Also, NA represents an information thatis not existed or is unavailable. Many of these soybeans is listed in aregistration database (GM APPROVAL DATABASE) in a website(http://www.isaaa.org/) of INTERNATINAL SERVICE for the ACQUISITION ofAGRI-BIOTECH APPLICATIONS, ISAAA).

[260-05(G94-1, G94-19, G168), DD-026005-3, NA], [A2704-12, ACS-GM005-3,Liberty Link (trademark) soybean], [A2704-21, ACS-GM004-2, Liberty Link(trademark) soybean], [A5547-127, ACS-GM006-4, Liberty Link (trademark)soybean], [A5547-35, ACS-GM008-6, Liberty Link (trademark) soybean],[CV127, BPS-CV127-9, Cultivance], [DAS44406-6, DAS-44406-6, NA],[DAS68416-4, DAS-68416-4, Enlist (trademark) Soybean],[DAS68416-4xMON89788, DAS-68416-4xMON-89788-1, NA], [DAS81419,DAS-81419-2, NA], [DAS81419xDAS44406-6, DAS-81419-2xDAS-44406-6, NA],[DP305423, DP-305423-1, Treus (trademark) or Plenish (trademark)],[DP305423xGTS40-3-2, DP-305423-1xMON-04032-6, NA], [DP356043,DP-356043-5, Optimum GAT (trademark)], [FG72(FG072-2,FG072-3),MST-FG072-3, NA], [FG72xA5547-127, MST-FG072-3xACS-GM006-4, NA],[GTS40-3-2(40-3-2), MON-04032-6, Roundup Ready (trademark) soybean],[GU262, ACS-GM003-1, Liberty Link (trademark) soybean], [IND-00410-5,IND-00410-5, Verdeca HB4 Soybean], [MON87701, MON-87701-2, NA],[MON87701xMON89788, MON-87701-2xMON-89788-1, Intacta (trademark) RoundupReady (trademark) 2 Pro], [MON87705, MON-87705-6, Vistive Gold(trademark)], [MON87705xMON87708, MON-87705-6xMON-87708-9, NA],[MON87705xMON87708xMON89788, MON-87705-6xMON-87708-9xMON-89788-1, NA],[MON87705xMON89788, MON-87705-6xMON-89788-1, NA], [MON87708,MON-87708-9, Genuity (registered trademark) Roundup Ready (trademark) 2Xtend (trademark)], [MON87708xMON89788, MON-87708-9xMON-89788-1, RoundupReady 2 Xtend (registered trademark)], [MON87712, MON-87712-4, NA],[MON87751, MON-87751-7, NA], [MON87751xMON87701xMON87708xMON89788,MON-87751-7xMON-87701-2xMON87708xMON89788, NA], [MON87769, MON87769-7,NA], [, MON87769xMON89788, MON-87769-7xMON-89788-1, NA], [MON89788,MON-89788-1, Genuity (registered trademark) Roundup Ready 2 Yield(trademark)], [SYHT0H2, SYN-000H2-5, Herbicide-tolerant Soybean line],[W62, ACS-GM002-9, Liberty Link (trademark) soybean], [W98, ACS-GM001-8,Liberty Link (trademark) soybean], [OT96-15, OT96-15, NA], [NA, NA, STS(registered trademark) soybean], [NA, NA, Credenz (registered trademark)soybean], [NA, NA, Enlist E3 (trademark)], [NA, NA, Enlist (trademark)Roundup Ready 2 Yield (registered trademark)], [NA, NA, Fukuminori],[NA, NA, Yumeminori], [DP305423 x MOV87708, DP-305423-1 x MON-87708-9,NA], [DP305423 x MOV87708 x MON89788, DP-305423-1 x MON-87708-9 xMON-89788-1, NA], [DP305423 x MON89788, DP-305423-1 x MON-89788-1, NA]

An application of the present compound, the present compound C, thepresent compound D, or the composition A can provide an effect of apromotion of the growth of a plant, such as an increase in the rate ofseedling establishment, an increase in the number of healthy leaves, anincrease in the height of the plant, an increase in the weight of theplant body, an increase in the leaf area, an increase in the number orweight of seeds, an increase in the number of occasion of flower settingor fruit setting, and a promoted growth of a root and the like. Also, anapplication of the present compound, the compound of the presentinvention, or the composition A can provide an increase of a resistanceagainst an abiotic stress such as a temperature stress (for example,high-temperature stress or low-temperature stress), water stress (forexample, drought stress or excess water stress), and a salt stress.

The present invention provides a composition having an excellentefficacy for controlling a plant disease, and a method for controllingplant diseases.

The present inventors have intensively studied to find out a compositionhaving an excellent efficacy for controlling a plant disease, and amethod for controlling a plant disease using the same composition, andas a result, found that a composition comprising the compoundrepresented by formula (IV) according to the above [15] and one or morecompounds selected from Group (B) (hereinafter, referred to as“Composition of the present invention”) has an excellent efficacy forcontrolling plant diseases.

The composition for controlling plant diseases of the present invention(that is, the composition of the present invention) comprises the abovecompound represented by formula (IV) (that is, the present compound A)and one or more compounds selected from Group (B) (that is, the presentcompound B).

The composition for controlling plant diseases of the present invention(that is, the composition of the present invention) can control plantdiseases.

Examples of the embodiments of the present composition A include thefollowing compounds.

[Embodiment A1] The present compound A wherein E⁴ represents a phenylgroup, or a 2-methyl phenyl group.

[Embodiment A2] The present compound A wherein E⁴ represents a phenylgroup, a 3-fluorophenyl group, a 3-methylphenyl group, a 3-methoxyphenylgroup, a 3-(trifluoromethoxy)phenyl group, or a 3-phenoxyphenyl group.

[Embodiment A3] The present compound A wherein E⁴ represents a phenylgroup, or a 4-methylphenyl group.

[Embodiment A4] The compound according to [Embodiment A1] to [EmbodimentA3] or the present compound A wherein A⁴ represents a nitrogen atom, andL⁴ represents NH.

[Embodiment A5] The compound according to [Embodiment A1] to [EmbodimentA3] or the present compound A wherein A⁴ represents CH, and L⁴represents an oxygen atom.

[Embodiment A6] The present compound A wherein E⁴ represents a2-thiazolyl group, or a 4-(trifluoromethyl)thizol-2-yl group.

[Embodiment A7] The present compound A wherein E⁴ represents a2-thiazolyl group, a 5-chlorothiazol-2-yl group, a 5-bromothiazol-2-ylgroup, a 5-(trifluoromethyl)thiazol-2-yl group, a5-cyclopropylthiazol-2-yl group, a 5-ethynylthiazol-2-yl group, or a(5-cyclopropylethynyl)thiazol-2-yl group.

[Embodiment A8] The present compound A wherein E⁴ represents a 3-thienylgroup.

[Embodiment A9] The compound according to [Embodiment A6] to [EmbodimentA8] wherein A⁴ represents a nitrogen atom and L⁴ represents NH.

[Embodiment A10] The compound according to [Embodiment A6] to[Embodiment A8] wherein A⁴ represents CH and L⁴ represents an oxygenatom.

[Embodiment A11] The present compound A wherein A⁴ represents CH, L⁴represents an oxygen atom, and E⁴ represents a phenyl group, a 2-methylphenyl group, a 3-methylphenyl group, a 4-methylphenyl group, a3-fluorophenyl group, a 3-methoxyphenyl group, a3-(trifluoromethoxy)phenyl group, a 3-phenoxyphenyl group, a 3-thienylgroup, a 2-thiazolyl group, a 4-(trifluoromethyl)thizol-2-yl group, a5-chlorothiazol-2-yl group, a 5-bromothiazol-2-yl group, a5-(trifluoromethyl)thiazol-2-yl group, a 5-cyclopropylthiazol-2-ylgroup, a 5-ethynylthiazol-2-yl group, or a(5-cyclopropylethynyl)thiazol-2-yl group, or A⁴ represents a nitrogenatom, L⁴ represents NH, and E⁴ represents a 2-methyl phenyl group, or a3-fluorophenyl group.

[Embodiment A12] The present compound A wherein A⁴ represents CH, L⁴represents an oxygen atom, and E⁴ represents a phenyl group, a 2-methylphenyl group, a 3-methylphenyl group, a 4-methylphenyl group, a3-fluorophenyl group, a 3-methoxyphenyl group, a3-(trifluoromethoxy)phenyl group, or a 3-phenoxyphenyl group, or

-   -   A⁴ represents a nitrogen atom, L⁴ represents NH, and E⁴        represents a 2-methyl phenyl group, or a 3-fluorophenyl group.

[Embodiment A13] The present compound A wherein A⁴ represents CH, L⁴represents an oxygen atom, and E⁴ represents a 3-thienyl group, a2-thiazolyl group, a 4-(trifluoromethyl)thizol-2-yl group, a5-chlorothiazol-2-yl group, a 5-bromothiazol-2-yl group, a5-(trifluoromethyl)thiazol-2-yl group, a 5-cyclopropylthiazol-2-ylgroup, a 5-ethynylthiazol-2-yl group, or a(5-cyclopropylethynyl)thiazol-2-yl group.

Examples of the embodiments of the composition of the present inventioninclude the following compositions.

[Embodiment Z1] A composition wherein a weight ratio of the abovecompound represented by formula (IV) according to [16] and one or moreof compounds selected from sub-group (B-1) is within a range of 1:0.01to 1:100.

[Embodiment Z2] A composition wherein a weight ratio of the abovecompound represented by formula (IV) according to [17] and one or moreof compounds selected from sub-group (B-1) is within a range of 1:0.01to 1:100.

[Embodiment Z3] A composition wherein a weight ratio of the abovecompound represented by formula (IV) according to [16] and one or moreof compounds selected from sub-group (B-2) is within a range of 1:0.01to 1:100.

[Embodiment Z4] A composition wherein a weight ratio of the abovecompound represented by formula (IV) according to [17] and one or moreof compounds selected from sub-group (B-2) is within a range of 1:0.1 to1:10.

[Embodiment Z5] A composition wherein a weight ratio of the abovecompound represented by formula (IV) according to [16] and one or moreof compounds selected from sub-group (B-3) is within a range of 1:0.1 to1:10.

[Embodiment Z6] A composition wherein a weight ratio of the abovecompound represented by formula (IV) according to [17] and one or moreof compounds selected from sub-group (B-3) is within a range of 1:0.1 to1:10

[Embodiment Z7] The composition for controlling plant diseases accordingto the above [15] wherein in the Group (B), the sub-group (B-1) is agroup consisting of pyraclostrobin, picoxystrobin, metyltetraprole,fenpicoxamid, and florylpicoxamid, and the sub-group (B-2) is a groupconsisting of fluxapyroxad, benzovindiflupyr, fluindapyr,pydiflumetofen,3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide,the above compound represented by formula (1), the above compoundrepresented by formula (2), and the above compound represented byformula (3), the sub-group (B-3) is a group consisting ofprothioconazolea and mefentrifluconazole, the sub-group (B-4) is a groupconsisting of 3-(2-methylphenyl)butan-2-ylN-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate,3-(4-fluoro-2-methylphenyl)butan-2-ylN-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate,3-(4-methoxy-2-methylphenyl)butan-2-ylN-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate,3-(2,4-dimethylphenyl)butan-2-ylN-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate,3-(2-methylphenyl)butan-2-ylN-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate,3-(4-fluoro-2-methylphenyl)butan-2-ylN-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate,3-(4-methoxy-2-methylphenyl)butan-2-ylN-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate,3-(2,4-dimethylphenyl)butan-2-ylN-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate,3-(2-methylphenyl)butan-2-ylN-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate,3-(4-fluoro-2-methylphenyl)butan-2-ylN-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate,3-(4-methoxy-2-methylphenyl)butan-2-ylN-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate, and3-(2,4-dimethylphenyl)butan-2-ylN-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate.

[Embodiment Z8] A composition wherein a weight ratio of the abovecompound represented by formula (IV) according to [15] and one or moreof compounds selected from sub-group (B-1) is within a range of 1:0.1 to1:10.

[Embodiment Z9] A composition wherein a weight ratio of the abovecompound represented by formula (TV) according to [15] and one or moreof compounds selected from sub-group (B-2) is within a range of 1:0.1 to1:10.

[Embodiment Z10] A composition wherein a weight ratio of the abovecompound represented by formula (TV) according to [15] and one or moreof compounds selected from sub-group (B-3) is within a range of 1:0.1 to1:10.

[Embodiment Z11] A composition wherein a weight ratio of the abovecompound represented by formula (TV) according to [15] and one or moreof compounds selected from sub-group (B-4) is within a range of 1:0.1 to1:10.

[Embodiment Z12] A composition wherein a weight ratio of the abovecompound represented by formula (TV) according to [Embodiment Z7] andone or more of compounds selected from sub-group (B-1) is within a rangeof 1:0.1 to 1:10.

[Embodiment Z13] A composition wherein a weight ratio of the abovecompound represented by formula (TV) according to [Embodiment Z7] andone or more of compounds selected from sub-group (B-2) is within a rangeof 1:0.1 to 1:10.

[Embodiment Z14] A composition wherein a weight ratio of the abovecompound represented by formula (TV) according to [Embodiment Z7] andone or more of compounds selected from sub-group (B-3) is within a rangeof 1:0.1 to 1:10.

[Embodiment Z15] A composition wherein a weight ratio of the abovecompound represented by formula (IV) according to [Embodiment Z7] andone or more of compounds selected from sub-group (B-4) is within a rangeof 1:0.1 to 1:10.

The present compound B is explained.

Examples of the present compound B include one or more of the compoundsselected from the following sub-group (B-1), sub-group (B-2), sub-group(B-3), and sub-group (B-4).

Sub-group (B-1): mitochondrial electron transport chain complex IIIinhibitor is a group consisting of coumoxystrobin, enoxastrobin,flufenoxystrobin, picoxystrobin, pyraoxystrobin, pyraclostrobin,mandestrobin, pyrametostrobin, triclopyricarb, trifloxystrobin,dimoxystrobinn, fenaminstrobin, metominostrobin, orysastrobin,fluoxastrobin, fenamidone, pyribencarb, metyltetraprole., cyazofamid,amisulbrom, fenpicoxamid, and florylpicoxamid.

Sub-group (B-2): mitochondrial electron transport chain complex IIinhibitor is a group consisting of bixafen, fluxapyroxad,benzovindiflupyr, fluindapyr, pydiflumetofen,3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide,a compound represented by formula (1) below, a compound represented byformula (2) below, and a compound represented by formula (3) below.

Sub-group (B-3): sterol biosynthesis inhibitor is a group consisting ofprothioconazolea and mefentrifluconazole.

Sub-group (B-4): A group consisting of 3-(2-methylphenyl)butan-2-ylN-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate,3-(4-fluoro-2-methylphenyl)butan-2-ylN-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate,3-(4-methoxy-2-methylphenyl)butan-2-ylN-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate,3-(2,4-dimethylphenyl)butan-2-ylN-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate,3-(2-methylphenyl)butan-2-ylN-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate,3-(4-fluoro-2-methylphenyl)butan-2-ylN-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate,3-(4-methoxy-2-methylphenyl)butan-2-ylN-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate,3-(2,4-dimethylphenyl)butan-2-ylN-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate,3-(2-methylphenyl)butan-2-ylN-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate,3-(4-fluoro-2-methylphenyl)butan-2-ylN-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate,3-(4-methoxy-2-methylphenyl)butan-2-ylN-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate, and3-(2,4-dimethylphenyl)butan-2-ylN-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate.

Coumoxystrobin, enoxastrobin, flufenoxystrobin, picoxystrobin,pyraoxystrobin, pyraclostrobin, mandestrobin, pyrametostrobin,triclopyricarb, trifloxystrobin, dimoxystrobinn, fenaminstrobin,metominostrobin, orysastrobin, fluoxastrobin, fenamidone, pyribencarb,metyltetraprole., cyazofamid, amisulbrom, fenpicoxamid, florylpicoxamid,bixafen, fluxapyroxad, benzovindiflupyr, fluindapyr, pydiflumetofen,3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide,prothioconazolea and mefentrifluconazole to be used in the presentinvention are all known compounds, and are described in, for exmaple,pages 247, 408, 514, 904, 979, 974, 709, 978, 1175, 1180, 376, 444, 779,832, 530, 442, 993, 789, 256, 45, 466, 498, 126, 558, 97, 515, 969, 652,966, 728 of “The Pesticide Manual-18th Edition (BCPC published) ISBN978-9998966-1-4”. These compounds can be obtained from commerciallyavailable formulations, or can be prepared by known methods.

The compound represented by formula (1), the compound represented byformula (2), and the compound represented by formula (3) are all knowncompounds, and described in, for example, WO 2014/095675 A1, and can beprepared by the method described in the publication.

3-(2-Methylphenyl)butan-2-ylN-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate,3-(4-fluoro-2-methylphenyl)butan-2-ylN-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate,3-(4-methoxy-2-methylphenyl)butan-2-ylN-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate,3-(2,4-dimethylphenyl)butan-2-ylN-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate,3-(2-methylphenyl)butan-2-ylN-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate,3-(4-fluoro-2-methylphenyl)butan-2-ylN-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate,3-(4-methoxy-2-methylphenyl)butan-2-ylN-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate,3-(2,4-dimethylphenyl)butan-2-ylN-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate,3-(2-methylphenyl)butan-2-ylN-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate,3-(4-fluoro-2-methylphenyl)butan-2-ylN-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate,3-(4-methoxy-2-methylphenyl)butan-2-ylN-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate, and3-(2,4-dimethylphenyl)butan-2-ylN-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate are all knowncompounds, and described in, for example, WO 2019/173665 A1, and can beprepared by the method described in the publication.

In the composition of the present invention, a weight ratio of thepresent compound A and the present compound B is usually within a rangeof 1:0.01 to 1:100, preferably 1:0.1 to 1:10.

Though the composition for controlling plant diseases of the presentinvention may be mere mixtures of the present compound A and the presentcompound B, the composition of the present invention is usually mixedwith the present compound A, and the present compound B, with solidcarrier(s), liquid carrier(s), oils and/or surfactant(s), and theothers, and if necessary, added by the other auxiliary agents forformulation, to formulate into emulsifiable concentrates, oil solutions,dust formulations, granules, wettable powders, wettable dispersiblegranules, flowables, dry flowables, microcapsules and the others. Inthese formulations, the total amount of the present compound A and thepresent compound B is within a range of usually 0.1 to 100% by weight,preferably 0.2 to 90% by weight, and more preferably 1 to 80% by weight.

Examples of the solid carrier include fine powders or granules of clays(for example, kaolin clay, diatomaceous earth, bentonite, or acid whiteclay), dry silica, wet silica, hydrated silica, talcs, ceramics, otherinorganic minerals (for example, sericite, quartz, sulfur, activecarbon, or calcium carbonate); chemical fertilizers (for example,ammonium sulfate, ammonium phosphate, ammonium nitrate, urea, orammonium chloride); as well as synthetic resins (for example, polyesterresins such as polypropylene, polyacrylonitrile, polymethyl methacrylateor polyethylene terephthalate; nylon resins (for example, nylon-6,nylon-11, or nylon-66); polyamide resins; polyvinyl chloride,polyvinylidene chloride, vinyl chloride-propylene copolymers, and theothers).

Examples of the above-mentioned liquid carriers include water; alcohols(for example, methanol, ethanol, isopropyl alcohol, butanol, hexanol,benzyl alcohol, ethylene glycol, propylene glycol or phenoxy ethanol);ketones (for Example, acetone, methyl ethyl ketone or cyclohexanone);aromatic hydrocarbons (for example, toluene, xylene, ethyl benzene,dodecyl benzene, phenyl xylyl ethane or methylnaphthalene); aliphatichydrocarbons (for example, hexane, cyclohexane, kerosene or light oil);esters (for example, ethyl acetate, butyl acetate, isopropyl myristate,ethyl oleate, diisopropyl adipate, diisobutyl adipate or propyleneglycol monomethyl ether acetate); nitriles (for Example, acetonitrile orisobutyronitrile); ethers (for example, diisopropyl ether, 1,4-dioxane,ethylene glycol dimethyl ether, diethyleneglycol dimethyl ether,diethylene glycol monomethyl ether, propylene glycol monomethyl ether,dipropylene glycol monomethyl ether or 3-methoxy-3-methyl-1-butanol);acid amides (for example, dimethylformamide or dimethylacetamide);halogenated hydrocarbons (for example, dichloromethane, trichloroethaneor carbon tetrachloride); sulfoxides (for example, dimethyl sulfoxide);propylene carbonate; and vegetable oils (for example, soybean oil orcottonseed oil).

Examples of the surfactants include nonionic surfactants such aspolyoxyethylenated alkyl ethers, polyoxyethylenated alkyl aryl ethers,and polyethylene glycol fatty acid esters; and anionic surfactants suchas alkyl sulfonates, alkylbenzene sulfonates and alkyl sulfates.Specific examples thereof include Nimbus (registered trademark), Assist(registered trademark), Aureo (registered trademark), Iharol (registeredtrademark), Silwet L-77 (registered trademark), BreakThru (registeredtrademark), SundanceII (registered trademark), Induce (registeredtrademark), Penetrator (registered trademark), AgriDex (registeredtrademark), Lutensol A8 (registered trademark), NP-7 (registeredtrademark), Triton (registered trademark), Nufilm (registeredtrademark), Emulgator NP7 (registered trademark), Emulad (registeredtrademark), TRITON X 45 (registered trademark), AGRAL 90 (registeredtrademark), AGROTIN (registered trademark), ARPON (registeredtrademark), EnSpray N (registered trademark), and BANOLE (registeredtrademark), and the others.

Examples of the other auxiliary agents for formulation include a binder,a dispersant, a colorant, and a stabilizer. Specific examples thereofinclude casein, gelatin, polysaccharides (for example, starch, gumarabic, cellulose derivatives and alginic acid), lignin derivatives,bentonite, water-soluble synthetic polymers (for example, polyvinylalcohol, polyvinyl pyrrolidone and polyacrylic acids), acidic isopropylphosphate, 2,6-di-tert-butyl-4-methylphenol, and a mixture of2-tert-butyl-4-methoxyphenol and 3-tert-butyl-4-methoxyphenol.

The composition of the present invention may be also prepared byformulating the present compound A and the present compound Brespectively by each of the above-mentioned methods, and as needed bydiluting the resulting formulations with water, and then mixing therespective formulation or the respective dilution thereof.

The composition of the present invention may further contain one or morekinds of other fungicide and/or pesticide.

The composition of the present invention can control plant diseaseswhich are caused by phytopathogenic microorganism such as fungi,Oomycete, Phytomyxea, and bacteria and the others. Examples of the fungiinclude Ascomycota, Basidiomycota, Blasocladiomycota, Chytridiomycota,Mucoromycota, and Olpidiomycota. Specific examples thereof include thefollowings. The descriptions in a parenthesis indicates an academic nameof phytopathogenic microorganism that causes each of the disease.

Rice Diseases:

-   -   blast (Pyricularia oryzae), brown spot (Cochliobolus        miyabeanus), sheath blight (Rhizoctonia solani), bakanae disease        (Gibberella fujikuroi), downy mildew (Sclerophthora macrospora),        false blast and head blight (Epicoccum nigrum), and seedling        blight (Trichoderma viride, Rhizopus oryzae);

Wheat Diseases:

-   -   powdery mildew (Blumeria graminis), fusarium blight (Fusarium        graminearum, Fusarium avenaceum, Fusarium culmorum, Microdochium        nivale), stripe rust (Puccinia striiformis), stem rust (Puccinia        graminis), leaf rust (Puccinia recondita), snow mould        (Microdochium nivale, Microdochium majus), typhula snow blight        (Typhula incarnata, Typhula ishikariensis), loose smut (Ustilago        tritici), stinking smut (Tilletia caries, Tilletia controversa),    -   eyespot (Pseudocercosporella herpotrichoides), leaf blotch        (Septoria tritici), glume blotch (Stagonospora nodorum), tan        spot (Pyrenophora tritici-repentis), rhizoctonia seeding blight        (Rhizoctonia solani), take-all disease (Gaeumannomyces        graminis), and blast (Pyricularia graminis-tritici);

Barley Diseases:

-   -   powdery mildew (Blumeria graminis), fusarium head blight        (Fusarium graminearum, Fusarium avenaceum, Fusarium culmorum,        Microdochium nivale), stripe rust (Puccinia striiformis), stem        rust (Puccinia graminis), dwarf leaf rust (Puccinia hordei),        loose smut (Ustilago nuda), scald (Rhynchosporium secalis), net        blotch (Pyrenophora teres), spot blotch (Cochliobolus sativus),        stripe (Pyrenophora graminea), Ramularia disease (Ramularia        collo-cygni), and    -   rhizoctonia seeding blight (Rhizoctonia solani);

Corn Diseases:

-   -   rust (Puccinia sorghi), southern rust (Puccinia polysora),        northern leaf blight (Setosphaeria turcica), tropical rust        (Physopella zeae), southern leaf blight (Cochliobolus        heterostrophus), anthracnose (Colletotrichum graminicola), gray        leaf spot (Cercospora zeae-maydis), eyespot (Kabatiella zeae),        phaeosphaeria leaf spot (Phaeosphaeria maydis), diplodia rot        (Stenocarpella maydis, Stenocarpella macrospora),    -   stalk rot (Fusarium graminearum, Fusarium verticilioides,        Colletotrichum graminicola),    -   smut (Ustilago maydis), and Physoderma brown spot and Physoderma        stalk rot (Physoderma maydis);

Cotton Diseases:

-   -   anthracnose (Colletotrichum gossypii), grey mildew (Ramularia        areola), alternaria leaf spot (Alternaria macrospora, Alternaria        gossypii), and black root rot (Thielaviopsis basicola);

Coffee Diseases:

-   -   rust (Hemileia vastatrix), and leaf spot (Cercospora        coffeicola);

Rape Seed Diseases:

-   -   sclerotinia rot (Sclerotinia sclerotiorum), gray leaf spot        (Alternaria brassicae), root rot (Phoma lingam), and light leaf        spot (Pyrenopeziza brassicae);

Sugar Cane Diseases:

-   -   rust (Puccinia melanocephela, Puccinia kuehnii), and smut        (Ustilago scitaminea);

Sunflower Diseases:

-   -   rust (Puccinia helianthi), and downy mildew (Plasmopara        halstedii);

Citrus Diseases:

-   -   melanose (Diaporthe citri), scab (Elsinoe fawcetti), green mold        (Penicillium digitatum), blue mold (Penicillium italicum),        Phytophthora rot (Phytophthora parasitica, Phytophthora        citrophthora), and aspergillus rot (Aspergillus niger);

Apple Diseases:

-   -   blossom blight (Monilinia mali), valsa canker (Valsa        ceratosperma), powdery mildew (Podosphaera leucotricha),        alternaria leaf spot (Alternaria alternata apple pathotype),        scab (Venturia inaequalis), bitter rot (Glomerella cingulata,        Colletotrichum acutatum),    -   blotch (Diplocarpon mali), ring rot (Botryosphaeria        berengeriana), crown rot (Phytophtora cactorum), and rust        (Gymnosporangium juniperi-virginianae, Gymnosporangium yamadae);

Pear Diseases:

-   -   scab (Venturia nashicola, Venturia pirina), black spot        (Alternaria alternata Japanese pear pathotype), and rust        (Gymnosporangium haraeanum);

Peach Diseases:

-   -   brown rot (Monilinia fructicola), scab (Cladosporium        carpophilum), Phomopsis rot (Phomopsis sp.), and leaf curl        (Taphrina deformans);

Grapes Diseases:

-   -   anthracnose (Elsinoe ampelina), ripe rot (Glomerella cingulata,        Colletotrichum acutatum), powdery mildew (Uncinula necator),        rust (Phakopsora ampelopsidis), black rot (Guignardia        bidwellii), and downy mildew (Plasmopara viticola);

Japanese Persimmon Diseases:

-   -   anthracnose (Gloeosporium kaki, Colletotrichum acutatum), and        leaf spot (Cercospora kaki, Mycosphaerella nawae);

Fig Diseases:

-   -   rust (Phakopsora nishidana));

Diseases of Gourd Family:

-   -   anthracnose (Colletotrichum lagenarium), powdery mildew        (Sphaerotheca fuliginea), gummy stem blight (Didymella        bryoniae), Corynespora leaf spot (Corynespora cassiicola),        fusarium wilt (Fusarium oxysporum), downy mildew        (Pseudoperonospora cubensis), phytophthora rot (Phytophthora        capsici), and damping-off (Pythium sp.);

Tomato Diseases:

-   -   early blight (Alternaria solani), leaf mold (Cladosporium        fulvum), Cercospora leaf mold (Pseudocercospora fuligena), late        blight (Phytophthora infestans), and powdery mildew (Leveillula        taurica);

Eggplant Diseases:

-   -   brown spot (Phomopsis vexans), and powdery mildew (Erysiphe        cichoracearum);

Cruciferous Vegetables Diseases:

-   -   alternaria leaf spot (Alternaria japonica), white spot        (Cercosporella brassicae), clubroot (Plasmodiophora brassicae),        downy mildew (Peronospora parasitica), and white rust (Albugo        candida);

Welsh Onion Disease:

-   -   rust (Puccinia allii);

Soybean Diseases:

-   -   purple stain (Cercospora kikuchii), sphaceloma scab (Elsinoe        glycines), pod and stem blight (Diaporthe phaseolorum var.        sojae), rust (Phakopsora pachyrhizi), target spot (Corynespora        cassiicola), anthracnose (Colletotrichum glycines,        Colletotrichum truncatum), Rhizoctonia rot (Rhizoctonia solani),        septoria brown spot (Septoria glycines), Cercospora leaf spot        (Cercospora sojina), stem rot (Sclerotinia sclerotiorum),        powdery mildew (Microsphaera diffusa), phytophthora stem and        root rot (Phytophthora sojae), downy mildew (Peronospora        manshurica), sudden death syndrome (Fusarium virguliforme), red        crown rot (Calonectria ilicicola), and Diaporthe/Phomopsis        complex (Diaporthe longicolla);

Kidney Bean Diseases:

-   -   stem rot (Sclerotinia sclerotiorum), rust (Uromyces        appendiculatus), angular leaf spot (Phaeoisariopsis griseola),        and anthracnose (Colletotrichum lindemuthianum), and Fusarium        root-rot (Fusarium solani);

Peanut Diseases:

-   -   leaf spot (Cercospora personata), brown leaf spot (Cercospora        arachidicola), southern blight (Sclerotium rolfsii), and        Cylindrocladium black rot (Calonectria ilicicola);

Garden Pea Disease:

-   -   powdery mildew (Erysiphe pisi), and root rot (Fusarium solani);

Potato Diseases:

-   -   early blight (Alternaria solani), late blight (Phytophthora        infestans), Pink rot (Phytophthora erythroseptica), powdery scab        (Spongospora subterranea f. sp. subterranea), verticillium wilt        (Verticillium albo-atrum, Verticillium dahliae, Verticillium        nigrescens), dry rot (Fusarium solani), and potato wart        (Synchytrium endobioticum);

Strawberry Disease:

-   -   powdery mildew (Sphaerotheca humuli);

Tea Diseases:

-   -   net blister blight (Exobasidium reticulatum), white scab        (Elsinoe leucospila), gray blight (Pestalotiopsis sp.), and        anthracnose (Colletotrichum theae-sinensis);

Tobacco Diseases:

-   -   brown spot (Alternaria longipes), anthracnose (Colletotrichum        tabacum), blue mold (Peronospora tabacina), and black shank        (Phytophthora nicotianae);

Sugar Beet Diseases:

-   -   cercospora leaf spot (Cercospora beticola), leaf blight        (Thanatephorus cucumeris), root rot (Thanatephorus cucumeris),        and aphanomyces root rot (Aphanomyces cochlioides), and rust        (Uromyces betae);

Rose Diseases:

-   -   black spot (Diplocarpon rosae), and powdery mildew (Sphaerotheca        pannosa);

Chrysanthemum Diseases:

-   -   leaf blight (Septoria chrysanthemi-indici), and white rust        (Puccinia horiana);

Onion Diseases:

-   -   botrytis leaf blight (Botrytis cinerea, Botrytis byssoidea,        Botrytis squamosa), gray-mold neck rot (Botrytis allii), and        small sclerotial neck rot (Botrytis squamosa);

Various Crops Diseases:

-   -   Botrytis rot (Botrytis cinerea), sclerotinia rot (Sclerotinia        sclerotiorum), seedling blight (Pythium aphanidermatum, Pythium        irregulare, Pythium ultimum);

Japanese Radish Disease:

-   -   alternaria leaf spot (Alternaria brassicicola);

Turfgrass Diseases:

-   -   dollar spot (Sclerotinia homoeocarpa), brown patch and large        patch (Rhizoctonia solani), and pythium bligt (Pythium        aphanidermatum);

Banana Disease:

-   -   Sigatoka disease (Mycosphaerella fijiensis, Mycosphaerella        musicola);

Lentils Disease:

-   -   ascochyta blight (Ascochyta lentis);

Chickpea Disease:

-   -   ascochyta blight (Ascochyta rabiei);

Green Pepper Disease:

-   -   anthracnose (Colletotrichum scovillei);

Mango Disease:

-   -   anthracnose (Colletotrichum acutatum);

Fruit Trees Diseases:

-   -   white root rot (Rosellinia necatrix), and violet root rot        (Helicobasidium mompa);    -   Postharvest diseases of fruits (for example, apple and pear)        Mucor rot diseases (Mucor piriformis);    -   Seed diseases or diseases in the early stages of the growth of        various plants caused by Aspergillus spp., Penicillium spp.,        Fusarium spp., Gibberella spp., Tricoderma spp., Thielaviopsis        spp., Rhizopus spp., Mucor spp., Corticium spp., Phoma spp.,        Rhizoctonia spp. or Diplodia spp.; and the like;

Viral Diseases:

-   -   Lettuce big-vein disease transmitted by Olpidium brassicae, and        viral diseases of several crops transmitted by Polymixa spp.        (e.g. Polymyxa betae and Polymyxa graminis);

Diseases Caused by Bacteria:

-   -   bacterial seedling blight of rice (Burkholderia plantarii),        bacterial spot of cucumber (Pseudomonas syringae pv.        Lachrymans), bacterial wilt of eggplant (Ralstonia        solanacearum), canker of citrus (Xanthomonas citri), bacterial        soft rot of Chinese cabbage (Erwinia carotovora), scab of potato        (Streptomyces scabiei), Goss's wilt of corn (Clavibacter        michiganensis), Pierce's disease of grapes, olive and peach        (Xylella fastidiosa), and crown gall of Rosacead plants such as        apple, peach, cherries (Agrobacterium tumefaciens).

In the above phytopathogenic microorganisms, variations within thespecies are not particularly limited. Namely, the phytopathogenicmicroorganisms also include any microorganisms that decrease asensitivity (which also referred to as “have a resistance”) to aspecific fungicide. The decrease of the sensitivity may be attributed toa mutation at a target site (target site mutations), or may beattributed to any factors other than target site mutation (non-targetsite mutations). Examples of the target site mutations include thosewherein amino acid substitution is/are caused at a protein as targetsite by a mutation of an open reading frame which corresponds to anamino acid sequence of a protein, and those wherein amino acid as atarget site is overexpressed by any mutations such as a deletion ofsuppressor sequence in promotor region, an amplification of an enhancersequence, and an increase of the copy number of a gene and the others.Examples of the non-target site mutations include an enhancement ofefflux function which exhausts extracellularly a fungicide inflowed in acell by ABC transporter, MFS transporter and the others. Also, adetoxification of a fungicide by a metabolism is included.

Examples of the above-mentioned specific fungicides include nucleic acidsynthesis inhibitors (such as phenylamide fungicides, acylamino acidfungicides, DNA topoisomerase type II fungicides), mitosis and celldivision-inhibitors (such as MBC fungicides, N-phenylcarbamatefungicides), respiratory inhibitors (such as QoI fungicides, QiIfungicides, SDHI fungicides), inhibitors for amino acid synthesis andprotein synthesis (such as anilino pyrimidine fungicides), signaltransduction inhibitors (such as phenylpyrrole fungicides,dicarboxyimide fungicides), inhibitors for lipid synthesis and cellmembrane synthesis (such as phosphorothioate fungicides, dithiolaneinhibitors, aromatic hydrocarbon fungicides, heteroaromatic fungicides,carbamate fungicides), sterol biosynthesis inhibitors (such as DMIfungicides including triazoles, hydroxyanilide fungicides,aminopyrazolinone fungicides), cell wall synthesis inhibitors (such aspolyoxin inhibitors, carboxylic amide fungicides), melanin synthesisinhibitors (such as MBI-R fungicides, MBI-D fungicides, MBI-Pfungicides), as well as the other fungicides (such as cyanoacetoamideoxime fungicides, phenyl acetamide fungicides).

Examples of the amino acid substitution at target site include thefollowings.

-   -   Cytochrome b: G143A, F129L, G137R, I147V, Y279C, Y279S, M295L,        A126T, Y132C, C133Y, G137V, G137A, G137S, M139V, T145F, T145R,        T145S, T145C, T145L, T145Y, T148M, T148V, T148L, T148I, T148T,        N256Y, N256K, N256I, E272D, E272G, E272Q, W273L, W273F, Y274S,        Y274F, L275F, L275S, L275T, L295F or L299F;    -   Cyp51 protein: A311G, A379G, A381G, A410T, A61V, D107V, D134G,        D282E, D411N, E297K, F120L, F219S, F449S, F489L, F495I,        G138C/R/S, G312A, G412A, G432S, G434C, G448S, G460D/L, G462A,        G464S, G484S, G510C, G54E/K/R/V/W, G54W, H147Y, H303Y, H399P,        I145F, I330T, I381V/Δ, I471T, I475T, K142R, K143E, K147Q, K175N,        K197N, L50S, L98H, M145L, M220K/I/T/V, M288L, N125I, N178S,        N22D, N284H, N513K, P216L, P384S, P394L, Q141H, Q88H, R467K,        S188N, S208T, S297T, S405F, S508T, S509T, S524T, S52T, S79T,        T289A, T440A, T454P, T469S, V101F, V136A/C/G, V490L, Y121F,        Y131F/H, Y132F/H/N, Y134F, Y134F, Y136F, Y137F, Y140F/H, Y145F,        Y431C, Y459C/D/N/S/P/A, Y461D/H/S/G/L/N/A, Y463D/H/N, Y491H,        S259F, G476S or Y68N;    -   β-tubulin: H6L/Y, Y50C/N/S, Q134K, A165V, E198A/D/G/K/L/Q/V,        F200Y, M257L, F200Y, F167Y, Q73R, or L240F;    -   SdhB: H277R/Y, P225H/F/L/T, N230I, H272L/R/V/Y, H278Y/R,        H249L/N/Y, H273Y, N225I/T, T268I/A, I269V, H242R, H257L or        T253I;    -   SdhC: H134R, P80H/L, A85V, S73P, T90I, I86F, N88S, H154Y/R,        K49E, R64K, N75S, G79R, S135R, N87S, H153R, H146R, I29V, N33T,        N34T, T79I/N, W80S, A84V, N86K/S/A, G90R, R151T/S, H152R, I161S,        G169D or H151R;    -   SdhD: H133R, H132R, S89P, G109V, D124E/N, H134R, G138V, D145G,        I50F, M114V or D129E;    -   OS-1(Shk1): E753K, G420D, I365N/R/S, V368F, Q369H/P, N373S,        T447S, F267L, L290S, T765R, Q777R, T489I, E599K or G736Y;    -   ERG27: S9G, F26S, P57A, T63I, G170R, V192I, L195F, N196T, A210G,        I232M, P238S/A, P250S, P269L, P298A, V309M, A314V, S336C, V365A,        E368D, N369D, E375K, A378T, L400F/S, Y408S, F412I/S/V/C, A461S        or R496T.

Also, examples of phytopathogenic microorganisms whose sensitivityagainst fungicides are decreased by overexpressing Cyp51 gene, and hostplants therefor include the followings.

Septoria tritici of wheat (Reference literature: Pest ManagementScience. 2012. 68(7). 1034-1040), Rhynchosporium secalis of barley(Reference literature: Molecular Bilogy and Evolution. 2014. 31(7).1793-1802), Phakopsora pachyrhizi of soybean (Reference literature: PestManagement Science. 2014. 70(3). 378-388), Venturia inaequalis of apple(Reference literature: Phytopathology. 2016. 106(6). 562-571),Penicillium digitatum of citrus (Reference literature: Applied andEnvironmental Microbiology. 2000. 66(8). 3421-3426).

The phytopathogenic microorganism which can be controlled by thecomposition of the present invention may be a plural of theabove-mentioned amino acid substitutions. In this case, a plural of theamino acid substitutions may be the identical proteins or the differentproteins. Also they may have the non-target site mutations and thetarget site mutations. For example, phytopathogenic microorganism whichcauses an amino acid substitution of G143A, F129L and G137R oncytochrome b; phytopathogenic microorganism which has an amino acidsubstitution of G143A on cytochrome b and also has an amino acidsubstitution with A311G on Cyp51; phytopathogenic microorganism whichhas an amino acid substitution of G143A and F129L on cytochrome b andalso has an amino acid with A311G on Cyp51; phytopathogenicmicroorganism which has an amino acid substitution of G143A and F129L oncytochrome b and has an amino acid substitution of H6L/Y on β-tubulin,and further is overexpressed by Cyp51 gene.

Examples of phytopathogenic microorganism having a target site mutationinclude the followings.

-   -   Alternaria alternata which has an amino acid substitution of        G143A on cytochrome b;    -   Alternaria arborescens which has an amino acid substitution of        G143A on cytochrome b;    -   Alternaria solani which has an amino acid substitution of F129L        on cytochrome b;    -   Alternaria tomato which has an amino acid substitution of G143A        on cytochrome b;    -   Botryotinia fuckeliana which has an amino acid substitution of        G143A on cytochrome b;    -   Glomerella graminicola which has an amino acid substitution of        G143A on cytochrome b;    -   Corynespora cassiicola which has an amino acid substitution of        G143A on cytochrome b;    -   Cercospora beticola which has an amino acid substitution of        G143A on cytochrome b;    -   Cercospora sojina which has an amino acid substitution of G143A        on cytochrome b;    -   Cladsporium carpophilum which has an amino acid substitution of        G143A on cytochrome b;    -   Colletotrichum graminicola which has an amino acid substitution        of G143A on cytochrome b;    -   Glomerella cingulata which has an amino acid substitution of        G143A on cytochrome b;    -   Blumeria graminis f. sp. hordei which has an amino acid        substitution of G143A on cytochrome b;    -   Blumeria graminis f. sp. tritici which has an amino acid        substitution of G143A on cytochrome b;    -   Parastagonospora nodorum which has an amino acid substitution of        G143A on cytochrome b;    -   Monographella nivalis which has an amino acid substitution of        G143A on cytochrome b;    -   Microdochium majus, nivale which has an amino acid substitution        of G143A on cytochrome b;    -   Mycosphaerella fijiensis which has an amino acid substitution of        G143A on cytochrome b;    -   Didymella rabiei which has an amino acid substitution of G143A        on cytochrome b;    -   Phakopsora pachyrhizi which has an amino acid substitution of        F129L on cytochrome b;    -   Plasmopara viticola which has an amino acid substitution of        F129L or G143A on cytochrome b;    -   Pleospora allii which has an amino acid substitution of G143A on        cytochrome b;    -   Podosphaera fusca which has an amino acid substitution of G143A        on cytochrome b;    -   Podosphaera xanthii which has an amino acid substitution of        G143A on cytochrome b;    -   Podosphaera xanthii which has an amino acid substitution of        G143A on cytochrome b;    -   Pseudoperonospora cubensis which has an amino acid substitution        of G143A on cytochrome b;    -   Magnaporthe oryzae which has an amino acid substitution of F129L        or G143A on cytochrome b;    -   Pyrenophora teres which has an amino acid substitution of F129L        on cytochrome b;    -   Pyrenophora tritici-repentis which has an amino acid        substitution of F129L, G137R or G143A on cytochrome b;    -   Pythium aphanidermatum which has an amino acid substitution of        F129L on cytochrome b;    -   Thanatephorus cucumeris which has an amino acid substitution of        F129L or G143A on cytochrome b;    -   Ramularia collo-cygni which has an amino acid substitution of        G143A on cytochrome b;    -   Rhynchosporium secalis which has an amino acid substitution of        G143A on cytochrome b;    -   Rhizoctonia solani which has an amino acid substitution of F129L        on cytochrome b;    -   Zymoseptoria tritici which has an amino acid substitution of        F129L, G137R or G143A on cytochrome b;    -   Erysiphe necator which has an amino acid substitution of G143A        on cytochrome b;    -   Venturia inaequalis which has an amino acid substitution of        G143A on cytochrome b;    -   Saccharomyces cerevisiae which has an amino acid substitution of        I147V on cytochrome b;    -   Saccharomyces cerevisiae which has an amino acid substitution of        L²⁷⁵F on cytochrome b;    -   Saccharomyces cerevisiae which has an amino acid substitution of        Y279C on cytochrome b;    -   Saccharomyces cerevisiae which has an amino acid substitution of        Y279S on cytochrome b;    -   Saccharomyces cerevisiae which has an amino acid substitution of        M295 on cytochrome b;    -   Puccinia horiana which has an amino acid substitution of L299F        on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of L299F on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of A126T on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of Y132C on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of C133Y on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of G137V on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of G137A on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of G137S on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of M139V on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of T145F on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of T145R on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of T145S on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of T145C on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of T145L on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of T145Y on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of T148M on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of T148V on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of T148L on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of T148I on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of T148T on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of N256Y on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of N256K on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of N256I on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of E272D on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of E272G on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of E272Q on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of W273L on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of W273F on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of Y274S on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of Y274F on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of L275S on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of L275T on cytochrome b;    -   fungi or Oomycota each of which has an amino acid substitution        of L295F on cytochrome b;    -   Ajellomyces capsulatus which has an amino acid substitution of        Y136F on Cyp51;    -   Aspergillus flavus which has an amino acid substitution of        Y132N, K197N, D282E, M288L, T469S, H399P, D411N or T454P on        Cyp51;    -   Aspergillus fumigatus which has an amino acid substitution of        N22D, S52T, G54E/K/R/V/W, Y68N, Q88H, L98H, V101F, Y121F, N125I,        G138C/R/S, Q141H, H147Y, P216L, F219S, M220K/I/T/V, T289A,        S297T, P394L, Y431C, G432S, G434C, T440A, G448S, Y491H or F495I        on Cyp51;    -   Aspergillus parasiticus which has an amino acid substitution of        G54W on Cyp51;    -   Candida albicans which has an amino acid substitution of A61V,        Y132F/H, K143E, S405F, F449S, G464S, R467K or I471T on Cyp51;    -   Cercospora beticola which has an amino acid substitution of        E297K, I330T or P384S on Cyp51;    -   Blumeria graminis f. sp. hordei which has an amino acid        substitution of Y136F, K147Q or S509T on Cyp51;    -   Blumeria graminis f. sp. tritici which has an amino acid        substitution of S79T, Y136F, or K175N on Cyp51;    -   Filobasidiella neoformans which has an amino acid substitution        of Y145F or G484S on Cyp51;    -   Monilinia fructicola which has an amino acid substitution of        Y136F on Cyp51;    -   Mycosphaerella fijiensis which has an amino acid substitution of        Y136F, A313G, A381G, Y461D, G462A or Y463D/H/N on Cyp51;    -   Phakopsora pachyrhizi which has an amino acid substitution of        F120L, Y131F/H, K142R, I145F or I475T on Cyp51;    -   Puccinia triticina which has an amino acid substitution of Y134F        on Cyp51;    -   Pyrenophora teres triticina which has an amino acid substitution        of F489L on Cyp51;    -   Pyrenopeziza brassicae which has an amino acid substitution of        S508T on Cyp51;    -   Saccharomyces cerevisiae which has an amino acid substitution of        Y140F/H on Cyp51;    -   Zymoseptoria tritici which has an amino acid substitution of        L50S, D107V, D134G, V136A/C/G, Y137F, M145L, N178S, S188N,        S208T, N284H, H303Y, A311G, G312A, A379G, I381V/L, A410T, G412A,        Y459C/D/N/S/P/A, G460D/A, Y461D/H/S, V490L, G510C, N513K or        S524T on Cyp51;    -   Erysiphe necator which has an amino acid substitution of Y136F        on Cyp51;    -   Emericella nidulans which has an amino acid substitution of        H6L/Y, Y50N/S, Q134K, A165V, E198D/K/Q, F200Y or M257L on        β-tubulin;    -   Botryotinia fuckeliana which has an amino acid substitution of        E198A/G/K/V or F200Y on β-tubulin;    -   Cochliobolus heterostrophus which has an amino acid substitution        of F167Y on β-tubulin;    -   Cercospora beticola which has an amino acid substitution of        F167Y or E198A on β-tubulin;    -   Gibberella fujikuroi which has an amino acid substitution of        Y50N, E198V or F200Y on β-tubulin;    -   Gibberella zeae which has an amino acid substitution of Y50C,        Q73R, F167Y, E198K/L/Q or F200Y on β-tubulin;    -   Helminthosporium solani which has an amino acid substitution of        E198A/Q on β-tubulin;    -   Hypomyces odoratus which has an amino acid substitution of Y50C        on β-tubulin;    -   Parastagonospora nodorum which has an amino acid substitution of        H6Y on β-tubulin;    -   Monilinia fructicola which has an amino acid substitution of H6Y        or E198A/K on β-tubulin;    -   Monilinia laxa which has an amino acid substitution of H6Y or        L240F on β-tubulin;    -   Microdochium majus which has an amino acid substitution of E198A        on β-tubulin;    -   Mycosphaerella fijiensis which has an amino acid substitution of        E198A on β-tubulin;    -   Neurospora crassa which has an amino acid substitution of F167Y        or E198G on β-tubulin;    -   Penicillium aurantiogriseum which has an amino acid substitution        of E198A/K or F200Y on β-tubulin;    -   Penicillium expansum which has an amino acid substitution of        F167Y or E198A/K/V on β-tubulin;    -   Penicillium italicum which has an amino acid substitution of        E198K or F200Y on β-tubulin;    -   Pyrenopeziza brassicae which has an amino acid substitution of        L²⁴⁰F on β-tubulin;    -   Rhynchosporium secalis which has an amino acid substitution of        E198G/K or F200Y on I-tubulin;    -   Sclerotinia homoeocarpa which has an amino acid substitution of        E198A/K on β-tubulin;    -   Sclerotinia sclerotiorum which has an amino acid substitution of        E198A on β-tubulin;    -   Zymoseptoria tritici which has an amino acid substitution of        E198A/G on β-tubulin;    -   Venturia inaequalis which has an amino acid substitution of        E198A/K, F200Y or L240F on β-tubulin;    -   Alternaria alternata which has an amino acid substitution of        H277R/Y on SdhB;    -   Alternaria solani which has an amino acid substitution of        H277R/Y on SdhB;    -   Botryotinia fuckeliana which has an amino acid substitution of        P225H/F/L/T, N230I or H272L/R/V/Y on SdhB;    -   Corynespora cassiicola which has an amino acid substitution of        H278Y/R on SdhB;    -   Stagonosporopsis cucurbitacearum which has an amino acid        substitution of H277R/Y on SdhB;    -   Eurotium oryzae which has an amino acid substitution of        H249L/N/Y on SdhB;    -   Pyrenophora teres which has an amino acid substitution of H277Y        on SdhB;    -   Sclerotinia sclerotiorum which has an amino acid substitution of        H273Y on SdhB;    -   Zymoseptoria tritici which has an amino acid substitution of        N225I/T, H273Y, T268I/A or I269V on SdhB;    -   Erysiphe necator which has an amino acid substitution of H242R        on SdhB;    -   Ustilago maydis which has an amino acid substitution of H257L on        SdhB;    -   Venturia inaequalis which has an amino acid substitution of        T253I on SdhB;    -   Alternaria alternata which has an amino acid substitution of        H134R on SdhC;    -   Botryotinia fuckeliana which has an amino acid substitution of        P80H/L or A85V on SdhC;    -   Corynespora cassiicola which has an amino acid substitution of        S73P on SdhC;    -   Eurotium oryzae which has an amino acid substitution of T90I on        SdhC;    -   Phakopsora pachyrhizi which has an amino acid substitution of        I86F, N88S or H154Y/R on SdhC;    -   Pyrenophora teres which has an amino acid substitution of K49E,        R64K, N75S, G79R, H134R or S135R on SdhC;    -   Ramularia collo-cygni which has an amino acid substitution of        N87S, H146R or H153R on SdhC;    -   Sclerotinia sclerotiorum which has an amino acid substitution of        H146R on SdhC;    -   Zymoseptoria tritici which has an amino acid substitution of        I29V, N33T, N34T, T79I/N, W80S, A84V, N86K/S/A, G90R, R151T/S,        H152R or I161S on SdhC;    -   Erysiphe necator which has an amino acid substitution of G169D        on SdhC;    -   Venturia inaequalis which has an amino acid substitution of        H151R on SdhC;    -   Alternaria alternata which has an amino acid substitution of        H133R on SdhD;    -   Alternaria solani which has an amino acid substitution of H133R        on SdhD;    -   Botryotinia fuckeliana which has an amino acid substitution of        H132R on SdhD;    -   Corynespora cassiicola which has an amino acid substitution of        S89P or G109V on SdhD;    -   Eurotium oryzae which has an amino acid substitution of D124E on        SdhD;    -   Pyrenophora teres which has an amino acid substitution of        D124E/N, H134R, G138V or D145G on SdhD;    -   Sclerotinia sclerotiorum which has an amino acid substitution of        H132R or D145G on SdhD;    -   Zymoseptoria tritici which has an amino acid substitution of        I50F, M114V or D129E on SdhD;    -   Phytophthora capsici which has an amino acid substitution of        Q1077K or V1109L/M on CesA3;    -   Phytophthora drechsleri which has an amino acid substitution of        V1109L on CesA3;    -   Phytophthora infestans which has an amino acid substitution of        G1105A/V or V1109L on CesA3;    -   Plasmopara viticola which has an amino acid substitution of        G1105S/V on CesA3;    -   Pseudoperonospora cubensis which has an amino acid substitution        of G1105V/W on CesA3;    -   Alternaria brassicicola which has an amino acid substitution of        E753K on OS-1(Shk1);    -   Alternaria longipes which has an amino acid substitution of        G420D on OS-1(Shk1);    -   Botryotinia fuckeliana which has an amino acid substitution of        I365N/R/S, V368F, Q369H/P, N373S or T447S on OS-1(Shk1);    -   Pleospora allii which has an amino acid substitution of F267L,        L290S, T765R or Q777R on OS-1(Shk1);    -   Sclerotinia sclerotiorum which has an amino acid substitution of        T489I, E599 K or G736Y on OS-1(Shk1);    -   Botryotinia fuckeliana which has an amino acid substitution of        S9G, F26S, P57A, T63I, G170R, V192I, L195F, N196T, A210G, I232M,        P238S/A, P250S, P269L, P298A, V309M, A314V, S336C, V365A, E368D,        N369D, E375K, A378T, L400F/S, Y408S, F412I/S/V/C, A461S or R496T        on ERG27.

Zymoseptoria tritici means the same genus as Septoria tritici.

Examples of the plants which the composition of the present inventioncan be used include the following plants.

Crops:

-   -   corn (dent corn, flint corn, flour corn, popcorn, glutinous        corn, sweet corn), rices (long grain rice, dhort grain rice,        medium grain rice, Japonica rice, tropical Japonica rice, paddy        rice, dry-land rice, floating rice, direct sowing rice,        transplanted rice, glutinous rice), wheat (bread wheat (hard        wheat, soft wheat, medium wheat, red wheat, white wheat),        macaroni wheat, spelt wheat, club wheat, autumn sowing type        thereof, spring sowing type thereof), barley (two-row barley        (=beer brewing barley), six-row barley), naked barley, pearl        barley, autumn sowing type thereof, spring sowing type thereof),        rye (autumn sowing type thereof, spring sowing type thereof),        triticale (autumn sowing type thereof, spring sowing type        thereof), oat (autumn sowing type thereof, spring sowing type        thereof), sorghum, cotton (upland cotton, pima cotton), soybean        (determinate type soybean, indeterminate soybean,        semi-determinate type soybean), groundnut (peanut), common bean        (kidney bean), Lima bean, Azuki bean, cowpea bean, mung bean,        urad dal bean, runner bean, rice bean, moth bean, tepary bean,        broad bean, pea, chickpea, lentil, lupin bean, pigeon pea,        alfalfa, buckwheat, sugar beet, rapeseed, canola (autumn sowing        type thereof, spring sowing type thereof), sun flower, sugar        cane, tobacco and the others;

Vegetables:

-   -   solanaceous vegetables (eggplant, tomato, pimento, pepper, bell        pepper and potato, and the others),    -   cucurbitaceous vegetables (cucumber, pumpkin, zucchini, water        melon, melon, and squash, and the others),    -   cruciferous vegetables (Japanese radish, white turnip,        horseradish, kohlrabi, Chinese cabbage, cabbage, leaf mustard,        broccoli and cauliflower, and the others),    -   asteraceous vegetables (burdock, crown daisy, artichoke and        lettuce, and the others),    -   liliaceous vegetables (green onion, onion, garlic and asparagus,        and the others),    -   ammiaceous vegetables (for example, carrot, parsley, celery and        parsnip, and the others),    -   chenopodiaceous vegetables (spinach and Swiss chard, and the        others),    -   lamiaceous vegetables (Perilla frutescens, mint, basil, and        lavender, and the others),    -   strawberry, sweet potato, Dioscorea japonica, colocasia, and the        others;

Fruits:

-   -   pomaceous fruits (apple, pear, Japanese pear, Chinese quince and        quince, and the others),    -   stone fleshy fruits (peach, plum, nectarine, Prunus mume, cherry        fruit, apricot and prune, and the other),    -   citrus fruits (Citrus unshiu, orange, lemon, lime and        grapefruit, and the other),    -   nuts (chestnut, walnuts, hazelnuts, almond, pistachio, cashew        nuts and macadamia nuts, and the other),    -   berry fruits (blueberry, cranberry, blackberry and raspberry,        and the other),    -   grape, kaki persimmon, olive, Japanese plum, banana, coffee,        date palm, coconuts,        and the others;

Others:

-   -   tea, mulberry, flowering plant, roadside trees (for example,        ash, birch, dogwood, Eucalyptus, Ginkgo biloba, lilac, maple,        Quercus, poplar, Judas tree, Liquidambar formosana, plane tree,        zelkova, Japanese arborvitae, fir wood, hemlock, juniper, Pinus,        Picea, and Taxus cuspidate), flowers, ornamental foliage plants,        sods, and grasses.

The above plants are not limited specifically, as long as they arebreeds that are usually cultivated.

The above plants may be also a plant that can be generated by a naturalcrossbreeding, a plant that can be generated by mutations, an F1 hybridplant, and a transgenic plant (which is also referred to as agenetically modified crop). In general, these plants havecharacteristics that are tolerance to herbicides, accumulation of toxicsubstances against pests (which is also referred to as pest resistance),suppression of sensitivity to diseases (which is also referred to asdisease resistance), increase of yield potential, improvement oftolerance to biological and abiotic stress factors, modification ofquality of products (for example, increase or decrease of the content ofingredient(s), change of composition, or improvement of storability andprocessability), and the like.

The method for controlling plant diseases of the present invention(hereinafter, referred to as “control method of the present invention”)is carried out by applying each of an effective amount of the presentcompound A and the present compound B, to a plant or soil where theplant is grows.

The plants encompasses the whole plant and a particular part of theplant. Examples of the particular part of the plants include stems andleaves, flowers, ears, fruits, trunks, branches, crowns, seeds, bulbs,and seedlings. Bulbs described herein represents discoid stems, corms,rhizomes, tubers, tuberous, seed tubers, and tuberous roots of a plant.In the present control method, the ratio of the applied amounts of thepresent compound A relative to the applied amounts of the presentcompound B is within a range of usually 1:0.01 to 1:100, and preferably1:0.1 to 1:10.

In the control method of the present invention, the present compound Aand the present compound B may be applied separately to a plant or soilwhere the plant grows in the same period, but are usually applied as thepresent composition in terms of a convenience on applying.

In the control method of the present invention, examples of the methodof applying the present compound A and the present compound B includefoliage treatment, soil treatment, root treatment, and seed treatment.

The foliage treatment includes, for example, a method of applying thepresent compounds onto surface of a plant to be grown by a foliarapplication or a stem application.

The root treatment includes, for example, a method of soaking a whole ora root of the plant into a medicinal solution comprising the presentcompound A and the present compound B, as well as a method of attachinga solid formulation comprising the present compound A, the presentcompound B and the solid carrier to a root of the plant.

The soil treatment includes, for example, soil broadcast, soilincorporation, and irrigation of the agent solution to a soil.

The seed treatment includes, for example, an applying of the presentcomposition to a seed of the plant to be prevented from the plantdisease. Specific examples of the treatment include spray treatment byspraying a suspension of the present composition in a mist form onto asurface of a seed, smear treatment by applying the wettable powder, theemulsifiable concentrate or the flowable formulation of the presentcomposition with added by small amounts of water or as itself to a seed,immersion treatment by immersing a seed into a solution of the presentcomposition for a certain period of time, film-coating treatment andpellet-coating treatment. Also the present composition can be applied tobulbs of the plant according to a similar method to the above spraytreatment and smear treatment.

Each dose of the present compound A and the present compound B in thecontrol method of the present invention may be varied depending on akind of plant to be treated, a kind or a frequency of an occurrence of aplant disease as a control subject, a dosage form, a treatment period, atreatment method, a treatment site, a climate condition, etc. In case ofan application to a foliage of the plant or a soil where the plant isgrown, a total amount of the present compound A and the present compoundB is usually 1 to 500 g, preferably 2 to 200 g, and more preferably 10to 100 g, per 1000 m². Also each dose of the present compound A and thepresent compound B in the treatment for seed is usually 0.001 to 10 g,and preferably 0.01 to 1 g, per 1 kg of seeds.

The emulsifiable concentrate, the wettable powder or the flowableformulation, etc., is usually applied by diluting them with water, andthen spreading them. In this case, usually, each concentration of thepresent compound A and the present compound B contain 0.0005 to 2% byweight, and preferably 0.005 to 1% by weight of the present compound Aand the present compound B in total. The dust formulation or thegranular formulation, etc., is usually applied as itself withoutdiluting them.

Examples

Hereinafter, the present invention is explained in more detail byPreparation Examples, Formulation Examples, and Test Examples, however,the present invention should not be limited to only the these Examples.

As used herein, Me represents a methyl group, Et represents an ethylgroup, Pr represents a propyl group, i-Pr represents an isopropyl group,Bu represents a butyl group, i-Bu represents an isobutyl group, t-Burepresents a t-butyl group, Pen represents a pentyl group, Hexrepresents a hexyl group, c-Pr represents a cyclopropyl group, c-Burepresents a cyclobutyl group, c-Pen represents a cyclopentyl group,c-Hex represents a cyclohexyl group, and Ph represents a phenyl group.

When the Ph group has any substituent(s), the substituent(s) isdescribed together with a substitution position before the symbol. Forexample, 3,4-Me₂-Ph represents a 3,4-dimethylphenyl group.

The preparation examples of the compounds disclosed herein (includingthe present compound C, the present compound A and the present compoundA) are described.

When a physical property of a compound is measured by a liquidchromatography/mass spectrometry analysis (hereinafter, referred to asLCMS), a measured molecular ion value [M+H]⁺ or [M−H]⁻ and a retentiontime (hereinafter, referred to as RT) is described. The measuredcondition for liquid chromatography (hereinafter, referred to as LC) andmass spectrometry (hereinafter, referred to as MS) is described below.

[LC Condition]

-   -   Column: L-column2 ODS, inner diameter 4.6 mm, length 30 m m,        particle size 3 μm    -   (Chemicals Evaluation and Research Institute, Japan)    -   UV measurement wavelength: 254 nm    -   Mobile phase: A solution: 0.1% aqueous formic acid solution,    -   B solution: 0.1% formic acid in acetonitrile    -   Flow Rate: 2.0 mL/min    -   Pump: LC-20 AD (manufacturing SHIMAZU) 2 umps (high pressure        gradient)    -   Gradient condition: The following concentration gradient shown        in [Table LC1] is liquid-transferred.

TABLE 1 [Table LC1] Time (min) A solution (%) B solution (%) 0.01 90 102.00 0 100 4.00 0 100 4.01 90 10

[MS Condition]

-   -   Detector: LCMS-2020 (manufacturing SHIMAZU)    -   Ionization method: DUIS

Reference Preparation Example 1

To a mixture of sodium hydride (60%, in oil) 0.75 g and THE 40 mL wasadded 5-btomo-2-methylphenol 4.54 g at 0° C., and the mixture wasstirred for 30 minutes. To the resulting mixture was added a mixture ofmethyl 2-(methoxyimino)-2-(methylsulfonyl)acetate (which was prepared bya method described in WO 99/67209 A1) and THE 25 mL, and the mixture wasstirred at room temperature for 1 hour. Water was added to the resultingmixture, and the mixture was extracted with ethyl acetate. The resultingorganic layer was dried over anhydrous magnesium, and concentrated underreduced pressure. The resulting residue was subjected to a silica gelcolumn chromatography to obtain an intermediate compound 1 representedby the following formula 0.36 g.

Intermediate compound 1: ¹H-NMR (CDCl₃) δ: 7.15 (1H, d), 7.07 (1H, d),6.84 (1H, s), 4.05 (3H, s), 3.85 (3H, s), 2.29 (3H, s).

Reference Preparation Example 2

A mixture of the intermediate compound 1 4.0 g, bis(pinacolato)diboron5.04 g, [1,1′-bis(diphenylphosphino)ferrocene]palladium (II) dichloride0.96 g, tripotassium phosphate 8.43 g, and dimethoxyethane 40 mL wasstirred at 80° C. under nitrogen atmosphere for 5 hours. The resultingmixture was concentrated under reduced pressure, and the resultingresidue was subjected to a silica gel column chromatography to obtain anintermediate compound 2 represented by the following formula.

Intermediate compound 2: ¹H-NMR (CDCl₃) δ: 7.47 (1H, d), 7.21 (1H, d),7.11 (1H, s), 4.03 (3H, s), 3.80 (3H, s), 2.37 (3H, s), 1.31 (12H, s).

Reference Preparation Example 3

To a mixture of methyl 2-(5-bromo-2-methylphenyl)acetate (which wasprepared by the method described in WO 2019/016269 A1) 19.4 g, methylformate 14.7 mL, and dimethoxyethane 150 mL was added potassiumtert-butoxide 19.7 g at 0° C., and the mixture was stirred at roomtemperature for 1 hour. To the resulting mixture was added 1Nhydrochloric acid, and the mixture was extracted with MTBE. Theresulting mixture was dried over anhydrous magnesium sulfate, andconcentrated under reduced pressure. To the resulting residue was addedDMF 100 mL, and the mixture was stirred, and thereto were addedpotassium carbonate 9.9 g, and dimethyl sulfate 6.8 mL at 0° C.successively, and the mixture was stirred at room temperature for 5hours. Water was added to the resulting mixture, and the mixture wasextracted with MTBE. The resulting organic layer was dried overanhydrous magnesium sulfate, and concentrated under reduced pressure.The resulting residue was subjected to a silica gel columnchromatography to obtain an intermediate compound 3 represented by thefollowing formula 14.2 g.

Intermediate compound 3: ¹H-NMR (CDCl₃) δ: 7.56 (1H, s), 7.33 (1H, dd),7.24 (1H, d), 7.09 (1H, d), 3.84 (3H, s), 3.70 (3H, s), 2.12 (3H, s).

Reference Preparation Example 3-1

The compounds which were prepared according to the Reference PreparationExample 3 and their physical property value are shown below.

Intermediate compound 4: ¹H-NMR (CDCl₃) δ: 7.57 (1H, s), 7.38-7.35 (2H,m), 7.29-7.26 (1H, m), 3.87 (3H, s), 3.72 (3H, s).

Reference Preparation Example 3-2

The compounds which can be prepared according to the Reference Exmaple 3are shown below.

A compound represented by formula (M1-a):

wherein a combination of R¹, R²² and R²³ represent any combinationsdescribed in [Table A1].

TABLE A1 Intermediate R¹ R²² R²³ 5 Cl H H 6 F H H 8 Et H H 9 c-Pr H H 10H Cl H 12 H H Cl

Reference Preparation Example 3-3

The compounds which were prepared according to the Reference PreparationExample 3 and their physical property value are shown below.

The compounds represented by formula (M1-a) wherein a combination of R¹,R²² and R²³ represent any combinations described in [Table A2].

TABLE A1-2 Intermediate R¹ R²² R²³ 7 OMe H H 11 H Me H 13 H H Me

Intermediate compound 7: ¹H-NMR (CDCl₃) δ: 7.50 (1H, s), 7.37 (1H, dd),7.28 (1H, d), 6.78 (1H, d), 3.83 (3H, s), 3.76 (3H, s), 3.69 (3H, s).

Intermediate compound 11: ¹H-NMR (CDCl₃) δ: 7.54 (1H, s), 7.51 (1H, s),7.23-7.15 (2H, m), 3.86 (3H, s), 3.74 (3H, s), 2.38 (3H, s).

Intermediate compound 13: ¹H-NMR (CDCl₃) δ: 7.54 (1H, s), 7.27 (1H, s),7.24 (1H, s), 7.05 (1H, s), 3.86 (3H, s), 3.74 (3H, s), 2.33 (3H, s).

Reference Preparation Example 4

A mixture of the intermediate compound 3 3.3 g, bis(pinacolato)diboron4.7 g, [1,1′-bis(diphenylphosphino)ferrocene]palladium (II) dichloride0.85 g, tripotassium phosphate 7.4 g, and dimethoxyethane 30 mL wasstirred at 80° C. under nitrogen atmosphere for 10 hours. The resultingmixture was concentrated under reduced pressure, and the resultingresidue was subjected to a silica gel column chromatography to obtain anintermediate compound 14 represented by the following formula 14.

Intermediate compound 14: ¹H-NMR (CDCl₃) δ: 7.67 (1H, dd), 7.55 (1H, s),7.54 (1H, d), 7.23 (1H, d), 3.80 (3H, s), 3.68 (3H, s), 2.19 (3H, s),1.32 (12H, s)

Reference Preparation Example 4-1

The compounds which were prepared according to the Reference PreparationExample 4 and their physical property value are shown below.

Intermediate compound 14-2: ¹H-NMR (CDCl₃) δ: 7.75 (1H, dd), 7.52 (1H,d), 7.26 (1H, d), 4.04 (3H, s), 3.86 (3H, s), 2.20 (3H, s), 1.33 (12H,s).

Intermediate compound 14-3: ¹H-NMR (CDCl₃) δ: 7.73 (1H, dd), 7.52 (1H,d), 7.24 (1H, d), 6.72 (1H, d), 3.94 (3H, s), 2.93 (3H, d), 2.20 (3H,s), 1.31 (12H, s).

Intermediate compound 14-4: ¹H-NMR (CDCl₃) δ: 7.68 (1H, d), 7.52 (1H,s), 7.24 (1H, dd), 7.15 (1H, d), 3.82 (3H, s), 3.71 (3H, s), 2.53 (3H,s), 1.32 (12H, s).

Intermediate compound 14-5: ¹H-NMR (CDCl₃) δ: 7.56 (1H, s), 7.54-7.51(2H, m), 7.19 (1H, s), 3.83 (3H, s), 3.71 (3H, s), 2.35 (3H, s), 1.33(12H, s).

Intermediate compound 14-6: ¹H-NMR (CDCl₃) δ: 7.81 (1H, dd), 7.76 (1H,d), 7.36 (1H, d), 3.72 (3H, s), 2.30 (3H, s), 1.33 (12H, s).

Intermediate compound 14-7: ¹H-NMR (CDCl₃) δ: 7.77 (1H, dd), 7.60 (1H,d), 7.51 (1H, s), 6.91 (1H, d), 3.81 (3H, s), 3.81 (3H, s), 3.68 (3H,s), 1.32 (12H, s).

Reference Preparation Example 5

A mixture of the intermediate compound 3 5.0 g,bis(triphenylphosphine)palladium(II) dichloride 0.61 g,tributyl(1-ethoxyvinyl)tin 7.0 mL, and 1,4-dioxane 30 mL was stirred at100° C. under nitrogen atmosphere for 5 hours. To the resulting mixturewas added 1N hydrochloric acid, and the mixture was stirred at roomtemperature for 30 minutes. The resulting mixture was concentrated underreduced pressure and extracted with ethyl acetate. The resulting organiclayers were concentrated under reduced pressure and the residue wassubjected to a silica gel column chromatography to obtain anintermediate compound 15 represented by the following formula 3.41 g.

Intermediate compound 15: ¹H-NMR (CDCl₃) δ: 7.82 (1H, dd), 7.71 (1H, d),7.60 (1H, s), 7.31 (1H, d), 3.84 (3H, s), 3.71 (3H, s), 2.57 (3H, s),2.24 (3H, s)

Reference Preparation Example 5-1

The compounds which were prepared according to the Reference PreparationExample 5-1 and their physical property value are shown below.

Intermediate compound 15-1: ¹H-NMR (CDCl₃) δ: ¹H-NMR (CDCl₃) δ: 8.00(1H, dd), 7.94 (1H, d), 7.48 (1H, d), 3.74 (3H, s), 2.61 (3H, s), 2.37(3H, s).

Reference Preparation Example 6

To a mixture of the intermediate compound 15 1.0 g, hydroxylaminehydrochloride salt 0.28 g, and methanol 12 mL was added pyridine 0.64 mLat 0° C., and the mixture was stirred at room temperature for 2.5 hours.The resulting mixture was diluted with ethyl acetate, and washed withwater and saturated brine successively. The resulting organic layerswere dried over anhydrous sodium sulfate, and concentrated under reducedpressure. The precipitated out solids were washed with a mixed solventof ethyl acetate and hexane (2:3) to obtain an intermediate compound 16represented by the following formula 0.91 g.

Intermediate compound 16: ¹H-NMR (CDCl₃) δ: 8.78 (1H, s), 7.59 (1H, s),7.48 (1H, dd), 7.38 (1H, d), 7.23 (1H, d), 3.83 (3H, s), 3.70 (3H, s),2.26 (3H, s), 2.19 (3H, s).

Reference Preparation Example 6-1

The compounds which were prepared according to the Reference PreparationExample 6 and their physical property value are shown below.

Intermediate compound 17: ¹H-NMR (CDCl₃) δ: 9.01 (1H, br s), 8.11 (1H,s), 7.59 (1H, s), 7.45 (1H, dd), 7.31 (1H, d), 7.23 (1H, d), 3.81 (3H,s), 3.70 (3H, s), 2.19 (3H, s).

Reference Preparation Example 7

A mixture of 5-bromo-2-methylaniline 12.5 g, triphosgene 29.3 g, andtoluene 120 mL was stirred under reflux for 2 hours. The resultingmixture was concentrated under reduced pressure, and to the resultingresidue were added 1,1-dimethylhydrazine 5.1 mL and toluene 100 mL underice-cooling successively, and the mixture was stirred at roomtemperature for 1.5 hours. The precipitated out solids were filtered,and the filtrates were washed with toluene to obtain an intermediatecompound 17 represented by the following formula 13.2 g.

Intermediate compound 17: ¹H-NMR (CDCl₃) δ: 8.23 (1H, d), 8.15 (1H, s),7.10 (1H, dd), 7.00 (1H, d), 5.42 (1H, s), 2.63 (6H, s), 2.20 (3H, s).

Reference Preparation Example 8

A mixture of the intermediate compound 17 10 g, triphosgene 22 g, anddichloromethane 350 mL was stirred at 60° C. for 8 hours. The resultingmixture was concentrated under reduced pressure, and water was added tothe resulting residue, and the mixture was extracted with ethyl acetate.The resulting organic layers were washed with saturated brine, and driedover anhydrous sodium sulfate, and concentrated under reduced pressure.The resulting residue was subjected to a silica gel columnchromatography to obtain an intermediate compound 18 represented by thefollowing formula 3.89 g.

Intermediate compound 18: ¹H-NMR (CDCl₃) δ: 7.54 (1H, dd), 7.35 (1H, d),7.25 (1H, d), 3.54 (3H, s), 2.17 (3H, s).

Reference Preparation Example 9

At room temperature, to a mixture of the intermediate compound 18 1.0 gand THE 15 mL was added sodium methoxide (28% methanol solution) 2.0 mL,and the mixture was stirred under reflux for 1 hour. To the resultingmixture was added aqueous saturated ammonium chloride solution, and themixture was extracted with ethyl acetate. The resulting organic layerswere washed with saturated brine, dried over anhydrous sodium sulfate,and concentrated under reduced pressure. The precipitated out solidswere washed with a mixed solvent of ethyl acetate and hexane (2:3) toobtain an intermediate compound 19 represented by the following formula0.71 g.

Intermediate compound 19: ¹H-NMR (CDCl₃) δ: 7.47 (1H, dd), 7.35 (1H, d),7.20 (1H, d), 3.95 (3H, s), 3.44 (3H, s), 2.17 (3H, s).

Reference Preparation Example 10

A mixture of the intermediate compound 2 1.5 g, meta chloro perbenzoicacid 1.16 g, ethanol 15 mL, acetonitrile 15 ml, and water 15 ml wasstirred at room temperature for 5 hours. To the resulting mixture wasadded aqueous sodium thiosulfate solution, and the mixture wasconcentrated under reduced pressure. To the resulting residue was addedaqueous saturated sodium bicarbonate solution, and the mixture wasextracted with ethyl acetate. The resulting organic layers were driedover anhydrous magnesium sulfate, concentrated under reduced pressure toobtain an intermediate compound 20 represented by the following formula1.05 g.

Intermediate compound 20: ¹H-NMR (CDCl₃) δ: 7.03 (1H, d), 6.50 (1H, dd),6.25 (1H, d), 4.64 (1H, s), 4.04 (3H, s), 3.82 (3H, s), 2.25 (3H, s).

Reference Preparation Example 11

To a mixture of methyl 2-(5-bromo-2-methylphenyl)acetate (which wasprepared by the method described in WO 2019/016269 A1) 20.0 g, isoamylnitrite 13.2 mL, and THE 160 mL was added sodium methoxide (28% methanolsolution) 25.4 mL, and the mixture was stirred at room temperature for 7hours. To the resulting mixture was added 1N hydrochloric acid, and themixture was extracted with ethyl acetate. The resulting organic layerswere washed with water and saturated brine successively, dried oversodium sulfate, and concentrated under reduced pressure. The resultingresidue was subjected to a silica gel column chromatography to obtain anintermediate compound represented 21 by the following formula 6.51 g.

Intermediate compound 21: ¹H-NMR (CDCl₃) δ: 9.25 (1H, s), 7.45 (1H, dd),7.29 (1H, d), 7.15 (1H, d), 3.87 (3H, s), 2.17 (3H, s).

Reference Preparation Example 12

To a mixture of the intermediate compound 21 6.51 g, potassium carbonate4.0 g, and DMF 60 ml was added dimethyl sulfate 2.7 ml at 0° C., and themixture was stirred at room temperature for 2 hours. To the resultingmixture was added aqueous ammonium chloride solution, and the mixturewas extracted with MTBE. The resulting organic layers were washed withwater and saturated brine successively, dried over anhydrous sodiumsulfate, and concentrated under reduced pressure. The resulting residuewas subjected to a silica gel column chromatography to obtain anintermediate compound 22 represented by the following formula 4.83 g.

Intermediate compound 22: ¹H-NMR (CDCl₃) δ: 7.42 (1H, dd), 7.23 (1H, d),7.12 (1H, d), 4.06 (3H, s), 3.88 (3H, s), 2.13 (3H, s).

Reference Preparation Example 13

To a mixture of the intermediate compound 22 2.0 g, and methanol 20 mlwas added methylamine (9.8 M methanol solution) 1.2 mL, and the mixturewas stirred at room temperature overnight. Water was added to theresulting mixture, and the mixture was extracted with ethyl acetate. Theresulting organic layers were dried over anhydrous sodium sulfate, andconcentrated under reduced pressure. The resulting residue was subjectedto a silica gel column chromatography to obtain an intermediate compoundrepresented 23 by the following formula 1.99 g.

Intermediate compound 23: ¹H-NMR (CDCl₃) δ: 7.40 (1H, dd), 7.22 (1H, d),7.10 (1H, d), 6.78 (1H, br s), 3.97 (3H, s), 2.94 (3H, d), 2.12 (3H, s).

Reference Preparation Example 14

To a mixture of hydrazine monohydrate 15 mL and ethanol 20 mL was addeda mixture of 4-acetylindane 2.0 g, acetic acid 0.2 mL and ethanol 17 mL,and the mixture was stirred at 40° C. for 4 hours. Water was added tothe resulting mixture, and the mixture was extracted with ethyl acetate.The resulting organic layers were dried over anhydrous sodium sulfate,and concentrated under reduced pressure. The resulting residue wassubjected to a silica gel column chromatography to obtain anintermediate compound 24 represented by the following formula 1.65 g.

Intermediate compound 24: ¹H-NMR (CDCl₃) δ: 7.20-7.12 (3H, m), 5.29 (2H,s), 3.03 (2H, t), 2.90 (2H, t), 2.13 (3H, s), 2.07-1.99 (2H, m).

Reference Preparation Example 15

A mixture of the intermediate compound 14 7.4 g, meta chloro perbenzoicacid (purity 70%, containing 30% water) 6.0 g, acetonitrile 30 mL,ethanol 30 mL, and water 30 mL was stirred at room temperature for 25minutes. To the resulting mixture were added aqueous sodium thiosulfatesolution and aqueous sodium hydrogencarbonate solution successively, andthe mixture was stirred at room temperature for 1 hour. The resultingmixture was concentrated under reduced pressure and extracted with ethylacetate. The resulting organic layers were concentrated under reducedpressure to obtain an intermediate compound 25 represented by thefollowing formula 5.7 g.

Intermediate compound 25: ¹H-NMR (CDCl₃) δ: 7.54 (1H, s), 7.08 (1H, d),6.71 (1H, dd), 6.60 (1H, d), 3.83 (3H, s), 3.70 (3H, s), 2.09 (3H, s).

Reference Preparation Example 15-1

The compounds which were prepared according to the Reference PreparationExample 15 and their physical property value are shown below.

Intermediate compound 25-2: ¹H-NMR (CDCl₃) δ: 7.10 (1H, d), 6.78 (1H,dd), 6.58 (1H, d), 4.94 (1H, br s), 4.05 (3H, s), 3.87 (3H, s), 2.10(3H, s).

Intermediate compound 25-3: ¹H-NMR (CDCl₃) δ: 7.05 (1H, d), 6.81 (1H,s), 6.70 (1H, dd), 6.51 (1H, d), 5.76 (1H, br s), 3.96 (3H, s), 2.95(3H, d), 2.07 (3H, s)

Intermediate compound 25-4: ¹H-NMR (CDCl₃) δ: 7.53 (1H, s), 7.10 (1H,d), 6.81 (1H, dd), 6.75 (1H, d), 4.86 (1H, br s), 3.84 (3H, s), 3.73(3H, s), 2.23 (3H, s)

Intermediate compound 25-5: ¹H-NMR (CDCl₃) δ: 7.53 (1H, s), 6.70 (1H,s), 6.62-6.57 (2H, m), 3.85 (3H, s), 3.73 (3H, s), 2.30 (3H, s).

Intermediate compound 25-6: ¹H-NMR (CDCl₃) δ: 7.16 (1H, d), 6.84-6.78(2H, m), 3.74 (3H, s), 2.17 (3H, s).

Intermediate compound 25-7: ¹H-NMR (CDCl₃) δ: 7.49 (1H, s), 6.81-6.73(2H, m), 6.68 (1H, d), 3.82 (3H, s), 3.73 (3H, s), 3.70 (3H, s).

Intermediate compound 25-8: ¹H-NMR (CDCl₃) δ: 7.54 (1H, s), 6.98 (1H,s), 6.55 (1H, s), 4.50 (1H, s), 3.83 (3H, s), 3.70 (3H, s), 2.21 (3H,s), 2.07 (3H, s).

Reference Preparation Example 16

To a mixture of 5-bromo-2-methyl benzoic acid 10.0 g, DMSO 0.3 mL, andTHE 30 mL was added dropwise oxalyl chloride 4.0 mL at 0° C. undernitrogen atmosphere, and the mixture was stirred at room temperature for1 hour. The resulting mixture was concentrated under reduced pressure toobtain 5-bromo-2-methyl benzoyl chloride.

To a mixture of THE 100 mL and aluminium chloride 12.4 g was addedsodium azide 18.1 g at 0° C. under nitrogen atmosphere, and the mixturewas stirred under reflux for 40 minutes. To the resulting mixture wasadded the above-obtained 5-bromo-2-methyl-benzoyl chloride under reflux,and the mixture was stirred under reflux for 90 minutes. After theresulting mixture was cooled to room temperature, aqueous sodium nitritesolution and 1N hydrochloric acid were added successively thereto, andthe mixture was extracted with ethyl acetate. The resulting organiclayers were dried over sodium sulfate, and concentrated under reducedpressure to obtain an intermediate compound 26 represented by thefollowing formula 11.6 g.

Intermediate compound 26: LCMS: 255 [M+H]⁺, RT=2.16 minutes

Reference Preparation Example 17

To a mixture of the intermediate compound 26 10.0 g, potassium carbonate16.3 g, and DMF 60 mL was added dimethyl sulfate 4.8 mL at 0° C., andthe mixture was stirred at room temperature for 2 hours. To theresulting mixture was added aqueous ammonium chloride solution, and themixture was extracted with ethyl acetate. The resulting organic layerswere washed with water and saturated brine successively, and dried overanhydrous sodium sulfate, and concentrated under reduced pressure toobtain an intermediate compound 27 represented by the following formula9.0 g.

Intermediate compound 27: ¹H-NMR (CDCl₃) δ: 7.54-7.50 (2H, m), 7.24 (1H,d), 3.72 (3H, s), 2.26 (3H, s).

Reference Preparation Example 18

To a mixture of 5-bromo-2-methylphenyl hydrazine hydrochloride salt 11.1g and chloroform 110 mL was added dropwise methyl chlorocarbonate 3.6mL, and the mixture was stirred at room temperature for 1 hour. Waterwas added to the resulting mixture, and the mixture was extracted withethyl acetate. The resulting organic layers were washed with saturatedbrine, dried over anhydrous sodium sulfate, and concentrated underreduced pressure. The resulting residue was subjected to a silica gelcolumn chromatography to obtain an intermediate compound 28 representedby the following formula 8.4 g.

Intermediate compound 28: ¹H-NMR (CDCl₃) δ: 7.02 (1H, d), 6.96-6.90 (2H,m), 6.52 (1H, s), 5.66 (1H, s), 3.78 (3H, s), 2.15 (3H, s).

Reference Preparation Example 19

To a mixture of the intermediate compound 28 7.0 g, triethylamine 7.5 mLand chloroform 70 mL was added triphosgene 3.2 g at 0° C., and themixture was stirred at room temperature for 4 hours. Water was added tothe resulting mixture, and the mixture was extracted with ethyl acetate.The resulting organic layers were washed with water and saturated brinesuccessively, dried over anhydrous sodium sulfate, and concentratedunder reduced pressure to obtain an intermediate compound 29 representedby the following formula 3.5 g.

Intermediate compound 29: ¹H-NMR (CDCl₃) δ: 7.54 (1H, d), 7.43 (1H, dd),7.18 (1H, d), 4.06 (3H, s), 2.31 (3H, s).

Reference Preparation Example 20

A mixture of the intermediate compound 22 3.5 g, hydroxylaminehydrochloride salt 1.3 g, potassium hydroxide 1.7 g, and methanol 30 mLwas stirred at room temperature for 24 hours. To the resulting mixturewas added 1N hydrochloric acid, and the mixture was extracted with ethylacetate. The resulting organic layers were washed with water andsaturated brine successively, dried over anhydrous sodium sulfate, andconcentrated under reduced pressure to obtain an intermediate compound30 represented by the following formula 3.1 g.

Intermediate compound 30: ¹H-NMR (CDCl₃) δ: 9.09 (1H, s), 7.63 (1H, s),7.44 (1H, dd), 7.25 (1H, d), 7.13 (1H, d), 3.99 (3H, s), 2.13 (3H, s).

Reference Preparation Example 21

To a mixture of the intermediate compound 30 2.6 g, potassium carbonate3.8 g, and DMF 30 mL was added 1,2-dibromoethane 1.6 mL at 0° C., andthe mixture was stirred at room temperature overnight. Water was addedto the resulting mixture, and the mixture was extracted with ethylacetate. The resulting organic layers were washed with saturated brine,dried over anhydrous sodium sulfate, and concentrated under reducedpressure. The resulting residue was subjected to a silica gel columnchromatography to obtain an intermediate compound 31 represented by thefollowing formula 1.4 g.

Intermediate compound 31: ¹H-NMR (CDCl₃) δ: 7.38 (1H, dd), 7.21 (1H, d),7.09 (1H, d), 4.53-4.49 (2H, m), 4.22-4.17 (2H, m), 3.99 (3H, s), 2.16(3H, s).

Reference Preparation Example 22

A mixture of the intermediate compound 3 0.56 g, 1-cyclohexen-1-ylboronic acid 0.24 g, [1,1′-

(diphenylphosphino)ferrocene]palladium (II) dichloride 0.064 g,tripotassium phosphate 0.74 g, water 1 mL, and dimethoxyethane 10 mL wasstirred at 80° C. under nitrogen atmosphere for 6 hours. Water was addedto the resulting mixture, and the mixture was extracted with ethylacetate. The resulting organic layers were washed with saturated brine,dried over anhydrous sodium sulfate, and concentrated under reducedpressure. The resulting residue was subjected to a silica gel columnchromatography to obtain an intermediate compound 32 represented by thefollowing formula 0.56 g.

Intermediate compound 32: ¹H-NMR (CDCl₃) δ: 7.56 (1H, s), 7.24 (1H, dd),7.17-7.11 (2H, m), 6.11-6.07 (1H, m), 3.82 (3H, s), 3.70 (3H, s),2.41-2.36 (2H, m), 2.21-2.16 (2H, m), 2.15 (3H, s), 1.79-1.72 (2H, m),1.67-1.60 (2H, m).

Reference Preparation Example 23

A mixture of2,2′-(4,6-dimethyl-1,3-phenylene)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane)0.61 g, methyl (Z)-2-iodo-3-methoxy-acrylate 0.42 g,2-(dicyclohexylphoshino)-2′,6′-dimethoxybiphenyl 0.06 g,tris(dibenzylideneacetone)dipalladium (0) 0.08 g, tripotassium phosphate0.74 g, water 2 mL, and toluene 8 mL was stirred at 100° C. undernitrogen atmosphere for 4 hours. Water was added to the resultingmixture, and the mixture was extracted with ethyl acetate. The resultingorganic layers were washed with saturated brine, dried over anhydroussodium sulfate, and concentrated under reduced pressure. The resultingresidue was subjected to a silica gel column chromatography to obtain anintermediate compound 33 represented by the following formula 0.28 g.

Intermediate compound 33: ¹H-NMR (CDCl₃) δ: 7.54 (1H, s), 7.50 (1H, s),7.04 (1H, s), 3.80 (3H, s), 3.68 (3H, s), 2.50 (3H, s), 2.14 (3H, s),1.31 (12H, s).

Preparation Example 1

A mixture of the intermediate compound 1 0.30 g, PdCl₂ (PPh₃)₂ 0.04 g,3,3-dimethyl-1-butyne 0.33 g, tetrabutyl ammonium fluoride (1 mol/L THEsolution) 3.5 mL and THE 6 mL was stirred at 60° C. under nitrogenatmosphere for 6 hours. To the resulting mixture was added aqueoussaturated sodium bicarbonate solution, and the mixture was extractedwith ethyl acetate. The resulting organic layers were dried over sodiumsulfate, and concentrated under reduced pressure. The residue wassubjected to a silica gel column chromatography (ethylacetate:hexane=1:4) to obtain the present compound 1-1 represented bythe following formula 0.08 g.

Present compound 1-1: ¹H-NMR (CDCl₃) δ: 7.10-6.98 (2H, m), 6.71 (1H, s),4.04 (3H, s), 3.82 (3H, s), 2.32 (3H, s), 1.29 (9H, s).

Preparation Example 1-1

The compounds which were prepared according to the Preparation Example 1and their physical property value are shown below.

A compound represented by formula (1a):

wherein a combination of R²⁰, Q, R² and L² represents any combinationsdescribed in [Table A2].

TABLE A2 Present Compound R²⁰ Q R³ L² 1-2 c-Pr Q7 — O 1-3 c-Pr Q3 OMe —1-4 t-Bu Q3 OMe — 1-5 c-Pr Q4 — — 1-6 t-Bu Q4 — — 1-7 c-Pr Q5 — — 1-8t-Bu Q5 — — 1-9 c-Pr Q6 — — 1-10 t-Bu Q6 — —

Present compound 1-2: LCMS: 288 [M+H]⁺, RT=2.15

Present compound 1-3: ¹H-NMR (CDCl₃) δ: 7.33 (1H, dd), 7.23-7.19 (2H,m), 3.93 (3H, s), 3.44 (3H, s), 2.19 (3H, s), 1.46-1.37 (1H, m),0.91-0.81 (2H, m), 0.81-0.74 (2H, m).

Present compound 1-4: ¹H-NMR (CDCl₃) δ: 7.34 (1H, dd), 7.22-7.21 (2H,m), 3.93 (3H, s), 3.44 (3H, s), 2.18 (3H, s), 1.28 (9H, s).

Present compound 1-5: ¹H-NMR (CDCl₃) δ: 7.40-7.35 (2H, m), 7.25 (1H, d),3.71 (3H, s), 2.26 (3H, s), 1.47-1.39 (1H, m), 0.90-0.84 (2H, m),0.82-0.76 (2H, m).

Present compound 1-6: ¹H-NMR (CDCl₃) δ: 7.41-7.37 (2H, m), 7.25 (1H, d),3.71 (3H, s), 2.27 (3H, s), 1.29 (9H, s).

Present compound 1-7: ¹H-NMR (CDCl₃) δ: 7.39 (1H, d), 7.30 (1H, dd),7.19 (1H, d), 4.04 (3H, s), 2.32 (3H, s), 1.47-1.39 (1H, m), 0.90-0.76(4H, m).

Present compound 1-8: ¹H-NMR (CDCl₃) δ: 7.41 (1H, d), 7.31 (1H, dd),7.19 (1H, d), 4.05 (3H, s), 2.32 (3H, s), 1.30 (9H, s).

Present compound 1-9: ¹H-NMR (CDCl₃) δ: 7.27 (1H, dd), 7.13-7.09 (2H,m), 4.51-4.46 (2H, m), 4.20-4.14 (2H, m), 3.96 (3H, s), 2.18 (3H, s),1.46-1.37 (1H, m), 0.87-0.80 (2H, m), 0.79-0.73 (2H, m).

Present compound 1-10: ¹H-NMR (CDCl₃) δ: 7.27 (1H, dd), 7.13-7.10 (2H,m), 4.51-4.47 (2H, m), 4.20-4.16 (2H, m), 3.97 (3H, s), 2.19 (3H, s),1.29 (9H, s).

Preparation Example 2

A mixture of the intermediate compound 1 0.30 g, 2-fluorophenylboronicacid 0.21 g, [1,1′-bis(diphenylphosphino)ferrocene]palladium (II)dichloride 0.07 g, tripotassium phosphate 0.63 g, dimethoxyethane 15 mLand water 0.1 mL was stirred at 80° C. under nitrogen atmosphere for 5hours. The resulting mixture was concentrated under reduced pressure,and the residue was subjected to a silica gel column chromatography(ethyl acetate:hexane=1:4) to obtain the present compound 2-1represented by the following formula 0.10 g.

Present compound 2-1: LCMS: 318 [M+H]⁺. RT=2.15 minutes

Preparation Example 2-1

The compounds which were prepared according to the Preparation Example 2and their physical property value are shown below.

A compound represented by formula (1b):

wherein E represents any substituents described in [Table A3].

TABLE A3 Present Compound E 2-2

2-3

2-4

2-5

2-9

2-10

Present compound 2-2: LCMS: 275 [M+H]⁺, RT=2.25 minutes

Present compound 2-3: ¹H-NMR (CDCl₃) δ: 7.59 (1H, s), 7.50-7.48 (2H, m),7.39 (1H, dd), 7.36-7.32 (2H, m), 7.26-7.21 (3H, m), 7.06 (2H, d), 3.84(3H, s), 3.72 (3H, s), 2.19 (3H, s).

Present compound 2-4: ¹H-NMR (CDCl₃) δ: 7.59 (1H, s), 7.42-7.39 (2H, m),7.39-7.36 (1H, m), 7.32-7.28 (2H, m), 7.24-7.21 (2H, m), 7.01 (2H, dd),3.84 (3H, s), 3.72 (3H, s), 2.19 (3H, s).

Present compound 2-5: ¹H-NMR (CDCl₃) δ: 7.67 (1H, d), 7.59 (1H, s), 7.39(1H, dd), 7.27-7.23 (2H, m), 6.38 (1H, d), 3.84 (3H, s), 3.79 (3H, s),3.71 (3H, s), 2.20 (3H, s).

Present compound 2-9: ¹H-NMR (CDCl₃) δ: 7.55 (1H, s), 7.18-7.10 (2H, m),7.03 (1H, d), 6.42 (1H, d), 5.66 (1H, dd), 3.81 (3H, s), 3.69 (3H, s),2.14 (3H, s), 1.58-1.48 (1H, m), 0.81-0.75 (2H, m), 0.50-0.44 (2H, m).

Present compound 2-10: ¹H-NMR (CDCl₃) δ: 7.55 (1H, s), 7.33-7.27 (2H,m), 7.25-7.18 (4H, m), 7.14 (1H, d), 7.09 (1H, d), 6.41 (1H, d),6.33-6.24 (1H, m), 3.81 (3H, s), 3.69 (3H, s), 3.52 (2H, d), 2.15 (3H,s).

A compound represented by formula (2b):

wherein a combination of R²⁴, R²⁵, R²⁶, R²⁷, R²⁸, Q, R³, and L²represents any combinations described in [Table A4].

TABLE A4 Present Compound R²⁴ R²⁵ R²⁶ R²⁷ R²⁸ Q R³ L² 2-6 H H H H H Q7 —O 2-7 H H H H H Q3 OMe — 2-8 F H H H H Q3 OMe — 2-11 H H H H F Q4 — —2-12 H H H H F Q5 — — 2-13 H H H H Cl Q5 — — 2-14 H H H H F Q6 — —

Present compound 2-6: ¹H-NMR (CDCl₃) δ: 7.52-7.49 (2H, m), 7.43-7.39(2H, m), 7.35-7.30 (1H, m), 7.27-7.26 (2H, m), 6.92 (1H, s), 4.05 (3H,s), 3.81 (3H, s), 2.39 (3H, s).

Present compound 2-7: ¹H-NMR (CDCl₃) δ: 7.59-7.55 (3H, m), 7.45-7.37(4H, m), 7.37-7.31 (1H, m), 3.95 (3H, s), 3.47 (3H, s), 2.26 (3H, s).

Present compound 2-8: ¹H-NMR (CDCl₃) δ: 7.56 (1H, dt), 7.46-7.39 (3H,m), 7.34-7.28 (1H, m), 7.21-7.11 (2H, m), 3.96 (3H, s), 3.47 (3H, s),2.27 (3H, s).

Present compound 2-11: ¹H-NMR (CDCl₃) δ: 7.63-7.59 (1H, m), 7.55 (1H,s), 7.47-7.42 (2H, m), 7.37-7.30 (1H, m), 7.24-7.12 (2H, m), 3.74 (3H,s), 2.34 (3H, s).

Present compound 2-12: ¹H-NMR (CDCl₃) δ: 7.58 (1H, s), 7.52 (1H, dt),7.43 (1H, td), 7.37 (1H, d), 7.35-7.29 (1H, m), 7.23-7.11 (2H, m), 4.05(3H, s), 2.39 (3H, s).

Present compound 2-13: ¹H-NMR (CDCl₃) δ: 7.49-7.45 (2H, m), 7.42 (1H,dd), 7.38-7.25 (4H, m), 4.05 (3H, s), 2.40 (3H, s).

Present compound 2-14: ¹H-NMR (CDCl₃) δ: 7.50 (1H, d), 7.47-7.42 (1H,m), 7.32-7.25 (3H, m), 7.21-7.15 (1H, m), 7.15-7.09 (1H, m), 4.53-4.48(2H, m), 4.20-4.15 (2H, m), 4.00 (3H, s), 2.27 (3H, s).

Present compound 2-15: ¹H-NMR (CDCl₃) δ: 7.55 (1H, s), 7.11 (1H, d),6.90 (1H, dd), 6.85 (1H, d), 3.82 (3H, s), 3.70 (3H, s), 2.13 (3H, s),1.89-1.81 (1H, m), 0.93-0.87 (2H, m), 0.68-0.63 (2H, m).

Preparation Example 3

To a mixture of the sodium hydride (in oil 60%) 0.04 g and DMF 3 mL wasadded the intermediate compound 16 0.25 g at 0° C., and the mixture wasstirred at room temperature for 30 minutes. To the resulting mixture wasadded (1-bromoethyl)benzene 0.19 mL at 0° C., and the mixture wasstirred at room temperature for 2 hours. To the resulting mixture wasadded aqueous ammonium chloride solution, and the mixture was extractedwith ethyl acetate. The resulting organic layers were washed with waterand saturated brine, dried over anhydrous sodium sulfate, andconcentrated under reduced pressure. The resulting residue was subjectedto a silica gel column chromatography (ethyl acetate:hexane=1:4) toobtain the present compound 3-1 represented by the following formula0.35 g.

Present compound 3-1: ¹H-NMR (CDCl₃) δ: 7.56 (1H, s), 7.48 (1H, dd),7.39-7.27 (6H, m), 7.17 (1H, d), 5.36 (1H, q), 3.80 (3H, s), 3.68 (3H,s), 2.25 (3H, s), 2.16 (3H, s), 1.60 (3H, d).

Preparation Example 3-1

The compounds which were prepared according to the Preparation Example 3and their physical property value are shown below.

A compound represented by formula (1c):

wherein a combination of R⁹ and R¹³ represents a combination describedin [Table A5].

TABLE A5 Present Compound R⁹ R¹⁵CR¹⁶R³⁶ 3-2 H CH(CH₃)Ph

Present compound 3-2: ¹H-NMR (CDCl₃) δ: 8.09 (1H, s), 7.55 (1H, s), 7.42(1H, dd), 7.39-7.28 (6H, m), 7.18 (1H, d), 5.33 (1H, q), 3.80 (3H, s),3.68 (3H, s), 2.16 (3H, s), 1.59 (3H, d).

Present compound 3-3: ¹H-NMR (CDCl₃) δ: 7.69 (1H, dd), 7.64 (1H, d),7.43-7.27 (6H, m), 5.23 (2H, s), 3.70 (3H, s), 2.28 (3H, s), 2.24 (3H,s).

Present compound 3-4: ¹H-NMR (CDCl₃): 7.70 (1H, dd), 7.64 (1H, d), 7.34(1H, d), 4.00 (2H, d), 3.72 (3H, s), 2.29 (3H, s), 2.24 (3H, s),1.27-1.14 (1H, m), 0.59-0.53 (2H, m), 0.34-0.28 (2H, m).

Preparation Example 4

To a mixture of the intermediate compound 3 0.50 g, phenol 0.25 g and1,4-dioxane 4 mL were added copper (I) iodide 0.1 g, N,N-dimethylglycinehydrochloride salt 0.22 g, and cesium carbonate 1.14 g successively atroom temperature, and the mixture was stirred at 110° C. for 7 hours.Water was added to the resulting mixture, and the mixture was extractedwith ethyl acetate. The resulting organic layers were washed with waterand saturated brine successively, dried over anhydrous sodium sulfate,and concentrated under reduced pressure. The resulting residue wassubjected to a silica gel column chromatography (ethylacetate:hexane=2:3) to obtain the present compound 4-1 represented bythe following formula 0.4 g.

Present compound 4-1: ¹H-NMR (CDCl₃) δ: 7.53 (1H, s), 7.32-7.30 (2H, m),7.17 (1H, d), 7.09-7.00 (3H, m), 6.87 (1H, dd), 6.82 (1H, d), 3.82 (3H,s), 3.70 (3H, s), 2.15 (3H, s).

Preparation Example 4-1

The compounds which were prepared according to the Preparation Example 4and their physical property value are shown below.

A compound represented by formula (1d):

wherein a combination of R²⁹, R³⁰, R³¹, R³², and R³³ represents anycombinations described in [Table A6].

TABLE A6 Present Compound R²⁹ R³⁰ R³¹ R³² R³³ 4-2 F H H H H 4-3 H H F HH 4-4 H Cl H H H 4-5 Me H

H H 4-6 H F H H H 4-7 H CF₃ H H H

Present compound 4-2: ¹H-NMR (CDCl₃) δ: 7.54 (1H, s), 7.19-7.11 (2H, m),7.10-7.00 (3H, m), 6.84 (1H, dd), 6.80 (1H, d), 3.82 (3H, s), 3.70 (3H,s), 2.14 (3H, s).

Present compound 4-3: ¹H-NMR (CDCl₃) δ: 7.53 (1H, s), 7.16 (1H, d),7.01-6.95 (4H, m), 6.82 (1H, dd), 6.77 (1H, d), 3.81 (3H, s), 3.69 (3H,s), 2.14 (3H, s).

Present compound 4-4: ¹H-NMR (CDCl₃) δ: 7.55 (1H, s), 7.22 (1H, s),7.20-7.19 (1H, m), 7.04-7.01 (1H, m), 7.00-6.99 (1H, m), 6.91-6.88 (2H,m), 6.82 (1H, d), 3.84 (3H, s), 3.71 (3H, s), 2.17 (3H, s).

Present compound 4-5: ¹H-NMR (CDCl₃) δ: 7.53 (1H, s), 7.51 (1H, d), 7.37(1H, dd), 7.15 (1H, d), 6.96 (1H, d), 6.82 (1H, dd), 6.72 (1H, d), 3.86(3H, s), 3.82 (3H, s), 3.70 (3H, s), 2.29 (3H, s), 2.16 (3H, s), 2.14(3H, s).

Present compound 4-6:1H-NMR (CDCl₃) δ: 7.55 (1H, s), 7.27-7.18 (2H, m),6.90 (1H, dd), 6.83 (1H, d), 6.81-6.68 (3H, m), 3.83 (3H, s), 3.71 (3H,s), 2.17 (3H, s).

Present compound 4-7: ¹H-NMR (CDCl₃) δ: 7.55 (1H, s), 7.41 (1H, t),7.33-7.28 (1H, m), 7.25-7.15 (3H, m), 6.90 (1H, dd), 6.82 (1H, d), 3.83(3H, s), 3.70 (3H, s), 2.17 (3H, s).

A compound represented by formula (2d):

wherein a combination of R¹⁹ and L represents ay combinations describedin [Table A7].

TABLE A7 Present Compound R¹⁹ L 4-8

O 4-9

NH 4-10

O

Present compound 4-8: ¹H-NMR (CDCl₃) δ: 7.36-7.29 (2H, m), 7.20 (1H, d),7.12-7.06 (1H, m), 7.03-7.00 (2H, m), 6.95 (1H, dd), 6.80 (1H, d), 4.06(3H, s), 3.87 (3H, s), 2.15 (3H, s).

Present compound 4-9: ¹H-NMR (CDCl₃) δ: 7.34-7.28 (2H, m), 7.18 (1H, d),7.10-7.05 (1H, m), 7.04-7.00 (2H, m), 6.93 (1H, dd), 6.78 (1H, d), 6.76(1H, br s), 3.96 (3H, s), 2.92 (3H, d), 2.15 (3H, s).

Present compound 4-10: ¹H-NMR (CDCl₃) δ: 7.21-7.03 (5H, m), 6.91 (1H,dd), 6.78 (1H, d), 4.05 (3H, s), 3.86 (3H, s), 2.15 (3H, s).

Preparation Example 4-2

The compounds which can be prepared according to the Preparation Exmaple4 are shown below.

A compound represented by formula (1d) wherein a combination of R²⁹,R³⁰, R³¹, R³², and R³³ represents any combinations described in [TableA8].

TABLE A8 Present Compound R²⁹ R³⁰ R³¹ R³² R³³ 4-11 F H H H F 4-16 H Me HMe H 4-17 H OCF₃ H H H 4-18 H H OCF₃ H H 4-19 CF₃ H H H H 4-21 Cl H H HH 4-22 H H Cl H H 4-23 F F H H H 4-24 F H F H H 4-25 F H H F H 4-26 H FF H H 4-27 H F H F H 4-28 OMe H H H H 4-29 H H OMe H H 4-30 CN H H H H4-31 H i-Pr H H H 4-32 H H CF₃ H H 4-33 OCF₃ H H H H 4-34 H t-Bu H H H4-35 H Ph H H H

Preparation Example 4-3

The compounds which were prepared according to the Preparation Example 4and their physical property value are shown below.

A compound represented by formula (1d) wherein a combination of R²⁹,R³⁰, R³¹, R³², and R³³ represents any combinations described in [TableA8-2].

TABLE A8-2 Present Compound R²⁹ R³⁰ R³¹ R³² R³³ 4-12 Me H H H H 4-13 HMe H H H 4-14 H H Me H H 4-15 H OMe H H H 4-20 H CN H H H

Present compound 4-12: ¹H-NMR (CDCl₃) δ: 7.52 (1H, s), 7.24-7.09 (3H,m), 7.02 (1H, td), 6.91 (1H, dd), 6.77 (1H, dd), 6.71 (1H, d), 3.81 (3H,s), 3.69 (3H, s), 2.25 (3H, s), 2.13 (3H, s).

Present compound 4-13: ¹H-NMR (CDCl₃) δ: 7.53 (1H, s), 7.18-7.15 (2H,m), 6.88-6.80 (5H, m), 3.81 (3H, s), 3.69 (3H, s), 2.31 (3H, s), 2.15(3H, s).

Present compound 4-14; 1H-NMR (CDCl₃) δ: 7.53 (1H, s), 7.24-7.20 (1H,m), 6.94-6.90 (2H, m), 6.83 (1H, dd), 6.79 (1H, d), 6.74-6.70 (2H, m),3.82 (3H, s), 3.70 (3H, s), 2.27 (3H, s), 2.14 (3H, s).

Present compound 4-15: ¹H-NMR (CDCl₃) δ: 7.54 (1H, s), 7.22-7.15 (2H,m), 6.88 (1H, dd), 6.82 (1H, d), 6.64-6.56 (3H, m), 3.82 (3H, s), 3.76(3H, s), 3.70 (3H, s), 2.15 (3H, s).

Present compound 4-20: ¹H-NMR (CDCl₃) δ: 7.57 (1H, s), 7.34-7.29 (1H,m), 7.25-7.17 (2H, m), 7.09-7.05 (2H, m), 6.89 (1H, dd), 6.82 (1H, d),3.86 (3H, s), 3.74 (3H, s), 2.18 (3H, s).

Preparation Example 5

To a mixture of the intermediate compound 19 0.25 g, 2-fluorophenol 0.12mL, and 1,4-dioxane 4 mL were added copper (I) iodide 0.08 g,N,N-dimethylglycine hydrochloride salt 0.18 g, and cesium carbonate 0.55g at room temperature, and the mixture was stirred at 110° C. for 7hours. The resulting mixture was diluted with ethyl acetate, andfiltered through Celite. The filtrates were washed with water andsaturated brine, dried over anhydrous sodium sulfate, and concentratedunder reduced pressure. The resulting residue was subjected to a silicagel column chromatography (ethyl acetate:hexane=1:2) to obtain thepresent compound 5-1 represented by the following formula 0.05 g.

Present compound 5-1: ¹H-NMR (CDCl₃) δ: 7.21-7.08 (5H, m), 6.97 (1H,dd), 6.83 (1H, d), 3.94 (3H, s), 3.43 (3H, s), 2.17 (3H, s).

Preparation Example 5-1

The compounds which were prepared according to the Preparation Example 5and their physical property value are shown below.

Present compound 5-2: LCMS: 345 [M+H]⁺, RT=1.98 minutes

Present compound 5-3: ¹H-NMR (CDCl₃) δ: 7.36-7.25 (2H, m), 7.09 (1H,dd), 7.04 (1H, d), 6.85-6.78 (2H, m), 6.75 (1H, dt), 3.71 (3H, s), 2.28(3H, s).

A compound represented by formula (2f):

wherein a combination of R¹, R²¹, R²², R²³, and E represents anycombinations described in [Table A9].

TABLE A9 Present Compound R¹ R²¹ R²² R²³ E 7-1 H F H H Me 7-2 F H H H Me7-3 Me H OMe H Me 7-4 H H H Me Me 7-5 Me H H H Me 7-6 H H H H CF₃ 7-7 HH Me H Me

Present compound 7-1: LCMS: 225 [M+H]⁺, RT=1.85

Present compound 7-2: ¹H-NMR (CDCl₃) δ: 7.58 (1H, s), 7.09-7.05 (1H, m),7.03 (1H, dd), 6.95 (1H, t), 3.86 (3H, s), 3.73 (3H, s), 2.32 (3H, s).

Present compound 7-3: LCMS: 251 [M+H]⁺, RT=1.88

Present compound 7-4: ¹H-NMR (CDCl₃) δ: 7.53 (1H, s), 6.91 (3H, bs),3.84 (3H, s), 3.73 (3H, s), 2.31 (6H, s).

Present compound 7-5: LCMS: 221 [M+H]⁺, RT=1.89

Present compound 7-6: ¹H-NMR (CDCl₃) δ: 7.61 (2H, bs), 7.53-7.51 (2H,m), 7.47-7.44 (1H, m), 3.89 (3H, s), 3.75 (3H, s).

Present compound 7-7: ¹H-NMR (CDCl₃) δ: 7.53 (1H, s), 7.13-7.03 (3H, m),3.84 (3H, s), 3.73 (3H, s), 2.26 (3H, s), 2.25 (3H, s).

A compound represented by formula (1h):

wherein R¹² represents the group described below.

Present compound 8-1 (R¹²=i-Pr): LCMS: 371 [M+H]⁺, RT=2.16 minutes

Present compound 8-2 (R¹²═CH₃CH(CH₃) CH₂): LCMS: 385 [M+H]⁺, RT=2.26minutes

Present compound 8-3 (R¹²=n-Pen): LCMS: 399 [M+H]⁺, RT=2.35 minutes

A compound represented by formula (1i):

wherein a combination of E, R¹ and R² represents any combinationsdescribed in [Table A10].

TABLE A10 Present Compound E R¹ R³ 9-1

H OMe 9-2

H OMe 9-3

H Me 9-4

H OMe 9-5

Me OMe

Present compound 9-1: LCMS: 334 [M+H]⁺, RT=1.53 minutes

Present compound 9-2: LCMS: 417 [M+H]⁺, RT=1.70 minutes

Present compound 9-3: LCMS: 401 [M+H]⁺, RT=1.57 minutes

Present compound 9-4: LCMS: 421 [M+H]⁺, RT=2.07 minutes

Present compound 9-5: LCMS: 354 [M+H]⁺, RT=2.01 minutes

Compound 9-6: LCMS: 388 [M+H]⁺, RT=2.21 minutes

Preparation Example 7

To a mixture of sodium hydride 0.03 g and DMF 3 mL was addedacetophenone oxime 0.10 g at 0° C., and the mixture was stirred at roomtemperature for 1 hour. To the resulting mixture was added a mixture ofmethyl (E)-2-(5-bromomethyl-2-methylphenyl)-3-methoxyacrylate (which wasprepared by the method described in WO 1999/028305 A1) 0.30 g and DMF 3mL, and the mixture was stirred at room temperature for 2 hours. To theresulting mixture was added aqueous ammonium chloride solution, and themixture was extracted with MTBE. The resulting organic layers werewashed with water and saturated brine successively, dried over anhydroussodium sulfate, and concentrated under reduced pressure. The resultingresidue was subjected to a silica gel column chromatography (hexane:ethyl acetate=1:4) to obtain the present compound 10-1 represented bythe following formula 0.07 g.

Present compound 10-1: ¹H-NMR (CDCl₃) δ: 7.67-7.62 (2H, m), 7.57 (1H,s), 7.36-7.28 (4H, m), 7.22 (1H, d), 7.16 (1H, s), 5.20 (2H, s), 3.79(3H, s), 3.68 (3H, s), 2.24 (3H, s), 2.18 (3H, s).

Preparation Example 7-1

The compounds which were prepared according to the Preparation Example 7and their physical property value are shown below.

Present compound 10-2: ¹H-NMR (CDCl₃) δ: 7.91 (1H, s), 7.83 (1H, d),7.62-7.57 (2H, m), 7.47 (1H, t), 7.29 (1H, d), 7.23 (1H, d), 7.17 (1H,s), 5.22 (2H, s), 3.80 (3H, s), 3.69 (3H, s), 2.26 (3H, s), 2.19 (3H,s). CH₃ CH₃

Present compound 10-3: ¹H-NMR (CDCl₃) δ: 7.66-7.61 (2H, m), 7.39-7.33(4H, m), 7.25 (1H, d), 7.16 (1H, d), 5.21 (2H, s), 4.03 (3H, s), 3.85(3H, s), 2.25 (3H, s), 2.19 (3H, s).

Present compound 10-4: ¹H-NMR (CDCl₃) δ: 7.58 (1H, s), 7.33-7.16 (5H,m), 7.01-6.91 (3H, m), 5.02 (2H, s), 3.80 (3H, s), 3.70 (3H, s), 2.20(3H, s).

Preparation Example 7-2

The compound which can be prepared according to the Preparation Example7 and their physical property value is shown below.

A compound represented by formula (2j):

wherein G⁶ represents any substituents described in [Table A11].

TABLE A11 Present Compound G⁶ 10-5

10-6

10-7

10-8

10-9

10-10

10-11

10-12

Preparation Example 8

A mixture of 1-[3-(trifluoromethyl)phenyl]ethane-1-one hydrazone 0.24 g,the intermediate compound 15 0.30 g and ethanol 6 mL was stirred at 80°C. for 2 hours. The resulting mixture was cooled to room temperature,and water was added thereto, and the mixture was extracted with ethylacetate. The resulting organic layers were washed with saturated brine,dried over anhydrous magnesium sulfate, and concentrated under reducedpressure. The resulting residue was subjected to a silica gel columnchromatography (ethyl acetate:hexane=2:1) to obtain the present compound11-1 represented by the following formula 0.21 g.

Present compound 11-1: ¹H-NMR (CDCl₃) δ: 8.15 (1H, s), 8.08 (1H, d),7.79 (1H, dd), 7.67-7.65 (2H, m), 7.61 (1H, s), 7.54 (1H, t), 7.29 (1H,d), 3.85 (3H, s), 3.72 (3H, s), 2.32 (3H, s), 2.29 (3H, s), 2.23 (3H,s).

Preparation Example 8-1

The compounds which were prepared according to the Preparation Example 8and their physical property value are shown below.

A compound represented by formula (1k):

wherein a combination of G⁵ and R⁷ represents any combinations describedin [Table A12].

TABLE A12 Present Compound G⁵ R⁷ 11-2

Me 11-3

Me 11-16

Me 11-17

Me 11-18

Me

Present compound 11-2: ¹H-NMR (CDCl₃) δ: 7.79 (1H, dd), 7.65 (1H, d),7.60 (1H, s), 7.28 (1H, d), 6.94 (1H, d), 3.84 (3H, s), 3.71 (3H, s),2.50 (3H, d), 2.43 (3H, s), 2.31 (3H, s), 2.23 (3H, s).

Present compound 11-3: ¹H-NMR (CDCl₃) δ: 8.20 (1H, dd), 7.77 (1H, dd),7.63 (1H, d), 7.60 (1H, s), 7.28 (1H, s), 6.75-6.69 (1H, m), 6.65-6.61(1H, m), 4.31 (2H, t), 3.84 (3H, s), 3.71 (3H, s), 3.00 (2H, t), 2.37(3H, s), 2.22 (3H, s).

Present compound 11-6: LCMS: 352 [M+H]⁺, RT=1.80

Present compound 11-7: ¹H-NMR (CDCl₃) δ: 7.78 (1H, dd), 7.66 (1H, d),7.60 (1H, s), 7.40 (1H, d), 7.29-7.27 (2H, m), 7.21 (1H, t), 3.84 (3H,s), 3.71 (3H, s), 3.23 (2H, t), 2.95 (2H, t), 2.30 (3H, s), 2.28 (3H,s), 2.22 (3H, s), 2.11-2.03 (2H, m).

Present compound 1 11-8: ¹H-NMR (CDCl₃) δ: 7.88 (1H, d), 7.80 (1H, dd),7.66 (1H, d), 7.60 (1H, s), 7.39 (1H, d), 7.29 (1H, d), 3.84 (3H, s),3.72 (3H, s), 2.46 (3H, s), 2.33 (3H, s), 2.23 (3H, s).

Preparation Example 8-2

The compounds which can be prepared according to the Preparation example8 are shown below.

The compounds represented by formula (1k) wherein a combination of G⁵and R⁷ represents any combinations described in [Table A13].

TABLE A13 Present Compound G⁵ R⁷ 11-4

Me 11-6

H 11-7

H 11-8

H 11-9

Me 11-10

Me 11-11

Me 11-12

Me 11-13

Et 11-14

Et 11-15

Et

Preparation Example 8-3

The compounds which were prepared according to the Preparation Example 8and their physical property value are shown below.

The compounds represented by formula (1k) wherein a combination of G⁵and R⁷ represents any combinations described in [Table A13-2].

TABLE A13-2 Present Compound G⁵ R⁷ 11-5

Me

Present compound 11-5: ¹H-NMR (CDCl₃) δ: 8.64 (1H, dq), 8.22 (1H, dt),7.79 (1H, dd), 7.74 (1H, td), 7.66 (1H, d), 7.60 (1H, s), 7.31-7.28 (2H,m), 3.85 (3H, s), 3.72 (3H, s), 2.37 (3H, s), 2.25 (3H, s), 2.23 (3H,s).

Preparation Example 8-4

The compounds which were prepared according to the Preparation Example 8and their physical property value are shown below.

Present compound 11-19: ¹H-NMR (CDCl₃) δ: 7.97 (1H, dd), 7.89 (1H, d),7.42 (1H, d), 6.96 (1H, d), 3.74 (3H, s), 2.50 (3H, d), 2.45 (3H, s),2.34 (6H, s).

Present compound 11-20: ¹H-NMR (CDCl₃) δ: 7.97 (1H, dd), 7.92 (1H, d),7.89 (1H, d), 7.44-7.30 (4H, m), 3.74 (3H, s), 3.12-3.06 (2H, m),2.96-2.90 (2H, m), 2.41 (3H, s), 2.33 (3H, s).

Preparation Example 9

A mixture of the present compound 2-9 0.23 g, 10% palladium/carbon 0.10g, ammonium formate 0.06 g, and THE 6 mL was stirred at 80° C. for 5hours. The resulting mixture was cooled to room temperature, and theretowas added aqueous saturated sodium hydrogencarbonate solution, and themixture was filtered through Celite (registered trademark). Theresulting filtrates were extracted with ethyl acetate, dried overanhydrous magnesium sulfate, and concentrated reduced pressure to obtainthe present compound 12-1 represented by the following formula 0.21 g.

Present compound 12-1: ¹H-NMR (CDCl₃) δ: 7.55 (1H, s), 7.13 (1H, d),7.04 (1H, dd), 6.92 (1H, d), 3.81 (3H, s), 3.70 (3H, s), 2.56 (2H, t),2.14 (3H, s), 1.64-1.54 (2H, m), 1.34-1.30 (3H, m), 0.91-0.86 (2H, m).

Preparation Example 9-1

The compounds which were prepared according to the Preparation Example 9and their physical property value are shown below.

Present compound 12-2: ¹H-NMR (CDCl₃) δ: 7.55 (1H, s), 7.30-7.25 (2H,m), 7.20-7.12 (4H, m), 7.05 (1H, dd), 6.93 (1H, d), 3.81 (3H, s), 3.69(3H, s), 2.68-2.59 (4H, m), 2.14 (3H, s), 2.00-1.91 (2H, m).

Present compound 12-3: ¹H-NMR (CDCl₃) δ: 7.56 (1H, s), 7.14 (1H, d),7.07 (1H, dd), 6.95 (1H, d), 3.82 (3H, s), 3.70 (3H, s), 2.51-2.41 (1H,m), 2.14 (3H, s), 1.92-1.69 (5H, m), 1.46-1.28 (5H, m).

Preparation Example 10

A mixture of the intermediate compound 14 0.27 g, benzylbromide 0.15 mL,[1,1′-bisdiphenylphosphino)ferrocene]palladium (II) dichloride 0.03 g,tripotassium phosphate 0.52 g, and dimethoxyethane 5 mL was stirredunder reflux for 5 hours under nitrogen atmosphere. The resultingmixture was filtered through Celite (registered trademark), and thefiltrates were concentrated under reduced pressure. The resultingresidue was subjected to a silica gel column chromatography (ethylacetate:hexane=1:3) to obtain the present compound 3-1 represented bythe following formula 0.09 g.

Present compound 13-1: ¹H-NMR (CDCl₃) δ: 7.53 (1H, d), 7.29-7.24 (2H,m), 7.21-7.11 (4H, m), 7.00 (1H, d), 6.95 (1H, s), 3.95 (2H, s), 3.79(3H, s), 3.68 (3H, s), 2.14 (3H, s).

Preparation Example 10-1

The compounds which were prepared according to the Preparation Example10 and their physical property value are shown below.

A compound represented by formula (11):

wherein G⁷ represents any substituents described in [Table A15].

TABLE A15 Present Compound G⁷ 13-2

13-3

13-4

Present compound 13-2: ¹H-NMR (CDCl₃) δ: 7.54 (1H, s), 7.18-7.11 (3H,m), 7.06-6.96 (4H, m), 3.96 (2H, s), 3.79 (3H, s), 3.68 (3H, s), 2.14(3H, s).

Present compound 13-3: ¹H-NMR (CDCl₃) δ: 7.52 (1H, s), 7.16-7.08 (5H,m), 6.95 (1H, dd), 6.89 (1H, d), 3.94 (2H, s), 3.80 (3H, s), 3.68 (3H,s), 2.25 (3H, s), 2.14 (3H, s).

Present compound 13-4: ¹H-NMR (CDCl₃) δ: 7.55 (1H, s), 7.16 (1H, d),7.00 (1H, dd), 6.93 (1H, d), 6.74-6.67 (2H, m), 6.65-6.59 (1H, m), 3.91(2H, s), 3.82 (3H, s), 3.70 (3H, s), 2.16 (3H, s).

Preparation Example 12

A mixture of the intermediate compound 25 0.30 g, sodium hydride (60%,in oil) 0.05 g, and DMF 5 mL was stirred under ice-cooling for 15minutes. To the resulting mixture was added5-chloro-3-methyl-1,2,4-thiadiazole 0.22 g, and the mixture was stirredat room temperature for 5 hours. To the resulting mixture was addedaqueous saturated ammonium chloride solution, and the mixture wasextracted with MTBE. The resulting organic layers were washed withsaturated brie, dried over anhydrous sodium sulfate, and concentratedunder reduced pressure. The resulting residue was subjected to a silicagel column chromatography (ethyl acetate:hexane=1:4) to obtain thepresent compound 14-1 represented by the following formula 0.41 g.

Present compound 14-1: ¹H-NMR (CDCl₃) δ: 7.58 (1H, s), 7.29 (1H, d),7.17 (1H, dd), 7.08 (1H, d), 3.85 (3H, s), 3.71 (3H, s), 2.51 (3H, s),2.20 (3H, s).

Preparation Example 12-1

The compounds which were prepared according to the Reference PreparationExample 3 and their physical property value are shown below.

A compound represented by formula (1m):

wherein G⁸ represents any substituents described in [Table A16].

TABLE A16 Present Compound G⁸ 14-2

14-3

Present compound 14-2: ¹H-NMR (CDCl₃) δ: 8.22-8.19 (2H, m), 7.60 (1H,s), 7.47-7.42 (3H, m), 7.32 (1H, d), 7.23 (1H, dd), 7.16 (1H, d), 3.86(3H, s), 3.73 (3H, s), 2.23 (3H, s).

Present compound 14-3: ¹H-NMR (CDCl₃) δ: 7.57 (1H, s), 7.26 (1H, d),7.14 (1H, dd), 7.04 (1H, d), 6.54 (1H, s), 3.85 (3H, s), 3.71 (3H, s),2.19 (3H, s).

A compound represented by formula (2m):

wherein a combination of R⁶⁰, R⁶¹, and Z⁴ represents any combinationsdescribed in [Table A16-2].

TABLE A16-2 Present Compound R⁶⁰ R⁶¹ Z⁴ 14-4 H H C 14-5 Me H C 14-6 Cl HC 14-7 Br H C 14-8 CF₃ H C 14-9 —C≡CH H C 14-10 —C≡C-c-Pr H C 14-11—C≡C—Si(CH₃)₃ H C 14-12 c-Pr H C 14-13 H Br C 14-14 H CF₃ C 14-15 H3-Br—Ph C 14-16 — Cl N

Present compound 14-4: ¹H-NMR (CDCl₃) δ: 7.56 (1H, s), 7.27-7.21 (2H,m), 7.15 (1H, dd), 7.04 (1H, d), 6.78 (1H, d), 3.84 (3H, s), 3.70 (3H,s), 2.18 (3H, s).

Present compound 14-5: ¹H-NMR (CDCl₃) δ: 7.56 (1H, s), 7.23 (1H, d),7.11 (1H, dd), 7.01 (1H, d), 6.87 (1H, s), 3.83 (3H, s), 3.70 (3H, s),2.32 (3H, d), 2.17 (3H, s).

Present compound 14-6: ¹H-NMR (CDCl₃) δ: 7.57 (1H, s), 7.25 (1H, d),7.12 (1H, dd), 7.05 (1H, s), 7.02 (1H, d), 3.84 (3H, s), 3.71 (3H, s),2.18 (3H, s).

Present compound 14-7: ¹H-NMR (CDCl₃) δ: 7.57 (1H, s), 7.27-7.24 (1H,m), 7.16 (1H, s), 7.12 (1H, dd), 7.02 (1H, d), 3.84 (3H, s), 3.71 (3H,s), 2.18 (3H, s).

Present compound 14-8: ¹H-NMR (CDCl₃) δ: 7.58 (1H, s), 7.56 (1H, q),7.29 (1H, d), 7.15 (1H, dd), 7.06 (1H, d), 3.85 (3H, s), 3.71 (3H, s),2.20 (3H, s).

Present compound 14-9: ¹H-NMR (CDCl₃) δ: 7.57 (1H, s), 7.40 (1H, s),7.26 (1H, d), 7.13 (1H, dd), 7.04 (1H, d), 3.84 (3H, s), 3.71 (3H, s),3.31 (1H, s), 2.18 (3H, s).

Present compound 14-10: LCMS: 370 [M+H]⁺, RT=2.24 minutes Presentcompound 14-11: ¹H-NMR (CDCl₃) δ: 7.57 (1H, s), 7.35 (1H, s), 7.27-7.22(1H, m), 7.12 (1H, dd), 7.02 (1H, d), 3.84 (3H, s), 3.71 (3H, s), 2.18(3H, s), 0.22 (9H, s).

Present compound 14-12: ¹H-NMR (CDCl₃) δ: 7.56 (1H, s), 7.23 (1H, d),7.11 (1H, dd), 7.00 (1H, d), 6.89 (1H, s), 3.83 (3H, s), 3.70 (3H, s),2.17 (3H, s), 1.92-1.83 (1H, m), 0.95-0.87 (2H, m), 0.69-0.61 (2H, m).

Present compound 14-13: ¹H-NMR (CDCl₃) δ: 7.57 (1H, s), 7.26 (1H, d),7.14 (1H, dd), 7.03 (1H, d), 6.69 (1H, s), 3.85 (3H, s), 3.71 (3H, s),2.19 (3H, s).

Present compound 14-14: ¹H-NMR (CDCl₃) δ: 7.58 (1H, s), 7.28 (1H, d),7.23-7.22 (1H, m), 7.17 (1H, dd), 7.07 (1H, d), 3.85 (3H, s), 3.71 (3H,s), 2.20 (3H, s).

Present compound 14-15: ¹H-NMR (CDCl₃) δ: 7.98 (1H, t), 7.76-7.72 (1H,m), 7.58 (1H, s), 7.44-7.40 (1H, m), 7.30-7.18 (3H, m), 7.12 (1H, d),6.99 (1H, s), 3.85 (3H, s), 3.72 (3H, s), 2.20 (3H, s).

Present compound 14-16: ¹H-NMR (CDCl₃) δ: 7.59 (1H, s), 7.32 (1H, d),7.17 (1H, dd), 7.08 (1H, d), 3.86 (3H, s), 3.72 (3H, s), 2.21 (3H, s).

A compound represented by formula (3m):

wherein a combination of R⁶², R⁶³ and R⁶⁴ represents any combinationsdescribed in [Table A16-3].

TABLE A16-3 Present Compound R⁶² R⁶³ R⁶⁴ 14-17 H H H 14-18 H F H 14-19 HCl H

Present compound 14-17: ¹H-NMR (CDCl₃) δ: 8.53 (2H, d), 7.57 (1H, s),7.26 (1H, d), 7.09-7.04 (1H, m), 7.03-6.96 (2H, m), 3.82 (3H, s), 3.70(3H, s), 2.19 (3H, s).

Present compound 14-18: ¹H-NMR (CDCl₃) δ: 8.39 (2H, s), 7.56 (1H, s),7.26 (1H, d), 7.04 (1H, dd), 6.95 (1H, d), 3.82 (3H, s), 3.69 (3H, s),2.19 (3H, s).

Present compound 14-19: ¹H-NMR (CDCl₃) δ: 8.37 (2H, s), 7.56 (1H, s),7.26 (1H, d), 6.93 (1H, dd), 6.83 (1H, d), 3.85 (3H, s), 3.71 (3H, s),2.18 (3H, s).

A compound represented by formula (4m):

wherein a combination of R⁶⁵, R⁶⁶ and R⁶⁷ represents any combinationsdescribed in [Table A16-4].

TABLE A16-4 Present Compound R⁶⁵ R⁶⁶ R⁶⁷ 14-20 H Cl H 14-21 H Cl F 14-22H Me H 14-23 H Pho H 14-24 H 2-CN-PhO H 14-25 H 2,6-F₂-PhO H

Present compound 14-20: ¹H-NMR (CDCl₃) δ: 8.60 (1H, s), 7.58 (1H, s),7.29 (1H, d), 7.01 (1H, dd), 6.91 (1H, d), 6.88 (1H, s), 3.85 (3H, s),3.71 (3H, s), 2.20 (3H, s).

Present compound 14-21: ¹H-NMR (CDCl₃) δ: 8.30 (1H, s), 7.58 (1H, s),7.29 (1H, d), 7.06 (1H, dd), 6.96 (1H, d), 3.84 (3H, s), 3.71 (3H, s),2.20 (3H, s).

Present compound 14-22: ¹H-NMR (CDCl₃) δ: 8.68 (1H, s), 7.57 (1H, s),7.27 (1H, d), 7.01 (1H, dd), 6.91 (1H, d), 6.69 (1H, s), 3.83 (3H, s),3.71 (3H, s), 2.47 (3H, s), 2.20 (3H, s).

Present compound 14-23: ¹H-NMR (CDCl₃) δ: 8.45 (1H, d), 7.57 (1H, s),7.47-7.41 (2H, m), 7.31-7.24 (2H, m), 7.17-7.12 (2H, m), 7.02 (1H, dd),6.93 (1H, d), 6.29 (1H, d), 3.84 (3H, s), 3.71 (3H, s), 2.19 (3H, s).

Present compound 14-24: ¹H-NMR (CDCl₃) δ: 8.42 (1H, d), 7.72 (1H, dd),7.69-7.64 (1H, m), 7.59 (1H, s), 7.37 (1H, td), 7.32-7.28 (2H, m), 7.05(1H, dd), 6.96 (1H, d), 6.49 (1H, d), 3.85 (3H, s), 3.72 (3H, s), 2.21(3H, s).

Present compound 14-25: ¹H-NMR (CDCl₃) δ: 8.41 (1H, d), 7.58 (1H, s),7.29 (1H, d), 7.25-7.17 (1H, m), 7.07-6.99 (3H, m), 6.95 (1H, d), 6.47(1H, d), 3.85 (3H, s), 3.72 (3H, s), 2.20 (3H, s).

A compound represented by formula (5m):

wherein a combination of R⁶⁸, R⁶⁹, R⁷⁰, R⁷, and Z⁵ represents anycombinations described in [Table A16-5].

TABLE A16-5 Present Compound R⁶⁸ R⁶⁹ R⁷⁰ R⁷¹ Z⁵ 14-26 H H H H S 14-27 HCl H H S 14-28 H H Cl H S 14-29 H F H H S 14-30 H Me H H S 14-31 H H OMeH S 14-32 H F H F S 14-33 H Cl H H O

Present compound 14-26: ¹H-NMR (CDCl₃) δ: 7.75 (1H, d), 7.66 (1H, d),7.58 (1H, s), 7.41-7.36 (1H, m), 7.31-7.20 (3H, m), 7.11 (1H, d), 3.85(3H, s), 3.72 (3H, s), 2.21 (3H, s).

Present compound 14-27: ¹H-NMR (CDCl₃) δ: 7.64 (1H, d), 7.62 (1H, d),7.58 (1H, s), 7.34 (1H, dd), 7.29 (1H, d), 7.22 (1H, dd), 7.11 (1H, d),3.85 (3H, s), 3.72 (3H, s), 2.21 (3H, s).

Present compound 14-28: ¹H-NMR (CDCl₃) δ: 7.72 (1H, d), 7.58 (1H, s),7.55 (1H, d), 7.29 (1H, d), 7.24-7.19 (2H, m), 7.11 (1H, d), 3.85 (3H,s), 3.72 (3H, s), 2.21 (3H, s).

Present compound 14-29: ¹H-NMR (CDCl₃) δ: 7.67 (1H, dd), 7.58 (1H, s),7.35 (1H, dd), 7.29 (1H, d), 7.22 (1H, dd), 7.13-7.07 (2H, m), 3.84 (3H,s), 3.72 (3H, s), 2.21 (3H, s).

Present compound 14-30: ¹H-NMR (CDCl₃) δ: 7.62 (1H, d), 7.58 (1H, s),7.44 (1H, s), 7.28 (1H, d), 7.24-7.17 (2H, m), 7.10 (1H, d), 3.84 (3H,s), 3.71 (3H, s), 2.42 (3H, s), 2.20 (3H, s).

Present compound 14-31: ¹H-NMR (CDCl₃) δ: 7.63 (1H, d), 7.57 (1H, s),7.27 (1H, d), 7.22 (1H, dd), 7.15 (1H, d), 7.10 (1H, d), 6.97 (1H, dd),3.84 (3H, s), 3.83 (3H, s), 3.71 (3H, s), 2.20 (3H, s).

Present compound 14-32: ¹H-NMR (CDCl₃) δ: 7.58 (1H, s), 7.29 (1H, d),7.23 (1H, dd), 7.19-7.15 (1H, m), 7.13 (1H, d), 6.95-6.88 (1H, m), 3.86(3H, s), 3.72 (3H, s), 2.21 (3H, s).

Present compound 14-33: ¹H-NMR (CDCl₃) δ: 7.58 (1H, s), 7.43-7.38 (2H,m), 7.29 (2H, d), 7.23 (1H, dd), 7.15 (1H, t), 3.84 (3H, s), 3.71 (3H,s), 2.19 (3H, s).

Present compound 14-34: ¹H-NMR (CDCl₃) δ: 7.95 (1H, t), 7.72 (1H, dt),7.46-7.40 (4H, m), 7.28-7.22 (1H, m), 7.05 (1H, s), 3.73 (3H, s), 2.34(3H, s).

A compound represented by formula (6m):

wherein a combination of R⁷², R⁷³, R⁷⁴, and R⁷⁵ represents anycombinations described in [Table A16-6].

TABLE A16-6 Present Compound R⁷² R⁷³ R⁷⁴ R⁷⁵ 4-59 Cl H H H 4-60 H H Cl H4-61 H H H Cl 4-62 H H F H 4-63 H H CF₃ H 4-64 Cl H Cl H 4-65 F H F H4-66 Cl H Cl Cl

Present compound 4-59: ¹H-NMR (CDCl₃) δ: 8.12 (1H, dd), 7.55 (1H, s),7.25-7.20 (2H, m), 7.16 (1H, dd), 6.89 (1H, dd), 6.81 (1H, d), 3.84 (3H,s), 3.71 (3H, s), 2.17 (3H, s).

Present compound 4-60: ¹H-NMR (CDCl₃) δ: 8.13 (1H, d), 7.60 (1H, dd),7.56 (1H, s), 7.24 (1H, d), 6.99 (1H, dd), 6.89 (1H, d), 6.84 (1H, d),3.83 (3H, s), 3.70 (3H, s), 2.18 (3H, s).

Present compound 4-61: ¹H-NMR (CDCl₃) δ: 7.60-7.53 (2H, m), 7.23 (1H,d), 7.03-6.97 (2H, m), 6.92 (1H, d), 6.71 (1H, d), 3.82 (3H, s), 3.70(3H, s), 2.18 (3H, s).

Present compound 4-62: ¹H-NMR (CDCl₃) δ: 8.03 (1H, d), 7.55 (1H, s),7.42-7.36 (1H, m), 7.23 (1H, d), 6.98 (1H, dd), 6.89 (1H, d), 6.86 (1H,dd), 3.82 (3H, s), 3.70 (3H, s), 2.17 (3H, s).

Present compound 4-63: ¹H-NMR (CDCl₃) δ: 8.46 (1H, s), 7.86 (1H, dd),7.57 (1H, s), 7.27 (1H, d), 7.02 (1H, dd), 6.97 (1H, d), 6.92 (1H, d),3.84 (3H, s), 3.71 (3H, s), 2.19 (3H, s).

Present compound 4-64: ¹H-NMR (CDCl₃) δ: 7.96 (1H, d), 7.74 (1H, d),7.56 (1H, s), 7.25 (1H, d), 7.01 (1H, dd), 6.91 (1H, d), 3.83 (3H, s),3.70 (3H, s), 2.18 (3H, s).

Present compound 4-65: ¹H-NMR (CDCl₃) δ: 7.71 (1H, t), 7.56 (1H, s),7.24 (1H, d), 7.09 (1H, td), 6.92 (1H, t), 6.85 (1H, d), 3.85 (3H, s),3.71 (3H, s), 2.19 (3H, s).

Present compound 4-66: ¹H-NMR (CDCl₃) δ: 7.81 (1H, s), 7.57 (1H, s),7.24 (1H, d), 7.04 (1H, dd), 6.93 (1H, d), 3.85 (3H, s), 3.71 (3H, s),2.19 (3H, s).

A compound represented by formula (7m):

wherein a combination of R⁷⁶, R⁷⁷, R⁷⁸, and R⁷⁹ represents anycombinations described in [Table A16-7].

TABLE A16-7 Present Compound R⁷⁶ R⁷⁷ R⁷⁸ R⁷⁹ 4-67 Cl H H H 4-68 H F H H

Present compound 4-67: ¹H-NMR (CDCl₃) δ: 8.55 (1H, s), 8.27 (1H, d),7.57 (1H, s), 7.28 (1H, d), 6.97 (1H, dd), 6.89 (1H, d), 6.71 (1H, d),3.85 (3H, s), 3.72 (3H, s), 2.20 (3H, s).

Present compound 4-68: ¹H-NMR (CDCl₃) δ: 8.05 (1H, d), 7.57 (1H, s),7.28 (1H, d), 6.96 (1H, dd), 6.88 (1H, d), 6.78 (1H, dd), 6.41 (1H, d),3.86 (3H, s), 3.72 (3H, s), 2.20 (3H, s).

Present compound 14-44: ¹H-NMR (CDCl₃) δ: 7.56 (1H, s), 7.13 (1H, s),7.03 (1H, s), 6.96 (1H, s), 3.84 (3H, s), 3.70 (3H, s), 2.23 (3H, s),2.16 (3H, s).

Preparation Example 12-2

The compounds which can be prepared according to the Preparation Example12 are shown below.

A compound represented by formula (8m):

wherein a combination of R⁸³, R⁸⁴, R⁸⁵, Z⁶ and L⁷ represents anycombinations described in [Table A16-8].

TABLE A16-8 Present Compound R⁸³ R⁸⁴ R⁸⁵ Z⁶ L⁷ 14-35 H H H C O 14-36 H H— N O 14-37 Cl H — N O 14-38 Br H — N O 14-39 CF₃ H — N O 14-40 —C≡CH H— N O 14-41 —C≡C-c-Pr H — N O 14-42 c-Pr H — N O 14-43 H CF₃ — N O 14-45H H H C NH 14-46 H H — N NH 14-47 Cl H — N NH 14-48 Br H — N NH 14-49CF₃ H — N NH 14-50 —C≡CH H — N NH 14-51 —C≡C-c-Pr H — N NH 14-52 c-Pr H— N NH 14-53 H CF₃ — N NH

Preparation Example 13

At room temperature, to a mixture of 1-bromo-3-(trifluoromethoxy)benzene0.20 g, copper (I) iodide 0.14 g, N,N′-dimethylcyclohexane-1,2-diamine0.14 mL, potassium carbonate 0.19 g, and DMF 4 mL was added theintermediate compound 25 0.15 g, and the mixture was stirred at 90° C.for 6 hours. Water was added to the resulting mixture, and the mixturewas extracted with MTBE. The resulting organic layers were washed withsaturated brine, dried over anhydrous sodium sulfate, and concentratedunder reduced pressure. The resulting residue was subjected to a silicagel column chromatography (ethyl acetate:hexane=1:3) to obtain thepresent compound 4-17 represented by the following formula 0.19 g.

Present compound 4-17: ¹H-NMR (CDCl₃) δ: 7.55 (1H, s), 7.29 (1H, t),7.21 (1H, d), 6.96-6.88 (3H, m), 6.86 (1H, s), 6.83 (1H, d), 3.83 (3H,s), 3.70 (3H, s), 2.17 (3H, s).

Preparation Example 13-1

The compounds which were prepared according to the Preparation Example13 and their physical property value are shown below.

The compounds represented by formula (1d) wherein a combination of R²⁹,R³⁰, R³¹, R³², and R³³ represents any combinations described in [TableA17].

TABLE A17 Present Compound R²⁹ R³⁰ R³¹ R³² R³³ 4-27 H F H F H 4-34 Ht-Bu H H H 4-36 H OPh H H H 4-21 Cl H H H H 4-22 H H Cl H H 4-24 F H F HH 4-28 OMe H H H H 4-29 H H OMe H H

Present compound 4-27: ¹H-NMR (CDCl₃) δ: 7.56 (1H, s), 7.23 (1H, d),6.91 (1H, dd), 6.84 (1H, d), 6.52-6.47 (2H, m), 6.38-6.33 (1H, m), 3.84(3H, s), 3.72 (3H, s), 2.18 (3H, s).

Present compound 4-34: ¹H-NMR (CDCl₃) δ: 7.53 (1H, s), 7.23 (1H, t),7.17 (1H, d), 7.12-7.08 (2H, m), 6.87 (1H, dd), 6.83-6.78 (2H, m), 3.82(3H, s), 3.69 (3H, s), 2.15 (3H, s), 1.30 (9H, s).

Present compound 4-36: ¹H-NMR (CDCl₃) δ: 7.53 (1H, s), 7.35-7.28 (2H,m), 7.25-7.19 (1H, m), 7.17 (1H, d), 7.12-7.06 (1H, m), 7.03-6.99 (2H,m), 6.89 (1H, dd), 6.83 (1H, d), 6.75-6.65 (3H, m), 3.79 (3H, s), 3.68(3H, s), 2.15 (3H, s).

Present compound 4-21: ¹H-NMR (CDCl₃) δ: 7.54 (1H, s), 7.43 (1H, dd),7.21-7.15 (2H, m), 7.03 (1H, td), 6.98 (1H, dd), 6.84 (1H, dd), 6.79(1H, d), 3.83 (3H, s), 3.70 (3H, s), 2.15 (3H, s).

Present compound 4-22: ¹H-NMR (CDCl₃) δ: 7.54 (1H, s), 7.28-7.23 (2H,m), 7.18 (1H, d), 6.97-6.92 (2H, m), 6.86 (1H, dd), 6.79 (1H, d), 3.83(3H, s), 3.70 (3H, s), 2.16 (3H, s).

Present compound 4-24: ¹H-NMR (CDCl₃) δ: 7.54 (1H, s), 7.15 (1H, d),7.08-7.00 (1H, m), 6.96-6.89 (1H, m), 6.85-6.77 (2H, m), 6.75 (1H, d),3.83 (3H, s), 3.70 (3H, s), 2.14 (3H, s).

Present compound 4-28: ¹H-NMR (CDCl₃) δ: 7.53 (1H, s), 7.13 (1H, d),7.11-7.06 (1H, m), 7.00-6.95 (2H, m), 6.91-6.86 (1H, m), 6.82-6.77 (2H,m), 3.84 (3H, s), 3.81 (3H, s), 3.68 (3H, s), 2.13 (3H, s).

Present compound 4-29: ¹H-NMR (CDCl₃) δ: 7.53 (1H, s), 7.13 (1H, d),7.01-6.95 (2H, m), 6.89-6.83 (2H, m), 6.79 (1H, dd), 6.75 (1H, d), 3.82(3H, s), 3.80 (3H, s), 3.70 (3H, s), 2.13 (3H, s).

A compound represented by formula (2p):

wherein a combination of L⁵, R³⁴, R³⁵, R³⁶, R³⁷, and R³⁸ represents anycombinations described in [Table A18].

TABLE A18 Present Compound L⁵ R³⁴ R³⁵ R³⁶ R³⁷ R³⁸ 4-37 O H F H H H 4-38NH H F H H H 4-39 O Me H H H H 4-40 NH Me H H H H

Present compound 4-37: ¹H-NMR (CDCl₃) δ: 7.32-7.22 (4H, m), 7.16 (1H,dd), 6.98 (1H, dd), 6.82 (1H, d), 4.06 (3H, s), 3.87 (3H, s), 2.17 (3H,s).

Present compound 4-38: ¹H-NMR (CDCl₃) δ: 7.28-7.19 (2H, m), 6.96 (1H,dd), 6.81-6.70 (5H, m), 3.97 (3H, s), 2.93 (3H, d), 2.16 (3H, s).

Present compound 4-39: ¹H-NMR (CDCl₃) δ: 7.25-7.21 (1H, m), 7.17-7.12(2H, m), 7.06-7.02 (1H, m), 6.90 (1H, dd), 6.85 (1H, dd), 6.69 (1H, d),4.04 (3H, s), 3.86 (3H, s), 2.24 (3H, s), 2.14 (3H, s).

Present compound 4-40: ¹H-NMR (CDCl₃) δ: 7.22 (1H, d), 7.16-7.10 (2H,m), 7.06-7.00 (1H, m), 6.92 (1H, d), 6.82 (1H, dd), 6.75 (1H, br s),6.69 (1H, d), 3.95 (3H, s), 2.90 (3H, d), 2.24 (3H, s), 2.13 (3H, s).

A compound represented by formula (20):

wherein G⁴ represents any substituents described in [Table A19] and[Tale 19-2].

TABLE A19 Present Compound G⁴ 4-41

4-42

4-43

4-44

4-45

4-46

TABLE A19-2 Present Compound G⁴ 4-69

4-70

4-71

4-72

4-73

4-74

4-75

4-76

4-77

Present compound 4-41: ¹H-NMR (CDCl₃) δ: 8.21-8.19 (1H, m), 7.64 (1H,ddd), 7.55 (1H, s), 7.23 (1H, d), 7.01 (1H, dd), 6.96 (1H, ddd), 6.91(1H, d), 6.86 (1H, dt), 3.82 (3H, s), 3.70 (3H, s), 2.17 (3H, s).

Present compound 4-42: ¹H-NMR (CDCl₃) δ: 7.55 (1H, s), 7.52-7.48 (1H,m), 7.21 (1H, d), 6.99 (1H, dd), 6.91 (1H, d), 6.84 (1H, d), 6.55 (1H,d), 3.83 (3H, s), 3.70 (3H, s), 2.47 (3H, s), 2.17 (3H, s).

Present compound 4-43: ¹H-NMR (CDCl₃) δ: 7.79 (1H, t), 7.56 (1H, s),7.36 (1H, d), 7.24 (1H, s), 7.05 (1H, dd), 7.00 (1H, d), 6.95 (1H, d),3.83 (3H, s), 3.70 (3H, s), 2.19 (3H, s).

Present compound 4-44: ¹H-NMR (CDCl₃) δ: 7.55 (1H, s), 7.50 (1H, t),7.22 (1H, d), 7.02 (1H, dd), 6.93 (1H, d), 6.42 (1H, d), 6.30 (1H, d),3.84 (3H, s), 3.82 (3H, s), 3.70 (3H, s), 2.18 (3H, s).

Present compound 4-45: ¹H-NMR (CDCl₃) δ: 7.71 (1H, q), 7.56 (1H, s),7.24 (1H, d), 7.01 (1H, dd), 6.92 (1H, d), 6.67 (1H, dd), 6.58 (1H, dd),3.84 (3H, s), 3.71 (3H, s), 2.18 (3H, s).

Present compound 4-46: ¹H-NMR (CDCl₃) δ: 7.92 (1H, d), 7.56 (1H, s),7.44 (1H, t), 7.24 (1H, d), 7.04 (1H, d), 6.98-6.94 (2H, m), 3.83 (3H,s), 3.70 (3H, s), 2.18 (3H, s).

Present compound 4-69: ¹H-NMR (CDCl₃) δ: 8.16 (1H, dd), 7.56 (1H, s),7.25 (1H, d), 7.01 (1H, dd), 6.91 (1H, d), 6.75-6.71 (1H, m), 6.55 (1H,dd), 3.83 (3H, s), 3.70 (3H, s), 2.18 (3H, s).

Present compound 4-70: ¹H-NMR (CDCl₃) δ: 8.10 (1H, d), 7.56 (1H, s),7.25 (1H, d), 7.02-6.96 (2H, m), 6.90 (1H, d), 6.88 (1H, d), 3.83 (3H,s), 3.71 (3H, s), 2.18 (3H, s).

Present compound 4-71: ¹H-NMR (CDCl₃) δ: 8.41 (1H, d), 8.33 (1H, dd),7.55 (1H, s), 7.32-7.28 (1H, m), 7.26-7.19 (2H, m), 6.89 (1H, dd), 6.82(1H, d), 3.84 (3H, s), 3.71 (3H, s), 2.17 (3H, s).

Present compound 4-72: ¹H-NMR (CDCl₃) δ: 7.89 (1H, dd), 7.54 (1H, s),7.19-7.14 (2H, m), 6.86-6.78 (3H, m), 4.01 (3H, s), 3.82 (3H, s), 3.69(3H, s), 2.15 (3H, s).

Present compound 4-73: ¹H-NMR (CDCl₃) δ: 7.97-7.95 (1H, m), 7.55 (1H,s), 7.47-7.41 (1H, m), 7.20 (1H, d), 6.92-6.84 (2H, m), 6.79 (1H, d),3.84 (3H, s), 3.71 (3H, s), 2.16 (3H, s).

Present compound 4-74: ¹H-NMR (CDCl₃) δ: 7.54 (1H, s), 7.22 (1H, dd),7.16 (1H, d), 6.91 (1H, dd), 6.88-6.85 (2H, m), 6.57 (1H, dd), 3.83 (3H,s), 3.70 (3H, s), 2.14 (3H, s).

Present compound 4-75: ¹H-NMR (CDCl₃) δ: 7.76 (1H, d), 7.60-7.54 (3H,m), 7.40-7.35 (2H, m), 7.19 (1H, d), 7.06 (1H, dd), 6.98 (1H, d), 5.99(1H, d), 3.83 (3H, s), 3.70 (3H, s), 2.16 (3H, s).

Present compound 4-76: ¹H-NMR (CDCl₃) δ: 7.81 (2H, d), 7.69 (1H, d),7.54 (1H, s), 7.46-7.35 (2H, m), 7.32 (1H, d), 7.28 (1H, dd), 7.21 (1H,d), 6.94 (1H, dd), 6.88 (1H, d), 3.83 (3H, s), 3.71 (3H, s), 2.18 (3H,s).

Present compound 4-77: ¹H-NMR (CDCl₃) δ: 8.26 (1H, dd), 7.86 (1H, dd),7.57 (1H, d), 7.55-7.45 (3H, m), 7.35 (1H, t), 7.19 (1H, d), 6.94 (1H,dd), 6.91 (1H, dd), 6.88 (1H, d), 3.82 (3H, s), 3.70 (3H, s), 2.17 (3H,s).

Present compound 4-47: ¹H-NMR (CDCl₃) δ: 7.50 (1H, s), 7.32-7.26 (2H,m), 7.23 (1H, d), 7.08-6.99 (2H, m), 6.96-6.92 (3H, m), 3.82 (3H, s),3.71 (3H, s), 2.22 (3H, s).

Present compound 4-48: ¹H-NMR (CDCl₃) δ: 7.52 (1H, s), 7.36-7.29 (2H,m), 7.11-7.00 (3H, m), 6.90 (1H, s), 6.82 (1H, s), 6.74-6.72 (1H, m),3.84 (3H, s), 3.73 (3H, s), 2.32 (3H, s).

Present compound 4-78: ¹H-NMR (CDCl₃) δ: 7.49 (1H, s), 7.22 (1H, d),7.19-7.13 (1H, m), 7.06 (1H, dd), 7.04-7.00 (2H, m), 6.92-6.86 (1H, m),6.85 (1H, d), 3.82 (3H, s), 3.70 (3H, s), 2.28 (3H, s).

Present compound 4-79: ¹H-NMR (CDCl₃) δ: 7.52 (1H, s), 7.20-7.03 (4H,m), 6.89 (1H, s), 6.80 (1H, s), 6.70 (1H, s), 3.84 (3H, s), 3.72 (3H,s), 2.32 (3H, s).

Present compound 4-80: ¹H-NMR (CDCl₃) δ: 7.48 (1H, s), 7.19-7.12 (1H,m), 7.06-6.98 (2H, m), 6.96-6.89 (2H, m), 6.86 (1H, d), 6.82-6.74 (1H,m), 3.81 (3H, s), 3.77 (3H, s), 3.70 (3H, s).

Present compound 4-81: ¹H-NMR (CDCl₃) δ: 7.53 (1H, s), 7.25-7.17 (1H,m), 7.12 (1H, s), 6.75 (1H, s), 6.73-6.67 (2H, m), 6.61 (1H, dt), 3.83(3H, s), 3.69 (3H, s), 2.16 (3H, s), 2.15 (3H, s).

Preparation Example 13-2

The compounds which can be prepared according to the Preparation Exmaple13 are shown below.

A compound represented by formula (2p) wheein L⁵, R³⁴, R³⁵, R³⁶, R³⁷,and R³⁸ represents any combinations described in [Table A20].

TABLE A20 Present Compound L⁵ R³⁴ R³⁵ R³⁶ R³⁷ R³⁸ 4-49 O H Me H H H 4-50O H H Me H H 4-51 O H OMe H H H 4-52 O H OCF₃ H H H 4-53 O H OPh H H H4-54 NH H Me H H H 4-55 NH H H Me H H 4-56 NH H OMe H H H 4-57 NH H OCF₃H H H 4-58 NH H OPh H H H

Preparation Example 1A

A mixture of the intermediate compound 25 0.20 g, benzylbromide 0.14 mL,potassium carbonate 0.25 g, and DMF 3 mL was stirred at room temperatureovernight. Water was added to the resulting mixture, and the mixture wasextracted with MTBE. The resulting organic layers were washed withsaturated brine, dried over anhydrous sodium sulfate, and concentratedunder reduced pressure. The resulting residue was subjected to a silicagel column chromatography (ethyl acetate:hexane=1:4) to obtain thepresent compound 1A-1 represented by the following formula 0.2 g.

Present compound 1A-1: ¹H-NMR (CDCl₃) δ: 7.54 (1H, s), 7.45-7.40 (2H,m), 7.40-7.34 (2H, m), 7.34-7.28 (1H, m), 7.13 (1H, d), 6.86 (1H, dd),6.76 (1H, d), 5.02 (2H, s), 3.81 (3H, s), 3.69 (3H, s), 2.11 (3H, s).

Preparation Example 1A-1

The compounds which were prepared according to the Preparation Example1A and their physical property value are shown below.

Present compound 1A-2: ¹H-NMR (CDCl₃) δ: 7.55 (1H, s), 7.52 (1H, td),7.33-7.26 (1H, m), 7.18-7.12 (2H, m), 7.09-7.04 (1H, m), 6.87 (1H, dd),6.77 (1H, d), 5.10 (2H, s), 3.82 (3H, s), 3.70 (3H, s), 2.11 (3H, s).

Present compound 1A-3: ¹H-NMR (CDCl₃) δ: 7.55 (1H, s), 7.43-7.39 (1H,m), 7.24-7.17 (3H, m), 7.14 (1H, d), 6.87 (1H, dd), 6.77 (1H, d), 4.99(2H, s), 3.82 (3H, s), 3.70 (3H, s), 2.37 (3H, s), 2.12 (3H, s).

Preparation Example 2A

To a mixture of sodium hydride (60%, in oil) 0.04 g, and DNF 2 mL wasadded 1-(4-chlorophenyl)-1H-pyrazole-3-ol 0.18 g at 0° C., and themixture was stirred at 0° C. for 30 minutes. To the resulting mixturewere added a mixture of methyl(E)-2-(5-bromomethyl-2-methylphenyl)-3-methoxyacryate (which wasprepared by a method described in WO 1999/028305 A1) 0.25 g and DMF 2mL, and the mixture was stirred at room temperature for 3.5 hours. Tothe resulting mixture was added aqueous ammonium chloride solution, andthe mixture was extracted with ethyl acetate. The resulting organiclayers were washed with water and saturated brine successively, driedover sodium sulfate, and concentrated under reduced pressure. Theresulting residue was was subjected to a silica gel columnchromatography (hexane: ethyl acetate=1:3) to obtain the presentcompound 2A-1 represented by the following formula 0.18 g.

Present compound 2A-1: ¹H-NMR (CDCl₃) δ: 7.69 (1H, d), 7.58-7.53 (3H,m), 7.39-7.32 (3H, m), 7.26-7.22 (2H, m), 5.92 (1H, d), 5.26 (2H, s),3.81 (3H, s), 3.69 (3H, s), 2.19 (3H, s).

Preparation Example 2A-1

The compounds which were prepared according to the Preparation Example2A and their physical property value are shown below.

Present compound 2A-2: ¹H-NMR (CDCl₃) δ: 7.68 (1H, t), 7.57 (1H, s),7.35 (1H, dd), 7.26-7.22 (3H, m), 6.93 (1H, d), 5.38 (2H, s), 3.81 (3H,s), 3.69 (3H, s), 2.18 (3H, s).

A compound represented by formula (1n):

wherein a combination of R⁸⁰, R⁸¹, and R⁸² represents any combinationsdescribed in [Table A21].

TABLE A21 Present Compound R⁸⁰ R⁸¹ R⁸² 2A-3 i-Pr H H 2A-4 H Cl H

Present compound 2A-3: ¹H-NMR (CDCl₃) δ: 7.55 (1H, s), 7.21 (1H, d),7.18 (1H, d), 7.04 (1H, dd), 6.99 (1H, d), 6.05 (1H, d), 5.22 (2H, s),3.81 (3H, s), 3.69 (3H, s), 3.05-2.97 (1H, m), 2.16 (3H, s), 1.30-1.25(6H, m).

Present compound 2A-4: ¹H-NMR (CDCl₃) δ: 7.56 (1H, s), 7.44 (1H, s),7.32 (1H, s), 7.21 (1H, d), 7.07 (1H, dd), 7.00 (1H, d), 5.21 (2H, s),3.82 (3H, s), 3.70 (3H, s), 2.17 (3H, s).

Preparation Example 3A

Under argon atmosphere, a mixture of the intermediate compoundrepresented 25 0.30 g, 4-chlorothiophenol 0.20 g,tris(dibenzylideneacetone)dipalladium (0) 0.05 g,1,1′-bis(diphenylphosphino)ferrocene 0.06 g, and diisopropylethylamine0.36 mL, and DMF 5 mL was stirred at 110° C. for 7 hours. Water wasadded to the resulting mixture, and the mixture was extracted with ethylacetate. The resulting organic layers were washed with saturated brine,dried over anhydrous sodium sulfate, and concentrated under reducedpressure. The resulting residue was subjected to a silica gel columnchromatography (ethyl acetate:hexane=1:3) to obtain the present compound3A-1 represented by the following formula 0.33 g.

Present compound 3A-1: ¹H-NMR (CDCl₃) δ: 7.55 (1H, s), 7.25-7.16 (7H,m), 3.83 (3H, s), 3.70 (3H, s), 2.18 (3H, s).

Preparation Example 4A

To a mixture of the intermediate compound 25 0.30 g, triphenylphosphine0.42 g, cyclohexanol 0.19 g, and chloroform 10 mL was addedbis(2-methoxyethyl) azodicarboxylate 0.41 g at 0° C., and the mixturewas stirred at room temperature for 16 hours. To the resulting mixturewas added aqueous saturated sodium hydrogencarbonate solution, and themixture was extracted with ethyl acetate. The resulting organic layerswere washed with water and saturated brine successively, dried overanhydrous magnesium sulfate, and concentrated under reduced pressure.The resulting residue was subjected to a silica gel columnchromatography (ethyl acetate:hexane=1:4) to obtain the present compoundA-1 represented by the following formula 0.13 g.

Present compound 4A-1: ¹H-NMR (CDCl₃) δ: 7.54 (1H, s), 7.10 (1H, d),6.77 (1H, dd), 6.66 (1H, d), 4.20-4.14 (1H, m), 3.82 (3H, s), 3.70 (3H,s), 2.10 (3H, s), 2.03-1.94 (2H, m), 1.83-1.73 (2H, m), 1.55-1.29 (6H,m).

Examples of the Present Compound prepared according to the above Processand Preparation Examples are shown below.

Each of Q8A to Q8P represents a substituent wherein a combination of L³,Z¹, Z² and Z³ in the group represented by Q8 represents a combinationshown below.

-   -   Q8A represents the substituent according to Q8 wherein L³        represents an oxygen atom, Z¹ represents an oxygen atom, Z²        represents a fluoromethyl group, and Z³ represents CH;    -   Q8B represents the substituent according to Q8 wherein L³        represents an oxygen atom, Z¹ represents an oxygen atom, Z²        represents a fluoromethyl group, and Z³ represents a nitrogen        atom;    -   Q8C represents the substituent according to Q8 wherein L³        represents a nitrogen atom, Z¹ represents an oxygen atom, Z²        represents a fluoromethyl group, and Z³ represents a nitrogen        atom;    -   Q8D represents the substituent according to Q8 wherein L³        represents an oxygen atom, Z¹ represents CH₂, Z² represents a        fluoromethyl group, and Z³ represents CH;    -   Q8E represents the substituent according to Q8 wherein L³        represents an oxygen atom, Z¹ represents CH₂, Z² represents a        fluoromethyl group, and Z³ represents a nitrogen atom;    -   Q8F represents the substituent according to Q8 wherein L³        represents a nitrogen atom, Z¹ represents CH₂, Z² represents a        fluoromethyl group, and Z³ represents a nitrogen atom;    -   Q8G represents the substituent according to Q8 wherein L³        represents an oxygen atom, Z¹ represents NCH₃, Z² represents a        fluoromethyl group, and Z³ represents CH;    -   Q8H represents the substituent according to Q8 wherein L³        represents an oxygen atom, Z¹ represents NCH₃, Z² represents a        fluoromethyl group, and Z³ represents a nitrogen atom;    -   Q8I represents the substituent according to Q8 wherein L³        represents a nitrogen atom, Z¹ represents NCH₃, Z² represents a        fluoromethyl group, and Z³ represents a nitrogen atom;    -   Q8J represents the substituent according to Q8 wherein L³        represents an oxygen atom, Z¹ represents a single bond, Z²        represents a fluoromethyl group, and Z³ represents CH;    -   Q8K represents the substituent according to Q8 wherein L³        represents an oxygen atom, Z¹ represents a single bond, Z²        represents a fluoromethyl group, and Z³ represents a nitrogen        atom;    -   Q8L represents the substituent according to Q8 wherein L³        represents a nitrogen atom, Z¹ represents a single bond, Z²        represents a fluoromethyl group, and Z³ represents a nitrogen        atom;    -   Q8M represents the substituent according to Q8 wherein L³        represents an oxygen atom, Z¹ represents an oxygen atom, Z²        represents a difluoromethyl group, and Z³ represents CH;    -   Q8N represents the substituent according to Q8 wherein L³        represents an oxygen atom, Z¹ represents CH₂, Z² represents a        difluoromethyl group, and Z³ represents CH;    -   Q8O represents the substituent according to Q8 wherein L³        represents an oxygen atom, Z¹ represents NCH₃, Z² represents a        difluoromethyl group, and Z³ represents CH; and    -   Q8P represents the substituent according to Q8 wherein L³        represents a nitrogen atom, Z¹ represents a single bond, Z²        represents a difluoromethyl group, and Z³ represents a nitrogen        atom.

A compound represented by formula (1A) (hereinafter, referred to asCompound (1A)):

wherein R¹ represents a methyl group, Q represents Q3, R³ represents amethoxy group, and R²⁰ represents any substituent selected from Group X(hereinafter, referred to as Compound group SX1).

-   -   Group X: a group consisting of Me, Et, Pr, i-Pr, (CH₂)₃CH₃,        CH₂CH(CH₃)₂, CH(CH₃) CH₂CH₃, t-Bu, CH₂c-Pr, (CH₂)₄CH₃,        (CH₂)₂CH(CH₃)₂, CH(CH₃)(CH₂)₂CH₃, CH(CH₂CH₃) CH₂CH₃, CH₂CH(CH₃)        CH₂CH₃, C(CH₃)₂CH₂CH₃, CH₂t-Bu, CH₂c-Bu, CH₂c-Pen, (CH₂)₂c-Pr,        (1-methylcyclopropyl)methyl, (2-methylcyclopropyl) methyl,        1-cyclopropylethyl, (CH₂)₃c-Pr, (CH₂)₅CH₃, (CH₂)₃CH(CH₃)₂,        (CH₂)₂CH(CH₃) CH₂CH₃, CH₂CH(CH₃)(CH₂)₂CH₃, CH(CH₃)(CH₂)₃CH₃,        CH₂CH(CH₂CH₃)₂, heptyl, CH₂CH═CH₂, CH₂CH═CHCH₃, CH₂CH═C(CH₃)₂,        CH₂CH═CF₂, CH₂CH═CCl₂, CH₂CH═CHCH₂CH₃, CH₂CH═CH(CH₂)₂CH₃,        CH₂C(CH₃)═CH₂, CH₂C(CH₃)═CHCH₃, CH₂C(CH₃)═C(CH₃)₂,        CH₂C(CH₃)═CHCH₂CH₃, CH₂CF═CH₂, CH₂CF═CHCH₃, CH₂CF═C(CH₃)₂,        CH₂CF═CF₂, CH₂CF═CHCH₂CH₃, CH₂CF═CH(CH₂)₂CH₃, CH₂CCl═CH₂,        CH₂CCl═CHCH₃, CH₂CCl═C(CH₃)₂, CH₂CCl═CCl₂, CH₂CCl═CHCH₂CH₃,        CH₂CCl═CH(CH₂)₂CH₃, (CH₂)₂CH═CH₂, (CH₂)₂CH═CHCH₃,        (CH₂)₂CH═CHCH₂CH₃, (CH₂)₂CH═C(CH₃)₂, (CH₂)₂C(CH₃)═CH₂,        (CH₂)₂C(CH₃)═CHCH₃, (CH₂)₃CH═CH₂, (CH₂)₃C(CH₃)═CH₂,        (CH₂)₄CH═CH₂, CH₂C═CH, CH₂C═CCH₃, CH₂C═CCH₂CH₃, CH₂C≡Cc-Pr,        (CH₂)₂C═CH, (CH₂)₂C═CCH₃, (CH₂)₂C═CCH₂CH₃, (CH₂)₃C≡CH,        (CH₂)₃C═CCH₃, CH₂Cl, CH₂Br, CH₂OCH₃, CH₂OCH₂CH₃, CH₂O(CH₂)₂CH₃,        CHF₂, CF₃, CH₂CF₃, CH₂CHF₂, CH₂CH₂CHF₂, CH₂CH₂CF₃, CH₂CF₂CF₃,        (CH₂)₂CF₂CF₃, CH₂(CF₂)₂CF₃, (CH₂)₂CF(CF₃)₂, (CH₂) 2 (CF₂)₅CF₃,        CF₃, CF₂CHF(CF₃), CF₂CHF(OCF₃), and CH₂CF₂CF₂H.

A compound according to Compound (1A) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, and R²⁰ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX2).

A compound according to Compound (1A) wherein R¹ represents a methylgroup, Q represents Q4, and R²⁰ represents any substituent selected fromGroup X (hereinafter, referred to as Compound group SX3).

A compound according to Compound (1A) wherein R¹ represents a chlorineatom, Q represents Q4, and R²⁰ represents any substituent selected fromGroup X (hereinafter, referred to as Compound group SX4).

A compound according to Compound (1A) wherein R¹ represents a methylgroup, Q represents Q5, and R²⁰ represents any substituent selected fromGroup X (hereinafter, referred to as Compound group SX5).

A compound according to Compound (1A) wherein R¹ represents a chlorineatom, Q represents Q5, and R²⁰ represents any substituent selected fromGroup X (hereinafter, referred to as Compound group SX6).

A compound according to Compound (1A) wherein R¹ represents a methylgroup, Q represents Q6, and R²⁰ represents any substituent selected fromGroup X (hereinafter, referred to as Compound group SX7).

A compound according to Compound (1A) wherein R¹ represents a chlorineatom, Q represents Q6, and R²⁰ represents any substituent selected fromGroup X (hereinafter, referred to as Compound group SX8).

A compound according to Compound (1A) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, and R²⁰ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX9).

A compound according to Compound (1A) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, and R²⁰ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX10).

A compound according to Compound (1A) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, and R²⁰ represents anysubstituent selected from Group X (hereinafter, referred to as Compoundgroup SX11).

A compound according to Compound (1A) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, and R²⁰ represents anysubstituent selected from Group X (hereinafter, referred to as Compoundgroup SX12).

A compound according to Compound (1A) wherein R¹ represents a methylgroup, Q represents Q8A, and R²⁰ represents any substituent selectedfrom Group X (hereinafter, referred to as Compound group SX13).

A compound according to Compound (1A) wherein R¹ represents a chlorineatom, Q represents Q8A, and R²⁰ represents any substituent selected fromGroup X (hereinafter, referred to as Compound group SX14).

A compound according to Compound (1A) wherein R¹ represents a methylgroup, Q represents Q8B, and R²⁰ represents any substituent selectedfrom Group X (hereinafter, referred to as Compound group SX15).

A compound according to Compound (1A) wherein R¹ represents a chlorineatom, Q represents Q8B, and R²⁰ represents any substituent selected fromGroup X (hereinafter, referred to as Compound group SX16).

A compound according to Compound (1A) wherein R¹ represents a methylgroup, Q represents Q8C, and R²⁰ represents any substituent selectedfrom Group X (hereinafter, referred to as Compound group SX17).

A compound according to Compound (1A) wherein R¹ represents a chlorineatom, Q represents Q8C, and R²⁰ represents any substituent selected fromGroup X (hereinafter, referred to as Compound group SX18).

A compound according to Compound (1A) wherein R¹ represents a methylgroup, Q represents Q8D, and R²⁰ represents any substituent selectedfrom Group X (hereinafter, referred to as Compound group SX19).

A compound according to Compound (1A) wherein R¹ represents a methylgroup, Q represents Q8E, and R²⁰ represents any substituent selectedfrom Group X (hereinafter, referred to as Compound group SX20).

A compound according to Compound (1A) wherein R¹ represents a methylgroup, Q represents Q8F, and R²⁰ represents any substituent selectedfrom Group X (hereinafter, referred to as Compound group SX21).

A compound according to Compound (1A) wherein R¹ represents a hydrogenatom, Q represents Q8G, and R²⁰ represents any substituent selected fromGroup X (hereinafter, referred to as Compound group SX22).

A compound according to Compound (1A) wherein R¹ represents a hydrogenatom, Q represents Q8H, and R²⁰ represents any substituent selected fromGroup X (hereinafter, referred to as Compound group SX23).

A compound according to Compound (1A) wherein R¹ represents a hydrogenatom, Q represents Q8I, and R²⁰ represents any substituent selected fromGroup X (hereinafter, referred to as Compound group SX24).

A compound according to Compound (1A) wherein R¹ represents a methylgroup, Q represents Q8J, and R²⁰ represents any substituent selectedfrom Group X (hereinafter, referred to as Compound group SX25).

A compound according to Compound (1A) wherein R¹ represents a chlorineatom, Q represents Q8J, and R²⁰ represents any substituent selected fromGroup X (hereinafter, referred to as Compound group SX26).

A compound according to Compound (1A) wherein R¹ represents a methylgroup, Q represents Q8K, and R²⁰ represents any substituent selectedfrom Group X (hereinafter, referred to as Compound group SX27).

A compound according to Compound (1A) wherein R¹ represents a chlorineatom, Q represents Q8K, and R²⁰ represents any substituent selected fromGroup X (hereinafter, referred to as Compound group SX28).

A compound according to Compound (1A) wherein R¹ represents a methylgroup, Q represents Q8L, and R²⁰ represents any substituent selectedfrom Group X (hereinafter, referred to as Compound group SX29).

A compound according to Compound (1A) wherein R¹ represents a chlorineatom, Q represents Q8L, and R²⁰ represents any substituent selected fromGroup X (hereinafter, referred to as Compound group SX30).

A compound according to Compound (1A) wherein R¹ represents a methylgroup, Q represents Q8M, and R²⁰ represents any substituent selectedfrom Group X (hereinafter, referred to as Compound group SX31).

A compound according to Compound (1A) wherein R¹ represents a methylgroup, Q represents Q8N, and R²⁰ represents any substituent selectedfrom Group X (hereinafter, referred to as Compound group SX32).

A compound according to Compound (1A) wherein R¹ represents a methylgroup, Q represents Q8O, and R²⁰ represents any substituent selectedfrom Group X (hereinafter, referred to as Compound group SX33).

A compound according to Compound (1A) wherein R¹ represents a methylgroup, Q represents Q8P, and R²⁰ represents any substituent selectedfrom Group X (hereinafter, referred to as Compound group SX34).

A compound represented by formula (1B) (hereinafter, referred to asCompound (1B)):

wherein R¹ represents a methyl group, Q represents Q3, R³ represents amethoxy group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX35).

Combination A consists of substituent numbers ZA1 to ZA312. Substituentnumbers ZA1 to ZA312 represent combinations of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) according to Compound (1B), compounds represented byformula (1D), compounds represented by formula (1E), compoundsrepresented by formula (1F), compounds represented by formula (1T),compounds represented by formula (1K), compounds represented by formula(1M), compounds represented by formula (1N), compounds represented byformula (1P), compounds represented by formula (1W), compoundsrepresented by formula (1Y), compounds represented by formula (1Z),compounds represented by formula (2F), compounds represented by formula(2H), compounds represented by formula (2J), compounds represented byformula (2L), compounds represented by formula (2N), compoundsrepresented by formula (2P), compounds represented by formula (3A),compounds represented by formula (3D), compounds represented by formula(3F), compounds represented by formula (3G), and compounds representedby formula (3H). And hereinafter, they are referred to as [substituentnumber; R^(X2), R^(X3), R^(X4), R^(X5), R^(X6)]. For example, thesubstituent number ZA2 refers to a combination wherein R^(X2) representsa methyl group, and each of R^(X3), R^(X4), R^(X5) and R^(X6) representsa hydrogen atom.

-   -   Combination A: [ZA1;H,H,H,H,H], [ZA2;Me,H,H,H,H],        [ZA3;F,H,H,H,H], [ZA4;Cl,H, H,H,H], [ZA5;OMe,H,H,H,H],        [ZA6;CF₃,H,H,H,H], [ZA7;H,Me,H,H,H], [ZA8;H,Et,H,H,H],        [ZA9;H,Pr,H,H,H], [ZA10;H,i-Pr,H,H,H], [ZA11;H,t-Bu,H,H,H],        [ZA12;H,OMe,H,H,H], [ZA13;H,OEt,H,H,H], [ZA14;H,OPr,H,H,H],        [ZA15;H,Oi-Pr,H,H,H], [ZA16;H,CF₃,H,H,H], [ZA17;H,CF₂H,H,H,H],        [ZA18;H,CF H₂,H,H,H], [ZA19;H,F,H,H,H], [ZA20;H,Cl,H,H,H],        [ZA21;H,Br,H,H,H], [ZA22;H,CN,H,H,H], [ZA23;H,Ph,H,H,H],        [ZA24;H,OPh,H,H,H], [ZA25;H,c-Pr,H,H,H], [ZA26;H,c-Pen,H,H,H],        [ZA27;H,c-Hex,H,H,H], [ZA28;H,H,Me,H,H], [ZA29;H,H,Et,H,H],        [ZA30;H,H,Pr,H,H], [ZA31;H,H,i-Pr,H,H1, [ZA32;H,H,t-Bu,H,H],        [ZA33;H,H,OMe,H,H], [ZA34;H,H,OEt,H,H], [ZA35;H,H,OPr,H,H],        [ZA36;H,H,Oi-Pr,H,H], [ZA37;H,H,CF₃,H,H], [ZA38;H,H,CF₂H,H,H],        [ZA39;H,H,CF H₂,H,H], [ZA40;H,H,F,H,H], [ZA41;H,H,Cl,H,H],        [ZA42;H,H,Br,H,H], [ZA43;H,H,CN,H,H], [ZA44;H,H,Ph,H,H],        [ZA45;H,H,OPh,H,H], [Z A46;H,H,c-Pr,H,H], [ZA47;H,H,c-Pen,H,H],        [ZA48;H,H,c-Hex,H,H], [ZA49;H,H,H,H,F], [ZA50;Me,H,H,H,F],        [ZA51;F,H,H,H,F], [ZA52;Cl,H,H,H,F], [ZA53;H,Me,H,H,F],        [ZA54;H,Et,H,H,F], [ZA 55;H,Pr,H,H,F], [ZA56;H,i-Pr,H,H,F],        [ZA57;H,t-Bu,H,H,F], [ZA58;H,OMe,H,H,F], [ZA59;H,OEt,H,H,F],        [ZA60;H,OPr,H,H,F], [ZA61;H,Oi-Pr,H,H,F], [ZA62;H,CF₃,H,H,F],        [ZA63;H,CF₂H,H,H,F], [ZA64;H,CF H₂,H,H,F], [ZA65;H,F,H,H,F],        [ZA66;H,Cl,H,H,F], [ZA67;H,Br,H,H,F], [ZA68;H,CN,H,H,F],        [ZA69;H,Ph,H,H,F], [ZA70;H,OPh,H,H,F], [ZA71;H,c-Pr,H,H,F],        [ZA72;H,c-Pen,H,H,F], [ZA73;H,c-Hex,H,H,F], [ZA74;H,H,Me,H,F],        [ZA75;H,H,Et,H,F], [ZA76;H,H,Pr,H,F], [ZA77;H,H,i-Pr,H,F],        [ZA78;H,H,t-Bu,H,F], [ZA79;H,H,OMe,H,F], [ZA80;H,H,OEt,H,F],        [ZA81;H,H,OPr,H,F], [ZA82;H,H,Oi-Pr,H,F], [ZA83;H,H,CF₃,H,F],        [ZA84;H,H,CF₂H,H,F], [ZA85;H,H,CF H₂,H,F], [ZA86;H,H,F,H,F],        [ZA87;H,H,Cl,H,F], [ZA88;H,H,Br,H,F], [ZA89;H,H,CN,H,F],        [ZA90;H,H,Ph,H,F], [ZA91;H,H,OPh,H,F], [Z A92;H,H,c-Pr,H,F],        [ZA93;H,H,c-Pen,H,F], [ZA94;H,H,c-Hex,H,F], [ZA95;H,H,H,H,Cl],        [ZA96;Me,H,H,H,Cl], [ZA97;F,H,H,H,Cl], [ZA98;Cl,H,H,H,Cl],        [ZA99;H,Me,H,H,Cl], [ZA100;H,Et,H,H, Cl], [ZA101;H,Pr,H,H,Cl],        [ZA102;H,i-Pr,H,H,Cl], [ZA103;H,t-Bu,H,H,Cl],        [ZA104;H,OMe,H,H,Cl], [ZA105;H,OEt,H,H,Cl],        [ZA106;H,OPr,H,H,Cl], [ZA107;H,Oi-Pr,H,H,Cl],        [ZA108;H,CF₃,H,H,Cl], [ZA109;H,CF₂H,H,H,Cl],        [ZA110;H,CFH₂,H,H,Cl], [ZA111;H,F,H,H,Cl], [ZA112;H,Cl,H,H,Cl],        [ZA 113;H,Br,H,H,Cl], [ZA114;H,CN,H,H,Cl], [ZA115;H,Ph,H,H,Cl],        [Z A116;H,OPh,H,H,Cl], [ZA117;H,c-Pr,H,H,Cl], [ZA118;H,H,H,F,F],        [ZA119;F,H,H,F,F], [ZA120;H,H,M e,H,Cl], [ZA121;H,H,Et,H,Cl],        [ZA122;H,H,Pr,H,Cl], [ZA123;H,H, i-Pr,H,Cl],        [ZA124;H,H,t-Bu,H,Cl], [ZA125;H,H,OMe,H,Cl],        [ZA126;H,H,OEt,H,Cl], [ZA127;H,H,OPr,H,Cl],        [ZA128;H,H,Oi-Pr,H,Cl], [ZA129;H,H,CF₃,H,Cl],        [ZA130;H,H,CF₂H,H,Cl], [ZA131; H,H,CFH₂,H,Cl],        [ZA132;H,H,F,H,Cl], [ZA133;H,H,Cl,H,Cl], [ZA13 4;H,H,Br,H,Cl],        [ZA135;H,H,CN,H,Cl], [ZA136;H,H,Ph,H,Cl], [ZA137;H,H,OPh,H,Cl],        [ZA138;H,H,c-Pr,H,Cl], [ZA139;H,H,c-Pen,H,Cl],        [ZA140;H,H,c-Hex,H,Cl], [ZA141;H,H,H,H,Me], [ZA142;Me,H,H,H,Me],        [ZA143;F,H,H,H,Me], [ZA144;Cl,H,H,H,Me], [ZA145;H,Me,H,H,Me],        [ZA146;H,E t,H,H,Me], [ZA147;H,Pr,H,H,Me],        [ZA148;H,i-Pr,H,H,Me], [ZA149;H,t-Bu,H,H,Me],        [ZA150;H,OMe,H,H,Me], [ZA151;H,OEt,H,H,Me],        [ZA152;H,OPr,H,H,Me], [ZA153;H,Oi-Pr,H,H,Me],        [ZA154;H,CF₃,H,H,Me], [ZA155;H,CF₂H,H,H,Me], [ZA15        6;H,CFH₂,H,H,Me], [ZA157;H,F,H,H,Me], [ZA158;H,Cl,H,H,Me], [ZA        159;H,Br,H,H,Me], [ZA160;H,CN,H,H,Me], [ZA161;H,Ph,H,H,Me], [Z        A162;H,OPh,H,H,Me], [ZA163;H,c-Pr,H,H,Me],        [ZA164;H,c-Pen,H,H,Me], [ZA165;H,c-Hex,H,H,Me],        [ZA166;H,H,Me,H,Me], [ZA167;H,H,Et,H,Me], [ZA168; H,H,Pr,H,Me],        [ZA169;H,H,i-Pr,H,Me], [ZA170;H,H,t-Bu,H,Me],        [ZA171;H,H,OMe,H,Me], [ZA172;H,H,OEt,H,Me],        [ZA173;H,H,OPr,H,Me], [ZA174;H,H,Oi-Pr,H,Me],        [ZA175;H,H,CF₃,H,Me], [ZA176;H,H,CF₂H,H,Me], [ZA177;        H,H,CFH₂,H,Me], [ZA178;H,H,F,H,Me], [ZA179;H,H,Cl,H,Me], [ZA18        0;H,H,Br,H,Me], [ZA181;H,H,CN,H,Me], [ZA182;H,H,Ph,H,Me], [ZA1        83;H,H,OPh,H,Me], [ZA184;H,H,c-Pr,H,Me], [ZA185;H,H,c-Pen,H,Me],        [ZA186;H,H,c-Hex,H,Me], [ZA187;H,H,H,H,OMe],        [ZA188;Me,H,H,H,OMe], [ZA189;F,H,H,H,OMe], [ZA190;Cl,H,H,H,OMe],        [ZA191;H,Me,H,H,OMe], [ZA19 2;H,Et,H,H,OMe],        [ZA193;H,Pr,H,H,OMe], [ZA194;H,i-Pr,H,H,OMe],        [ZA195;H,t-Bu,H,H,OMe], [ZA196;H,OMe,H,H,OMe],        [ZA197;H,OEt,H,H,OMe], [ZA 198;H,OPr,H,H,OMe],        [ZA199;H,Oi-Pr,H,H,OMe], [ZA200;H,CF₃,H,H,OMe],        [ZA201;H,CF₂H,H,H,OMe], [ZA202;H,CFH₂,H,H,OMe], [ZA203;H,F,H,        H,OMe], [ZA204;H,Cl,H,H,OMe], [ZA205;H,Br,H,H,OMe], [ZA206;H,C        N,H,H,OMe], [ZA207;H,Ph,H,H,OMe], [ZA208;H,OPh,H,H,OMe], [ZA20        9;H,c-Pr,H,H,OMe], [ZA210;H,c-Pen,H,H,OMe],        [ZA211;H,c-Hex,H,H,OMe], [ZA212;H,H,Me,H,OMe],        [ZA213;H,H,Et,H,OMe], [ZA2 14;H,H,Pr,H,OMe],        [ZA215;H,H,i-Pr,H,OMe], [ZA216;H,H,t-Bu,H,OMe],        [ZA217;H,H,OMe,H,OMe], [ZA218;H,H,OEt,H,OMe], [ZA21        9;H,H,OPr,H,OMe], [ZA220;H,H,Oi-Pr,H,OMe],        [ZA221;H,H,CF₃,H,OMe], [ZA222;H,H,CF₂H,H,OMe], [ZA2        23;H,H,CFH₂,H,OMe], [ZA224;H,H,F,H,OMe], [ZA225;H,H,Cl,H,OMe],        [ZA226;H,H,Br,H,OMe], [ZA227;H,H,CN,H,OMe], [ZA228;H,H,Ph,H,        OMe], [ZA229;H,H,OPh,H,OMe], [ZA230;H,H,c-Pr,H,OMe],        [ZA231;H,H,c-Pen,H,OMe], [ZA232;H,H,c-Hex,H,OMe],        [ZA233;H,H,H,H,CF₃], [ZA234;Me,H,H,H,CF₃], [ZA235; F,H,H,H,CF₃],        [ZA236;Cl,H,H,H,CF₃], [ZA237;H,Me,H,H,CF₃], [ZA23        8;H,Et,H,H,CF₃], [ZA239;H,Pr,H,H,CF₃], [ZA240;H,i-Pr,H,H,CF₃],        [ZA241;H,t-Bu,H,H,CF₃], [ZA242;H,OMe,H,H,CF₃],        [ZA243;H,OEt,H,H,CF₃], [ZA2 44;H,OPr,H,H,CF₃],        [ZA245;H,Oi-Pr,H,H,CF₃], [ZA246;H,CF₃,H,H,CF₃],        [ZA247;H,CF₂H,H,H,CF₃], [ZA 248;H,CFH₂,H,H,CF₃],        [ZA249;H,F,H,H,CF₃], [ZA250;H,Cl,H,H,CF₃], [ZA251;H,Br,H,H,CF₃],        [ZA252;H,CN,H,H,CF₃], [ZA253;H,Ph,H,H, CF₃],        [ZA254;H,OPh,H,H,CF₃], [ZA255;H,c-Pr,H,H,CF₃],        [ZA256;H,c-Pen,H,H,CF₃], [ZA257;H,c-Hex,H,H,CF₃],        [ZA258;H,H,Me,H,CF₃], [ZA259;H,H,Et,H,CF₃], [ZA26        0;H,H,Pr,H,CF₃], [ZA261;H,H,i-Pr,H,CF₃], [ZA262;H,H,t-Bu,H,CF₃],        [ZA263;H,H,OMe,H,CF₃], [ZA264;H,H,OEt,H,CF₃],        [ZA265;H,H,OPr,H,CF₃], [ZA266;H,H,Oi-Pr,H,CF₃],        [ZA267;H,H,CF₃,H,CF₃], [ZA268;H,H,CF₂H,H,CF₃], [ZA26        9;H,H,CFH₂,H,CF₃], [ZA270;H,H,F,H,CF₃], [ZA271;H,H,Cl,H,CF₃],        [ZA272;H,H,Br,H,CF₃], [ZA273;H,H,CN,H,CF₃],        [ZA274;H,H,Ph,H,CF₃], [ZA275;H,H,OPh,H,CF₃],        [ZA276;H,H,c-Pr,H,CF₃], [ZA277;H,H,c-Pen,H,CF₃],        [ZA278;H,H,c-Hex,H,CF₃], [ZA279;H,F,F,H,H], [ZA280;H,F,H,F,H],        [ZA281;H,F,F,F,H], [ZA282;F,F,F,H,H], [ZA283;F,F,H,F,H],        [ZA284;F,H,F,H,F], [ZA285;F,F,F,F,F], [ZA286;F,F,H,F,F],        [ZA287;H,OMe,H,OMe,H], [ZA288;H,F,Cl,H,H], [ZA289;H,F,Me,H,H],        [ZA290;H,F,OMe,H,H], [ZA291;H,F,CF₃,H,H], [ZA292;H,Cl,F,H,H],        [ZA293;H,Cl,Cl,H,H], [ZA294;H,Cl,Me,H,H], [ZA295;H,Cl,OMe,H,H],        [ZA296;H,Cl,CF₃,H,H], [ZA297;H,Me,F,H,H], [ZA298;H,Me,Cl,H,H],        [ZA299;H,Me,Me,H,H], [ZA300;H,Me,OMe,H,H], [ZA301;H,Me,CF₃,H,H],        [ZA302;H,OMe,F,H,H], [ZA303;H,OMe,Cl,H,H], [ZA304;H,OMe,Me,H,H],        [ZA305;H,OMe,OMe,H,H], [ZA306;H,OMe,CF₃,H,H],        [ZA307;H,CF₃,F,H,H], [ZA308; H,CF₃,Cl,H,H], [ZA309;H,CF₃,F,H,H],        [ZA310;H,CF₃,Cl,H,H], [ZA31 1;H,CF₃,F,H,H], [ZA312;H,Cl,H,Cl,H]

A compound according to Compound (1B) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX36).

A compound according to Compound (1B) wherein R¹ represents a methylgroup, Q represents Q4, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX37).

A compound according to Compound (1B) wherein R¹ represents a chlorineatom, Q represents Q4, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX38).

A compound according to Compound (1B) wherein R¹ represents a methylgroup, Q represents Q5, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX39).

A compound according to Compound (1B) wherein R¹ represents a chlorineatom, Q represents Q5, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX40).

A compound according to Compound (1B) wherein R¹ represents a methylgroup, Q represents Q6, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX41).

A compound according to Compound (1B) wherein R¹ represents a chlorineatom, Q represents Q6, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX42).

A compound according to Compound (1B) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, and a combinationof R^(X2), R^(X3), Rx, R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX43).

A compound according to Compound (1B) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, and a combinationof R^(X2), R^(X3), Rx, R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX44).

A compound according to Compound (1B) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, and a combination of R^(X2),R^(X3), Rx, R^(X5) and R^(X6) represents any combination described inCombination A (hereinafter, referred to as Compound group SX45).

A compound according to Compound (1B) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, and a combination of R^(X2),R^(X3), Rx, R^(X5) and R^(X6) represents any combination described inCombination A (hereinafter, referred to as Compound group SX46).

A compound according to Compound (1B) wherein R¹ represents a methylgroup, Q represents Q8A, and a combination of R^(X2), R^(X3), Rx, R^(X5)and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX47).

A compound according to Compound (1B) wherein R¹ represents a chlorineatom, Q represents Q8A, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX48).

A compound according to Compound (1B) wherein R¹ represents a methylgroup, Q represents Q8B, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX49).

A compound according to Compound (1B) wherein R¹ represents a chlorineatom, Q represents Q8B, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX50).

A compound according to Compound (1B) wherein R¹ represents a methylgroup, Q represents Q8C, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX51).

A compound according to Compound (1B) wherein R¹ represents a chlorineatom, Q represents Q8C, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX52).

A compound according to Compound (1B) wherein R¹ represents a methylgroup, Q represents Q8D, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX53).

A compound according to Compound (1B) wherein R¹ represents a methylgroup, Q represents Q8E, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX54).

A compound according to Compound (1B) wherein R¹ represents a methylgroup, Q represents Q8F, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX55).

A compound according to Compound (1B) wherein R¹ represents a hydrogenatom, Q represents Q8G, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX56).

A compound according to Compound (1B) wherein R¹ represents a hydrogenatom, Q represents Q8H, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX57).

A compound according to Compound (1B) wherein R¹ represents a hydrogenatom, Q represents Q8I, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX58).

A compound according to Compound (1B) wherein R¹ represents a methylgroup, Q represents Q8J, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX59).

A compound according to Compound (1B) wherein R¹ represents a chlorineatom, Q represents Q8J, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX60).

A compound according to Compound (1B) wherein R¹ represents a methylgroup, Q represents Q8K, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX61).

A compound according to Compound (1B) wherein R¹ represents a chlorineatom, Q represents Q8K, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX62).

A compound according to Compound (1B) wherein R¹ represents a methylgroup, Q represents Q8L, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX63).

A compound according to Compound (1B) wherein R¹ represents a chlorineatom, Q represents Q8L, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX64).

A compound according to Compound (1B) wherein R¹ represents a methylgroup, Q represents Q8M, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX65).

A compound according to Compound (1B) wherein R¹ represents a methylgroup, Q represents Q8N, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX66).

A compound according to Compound (1B) wherein R¹ represents a methylgroup, Q represents Q8O, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX67).

A compound according to Compound (1B) wherein R¹ represents a methylgroup, Q represents Q8P, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX68).

A compound represented by formula (1C) (hereinafter, referred to asCompound (1C)):

wherein R¹ represents a methyl group, Q represents Q3, R³ represents amethoxy group, R⁷ represents a methyl group, and R¹³ represents anysubstituent selected from Group X (hereinafter, referred to as Compoundgroup SX69).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R⁷ represents amethyl group, and R¹³ represents any substituent selected from Group X(hereinafter, referred to as Compound group SX70).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q4, R⁷ represents a methyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX71).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q4, R⁷ represents a methyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX72).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q5, R⁷ represents a methyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX73).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q5, R⁷ represents a methyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX74).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q6, R⁷ represents a methyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX75).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q6, R⁷ represents a methyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX76).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R⁷ represents amethyl group, and R¹³ represents any substituent selected from Group X(hereinafter, referred to as Compound group SX77).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R⁷ represents amethyl group, and R¹³ represents any substituent selected from Group X(hereinafter, referred to as Compound group SX78).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R⁷ represents a methyl group,and R¹³ represents any substituent selected from Group X (hereinafter,referred to as Compound group SX79).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R⁷ represents a methyl group,and R¹³ represents any substituent selected from Group X (hereinafter,referred to as Compound group SX80).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8A, R⁷ represents a methyl group, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX81).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q8A, R⁷ represents a methyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX82).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8B, R⁷ represents a methyl group, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX83).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q8B, R⁷ represents a methyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX84).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8C, R⁷ represents a methyl group, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX85).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q8C, R⁷ represents a methyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX86).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8D, R⁷ represents a methyl group, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX87).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8E, R⁷ represents a methyl group, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX88).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8F, R⁷ represents a methyl group, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX89).

A compound according to Compound (1C) wherein R¹ represents a hydrogenatom, Q represents Q8G, R⁷ represents a methyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX90).

A compound according to Compound (1C) wherein R¹ represents a hydrogenatom, Q represents Q8H, R⁷ represents a methyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX91).

A compound according to Compound (1C) wherein R¹ represents a hydrogenatom, Q represents Q8I, R⁷ represents a methyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX92).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8J, R⁷ represents a methyl group, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX93).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q8J, R⁷ represents a methyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX94).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8K, R⁷ represents a methyl group, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX95).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q8K, R⁷ represents a methyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX96).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8L, R⁷ represents a methyl group, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX97).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q8L, R⁷ represents a methyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX98).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8M, R⁷ represents a methyl group, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX99).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8N, R⁷ represents a methyl group, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX100).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8O, R⁷ represents a methyl group, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX101).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8P, R⁷ represents a methyl group, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX102).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, R⁷ represents anethyl group, and R¹³ represents any substituent selected from Group X(hereinafter, referred to as Compound group SX103).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R⁷ represents anethyl group, and R¹³ represents any substituent selected from Group X(hereinafter, referred to as Compound group SX104).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q4, R⁷ represents an ethyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX105).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q4, R⁷ represents an ethyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX106).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q5, R⁷ represents an ethyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX107).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q5, R⁷ represents an ethyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX108).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q6, R⁷ represents an ethyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX109).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q6, R⁷ represents an ethyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX110).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R⁷ represents anethyl group, and R¹³ represents any substituent selected from Group X(hereinafter, referred to as Compound group SX111).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R⁷ represents anethyl group, and R¹³ represents any substituent selected from Group X(hereinafter, referred to as Compound group SX112).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R⁷ represents an ethyl group,and R¹³ represents any substituent selected from Group X (hereinafter,referred to as Compound group SX113).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R⁷ represents an ethyl group,and R¹³ represents any substituent selected from Group X (hereinafter,referred to as Compound group SX114).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8A, R⁷ represents an ethyl group, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX115).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q8A, R⁷ represents an ethyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX116).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8B, R⁷ represents an ethyl group, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX117).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q8B, R⁷ represents an ethyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX118).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8C, R⁷ represents an ethyl group, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX119).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q8C, R⁷ represents an ethyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX120).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8D, R⁷ represents an ethyl group, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX121).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8E, R⁷ represents an ethyl group, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX122).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8F, R⁷ represents an ethyl group, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX123).

A compound according to Compound (1C) wherein R¹ represents a hydrogenatom, Q represents Q8G, R⁷ represents an ethyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX124).

A compound according to Compound (1C) wherein R¹ represents a hydrogenatom, Q represents Q8H, R⁷ represents an ethyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX125).

A compound according to Compound (1C) wherein R¹ represents a hydrogenatom, Q represents Q8I, R⁷ represents an ethyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX126).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8J, R⁷ represents an ethyl group, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX127).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q8J, R⁷ represents an ethyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX128).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8K, R⁷ represents an ethyl group, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX129).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q8K, R⁷ represents an ethyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX130).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8L, R⁷ represents an ethyl group, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX131).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q8L, R⁷ represents an ethyl group, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX132).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8M, R⁷ represents an ethyl group, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX133).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8N, R⁷ represents an ethyl group, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX134).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8O, R⁷ represents an ethyl group, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX135).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8P, R⁷ represents an ethyl group, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX136).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, R⁷ represents ahydrogen atom, and R¹³ represents any substituent selected from Group X(hereinafter, referred to as Compound group SX137).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R⁷ represents ahydrogen atom, and R¹³ represents any substituent selected from Group X(hereinafter, referred to as Compound group SX138).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q4, R⁷ represents a hydrogen atom, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX139).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q4, R⁷ represents a hydrogen atom, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX140).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q5, R⁷ represents a hydrogen atom, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX141).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q5, R⁷ represents a hydrogen atom, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX142).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q6, R⁷ represents a hydrogen atom, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX143).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q6, R⁷ represents a hydrogen atom, and R¹³ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX144).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R⁷ represents ahydrogen atom, and R¹³ represents any substituent selected from Group X(hereinafter, referred to as Compound group SX145).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R⁷ represents ahydrogen atom, and R¹³ represents any substituent selected from Group X(hereinafter, referred to as Compound group SX146).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R⁷ represents a hydrogen atom,and R¹³ represents any substituent selected from Group X (hereinafter,referred to as Compound group SX147).

-   -   A compound according to Compound (1C) wherein R¹ represents a        chlorine atom, Q represents Q7, L² represents NH, R⁷ represents        a hydrogen atom, and R¹³ represents any substituent selected        from Group X (hereinafter, referred to as Compound group SX148).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8A, R⁷ represents a hydrogen atom, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX149).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q8A, R⁷ represents a hydrogen atom, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX150).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8B, R⁷ represents a hydrogen atom, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX151).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q8B, R⁷ represents a hydrogen atom, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX152).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8C, R⁷ represents a hydrogen atom, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX153).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q8C, R⁷ represents a hydrogen atom, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX154).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8D, R⁷ represents a hydrogen atom, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX155).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8E, R⁷ represents a hydrogen atom, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX156).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8F, R⁷ represents a hydrogen atom, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX157).

A compound according to Compound (1C) wherein R¹ represents a hydrogenatom, Q represents Q8G, R⁷ represents a hydrogen atom, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX158).

A compound according to Compound (1C) wherein R¹ represents a hydrogenatom, Q represents Q8H, R⁷ represents a hydrogen atom, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX159).

A compound according to Compound (1C) wherein R¹ represents a hydrogenatom, Q represents Q8I, R⁷ represents a hydrogen atom, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX160).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8J, R⁷ represents a hydrogen atom, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX161).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q8J, R⁷ represents a hydrogen atom, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX162).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8K, R⁷ represents a hydrogen atom, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX163).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q8K, R⁷ represents a hydrogen atom, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX164).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8L, R⁷ represents a hydrogen atom, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX165).

A compound according to Compound (1C) wherein R¹ represents a chlorineatom, Q represents Q8L, R⁷ represents a hydrogen atom, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX166).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8M, R⁷ represents a hydrogen atom, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX167).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8N, R⁷ represents a hydrogen atom, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX168).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8O, R⁷ represents a hydrogen atom, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX169).

A compound according to Compound (1C) wherein R¹ represents a methylgroup, Q represents Q8P, R⁷ represents a hydrogen atom, and R¹³represents any substituent selected from Group X (hereinafter, referredto as Compound group SX170).

A compound represented by formula (1D) (hereinafter, referred to asCompound (1D)):

wherein R¹ represents a methyl group, Q represents Q3, R³ represents amethoxy group, R⁷ represents a methyl group, and a combination ofR^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX171).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R⁷ represents amethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX172).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q4, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX173).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q4, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX174).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q5, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX175).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q5, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX176).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q6, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX177).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q6, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX178).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R⁷ represents amethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX179).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R⁷ represents amethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX180).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R⁷ represents a methyl group,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX181).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R⁷ represents a methyl group,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX182).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8A, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX183).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q8A, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX184).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8B, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX185).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q8B, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX186).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8C, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX187).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q8C, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX188).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8D, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX189).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8E, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX190).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8F, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX191).

A compound according to Compound (1D) wherein R¹ represents a hydrogenatom, Q represents Q8G, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX192).

A compound according to Compound (1D) wherein R¹ represents a hydrogenatom, Q represents Q8H, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX193).

A compound according to Compound (1D) wherein R¹ represents a hydrogenatom, Q represents Q8I, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX194).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8J, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX195).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q8J, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX196).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8K, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX197).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q8K, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX198).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8L, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX199).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q8L, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX200).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8M, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX201).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8N, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX202).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8O, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX203).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8P, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX204).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, R⁷ represents anethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX205).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R⁷ represents anethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX206).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q4, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX207).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q4, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX208).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q5, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX209).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q5, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX210).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q6, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX211).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q6, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX212).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R⁷ represents anethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX213).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R⁷ represents anethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX214).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R⁷ represents an ethyl group,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX215).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R⁷ represents an ethyl group,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX216).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8A, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX217).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q8A, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX218).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8B, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX219).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q8B, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX220).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8C, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX221).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q8C, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX222).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8D, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX223).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8E, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX224).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8F, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX225).

A compound according to Compound (1D) wherein R¹ represents a hydrogenatom, Q represents Q8G, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX226).

A compound according to Compound (1D) wherein R¹ represents a hydrogenatom, Q represents Q8H, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX227).

A compound according to Compound (1D) wherein R¹ represents a hydrogenatom, Q represents Q8I, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX228).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8J, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX229).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q8J, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX230).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8K, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX231).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q8K, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX232).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8L, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX233).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q8L, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX234).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8M, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX235).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8N, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX236).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8O, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX237).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8P, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX238).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, R⁷ represents ahydrogen atom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX239).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R⁷ represents ahydrogen atom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX240).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q4, R⁷ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX241).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q4, R⁷ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX242).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q5, R⁷ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX243).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q5, R⁷ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX244).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q6, R⁷ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX245).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q6, R⁷ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX246).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R⁷ represents ahydrogen atom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX247).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R⁷ represents ahydrogen atom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX248).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R⁷ represents a hydrogen atom,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX249).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R⁷ represents a hydrogen atom,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX250).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8A, R⁷ represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) (hereinafter,referred to as Compound group SX251).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q8A, R⁷ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX252).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8B, R⁷ represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX253).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q8B, R⁷ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX254).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8C, R⁷ represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX255).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q8C, R⁷ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX256).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8D, R⁷ represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX257).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8E, R⁷ represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX258).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8F, R⁷ represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX259).

A compound according to Compound (1D) wherein R¹ represents a hydrogenatom, Q represents Q8G, R⁷ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX260).

A compound according to Compound (1D) wherein R¹ represents a hydrogenatom, Q represents Q8H, R⁷ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX261).

A compound according to Compound (1D) wherein R¹ represents a hydrogenatom, Q represents Q8I, R⁷ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX262).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8J, R⁷ represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX263).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q8J, R⁷ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX264).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8K, R⁷ represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX265).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q8K, R⁷ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX266).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8L, R⁷ represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX267).

A compound according to Compound (1D) wherein R¹ represents a chlorineatom, Q represents Q8L, R⁷ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX268).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8M, R⁷ represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX269).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8N, R⁷ represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX270).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8O, R⁷ represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) (hereinafter,referred to as Compound group SX271).

A compound according to Compound (1D) wherein R¹ represents a methylgroup, Q represents Q8P, R⁷ represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX272).

A compound represented by formula (1G) (hereinafter, referred to asCompound (1G)):

wherein R¹ represents a methyl group, Q represents Q3, R³ represents amethoxy group, and R¹⁹ represents any substituent selected from Group Y(hereinafter, referred to as Compound group SX273).

-   -   Group Y: a group consisting of Et, Pr, i-Pr, (CH₂)₃CH₃,        CH₂CH(CH₃)₂, CH(CH₃)CH₂CH₃, t-Bu, CH₂c-Pr, (CH₂)₄CH₃,        (CH₂)₂CH(CH₃)₂, CH(CH₃)(CH₂)₂CH₃, CH(CH₂CH₃)CH₂CH₃,        CH₂CH(CH₃)CH₂CH₃, C(CH₃)₂CH₂CH₃, CH₂t-Bu, CH₂c-Bu, CH₂c-Pen,        (CH₂)₂c-Pr, (1-methylcyclopropyl)methyl,        (2-methylcyclopropyl)methyl, 1-cyclopropylethyl, (CH₂)₃c-Pr,        (CH₂)₅CH₃, (CH₂)₃CH(CH₃)₂, (CH₂)₂CH(CH₃)CH₂CH₃,        CH₂CH(CH₃)(CH₂)₂CH₃, CH(CH₃)(CH₂)₃CH₃, CH₂CH(CH₂CH₃)₂, heptyl,        CH₂CH═CH₂, CH₂CH═CHCH₃, CH₂CH═C(CH₃)₂, CH₂CH═CF₂, CH₂CH═CCl₂,        CH₂CH═CHCH₂CH₃, CH₂CH═CH(CH₂)₂CH₃, CH₂C(CH₃)═CH₂,        CH₂C(CH₃)═CHCH₃, CH₂C(CH₃)═C(CH₃)₂, CH₂C(CH₃)═CHCH₂CH₃,        CH₂CF═CH₂, CH₂CF═CHCH₃, CH₂CF═C(CH₃)₂, CH₂CF═CF₂,        CH₂CF═CHCH₂CH₃, CH₂CF═CH(CH₂)₂CH₃, CH₂CCl═CH₂, CH₂CCl═CHCH₃,        CH₂CCl═C(CH₃)₂, CH₂CCl═CCl₂, CH₂CCl═CHCH₂CH₃,        CH₂CCl═CH(CH₂)₂CH₃, (CH₂)₂CH═CH₂, (CH₂)₂CH═CHCH₃,        (CH₂)₂CH═CHCH₂CH₃, (CH₂)₂CH═C(CH₃)₂, (CH₂)₂C(CH₃)═CH₂,        (CH₂)₂C(CH₃)═CHCH₃, (CH₂)₃CH═CH₂, (CH₂)₃C(CH₃)═CH₂,        (CH₂)₄CH═CH₂, CH₂C≡CH, CH₂C≡CCH₃, CH₂C≡CCH₂CH₃, CH₂C≡Cc-Pr,        (CH₂)₂C≡CH, (CH₂)₂C≡CCH₃, (CH₂)₂C≡CCH₂CH₃, (CH₂)₃C═CH,        (CH₂)₃C═CCH₃, CH₂Cl, CH₂Br, CH₂OCH₃, CH₂OCH₂CH₃, CH₂O(CH₂)₂CH₃,        CHF₂, CF₃, CH₂CF₃, CH₂CHF₂, CH₂CH₂CHF₂, CH₂CH₂CF₃, CH₂CF₂CF₃,        (CH₂)₂CF₂CF₃, CH₂(CF₂)₂CF₃, (CH₂)₂CF(CF₃)₂, (CH₂)₂(CF₂)₅CF₃,        CF₃, CF₂CHF(CF₃), CF₂CHF(OCF₃), CH₂CF₂CF₂H, c-Pr, and c-Bu.

A compound according to Compound (1G) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, and R¹⁹ representsany substituent selected from Group Y (hereinafter, referred to asCompound group SX274).

A compound according to Compound (1G) wherein R¹ represents a methylgroup, Q represents Q4, and R¹⁹ represents any substituent selected fromGroup Y (hereinafter, referred to as Compound group SX275).

A compound according to Compound (1G) wherein R¹ represents a chlorineatom, Q represents Q4, and R¹⁹ represents any substituent selected fromGroup Y (hereinafter, referred to as Compound group SX276).

A compound according to Compound (1G) wherein R¹ represents a methylgroup, Q represents Q5, and R¹⁹ represents any substituent selected fromGroup Y (hereinafter, referred to as Compound group SX277).

A compound according to Compound (1G) wherein R¹ represents a chlorineatom, Q represents Q5, and R¹⁹ represents any substituent selected fromGroup Y (hereinafter, referred to as Compound group SX278).

A compound according to Compound (1G) wherein R¹ represents a methylgroup, Q represents Q6, and R¹⁹ represents any substituent selected fromGroup Y (hereinafter, referred to as Compound group SX279).

A compound according to Compound (1G) wherein R¹ represents a chlorineatom, Q represents Q6, and R¹⁹ represents any substituent selected fromGroup Y (hereinafter, referred to as Compound group SX280).

A compound according to Compound (1G) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, and R¹⁹ representsany substituent selected from Group Y (hereinafter, referred to asCompound group SX281).

A compound according to Compound (1G) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, and R¹⁹ representsany substituent selected from Group Y (hereinafter, referred to asCompound group SX282).

A compound according to Compound (1G) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, and R¹⁹ represents anysubstituent selected from Group Y (hereinafter, referred to as Compoundgroup SX283).

A compound according to Compound (1G) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, and R¹⁹ represents anysubstituent selected from Group Y (hereinafter, referred to as Compoundgroup SX284).

A compound according to Compound (1G) wherein R¹ represents a methylgroup, Q represents Q8A, and R¹⁹ represents any substituent selectedfrom Group Y (hereinafter, referred to as Compound group SX285).

A compound according to Compound (1G) wherein R¹ represents a chlorineatom, Q represents Q8A, and R¹⁹ represents any substituent selected fromGroup Y (hereinafter, referred to as Compound group SX286).

A compound according to Compound (1G) wherein R¹ represents a methylgroup, Q represents Q8B, and R¹⁹ represents any substituent selectedfrom Group Y (hereinafter, referred to as Compound group SX287).

A compound according to Compound (1G) wherein R¹ represents a chlorineatom, Q represents Q8B, and R¹⁹ represents any substituent selected fromGroup Y (hereinafter, referred to as Compound group SX288).

A compound according to Compound (1G) wherein R¹ represents a methylgroup, Q represents Q8C, and R¹⁹ represents any substituent selectedfrom Group Y (hereinafter, referred to as Compound group SX289).

A compound according to Compound (1G) wherein R¹ represents a chlorineatom, Q represents Q8C, and R¹⁹ represents any substituent selected fromGroup Y (hereinafter, referred to as Compound group SX290).

A compound according to Compound (1G) wherein R¹ represents a methylgroup, Q represents Q8D, and R¹⁹ represents any substituent selectedfrom Group Y (hereinafter, referred to as Compound group SX291).

A compound according to Compound (1G) wherein R¹ represents a methylgroup, Q represents Q8E, and R¹⁹ represents any substituent selectedfrom Group Y (hereinafter, referred to as Compound group SX292).

A compound according to Compound (1G) wherein R¹ represents a methylgroup, Q represents Q8F, and R¹⁹ represents any substituent selectedfrom Group Y (hereinafter, referred to as Compound group SX293).

A compound according to Compound (1G) wherein R¹ represents a hydrogenatom, Q represents Q8G, and R¹⁹ represents any substituent selected fromGroup Y (hereinafter, referred to as Compound group SX294).

A compound according to Compound (1G) wherein R¹ represents a hydrogenatom, Q represents Q8H, and R¹⁹ represents any substituent selected fromGroup Y (hereinafter, referred to as Compound group SX295).

A compound according to Compound (1G) wherein R¹ represents a hydrogenatom, Q represents Q8I, and R¹⁹ represents any substituent selected fromGroup Y (hereinafter, referred to as Compound group SX296).

A compound according to Compound (1G) wherein R¹ represents a methylgroup, Q represents Q8J, and R¹⁹ represents any substituent selectedfrom Group Y (hereinafter, referred to as Compound group SX297).

A compound according to Compound (1G) wherein R¹ represents a chlorineatom, Q represents Q8J, and R¹⁹ represents any substituent selected fromGroup Y (hereinafter, referred to as Compound group SX298).

A compound according to Compound (1G) wherein R¹ represents a methylgroup, Q represents Q8K, and R¹⁹ represents any substituent selectedfrom Group Y (hereinafter, referred to as Compound group SX299).

A compound according to Compound (1G) wherein R¹ represents a chlorineatom, Q represents Q8K, and R¹⁹ represents any substituent selected fromGroup Y (hereinafter, referred to as Compound group SX300).

A compound according to Compound (1G) wherein R¹ represents a methylgroup, Q represents Q8L, and R¹⁹ represents any substituent selectedfrom Group Y (hereinafter, referred to as Compound group SX301).

A compound according to Compound (1G) wherein R¹ represents a chlorineatom, Q represents Q8L, and R¹⁹ represents any substituent selected fromGroup Y (hereinafter, referred to as Compound group SX302).

A compound according to Compound (1G) wherein R¹ represents a methylgroup, Q represents Q8M, and R¹⁹ represents any substituent selectedfrom Group Y (hereinafter, referred to as Compound group SX303).

A compound according to Compound (1G) wherein R¹ represents a methylgroup, Q represents Q8N, and R¹⁹ represents any substituent selectedfrom Group Y (hereinafter, referred to as Compound group SX304).

A compound according to Compound (1G) wherein R¹ represents a methylgroup, Q represents Q8O, and R¹⁹ represents any substituent selectedfrom Group Y (hereinafter, referred to as Compound group SX305).

A compound represented by formula (1H) (hereinafter, referred to asCompound (1H)):

wherein R¹ represents a methyl group, Q represents Q3, R³ represents amethoxy group, R⁷ represents a methyl group, and R¹⁷ represents anysubstituent selected from Group X (hereinafter, referred to as Compoundgroup SX306).

A compound according to Compound (1H) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R⁷ represents amethyl group, and R¹⁷ represents any substituent selected from Group X(hereinafter, referred to as Compound group SX307).

A compound according to Compound (1H) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, R⁷ represents anethyl group, and R¹⁷ represents any substituent selected from Group X(hereinafter, referred to as Compound group SX308).

A compound according to Compound (1H) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R⁷ represents anethyl group, and R¹⁷ represents any substituent selected from Group X(hereinafter, referred to as Compound group SX309).

A compound according to Compound (1H) wherein R¹ represents a methylgroup, Q represents Q4, R⁷ represents a methyl group, and R¹⁷ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX310).

A compound according to Compound (1H) wherein R¹ represents a chlorineatom, Q represents Q4, R⁷ represents a methyl group, and R¹⁷ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX311).

A compound according to Compound (1H) wherein R¹ represents a methylgroup, Q represents Q4, R⁷ represents an ethyl group, and R¹⁷ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX312).

A compound according to Compound (1H) wherein R¹ represents a chlorineatom, Q represents Q4, R⁷ represents an ethyl group, and R¹⁷ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX313).

A compound according to Compound (1H) wherein R¹ represents a methylgroup, Q represents Q5, R⁷ represents a methyl group, and R¹⁷ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX314).

A compound according to Compound (1H) wherein R¹ represents a chlorineatom, Q represents Q5, R⁷ represents a methyl group, and R¹⁷ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX315).

A compound according to Compound (1H) wherein R¹ represents a methylgroup, Q represents Q5, R⁷ represents an ethyl group, and R¹⁷ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX316).

A compound according to Compound (1H) wherein R¹ represents a chlorineatom, Q represents Q5, R⁷ represents an ethyl group, and R¹⁷ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX317).

A compound according to Compound (1H) wherein R¹ represents a methylgroup, Q represents Q6, R⁷ represents a methyl group, and R¹⁷ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX318).

A compound according to Compound (1H) wherein R¹ represents a chlorineatom, Q represents Q6, R⁷ represents a methyl group, and R¹⁷ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX319).

A compound according to Compound (1H) wherein R¹ represents a methylgroup, Q represents Q6, R⁷ represents an ethyl group, and R¹⁷ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX320).

A compound according to Compound (1H) wherein R¹ represents a chlorineatom, Q represents Q6, R⁷ represents an ethyl group, and R¹⁷ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX321).

A compound according to Compound (1H) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R⁷ represents amethyl group, and R¹⁷ represents any substituent selected from Group X(hereinafter, referred to as Compound group SX322).

A compound according to Compound (1H) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R⁷ represents amethyl group, and R¹⁷ represents any substituent selected from Group X(hereinafter, referred to as Compound group SX323).

A compound according to Compound (1H) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R⁷ represents anethyl group, and R¹⁷ represents any substituent selected from Group X(hereinafter, referred to as Compound group SX324).

A compound according to Compound (1H) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R⁷ represents anethyl group, and R¹⁷ represents any substituent selected from Group X(hereinafter, referred to as Compound group SX325).

A compound according to Compound (1H) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R⁷ represents a methyl group,and R¹⁷ represents any substituent selected from Group X (hereinafter,referred to as Compound group SX326).

A compound according to Compound (1H) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R⁷ represents a methyl group,and R¹⁷ represents any substituent selected from Group X (hereinafter,referred to as Compound group SX327).

A compound according to Compound (1H) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R⁷ represents an ethyl group,and R¹⁷ represents any substituent selected from Group X (hereinafter,referred to as Compound group SX328).

A compound according to Compound (1H) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R⁷ represents an ethyl group,and R¹⁷ represents any substituent selected from Group X (hereinafter,referred to as Compound group SX329).

A compound according to Compound (1H) wherein R¹ represents a methylgroup, Q represents Q8A, R⁷ represents a methyl group, and R¹⁷represents any substituent selected from Group X (hereinafter, referredto as Compound group SX330).

A compound according to Compound (1H) wherein R¹ represents a chlorineatom, Q represents Q8A, R⁷ represents a methyl group, and R¹⁷ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX331).

A compound according to Compound (1H) wherein R¹ represents a methylgroup, Q represents Q8A, R⁷ represents an ethyl group, and R¹⁷represents any substituent selected from Group X (hereinafter, referredto as Compound group SX332).

A compound according to Compound (1H) wherein R¹ represents a chlorineatom, Q represents Q8A, R⁷ represents an ethyl group, and R¹⁷ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX333).

A compound according to Compound (1H) wherein R¹ represents a methylgroup, Q represents Q8D, R⁷ represents a methyl group, and R¹⁷represents any substituent selected from Group X (hereinafter, referredto as Compound group SX334).

A compound according to Compound (1H) wherein R¹ represents a chlorineatom, Q represents Q8D, R⁷ represents a methyl group, and R¹⁷ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX335).

A compound according to Compound (1H) wherein R¹ represents a methylgroup, Q represents Q8D, R⁷ represents an ethyl group, and R¹⁷represents any substituent selected from Group X (hereinafter, referredto as Compound group SX336).

A compound according to Compound (1H) wherein R¹ represents a chlorineatom, Q represents Q8D, R⁷ represents an ethyl group, and R¹⁷ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX337).

A compound according to Compound (1H) wherein R¹ represents a methylgroup, Q represents Q8J, R⁷ represents a methyl group, and R¹⁷represents any substituent selected from Group X (hereinafter, referredto as Compound group SX338).

A compound according to Compound (1H) wherein R¹ represents a chlorineatom, Q represents Q8J, R⁷ represents a methyl group, and R¹⁷ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX339).

A compound according to Compound (1H) wherein R¹ represents a methylgroup, Q represents Q8J, R⁷ represents an ethyl group, and R¹⁷represents any substituent selected from Group X (hereinafter, referredto as Compound group SX340).

A compound according to Compound (1H) wherein R¹ represents a chlorineatom, Q represents Q8J, R⁷ represents an ethyl group, and R¹⁷ representsany substituent selected from Group X (hereinafter, referred to asCompound group SX341).

A compound represented by formula (1I) (hereinafter, referred to asCompound (1I)):

wherein R¹ represents a methyl group, Q represents Q3, R³ represents amethoxy group, R⁷ represents a methyl group, and a combination ofR^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX342).

A compound according to Compound (1I) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R⁷ represents amethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX343).

A compound according to Compound (1I) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, R⁷ represents anethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX344).

A compound according to Compound (1I) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R⁷ represents anethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX345).

A compound according to Compound (1I) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, R⁷ represents acyclopropyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5)and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX346).

A compound according to Compound (1I) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R⁷ represents acyclopropyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5)and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX347).

A compound according to Compound (1I) wherein R¹ represents a methylgroup, Q represents Q4, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) (hereinafter, referred toas Compound group SX348).

A compound according to Compound (1I) wherein R¹ represents a chlorineatom, Q represents Q4, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX349).

A compound according to Compound (1I) wherein R¹ represents a methylgroup, Q represents Q4, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX350).

A compound according to Compound (1I) wherein R¹ represents a chlorineatom, Q represents Q4, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX351).

A compound according to Compound (1I) wherein R¹ represents a methylgroup, Q represents Q4, R⁷ represents a cyclopropyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX352).

A compound according to Compound (1I) wherein R¹ represents a chlorineatom, Q represents Q4, R⁷ represents a cyclopropyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX353).

A compound according to Compound (1I) wherein R¹ represents a methylgroup, Q represents Q5, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX354).

A compound according to Compound (1I) wherein R¹ represents a chlorineatom, Q represents Q5, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX355).

A compound according to Compound (1I) wherein R¹ represents a methylgroup, Q represents Q5, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX356).

A compound according to Compound (1I) wherein R¹ represents a chlorineatom, Q represents Q5, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX357).

A compound according to Compound (1I) wherein R¹ represents a methylgroup, Q represents Q5, R⁷ represents a cyclopropyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX358).

A compound according to Compound (1I) wherein R¹ represents a chlorineatom, Q represents Q5, R⁷ represents a cyclopropyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX359).

A compound according to Compound (1I) wherein R¹ represents a methylgroup, Q represents Q6, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX360).

A compound according to Compound (1I) wherein R¹ represents a chlorineatom, Q represents Q6, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX361).

A compound according to Compound (1I) wherein R¹ represents a methylgroup, Q represents Q6, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX362).

A compound according to Compound (1I) wherein R¹ represents a chlorineatom, Q represents Q6, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX363).

A compound according to Compound (1I) wherein R¹ represents a methylgroup, Q represents Q6, R⁷ represents a cyclopropyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX364).

A compound according to Compound (1I) wherein R¹ represents a chlorineatom, Q represents Q6, R⁷ represents a cyclopropyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX365).

A compound according to Compound (1I) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R⁷ represents amethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX366).

A compound according to Compound (1I) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R⁷ represents amethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX367).

A compound according to Compound (1I) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R⁷ represents anethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX368).

A compound according to Compound (1I) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R⁷ represents anethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX369).

A compound according to Compound (1I) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R⁷ represents a methyl group,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX370).

A compound according to Compound (1I) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R⁷ represents a methyl group,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX371).

A compound according to Compound (1I) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R⁷ represents an ethyl group,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX372).

A compound according to Compound (1I) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R⁷ represents an ethyl group,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX373).

A compound according to Compound (1I) wherein R¹ represents a methylgroup, Q represents Q8A, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX374).

A compound according to Compound (1I) wherein R¹ represents a chlorineatom, Q represents Q8A, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX375).

A compound according to Compound (1I) wherein R¹ represents a methylgroup, Q represents Q8A, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX376).

A compound according to Compound (1I) wherein R¹ represents a chlorineatom, Q represents Q8A, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX377).

A compound according to Compound (1I) wherein R¹ represents a methylgroup, Q represents Q8D, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX378).

A compound according to Compound (1I) wherein R¹ represents a chlorineatom, Q represents Q8D, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX379).

A compound according to Compound (1I) wherein R¹ represents a methylgroup, Q represents Q8D, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX380).

A compound according to Compound (1I) wherein R¹ represents a chlorineatom, Q represents Q8D, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX381).

A compound according to Compound (1I) wherein R¹ represents a methylgroup, Q represents Q8J, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX382).

A compound according to Compound (1I) wherein R¹ represents a chlorineatom, Q represents Q8J, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX383).

A compound according to Compound (1I) wherein R¹ represents a methylgroup, Q represents Q8J, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX384).

A compound according to Compound (1I) wherein R¹ represents a chlorineatom, Q represents Q8J, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX385).

A compound represented by formula (1J) (hereinafter, referred to asCompound (1J)):

[wherein G represents any one of formulae G1 to G35

wherein R¹ represents a methyl group, Q represents Q3, R³ represents amethoxy group, and a combination of structure of G and substituents ofR^(X7), R^(X8), R^(X9) and R^(X10) applied to the structure of Grepresents any combination described in Combination B (hereinafter,referred to as Compound group SX386).

Combination B consists of substituent numbers ZB1 to ZB1562. Substituentnumbers ZB1 to ZB1562 represent combinations of structure of G andsubstituents of R^(X7), R^(X8), R^(X9) and R^(X10) applied to thestructure of G according to Compound (1J), compounds represented byformula (2B), and compounds represented by formula (2C); combinations ofstructure of G³ and substituents of R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G³ according to compounds represented byformula (2K), compounds represented by formula (2M), and compoundsrepresented by formula (20); and combinations of structure of G⁵ andsubstituents of R^(X7), R^(X8), R^(X9) and R^(X10) applied to thestructure of G⁵ according to compounds represented by formula (3C),compounds represented by formula (3E), and compounds represented byformula (2T). And hereinafter, they are referred to as [substituentnumber; G, R^(X7), R^(X8), R^(X9), R^(X1)]. For example, the substituentnumber ZB2 refers to a combination wherein G, G³ or G⁵ represents G1,R^(X7) represents a methyl group, and each of R^(X8), R^(X9) and R^(X10)represents a hydrogen atom.

-   -   Combination B: [ZB1;G1,H,H,H,H], [ZB2;G1,Me,H,H,H],        [ZB3;G1,Et,H,H,H], [ZB4;G 1,Pr,H,H,H], [ZB5;G1,i-Pr,H,H,H],        [ZB6;G1,c-Pr,H,H,H], [ZB7;G1,Ph,H,H,H], [ZB8;G1,OMe,H,H,H],        [ZB9;G1,OEt, H,H,H], [ZB10;G1,OPh,H,H,H], [ZB11;G1,CF₃,H,H,H],        [ZB12;G1,F,H,H,H], [ZB13;G1,Cl,H,H,H], [ZB14;G1,Br,H,H,H],        [ZB15;G,CN,H,H,H], [ZB16;G1,H,Me,H,H], [ZB17;G1,H,Et,H,H],        [ZB18;G1,H,Pr,H,H], [ZB19;G1,H,i-Pr,H,H], [ZB20;G1,H,c-Pr,H,H],        [ZB21;G1,H,Ph,H,H], [ZB22;G1,H,OMe,H,H], [ZB23;G1,H,O Et,H,H],        [ZB24;G1,H,OPh,H,H], [ZB25;G1,H,CF₃,H,H], [ZB26;G1,H, F,H,H],        [ZB27;G1,H,Cl,H,H], [ZB28;G1,H,Br,H,H], [ZB29;G1,H,CN, H,H],        [ZB30;G1,H,H,Me,H], [ZB31;G1,H,H,Et,H], [ZB32;G1,H,H,Pr, H],        [ZB33;G1,H,H,i-Pr,H], [ZB34;G1,H,H,c-Pr,H], [ZB35;G1,H,H,Ph,H],        [ZB36;G1,H,H,OMe,H], [ZB37;G1,H,H,O Et,H], [ZB38;G1,H,H,OPh,H],        [ZB39;G1,H,H,CF₃,H], [ZB40;G1,H,H, F,H], [ZB41;G1,H,H,Cl,H],        [ZB42;G1,H,H,Br,H], [ZB43;G1,H,H,CN, H], [ZB44;G1,H,H,H,Me],        [ZB45;G1,H,H,H,Et], [ZB46;G1,H,H,H,Pr], [ZB47;G1,H,H,H,i-Pr],        [ZB48;G1,H,H,H,c-Pr], [ZB49;G1,H,H,H,Ph], [ZB50;G1,H,H,H,OMe],        [ZB51;G1,H,H,H,O Et], [ZB52;G1,H,H,H,OPh], [ZB53;G1,H,H,H,CF₃],        [ZB54;G1,H,H,H, F], [ZB55;G1,H,H,H,Cl], [ZB56;G1,H,H,H,Br],        [ZB57;G1,H,H,H,CN], [ZB58;G2,H,H,H,H], [ZB59;G2,Me,H,H,H],        [ZB60;G2,Et,H,H,H], [Z B61;G2,Pr,H,H,H], [ZB62;G2,i-Pr,H,H,H],        [ZB63;G2,c-Pr,H,H,H], [ZB64;G2,Ph,H,H,H], [ZB65;G2,OMe,H,H,H],        [ZB66;G2,O Et,H,H,H], [ZB67;G2,OPh,H,H,H], [ZB68;G2,CF₃,H,H,H],        [ZB69;G2, F,H,H,H], [ZB70;G2,Cl,H,H,H], [ZB71;G2,Br,H,H,H],        [ZB72;G2,CN, H,H,H], [ZB73;G2,H,Me,H,H], [ZB74;G2,H,Et,H,H],        [ZB75;G2,H,Pr, H,H], [ZB76;G2,H,i-Pr,H,H], [ZB77;G2,H,c-Pr,H,H],        [ZB78;G2,H,Ph,H,H], [ZB79;G2,H,OMe,H,H], [ZB80;G2,H,O Et,H,H],        [ZB81;G2,H,OPh,H,H], [ZB82;G2,H,CF₃,H,H], [ZB83;G2,H, F,H,H],        [ZB84;G2,H,Cl,H,H], [ZB85;G2,H,Br,H,H], [ZB86;G2,H,CN, H,H],        [ZB87;G2,H,H,Me,H], [ZB88;G2,H,H,Et,H], [ZB89;G2,H,H,Pr, H],        [ZB90;G2,H,H,i-Pr,H], [ZB91;G2,H,H,c-Pr,H], [ZB92;G2,H,H,Ph,H],        [ZB93;G2,H,H,OMe,H], [ZB94;G2,H,H,O Et,H], [ZB95;G2,H,H,OPh,H],        [ZB96;G2,H,H,CF₃,H], [ZB97;G2,H,H, F,H], [ZB98;G2,H,H,Cl,H],        [ZB99;G2,H,H,Br,H], [ZB100;G2,H,H,CN,H], [ZB101;G2,H,H,H,Me],        [ZB102;G2,H,H,H,Et], [ZB103;G2,H,H,H,Pr], [ZB104;G2,H,H,H,i-Pr],        [ZB105;G2,H,H,H,c-Pr], [ZB106;G2,H,H,H,Ph],        [ZB107;G2,H,H,H,OMe], [ZB108;G2,H,H, H,OEt],        [ZB109;G2,H,H,H,OPh], [ZB110;G2,H,H,H,CF₃], [ZB111;G2, H,H,H,F],        [ZB112;G2,H,H,H,Cl], [ZB113;G2,H,H,H,Br], [ZB114;G2, H,H,H,CN],        [ZB115;G3,H,H,H,H], [ZB116;G3,Me,H,H,H], [ZB117;G3, Et,H,H,H],        [ZB118;G3,Pr,H,H,H], [ZB119;G3,i-Pr,H,H,H],        [ZB120;G3,c-Pr,H,H,H], [ZB121;G3,Ph,H,H,H],        [ZB122;G3,OMe,H,H,H], [ZB123;G 3,OEt,H,H,H],        [ZB124;G3,OPh,H,H,H], [ZB125;G3,CF₃,H,H,H], [ZB1 26;G3,F,H,H,H],        [ZB127;G3,Cl,H,H,H], [ZB128;G3,Br,H,H,H], [ZB1 29;G3,CN,H,H,H],        [ZB130;G3,H,Me,H,H], [ZB131;G3,H,Et,H,H], [ZB 132;G3,H,Pr,H,H],        [ZB133;G3,H,i-Pr,H,H], [ZB134;G3,H,c-Pr,H,H],        [ZB135;G3,H,Ph,H,H], [ZB136;G3,H,OMe,H,H], [ZB137;G3,        H,OEt,H,H], [ZB138;G3,H,OPh,H,H], [ZB139;G3,H,CF₃,H,H],        [ZB140;G3,H,F,H,H], [ZB141;G3,H,Cl,H,H], [ZB142;G3,H,Br,H,H],        [ZB143;G3,H,CN,H,H], [ZB144;G3,H,H,Me,H], [ZB145;G3,H,H,Et,H],        [ZB14 6;G3,H,H,Pr,H], [ZB147;G3,H,H,i-Pr,H],        [ZB148;G3,H,H,c-Pr,H], [ZB149;G3,H,H,Ph,H],        [ZB150;G3,H,H,OMe,H], [ZB151;G3,H, H,OEt,H],        [ZB152;G3,H,H,OPh,H], [ZB153;G3,H,H,CF₃,H], [ZB154;G 3,H,H,F,H],        [ZB155;G3,H,H,Cl,H], [ZB156;G3,H,H,Br,H], [ZB157;G 3,H,H,CN,H],        [ZB158;G3,H,H,H,Me], [ZB159;G3,H,H,H,Et], [ZB160; G3,H,H,H,Pr],        [ZB161;G3,H,H,H,i-Pr], [ZB162;G3,H,H,H,c-Pr],        [ZB163;G3,H,H,H,Ph], [ZB164;G3,H,H,H,OMe], [ZB165;G3,H,H,        H,OEt], [ZB166;G3,H,H,H,OPh], [ZB167;G3,H,H,H,CF₃], [ZB168;G3,        H,H,H,F], [ZB169;G3,H,H,H,Cl], [ZB170;G3,H,H,H,Br], [ZB171;G3,        H,H,H,CN], [ZB172;G4,H,H,H,-], [ZB173;G4,Me,H,H,-], [ZB174;G4,        Et,H,H,-], [ZB175;G4,Pr,H,H,-], [ZB176;G4,i-Pr,H,H,-],        [ZB177;G4,c-Pr,H,H,-], [ZB178;G4,Ph,H,H,-],        [ZB179;G4,OMe,H,H,-], [ZB180;G 4,OEt,H,H,-],        [ZB181;G4,OPh,H,H,-], [ZB182;G4,CF₃,H,H,-], [ZB1 83;G4,F,H,H,-],        [ZB184;G4,Cl,H,H,-], [ZB185;G4,Br,H,H,-], [ZB1 86;G4,CN,H,H,-],        [ZB187;G4,H,Me,H,-], [ZB188;G4,H,Et,H,-], [ZB 189;G4,H,Pr,H,-],        [ZB190;G4,H,i-Pr,H,-], [ZB191;G4,H,c-Pr,H,-],        [ZB192;G4,H,Ph,H,-], [ZB193;G4,H,OMe,H,-], [ZB194;G4,        H,OEt,H,-], [ZB195;G4,H,OPh,H,-], [ZB196;G4,H,CF₃,H,-],        [ZB197;G4,H,F,H,-], [ZB198;G4,H,Cl,H,-], [ZB199;G4,H,Br,H,-],        [ZB200;G4,H,CN,H,-], [ZB201;G4,H,H,Me,-], [ZB202;G4,H,H,Et,-],        [ZB203;G4,H,H,Pr,-], [ZB204;G4,H,H,i-Pr,-],        [ZB205;G4,H,H,c-Pr,-], [ZB206;G4,H,H,Ph,-],        [ZB207;G4,H,H,OMe,-], [ZB208;G4,H, H,OEt,-],        [ZB209;G4,H,H,OPh,-], [ZB210;G4,H,H,CF₃,-], [ZB211;G 4,H,H,F,-],        [ZB212;G4,H,H,Cl,-], [ZB213;G4,H,H,Br,-], [ZB214;G 4,H,H,CN, -],        [ZB215;G5,H,H,H, -], [ZB216;G5,Me,H,H, -], [ZB217;G 5,Et,H,H,-],        [ZB218;G5,Pr,H,H,-], [ZB219;G5,i-Pr,H,H,-],        [ZB220;G5,c-Pr,H,H,-], [ZB221;G5,Ph,H,H,-],        [ZB222;G5,OMe,H,H,-], [ZB223;G 5,OEt,H,H,-],        [ZB224;G5,OPh,H,H,-], [ZB225;G5,CF₃,H,H,-], [ZB2 26;G5,F,H,H,-],        [ZB227;G5,Cl,H,H,-], [ZB228;G5,Br,H,H,-], [ZB2 29;G5,CN,H,H,H-],        [ZB230;G5,H,Me,H,-], [ZB231;G5,H,Et,H,-], [ZB 232;G5,H,Pr,H,-],        [ZB233;G5,H,i-Pr,H,-], [ZB234;G5,H,c-Pr,H,-],        [ZB235;G5,H,Ph,H,-], [ZB236;G5,H,OMe,H,-], [ZB237;G5,        H,OEt,H,-], [ZB238;G5,H,OPh,H,-], [ZB239;G5,H,CF₃,H,-],        [ZB240;G5,H,F,H,-], [ZB241;G5,H,Cl,H,-], [ZB242;G5,H,Br,H,-],        [ZB243;G5,H,CN,H,-], [ZB244;G5,H,H,Me,-], [ZB245;G5,H,H,Et,-],        [ZB24 6;G5,H,H,Pr,-], [ZB247;G5,H,H,i-Pr,-],        [ZB248;G5,H,H,c-Pr,-], [ZB249;G5,H,H,Ph,-],        [ZB250;G5,H,H,OMe,-], [ZB251;G5,H, H,OEt,-],        [ZB252;G5,H,H,OPh,-], [ZB253;G5,H,H,CF₃,-], [ZB254;G 5,H,H,F,-],        [ZB255;G5,H,H,Cl,-], [ZB256;G5,H,H,Br,-], [ZB257;G 5,H,H,CN,-],        [ZB258;G6,H,H,H,-], [ZB259;G6,Me,H,H,-], [ZB260;G 6,Et,H,H,-],        [ZB261;G6,Pr,H,H,-], [ZB262;G6,i-Pr,H,H,-],        [ZB263;G6,c-Pr,H,H,-], [ZB264;G6,Ph,H,H,-],        [ZB265;G6,OMe,H,H,-], [ZB266;G 6,OEt,H,H,-],        [ZB267;G6,OPh,H,H,-], [ZB268;G6,CF₃,H,H,-], [ZB2 69;G6,F,H,H,-],        [ZB270;G6,Cl,H,H,-], [ZB271;G6,Br,H,H,-], [ZB2 72;G6,CN,H,H,-],        [ZB273;G6,H,Me,H,-], [ZB274;G6,H,Et,H,-], [ZB 275;G6,H,Pr,H,-],        [ZB276;G6,H,i-Pr,H,-], [ZB277;G6,H,c-Pr,H,-],        [ZB278;G6,H,Ph,H,-], [ZB279;G6,H,OMe,H,-], [ZB280;G6,        H,OEt,H,-], [ZB281;G6,H,OPh,H,-], [ZB282;G6,H,CF₃,H,-],        [ZB283;G6,H,F,H,-], [ZB284;G6,H,Cl,H,-], [ZB285;G6,H,Br,H,-],        [ZB286;G6,H,CN,H,-], [ZB287;G6,H,H,Me,-], [ZB288;G6,H,H,Et,-],        [ZB28 9;G6,H,H,Pr,-], [ZB290;G6,H,H,i-Pr,-],        [ZB291;G6,H,H,c-Pr,-], [ZB292;G6,H,H,Ph,-],        [ZB293;G6,H,H,OMe,-], [ZB294;G6,H, H,OEt,-],        [ZB295;G6,H,H,OPh,-], [ZB296;G6,H,H,CF₃,-], [ZB297;G 6,H,H,F,-],        [ZB298;G6,H,H,Cl,-], [ZB299;G6,H,H,Br,-], [ZB300;G 6,H,H,CN,-],        [ZB301;G7,H,H,H,-], [ZB302;G7,Me,H,H,-], [ZB303;G 7,Et,H,H,-],        [ZB304;G7,Pr,H,H,-], [ZB305;G7,i-Pr,H,H,-],        [ZB306;G7,c-Pr,H,H,-], [ZB307;G7,Ph,H,H,-],        [ZB308;G7,OMe,H,H,-], [ZB309;G 7,OEt,H,H,-],        [ZB310;G7,OPh,H,H,-], [ZB311;G7,CF₃,H,H,-], [ZB3 12;G7,F,H,H,-],        [ZB313;G7,Cl,H,H,-], [ZB314;G7,Br,H,H,-], [ZB3 15;G7,CN,H,H,-],        [ZB316;G7,H,Me,H,-], [ZB317;G7,H,Et,H,-], [ZB 318;G7,H,Pr,H,-],        [ZB319;G7,H,i-Pr,H,-], [ZB320;G7,H,c-Pr,H,-],        [ZB321;G7,H,Ph,H,-], [ZB322;G7,H,OMe,H,-], [ZB323;G7,        H,OEt,H,-], [ZB324;G7,H,OPh,H,-], [ZB325;G7,H,CF₃,H,-],        [ZB326;G7,H,F,H,-], [ZB327;G7,H,Cl,H,-], [ZB328;G7,H,Br,H,-],        [ZB329;G7,H,CN,H,-], [ZB330;G7,H,H,Me,-], [ZB331;G7,H,H,Et,-],        [ZB33 2;G7,H,H,Pr,-], [ZB333;G7,H,H,i-Pr,-],        [ZB334;G7,H,H,c-Pr,-], [ZB335;G7,H,H,Ph,-],        [ZB336;G7,H,H,OMe,-], [ZB337;G7,H, H,OEt,-],        [ZB338;G7,H,H,OPh,-], [ZB339;G7,H,H,CF₃,-], [ZB340;G 7,H,H,F,-],        [ZB341;G7,H,H,Cl,-], [ZB342;G7,H,H,Br,-], [ZB343;G 7,H,H,CN,-],        [ZB344;G8,H,H,H,-], [ZB345;G8,Me,H,H,-], [ZB346;G 8,Et,H,H,-],        [ZB347;G8,Pr,H,H,-], [ZB348;G8,i-Pr,H,H,-],        [ZB349;G8,c-Pr,H,H,-], [ZB350;G8,Ph,H,H,-],        [ZB351;G8,OMe,H,H,-], [ZB352;G 8,OEt,H,H,-],        [ZB353;G8,OPh,H,H,-], [ZB354;G8,CF₃,H,H,-], [ZB3 55;G8,F,H,H,-],        [ZB356;G8,Cl,H,H,-], [ZB357;G8,Br,H,H,-], [ZB3 58;G8,CN,H,H,-],        [ZB359;G8,H,Me,H,-], [ZB360;G8,H,Et,H,-], [ZB 361;G8,H,Pr,H,-],        [ZB362;G8,H,i-Pr,H,-], [ZB363;G8,H,c-Pr,H,-],        [ZB364;G8,H,Ph,H,-], [ZB365;G8,H,OMe,H,-], [ZB366;G8,        H,OEt,H,-], [ZB367;G8,H,OPh,H,-], [ZB368;G8,H,CF₃,H,-],        [ZB369;G8,H,F,H,-], [ZB370;G8,H,Cl,H,-], [ZB371;G8,H,Br,H,-],        [ZB372;G8,H,CN,H,-], [ZB373;G8,H,H,Me,-], [ZB374;G8,H,H,Et,-],        [ZB37 5;G8,H,H,Pr,-], [ZB376;G8,H,H,i-Pr,-],        [ZB377;G8,H,H,c-Pr,-], [ZB378;G8,H,H,Ph,-],        [ZB379;G8,H,H,OMe,-], [ZB380;G8,H, H,OEt,-],        [ZB381;G8,H,H,OPh,-], [ZB382;G8,H,H,CF₃,-], [ZB383;G 8,H,H,F,-],        [ZB384;G8,H,H,Cl,-], [ZB385;G8,H,H,Br,-], [ZB386;G 8,H,H,CN,-],        [ZB387;G9,H,H,H,-], [ZB388;G9,Me,H,H,-], [ZB389;G 9,Et,H,H,-],        [ZB390;G9,Pr,H,H,-], [ZB391;G9,i-Pr,H,H,-],        [ZB392;G9,c-Pr,H,H,-], [ZB393;G9,Ph,H,H,-],        [ZB394;G9,OMe,H,H,-], [ZB395;G 9,OEt,H,H,-],        [ZB396;G9,OPh,H,H,-], [ZB397;G9,CF₃,H,H,-], [ZB3 98;G9,F,H,H,-],        [ZB399;G9,Cl,H,H,-], [ZB400;G9,Br,H,H,-], [ZB401;G9,CN,H,H,-],        [ZB402;G9,H,Me,H,-], [ZB403;G9,H,Et,H,-], [ZB404;G9,H,Pr,H,-],        [ZB405;G9,H,i-Pr,H,-], [ZB406;G9,H,c-Pr,H,-],        [ZB407;G9,H,Ph,H,-], [ZB408;G9,H,OMe,H,-], [ZB409;G9,        H,OEt,H,-], [ZB410;G9,H,OPh,H,-], [ZB411;G9,H,CF₃,H,-],        [ZB412;G9,H,F,H,-], [ZB413;G9,H,Cl,H,-], [ZB414;G9,H,Br,H,-],        [ZB415;G9,H,CN,H,-], [ZB416;G9,H,H,Me,-], [ZB417;G9,H,H,Et,-],        [ZB41 8;G9,H,H,Pr,-], [ZB419;G9,H,H,i-Pr,-],        [ZB420;G9,H,H,c-Pr,-], [ZB421;G9,H,H,Ph,-],        [ZB422;G9,H,H,OMe,-], [ZB423;G9,H, H,OEt,-],        [ZB424;G9,H,H,OPh,-], [ZB425;G9,H,H,CF₃,-], [ZB426;G 9,H,H,F,-],        [ZB427;G9,H,H,Cl,-], [ZB428;G9,H,H,Br,-], [ZB429;G 9,H,H,CN,-],        [ZB430;G10,H,H,H,-], [ZB431;G10,Me,H,H,-], [ZB432;G10,Et,H,H,-],        [ZB433;G10,Pr,H,H,-], [ZB434;G10,i-Pr,H,H,-],        [ZB435;G10,c-Pr,H,H,-], [ZB436;G10,Ph,H,H,-],        [ZB437;G10,OMe,H,H,-], [ZB438;G10,OEt,H,H,-],        [ZB439;G10,OPh,H,H,-], [ZB440;G10,CF₃,H,H,-],        [ZB441;G10,F,H,H,-], [ZB442;G10,Cl,H,H,-], [ZB443;G10,Br,H,H,-],        [ZB444;G10,CN,H,H,-], [ZB445;G10,H,Me,H,-], [ZB446;G10,H,        Et,H,-], [ZB447;G10,H,Pr,H,-], [ZB448;G10,H,i-Pr,H,-],        [ZB449;G10,H,c-Pr,H,-], [ZB450;G10,H,Ph,H,-],        [ZB451;G10,H,OMe,H,-], [ZB452;G 10,H,OEt,H, -],        [ZB453;G10,H,OPh,H, -], [ZB454;G10,H,CF₃,H,-],        [ZB455;G10,H,F,H,-], [ZB456;G10,H,Cl,H,-], [ZB457;G10,H,Br,H,-],        [ZB458;G10,H,CN,H,-], [ZB459;G10,H,H,Me,-], [ZB460;G10,H,H,        Et,-], [ZB461;G10,H,H,Pr,-], [ZB462;G10,H,H,i-Pr,-],        [ZB463;G10,H,H,c-Pr,-], [ZB464;G10,H,H,Ph,-],        [ZB465;G10,H,H,OMe,-], [ZB466;G10,H,H,OEt,-],        [ZB467;G10,H,H,OPh,-], [ZB468;G10,H,H,CF₃,-], [ZB        469;G10,H,H,F,-], [ZB470;G10,H,H,Cl,-], [ZB471;G10,H,H,Br,-],        [ZB472;G10,H,H,CN,-], [ZB473;G11,H,H,H,-], [ZB474;G11,H,Me,H,-],        [ZB475;G11,H,Et,H,-], [ZB476;G11,H,Pr,H,-],        [ZB477;G11,H,i-Pr,H,-], [ZB478;G11,H,c-Pr,H,-],        [ZB479;G11,H,Ph,H,-], [ZB480;G11,H,OMe,H,-], [ZB481;G        11,H,OEt,H, -], [ZB482;G11,H,OPh,H, -], [ZB483;G11,H,CF₃,H,-],        [ZB484;G11,HF,H,-], [ZB485;G11,H,Cl,H,-], [ZB486;G11,H,Br,H,-],        [ZB487;G11,H,CN,H,-], [ZB488;G11,H,H,Me,-], [ZB489;G11,H,H,E        t,-], [ZB490;G11,H,H,Pr,-], [ZB491;G11,H,H,i-Pr,-],        [ZB492;G11,H,H,c-Pr,-], [ZB493;G11,H,H,Ph,-],        [ZB494;G11,H,H,OMe,-], [ZB495;G11,H,H,OEt,-],        [ZB496;G11,H,H,OPh,-], [ZB497;G11,H,H,CF₃,-], [ZB        498;G11,H,H,F,-], [ZB499;G11,H,H,Cl,-], [ZB500;G11,H,H,Br,-],        [ZB501;G11,H,H,CN,-], [ZB502;G11,Me,H,H,-], [ZB503;G11,Me,Me,        H,-], [ZB504;G11,Me,Et,H,-], [ZB505;G11,Me,Pr,H,-],        [ZB506;G11,Me,i-Pr,H,-], [ZB507;G11,Me,c-Pr,H,-],        [ZB508;G11,Me,Ph,H,-], [ZB509;G11,Me,OMe,H,-],        [ZB510;G11,Me,OEt,H,-], [ZB511;G11,Me,OPh,H,-],        [ZB512;G11,Me,CF₃,H,-], [ZB513;G11,Me,F,H,-],        [ZB514;G11,Me,Cl,H,-], [ZB515;G11,M e,Br,H,-],        [ZB516;G11,Me,CN,H,-], [ZB517;G11,Me,H,Me,-], [ZB51        8;G11,Me,H,Et,-], [ZB519;G11,Me,H,Pr,-],        [ZB520;G11,Me,H,i-Pr,-], [ZB521;G11,Me,H,c-Pr,-],        [ZB522;G11,Me,H,Ph,-], [ZB523;G11,Me,H,OMe,-], [ZB524;G        11,Me,H,OEt,-], [ZB525;G11,Me,H,OPh,-], [ZB526;G11,Me,H,CF₃,-],        [ZB527;G11,Me,H,F,-], [ZB528;G11,Me,H,Cl,-], [ZB529;G11,Me,        H,Br,-], [ZB530;G11,Me,H,CN,-], [ZB531;G12,H,H,H,-], [ZB532;G1        2,Me,H,H,-], [ZB533;G12,Et,H,H,-], [ZB534;G12,Pr,H,H,-], [ZB53        5;G12,i-Pr,H,H,-], [ZB536;G12,c-Pr,H,H,-], [ZB537;G12,Ph,H,H,-],        [ZB538;G12,OMe,H,H,-], [ZB539;G12,OEt,H,H,-],        [ZB540;G12,OPh,H,H,-], [ZB541;G12,CF₃,H,H,-],        [ZB542;G12,F,H,H,-], [ZB543;G12,Cl,H,H,-], [ZB544;G12,Br,H,H,-],        [ZB545;G12,CN,H,H,-], [ZB546;G12,H,Me,H,-], [ZB547;G12,H,        Et,H,-], [ZB548;G12,H,Pr,H,-], [ZB549;G12,H,i-Pr,H,-],        [ZB550;G12,H,c-Pr,H,-], [ZB551;G12,H,Ph,H,-],        [ZB552;G12,H,OMe,H,-], [ZB553;G 12,H,OEt,H, -],        [ZB554;G12,H,OPh,H, -], [ZB555;G12,H,CF₃,H,-],        [ZB556;G12,H,F,H,-], [ZB557;G12,H,Cl,H,-], [ZB558;G12,H,Br,H,-],        [ZB559;G12,H,CN,H,-], [ZB560;G12,H,H,Me,-], [ZB561;G12,H,H,        Et,-], [ZB562;G12,H,H,Pr,-], [ZB563;G12,H,H,i-Pr,-],        [ZB564;G12,H,H,c-Pr,-], [ZB565;G12,H,H,Ph,-],        [ZB566;G12,H,H,OMe,-], [ZB567;G12,H,H,OEt,-],        [ZB568;G12,H,H,OPh,-], [ZB569;G12,H,H,CF₃,-], [ZB        570;G12,H,H,F,-], [ZB571;G12,H,H,Cl,-], [ZB572;G12,H,H,Br,-],        [ZB573;G12,H,H,CN,-], [ZB574;G13,H,H,H,-], [ZB575;G13,Me,H,H,-],        [ZB576;G13,Et,H,H,-], [ZB577;G13,Pr,H,H,-],        [ZB578;G13,i-Pr,H,H,-], [ZB579;G13,c-Pr,H,H,-],        [ZB580;G13,Ph,H,H,-], [ZB581;G13,OMe,H,H,-],        [ZB582;G13,OEt,H,H,-], [ZB583;G13,OPh,H,H,-],        [ZB584;G13,CF₃,H,H,-],[ZB585;G13,F,H,H,-], [ZB586;G13,Cl,H,H,-],        [ZB587;G13,Br,H,H, -], [ZB588;G13,CN,H,H, -], [ZB589;G13,H,H,Me,        -], [ZB590;G13,H, H,Et,-], [ZB591;G13,H,H,Pr,-],        [ZB592;G13,H,H,i-Pr,-], [ZB593;G13,H,H,c-Pr,-],        [ZB594;G13,H,H,Ph,-], [ZB595;G13,H,H,OMe,-],        [ZB596;G13,H,H,OEt,-], [ZB597;G13,H,H,OPh,-],        [ZB598;G13,H,H,CF₃,-], [ZB 599;G13,H,H,F,-],        [ZB600;G13,H,H,Cl,-], [ZB601;G13,H,H,Br,-],        [ZB602;G13,H,H,CN,-], [ZB603;G13,H,Me,H,-],        [ZB604;G13,Me,Me,H,-], [ZB605;G13,E t,Me,H,-],        [ZB606;G13,Pr,Me,H,-], [ZB607;G13,i-Pr,Me,H,-],        [ZB608;G13,c-Pr,Me,H,-], [ZB609;G13,Ph,Me,H,-],        [ZB610;G13,OMe,Me,H,-], [ZB 611;G13,OEt,Me,H,-],        [ZB612;G13,OPh,Me,H,-], [ZB613;G13,CF₃,M e,H,-],        [ZB614;G13,F,Me,H,-], [ZB615;G13,Cl,Me,H,-], [ZB616;G1        3,Br,Me,H,-], [ZB617;G13,CN,Me,H,-], [ZB618;G13,H,Me,Me,-], [Z        B619;G13,H,Me,Et,-], [ZB620;G13,H,Me,Pr,-],        [ZB621;G13,H,Me,i-Pr,-], [ZB622;G13,H,Me,c-Pr,-],        [ZB623;G13,H,Me,Ph,-], [ZB624;G13,H,Me,OMe,-], [ZB625;G        13,H,Me,OEt,-], [ZB626;G13,H,Me,OPh,-], [ZB627;G13,H,Me,CF₃,-],        [ZB628;G13,H,Me,F,-], [ZB629;G13,H,Me,Cl,-], [ZB630;G13,H,M        e,Br,-], [ZB631;G13,H,Me,CN,-], [ZB632;G14,H,H,H,-], [ZB633;G1        4,Me,H,H,-], [ZB634;G14,Et,H,H,-], [ZB635;G14,Pr,H,H,-], [ZB63        6;G14,i-Pr,H,H,-], [ZB637;G14,c-Pr,H,H,-], [ZB638;G14,Ph,H,H,-],        [ZB639;G14,OMe,H,H,-], [ZB640;G14,OEt,H,H,-],        [ZB641;G14,OPh,H,H,-], [ZB642;G14,CF₃,H,H,-],        [ZB643;G14,F,H,H,-], [ZB644;G14,Cl,H,H,-], [ZB645;G14,Br,H,H,-],        [ZB646;G14,CN,H,H,-], [ZB647;G14,H,Me,H,-], [ZB648;G14,H,        Et,H,-], [ZB649;G14,H,Pr,H,-], [ZB650;G14,H,i-Pr,H,-],        [ZB651;G14,H,c-Pr,H,-], [ZB652;G14,H,Ph,H,-],        [ZB653;G14,H,OMe,H,-], [ZB654;G 14,H,OEt,H,-],        [ZB655;G14,H,OPh,H,-], [ZB656;G14,H,CF₃,H,-],        [ZB657;G14,H,F,H,-], [ZB658;G14,H,Cl,H,-], [ZB659;G14,H,Br,H,-],        [ZB660;G14,H,CN,H,-], [ZB661;G14,H,H,Me,-], [ZB662;G14,H,H,        Et,-], [ZB663;G14,H,H,Pr,-], [ZB664;G14,H,H,i-Pr,-],        [ZB665;G14,H,H,c-Pr,-], [ZB666;G14,H,H,Ph,-],        [ZB667;G14,H,H,OMe,-], [ZB668;G14,H,H,OEt,-],        [ZB669;G14,H,H,OPh,-], [ZB670;G14,H,H,CF₃,-], [ZB        671;G14,H,H,F,-], [ZB672;G14,H,H,Cl,-], [ZB673;G14,H,H,Br,-],        [ZB674;G14,H,H,CN,-], [ZB675;G15,H,H,H,-], [ZB676;G15,Me,H,H,-],        [ZB677;G15,Et,H,H,-], [ZB678;G15,Pr,H,H,-],        [ZB679;G15,i-Pr,H,H,-], [ZB680;G15,c-Pr,H,H,-],        [ZB681;G15,Ph,H,H,-], [ZB682;G15,OMe,H,H,-],        [ZB683;G15,OEt,H,H,-], [ZB684;G15,OPh,H,H,-],        [ZB685;G15,CF₃,H,H,-], [ZB686;G15,F,H,H,-],        [ZB687;G15,Cl,H,H,-], [ZB688;G15,Br,H,H,-],        [ZB689;G15,CN,H,H,-], [ZB690;G15,H,Me,H,-], [ZB691;G15,H,        Et,H,-], [ZB692;G15,H,Pr,H,-], [ZB693;G15,H,i-Pr,H,-],        [ZB694;G15,H,c-Pr,H,-], [ZB695;G15,H,Ph,H,-],        [ZB696;G15,H,OMe,H,-], [ZB697;G 15,H,OEt,H, -],        [ZB698;G15,H,OPh,H, -], [ZB699;G15,H,CF₃,H,-],        [ZB700;G15,H,F,H,-], [ZB701;G15,H,Cl,H,-], [ZB702;G15,H,Br,H,-],        [ZB703;G15,H,CN,H,-], [ZB704;G15,H,H,Me,-], [ZB705;G15,H,H,        Et,-], [ZB706;G15,H,H,Pr,-], [ZB707;G15,H,H,i-Pr,-],        [ZB708;G15,H,H,c-Pr,-], [ZB709;G15,H,H,Ph,-],        [ZB710;G15,H,H,OMe,-], [ZB711;G15,H,H,OEt,-],        [ZB712;G15,H,H,OPh,-], [ZB713;G15,H,H,CF₃,-], [ZB        714;G15,H,H,F,-], [ZB715;G15,H,H,Cl,-], [ZB716;G15,H,H,Br,-],        [ZB717;G15,H,H,CN,-], [ZB718;G16,H,H,-,-], [ZB719;G16,Me,H,-,-],        [ZB720;G16,Et,H,-,-], [ZB721;G16,Pr,H,-,-],        [ZB722;G16,i-Pr,H,-,-], [ZB723;G16,c-Pr,H,-,-],        [ZB724;G16,Ph,H,-,-], [ZB725;G16,OMe,H,-,-], [ZB726;G16,OEt,H,        -, -], [ZB727;G16,OPh,H, -, -], [ZB728;G16,CF₃,H, -,-],        [ZB729;G16,F,H,-,-], [ZB730;G16,Cl,H,-,-], [ZB731;G16,Br,H,-,-],        [ZB732;G16,CCN,H,-,-], [ZB733;G16,H,Me,-,-], [ZB734;G16,H,        Et,-,-], [ZB735;G16,H,Pr,-,-], [ZB736;G16,H,i-Pr,-,-],        [ZB737;G16,H,c-Pr,-,-], [ZB738;G16,H,Ph,-,-],        [ZB739;G16,H,OMe,-,-], [ZB740;G 16,H,OEt,-,-],        [ZB741;G16,H,OPh,-,-], [ZB742;G16,H,CF₃,-,-],        [ZB743;G16,H,F,-,-], [ZB744;G16,H,Cl,-,-], [ZB745;G16,H,Br,-,-],        [ZB746;G16,H,CN,-,-], [ZB747;G17,H,H,-,-], [ZB748;G17,Me,H,        -,-], [ZB749;G17,Et,H,-,-], [ZB750;G17,Pr,H,-,-],        [ZB751;G17,i-Pr,H,-,-], [ZB752;G17,c-Pr,H,-,-],        [ZB753;G17,Ph,H,-,-], [ZB754;G17,OMe,H,-,-], [ZB755;G17,OEt,H,        -, -], [ZB756;G17,OPh,H, -, -], [ZB757;G17,CF₃,H, -,-],        [ZB758;G17,F,H,-,-], [ZB759;G17,Cl,H,-,-], [ZB760;G17,Br,H,-,-],        [ZB761;G17,CCN,H,-,-], [ZB762;G17,H,Me,-,-], [ZB763;G17,H,        Et,-,-], [ZB764;G17,H,Pr,-,-], [ZB765;G17,H,i-Pr,-,-],        [ZB766;G17,H,c-Pr,-,-], [ZB767;G17,H,Ph,-,-],        [ZB768;G17,H,OMe,-,-], [ZB769;G 17,H,OEt,-,-],        [ZB770;G17,H,OPh,-,-], [ZB771;G17,H,CF₃,-,-],        [ZB772;G17,H,F,-,-], [ZB773;G17,H,Cl,-,-], [ZB774;G17,H,Br,-,-],        [ZB775;G17,H,CN,-,-], [ZB776;G18,H,H,-,-], [ZB777;G18,Me,H,        -,-], [ZB778;G18,Et,H,-,-], [ZB779;G18,Pr,H,-,-],        [ZB780;G18,i-Pr,H,-,-], [ZB781;G18,c-Pr,H,-,-],        [ZB782;G18,Ph,H,-,-], [ZB783;G18,OMe,H,-,-], [ZB784;G18,OEt,H,        -, -], [ZB785;G18,OPh,H, -, -], [ZB786;G18,CF₃,H, -,-],        [ZB787;G18,F,H,-,-], [ZB788;G18,Cl,H,-,-], [ZB789;G18,Br,H,-,-],        [ZB790;G18,CN,H,-,-], [ZB791;G18,H,Me,-,-], [ZB792;G18,H,        Et,-,-], [ZB793;G18,H,Pr,-,-], [ZB794;G18,H,i-Pr,-,-],        [ZB795;G18,H,c-Pr,-,-], [ZB796;G18,H,Ph,-,-],        [ZB797;G18,H,OMe,-,-], [ZB798;G 18,H,OEt,-,-],        [ZB799;G18,H,OPh,-,-], [ZB800;G18,H,CF₃,-,-],        [ZB801;G18,H,F,-,-], [ZB802;G18,H,Cl,-,-], [ZB803;G18,H,Br,-,-],        [ZB804;G18,H,CN,-,-], [ZB805;G19,H,H,-,-], [ZB806;G19,Me,H,-,-],        [ZB807;G19,Et,H,-,-], [ZB808;G19,Pr,H,-,-], [ZB809;G19,        i-Pr,H,-,-], [ZB810;G19,c-Pr,H,-,-], [ZB811;G19,Ph,H,-,-],        [ZB812;G19,OMe,H,-,-], [ZB813;G19,OEt,H, -, -],        [ZB814;G19,OPh,H, -, -], [ZB815;G19,CF₃,H, -,-],        [ZB816;G19,F,H,-,-], [ZB817;G19,Cl,H,-,-], [ZB818;G19,Br,H,-,-],        [ZB819;G19,CN,H,-,-], [ZB820;G19,H,Me,-,-], [ZB821;G19,H,        Et,-,-], [ZB822;G19,H,Pr,-,-], [ZB823;G19,H,i-Pr,-,-],        [ZB824;G19,H,c-Pr,-,-], [ZB825;G19,H,Ph,-,-],        [ZB826;G19,H,OMe,-,-], [ZB827;G 19,H,OEt,-,-],        [ZB828;G19,H,OPh,-,-], [ZB829;G19,H,CF₃,-,-],        [ZB830;G19,H,F,-,-], [ZB831;G19,H,Cl,-,-], [ZB832;G19,H,Br,-,-],        [ZB833;G19,H,CN,-,-], [ZB834;G20,H,H,-,-], [ZB835;G20,Me,H,        -,-], [ZB836;G20,Et,H,-,-], [ZB837;G20,Pr,H,-,-],        [ZB838;G20,i-Pr,H,-,-], [ZB839;G20,c-Pr,H,-,-],        [ZB840;G20,Ph,H,-,-], [ZB841;G20,OMe,H,-,-], [ZB842;G20,OEt,H,        -, -], [ZB843;G20,OPh,H, -, -], [ZB844;G20,CF₃,H, -,-],        [ZB845;G20,F,H,-,-], [ZB846;G20,Cl,H,-,-], [ZB847;G20,Br,H,-,-],        [ZB848;G20,CN,H,-,-], [ZB849;G20,H,Me,-,-], [ZB850;G20,H,        Et,-,-], [ZB851;G20,H,Pr,-,-], [ZB852;G20,H,i-Pr,-,-],        [ZB853;G20,H,c-Pr,-,-], [ZB854;G20,H,Ph,-,-],        [ZB855;G20,H,OMe,-,-], [ZB856;G 20,H,OEt,-,-],        [ZB857;G20,H,OPh,-,-], [ZB858;G20,H,CF₃,-,-],        [ZB859;G20,H,F,-,-], [ZB860;G20,H,Cl,-,-], [ZB861;G20,H,Br,-,-],        [ZB862;G20,H,CN,-,-], [ZB863;G21,H,H,-,-], [ZB864;G21,Me,H,        -,-], [ZB865;G21,Et,H,-,-], [ZB866;G21,Pr,H,-,-],        [ZB867;G21,i-Pr,H,-,-], [ZB868;G21,c-Pr,H,-,-],        [ZB869;G21,Ph,H,-,-], [ZB870;G21,OMe,H,-,-], [ZB871;G21,OEt,H,        -,-], [ZB872;G21,OPh,H, -,-], [ZB873;G21,CF₃,H,-,-],        [ZB874;G21,F,H,-,-], [ZB875;G21,Cl,H,-,-], [ZB876;G21,Br,H,-,-],        [ZB877;G21,CN,H,-,-], [ZB878;G21,H,Me,-,-], [ZB879;G21,H,        Et,-,-], [ZB880;G21,H,Pr,-,-], [ZB881;G21,H,i-Pr,-,-],        [ZB882;G21,H,c-Pr,-,-], [ZB883;G21,H,Ph,-,-],        [ZB884;G21,H,OMe,-,-], [ZB885;G 21,H,OEt,-,-],        [ZB886;G21,H,OPh,-,-], [ZB887;G21,H,CF₃,-,-],        [ZB888;G21,H,F,-,-], [ZB889;G21,H,Cl,-,-], [ZB890;G21,H,Br,-,-],        [ZB891;G21,H,CN,-,-], [ZB892;G22,H,H,-,-], [ZB893;G22,Me,H,        -,-], [ZB894;G22,Et,H,-,-], [ZB895;G22,Pr,H,-,-],        [ZB896;G22,i-Pr,H,-,-], [ZB897;G22,c-Pr,H,-,-],        [ZB898;G22,Ph,H,-,-], [ZB899;G22,OMe,H,-,-],        [ZB900;G22,OEt,H,-,-], [ZB901;G22,OPh,H,-,-], [ZB902;G22,CF₃,        H,-,-], [ZB903;G22,F,H,-,-], [ZB904;G22,Cl,H,-,-], [ZB905;G22,        Br,H,-,-], [ZB906;G22,CN,H,-,-], [ZB907;G22,H,Me,-,-], [ZB908;        G22,H,Et,-,-], [ZB909;G22,H,Pr,-,-], [ZB910;G22,H,i-Pr,-,-],        [ZB911;G22,H,c-Pr,-,-], [ZB912;G22,H,Ph,-,-],        [ZB913;G22,H,OMe,-,-], [ZB914;G 22,H,OEt,-,-],        [ZB915;G22,H,OPh,-,-], [ZB916;G22,H,CF₃,-,-],        [ZB917;G22,H,F,-,-], [ZB918;G22,H,Cl,-,-], [ZB919;G22,H,Br,-,-],        [ZB920;G22,H,CN,-,-], [ZB921;G23,H,H,-,-], [ZB922;G23,Me,H,        -,-], [ZB923;G23,Et,H,-,-], [ZB924;G23,Pr,H,-,-],        [ZB925;G23,i-Pr,H,-,-], [ZB926;G23,c-Pr,H,-,-],        [ZB927;G23,Ph,H,-,-], [ZB928;G23,OMe,H,-,-], [ZB929;G23,OEt,H,        -, -], [ZB930;G23,OPh,H, -, -], [ZB931;G23,CF₃,H, -, -],        [ZB932;G23,F,H,-,-], [ZB933;G23,Cl,H,-,-], [ZB934;G23,Br,H,-,-],        [ZB935;G23,CCN,H,-,-], [ZB936;G23,H,Me,-,-], [ZB937;G23,H,        Et,-,-], [ZB938;G23,H,Pr,-,-], [ZB939;G23,H,i-Pr,-,-],        [ZB940;G23,H,c-Pr,-,-], [ZB941;G23,H,Ph,-,-],        [ZB942;G23,H,OMe,-,-], [ZB943;G 23,H,OEt,-,-],        [ZB944;G23,H,OPh,-,-], [ZB945;G23,H,CF₃,-,-],        [ZB946;G23,H,F,-,-], [ZB947;G23,H,Cl,-,-], [ZB948;G23,H,Br,-,-],        [ZB949;G23,H,CN,-,-], [ZB950;G24,H,H,-,-], [ZB951;G24,Me,H,        -,-], [ZB952;G24,Et,H,-,-], [ZB953;G24,Pr,H,-,-],        [ZB954;G24,i-Pr,H,-,-], [ZB955;G24,c-Pr,H,-,-],        [ZB956;G24,Ph,H,-,-], [ZB957;G24,OMe,H,-,-], [ZB958;G24,OEt,H,        -, -], [ZB959;G24,OPh,H, -, -], [ZB960;G24,CF₃,H, -,-],        [ZB961;G24,F,H,-,-], [ZB962;G24,Cl,H,-,-], [ZB963;G24,Br,H,-,-],        [ZB964;G24,CN,H,-,-], [ZB965;G24,H,Me,-,-], [ZB966;G24,H,        Et,-,-], [ZB967;G24,H,Pr,-,-], [ZB968;G24,H,i-Pr,-,-],        [ZB969;G24,H,c-Pr,-,-], [ZB970;G24,H,Ph,-,-],        [ZB971;G24,H,OMe,-,-], [ZB972;G 24,H,OEt,-,-],        [ZB973;G24,H,OPh,-,-], [ZB974;G24,H,CF₃,-,-],        [ZB975;G24,H,F,-,-], [ZB976;G24,H,Cl,-,-], [ZB977;G24,H,Br,-,-],        [ZB978;G24,H,CN,-,-], [ZB979;G25,H,H,H,-], [ZB980;G25,H,Me,        H,-], [ZB981;G25,H,Et,H,-], [ZB982;G25,H,Pr,H,-],        [ZB983;G25,H,i-Pr,H,-], [ZB984;G25,H,c-Pr,H,-],        [ZB985;G25,H,Ph,H,-], [ZB986;G25,H,OMe,H,-], [ZB987;G        25,H,OEt,H, -], [ZB988;G25,H,OPh,H, -], [ZB989;G25,H,CF₃,H,-],        [ZB990;G25,H,F,H,-], [ZB991;G25,H,Cl,H,-], [ZB992;G25,H,Br,H,-],        [ZB993;G25,H,CN,H,-], [ZB994;G25,H,H,Me,-], [ZB995;G25,H,H,        Et,-], [ZB996;G25,H,H,Pr,-], [ZB997;G25,H,H,i-Pr,-],        [ZB998;G25,H,H,c-Pr,-], [ZB999;G25,H,H,Ph,-],        [ZB1000;G25,H,H,OMe,-], [ZB1001;G 25,H,H,OEt,-],        [ZB1002;G25,H,H,OPh,-], [ZB1003;G25,H,H,CF₃,-],        [ZB1004;G25,H,H,F,-], [ZB1005;G25,H,H,Cl,-],        [ZB1006;G25,H,H,Br,-], [ZB1007;G25,H,H,CN,-],        [ZB1008;G25,Me,H,H,-], [ZB1009; G25,Me,Me,H,-],        [ZB1010;G25,Me,Et,H,-], [ZB1011;G25,Me,Pr,H,-],        [ZB1012;G25,Me,i-Pr,H,-], [ZB1013;G25,Me,c-Pr,H,-],        [ZB1014;G25,Me,Ph,H,-], [ZB1015;G25,Me,OMe,H,-], [ZB1        016;G25,Me,OEt,H,-], [ZB1017;G25,Me,OPh,H,-], [ZB1018;G25,Me,        CF₃,H,-], [ZB1019;G25,Me,F,H,-], [ZB1020;G25,Me,Cl,H,-], [ZB10        21;G25,Me,Br,H,-], [ZB1022;G25,Me,CN,H,-], [ZB1023;G25,Me,H,M        e,-], [ZB1024;G25,Me,H,Et,-], [ZB1025;G25,Me,H,Pr,-], [ZB1026;        G25,Me,H,i-Pr,-], [ZB1027;G25,Me,H,c-Pr,-],        [ZB1028;G25,Me,H,Ph,-], [ZB1029;G25,Me,H,OMe,-], [ZB103        0;G25,Me,H,OEt,-], [ZB1031;G25,Me,H,OPh,-], [ZB1032;G25,Me,H,        CF₃,-], [ZB1033;G25,Me,H,F,-], [ZB1034;G25,Me,H,Cl,-],        [ZB1035;G25,Me,H,Br,-], [ZB1036;G25,Me,H,CN,-],        [ZB1037;G26,H,H,H,-], [ZB1038;G26,H,Me,H,-],        [ZB1039;G26,H,Et,H,-], [ZB1040;G26,H, Pr,H,-],        [ZB1041;G26,H,i-Pr,H,-], [ZB1042;G26,H,c-Pr,H,-],        [ZB1043;G26,H,Ph,H,-], [ZB1044;G26,H,OMe,H,-], [ZB104        5;G26,H,OEt,H,-], [ZB1046;G26,H,OPh,H,-],        [ZB1047;G26,H,CF₃,H,-], [ZB1048;G26,H,F,H,-],        [ZB1049;G26,H,Cl,H,-], [ZB1050;G26, H,Br,H,-],        [ZB1051;G26,H,CN,H,-], [ZB1052;G26,H,H,Me,-], [ZB10        53;G26,H,H,Et,-], [ZB1054;G26,H,H,Pr,-],        [ZB1055;G26,H,H,i-Pr,-], [ZB1056;G26,H,H,c-Pr,-],        [ZB1057;G26,H,H,Ph,-], [ZB1058;G26,H,H,OMe,-], [ZB1059;        G26,H,H,OEt,-], [ZB1060;G26,H,H,OPh,-], [ZB1061;G26,H,H,CF₃,-],        [ZB1062;G26,H,H,F,-], [ZB1063;G26,H,H,Cl,-], [ZB1064;G26,H,        H,Br,-], [ZB1065;G26,H,H,CN,-], [ZB1066;G26,Me,H,H,-],        [ZB1067;G26,Me,Me,H,-], [ZB1068;G26,Me,Et,H,-],        [ZB1069;G26,Me,Pr,H,-], [ZB1070;G26,Me,i-Pr,H,-],        [ZB1071;G26,Me,c-Pr,H,-], [ZB1072;G26,Me,Ph,H,-],        [ZB1073;G26,Me,OMe,H,-], [ZB1 074;G26,Me,OEt,H,-],        [ZB1075;G26,Me,OPh,H,-], [ZB1076;G26,Me, CF₃,H,-],        [ZB1077;G26,Me,F,H,-], [ZB1078;G26,Me,Cl,H,-], [ZB10        79;G26,Me,Br,H,-], [ZB1080;G26,Me,CN,H,-], [ZB1081;G26,Me,H,M        e,-], [ZB1082;G26,Me,H,Et,-], [ZB1083;G26,Me,H,Pr,-], [ZB1084;        G26,Me,H,i-Pr,-], [ZB1085;G26,Me,H,c-Pr,-],        [ZB1086;G26,Me,H,Ph,-], [ZB1087;G26,Me,H,OMe,-], [ZB108        8;G26,Me,H,OEt,-], [ZB1089;G26,Me,H,OPh,-], [ZB1090;G26,Me,H,        CF₃,-], [ZB1091;G26,Me,H,F,-], [ZB1092;G26,Me,H,Cl,-],        [ZB1093;G26,Me,H,Br,-], [ZB1094;G26,Me,H,CN,-],        [ZB1095;G27,H,H,H,-],[ZB1096;G27,Me,H,H,-],        [ZB1097;G27,Et,H,H,-], [ZB1098;G27,Pr,H,H,-],        [ZB1099;G27,i-Pr,H,H,-], [ZB1100;G27,c-Pr,H,H,-],        [ZB1101;G27,Ph,H,H,-], [ZB1102;G27,OMe,H,H,-], [ZB1        103;G27,OEt,H,H,-], [ZB1104;G27,OPh,H,H,-],        [ZB1105;G27,CF₃,H,H,-], [ZB1106;G27,F,H,H,-],        [ZB1107;G27,Cl,H,H,-], [ZB1108;G2 7,Br,H,H,-],        [ZB1109;G27,CN,H,H,-], [ZB1110;G27,H,Me,H,-], [ZB        1111;G27,H,Et,H,-], [ZB1112;G27,H,Pr,H,-],        [ZB1113;G27,H,i-Pr,H,-], [ZB1114;G27,H,c-Pr,H,-],        [ZB1115;G27,H,Ph,H,-], [ZB1116;G27,H,OMe,H,-], [ZB111        7;G27,H,OEt,H,-], [ZB1118;G27,H,OPh,H,-],        [ZB1119;G27,H,CF₃,H,-], [ZB1120;G27,H,F,H,-],        [ZB1121;G27,H,Cl,H,-], [ZB1122;G27, H,Br,H,-],        [ZB1123;G27,H,CN,H,-], [ZB1124;G27,H,H,Me,-], [ZB11        25;G27,H,H,Et,-], [ZB1126;G27,H,H,Pr,-],        [ZB1127;G27,H,H,i-Pr,-], [ZB1128;G27,H,H,c-Pr,-],        [ZB1129;G27,H,H,Ph,-], [ZB1130;G27,H,H,OMe,-], [ZB1131;        G27,H,H,OEt,-], [ZB1132;G27,H,H,OPh,-], [ZB1133;G27,H,H,CF₃,-],        [ZB1134;G27,H,H,F,-], [ZB1135;G27,H,H,Cl,-], [ZB1136;G27,H,        H,Br,-], [ZB1137;G27,H,H,CN,-], [ZB1138;G28,H,H,-,-], [ZB1139;        G28,Me,H,-,-], [ZB1140;G28,Cl,H,-,-], [ZB1141;G28,CF₃,H,-,-],        [ZB1142;G28,H,Me,-,-], [ZB1143;G28,H,Cl,-,-], [ZB1144;G28,H,C        F₃,-,-], [ZB1145;G28,H,SH,-,-], [ZB1146;G29,H,H,H,-], [ZB1147;        G29,H,Me,H,-], [ZB1148;G29,H,Et,H,-], [ZB1149;G29,H,Pr,H,-],        [ZB1150;G29,H,i-Pr,H,-], [ZB1151;G29,H,c-Pr,H,-],        [ZB1152;G29,H,Ph,H,-], [ZB1153;G29,H,OMe,H,-], [ZB115        4;G29,H,OEt,H,-], [ZB1155;G29,H,OPh,H,-],        [ZB1156;G29,H,CF₃,H,-], [ZB1157;G29,H,F,H,-],        [ZB1158;G29,H,Cl,H,-], [ZB1159;G29, H,Br,H,-],        [ZB1160;G29,H,CN,H,-], [ZB1161;G29,H,H,Me,-], [ZB11        62;G29,H,H,Et,-], [ZB1163;G29,H,H,Pr,-],        [ZB1164;G29,H,H,i-Pr,-], [ZB1165;G29,H,H,c-Pr,-],        [ZB1166;G29,H,H,Ph,-], [ZB1167;G29,H,H,OMe,-], [ZB1168;        G29,H,H,OEt,-], [ZB1169;G29,H,H,OPh,-], [ZB1170;G29,H,H,CF₃,-],        [ZB1171;G29,H,H,F,-], [ZB1172;G29,H,H,Cl,-], [ZB1173;G29,H,        H,Br,-], [ZB1174;G29,H,H,CN,-], [ZB1175;G29,Me,H,H,-],        [ZB1176;G29,Me,Me,H,-], [ZB1177;G29,Me,Et,H,-],        [ZB1178;G29,Me,Pr,H,-], [ZB1179;G29,Me,i-Pr,H,-],        [ZB1180;G29,Me,c-Pr,H,-], [ZB1181;G29,Me,Ph,H,-],        [ZB1182;G29,Me,OMe,H,-], [ZB1 183;G29,Me,OEt,H,-],        [ZB1184;G29,Me,OPh,H,-], [ZB1185;G29,Me, CF₃,H,-],        [ZB1186;G29,Me,F,H,-], [ZB1187;G29,Me,Cl,H,-], [ZB11        88;G29,Me,Br,H,-], [ZB1189;G29,Me,CN,H,-], [ZB1190;G29,Me,H,M        e,-], [ZB1191;G29,Me,H,Et,-], [ZB1192;G29,Me,H,Pr,-], [ZB1193;        G29,Me,H,i-Pr,-], [ZB1194;G29,Me,H,c-Pr,-],        [ZB1195;G29,Me,H,Ph,-], [ZB1196;G29,Me,H,OMe,-], [ZB119        7;G29,Me,H,OEt,-], [ZB1198;G29,Me,H,OPh,-], [ZB1199;G29,Me,H,        CF₃,-], [ZB1200;G29,Me,H,F,-], [ZB1201;G29,Me,H,Cl,-],        [ZB1202;G29,Me,H,Br,-], [ZB1203;G29,Me,H,CN,-],        [ZB1204;G30,H,H,H,-], [ZB1205;G30,Me,H,H,-],        [ZB1206;G30,Et,H,H,-], [ZB1207;G30,Pr,H,H,-],        [ZB1208;G30,i-Pr,H,H,-], [ZB1209;G30,c-Pr,H,H,-],        [ZB1210;G30,Ph,H,H,-], [ZB1211;G30,OMe,H,H,-], [ZB1        212;G30,OEt,H,H,-], [ZB1213;G30,OPh,H,H,-],        [ZB1214;G30,CF₃,H,H,-], [ZB1215;G30,F,H,H,-],        [ZB1216;G30,Cl,H,H,-], [ZB1217;G3 0,Br,H,H,-],        [ZB1218;G30,CN,H,H,-], [ZB1219;G30,H,Me,H,-], [ZB        1220;G30,H,Et,H,-], [ZB1221;G30,H,Pr,H,-],        [ZB1222;G30,H,i-Pr,H,-], [ZB1223;G30,H,c-Pr,H,-],        [ZB1224;G30,H,Ph,H,-], [ZB1225;G30,H,OMe,H,-], [ZB122        6;G30,H,OEt,H,-], [ZB1227;G30,H,OPh,H,-],        [ZB1228;G30,H,CF₃,H,-], [ZB1229;G30,H,F,H,-],        [ZB1230;G30,H,Cl,H,-], [ZB1231;G30, H,Br,H,-],        [ZB1232;G30,H,CN,H,-], [ZB1233;G30,H,H,Me,-], [ZB12        34;G30,H,H,Et,-], [ZB1235;G30,H,H,Pr,-],        [ZB1236;G30,H,H,i-Pr,-], [ZB1237;G30,H,H,c-Pr,-],        [ZB1238;G30,H,H,Ph,-], [ZB1239;G30,H,H,OMe,-], [ZB1240;        G30,H,H,OEt,-], [ZB1241;G30,H,H,OPh,-], [ZB1242;G30,H,H,CF₃,-],        [ZB1243;G30,H,H,F,-], [ZB1244;G30,H,H,Cl,-], [ZB1245;G30,H,        H,Br,-], [ZB1246;G30,H,H,CN,-], [ZB1247;G30,H,Oi-Pr,H,-],        [ZB1248;G30,H,Oc-Pr,H,-], [ZB1249;G30,H,Ot-Bu,H,-],        [ZB1250;G30,H,OCF₃,H,-], [ZB1251;G30,H,OCHF₂,H, -], [Z        B1252;G30,H,OPr,H,-], [ZB1253;G30,H,OCH₂Ph,H,-], [ZB1253;G30,        H,OCH₂-i-Pr,H,-], [ZB1253;G30,H,OCH₂-c-Pr,H,-],        [ZB1253;G30,H,OCH₂-t-Bu,H,-], [ZB1254;G31,H,-,-,-],        [ZB1255;G31,Me,-,-,-], [ZB1256; G31,Et,-,-,-],        [ZB1257;G31,Pr,-,-,-], [ZB1258;G31,i-Pr,-,-,-],        [ZB1259;G31,c-Pr,-,-,-], [ZB1260;G31,Ph,-,-,-],        [ZB1261;G31,OMe,-,-,-], [ZB1 262;G31,OEt,-,-,-],        [ZB1263;G31,OPh,-,-,-], [ZB1264;G31,CF₃,-,-,-],        [ZB1265;G31,F,-,-,-], [ZB1266;G31,Cl,-,-,-], [ZB1267;G3        1,Br,-,-,-], [ZB1268;G31, CN,-,-,-], [ZB1269;G31, t-Bu,-,-,-],        [ZB1270;G32,H,-,-,-], [ZB1271;G32,Me,-,-,-], [ZB127        2;G32,Et,-,-,-], [ZB1273;G32,Pr,-,-,-], [ZB1274;G32,i-Pr,-,-,-],        [ZB1275;G32,c-Pr,-,-,-], [ZB1276;G32,Ph,-,-,-],        [ZB1277;G32,OMe,-,-,-], [ZB1 278;G32,OEt,-,-,-],        [ZB1279;G32,OPh,-,-,-], [ZB1280;G32,CF₃,-,-,-],        [ZB1281;G32,F,-,-,-], [ZB1282;G32,Cl,-,-,-], [ZB1283;G3        2,Br,-,-,-], [ZB1284;G32,CN,-,-,-], [ZB1285;G32,t-Bu,-,-,-],        [ZB1286;G33,H,-,-,-], [ZB1287;G33,Me,-,-,-], [ZB128        8;G33,Et,-,-,-], [ZB1289;G33,Pr,-,-,-], [ZB1290;G33,i-Pr,-,-,-],        [ZB1291;G33,c-Pr,-,-,-], [ZB1292;G33,Ph,-,-,-],        [ZB1293;G33,OMe,-,-,-], [ZB1 294;G33,OEt,-,-,-],        [ZB1295;G33,OPh,-,-,-], [ZB1296;G33,CF₃,-,-,-],        [ZB1297;G33,F,-,-,-], [ZB1298;G33,Cl,-,-,-], [ZB1299;G3        3,Br,-,-,-], [ZB1300;G33,CN,-,-,-], [ZB1301;G33,t-Bu,-,-,-],        [ZB1302;G34,H,-,-,-], [ZB1303;G34,Me,-,-,-], [ZB130        4;G34,Et,-,-,-], [ZB1305;G34,Pr,-,-,-], [ZB1306;G34,i-Pr,-,-,-],        [ZB1307;G34,c-Pr,-,-,-], [ZB1308;G34,Ph,-,-,-],        [ZB1309;G34,OMe,-,-,-], [ZB1 310;G34,OEt,-,-,-],        [ZB1311;G34,OPh,-,-,-], [ZB1312;G34,CF₃,-,-,-],        [ZB1313;G34,F,-,-,-], [ZB1314;G34,Cl,-,-,-], [ZB1315;G3        4,Br,-,-,-], [ZB1316;G34,CN,-,-,-], [ZB1317;G34,t-Bu,-,-,-],        [ZB1318;G12,t-Bu,H,H,-], [ZB1319;G12,CH(Me)Et,H,H,-],        [ZB1320;G12,CH(Et)₂,H,H,-], [ZB1321;G12,CH₂(i-Pr),H,H,-],        [ZB1322;G12,C(Me)=CH(Me),H,H,-], [ZB1323;G12,C(Me)=CH₂,H,H,-],        [ZB1324;G12,CH═CH(Me),H,H,-], [ZB1325;G12,CH═CH₂,H,H,-],        [ZB1326;G12,CC(c-Pr),H,H,-], [ZB1327;G12,CC(Me),H,H,-],        [ZB1328;G12,CHF₂,H,H,-], [ZB1329;G12,CF₂Me,H,H,-],        [ZB1330;G12,CF₂CF₃,H,H,-], [ZB1331;G12,C(CF₃)CH₂,H,H,-],        [ZB1332;G12,CF₂Cl,H,H,-], [ZB1333;G12,C H(Me)CF₃,H,H,-],        [ZB1334;G12,c-Bu,H,H,-], [ZB1335;G12,c-Pen,H,H,-],        [ZB1336;G12,c-Hex,H,H,-], [ZB1337;G12,1-Me-(c-Pr),H,H,-],        [ZB1338;G12,1-F-(c-Pr),H,H,-], [ZB1339;G12,2,2-F₂-(c-Pr),H,H,-],        [ZB1340;G12,I,H,H, -], [ZB1341;G12,CH₂CN,H,H, -], [Z        B1342;G12,CH₂OMe,H,H,-], [ZB1343;G12,CH₂SMe,H,H,-], [ZB1344;G        12,c-hexen-1-yl,H,H,-], [ZB1345;G12,OPr,H,H,-],        [ZB1346;G12,O(i-Pr),H,H,-], [ZB1347;G12,OCHF₂,H,H,-],        [ZB1348;G12,SCF₃,H,H,-],[ZB1349;G12,C(Me)=NOMe,H,H,-],        [ZB1350;G12,H,t-Bu,H,-], [ZB1351;G12,H,c-Bu,H,-],        [ZB1352;G12,H,c-Pen,H,-], [ZB1353;G12,H,CCH,H,-],        [ZB1354;G12,H,CH₂OMe,H,-], [ZB1355;G12,H,I,H,-],        [ZB1356;G12,H,S(i-Pr),H,-], [ZB1357;G12,Me,Me,H, -],        [ZB1358;G12,Pr,Me,H, -], [ZB1 359;G12,i-Pr,Me,H,-],        [ZB1360;G12,CHF₂,Me,H,-],        [ZB1361;G12,CF₃,Me,H,-],[ZB1362;G12,c-Pr,Me,H,-],        [ZB1363;G12,c-Hex,Me,H,-], [ZB1364;G12,OMe,Me,H,-],        [ZB1365;G12,O(i-Pr),Me,H,-], [ZB1366;G12,F,Me,H,-],        [ZB1367;G12,Cl,Me,H,-], [Z B1368;G12,Br,Me,H,-],        [ZB1369;G12,i-Pr,F,H,-], [ZB1370;G12,Me,F,H,-],        [ZB1371;G12,Pr,F,H,-], [ZB13 72;G12,CHF₂,F,H,-],        [ZB1373;G12,CF₃,F,H,-], [ZB1374;G12,c-Pr,F,H,-],        [ZB1375;G12,c-Hex,F,H,-], [ZB1376;G12,OMe,F,H,-],        [ZB1377;G12,O(i-Pr),F,H,-], [ZB1378;G12,F,F,H,-],        [ZB1379;G12,Cl,F,H,-], [ZB13 80;G12,Br,F,H,-],        [ZB1381;G12,Pr,Cl,H,-], [ZB1382;G12,i-Pr,Cl,H,-],        [ZB1383;G12,c-Hex,Cl,H,-], [ZB1384;G12,Cl,Cl,H,-],        [ZB1385;G12,O(i-Pr),Cl,H,-], [ZB1386;G12,Me,Cl,H,-],        [ZB1387;G12,CHF₂,Cl,H, -], [ZB1388;G12,CF₃,Cl,H,-],        [ZB1389;G12,c-Pr,Cl,H,-], [ZB1390;G12,OMe,Cl,H,-],        [ZB1391;G12,F,Cl,H,-], [Z B1392;G12,Br,Cl,H,-],        [ZB1393;G12,Me,Br,H,-], [ZB1394;G12,c-Hex,Br,H,-],        [ZB1395;G12,Pr,Br,H,-], [ZB1396;G12,i-Pr,Br,H,-],        [ZB1397;G12,CHF₂,Br,H,-], [ZB1398;G12,CF₃,Br,H,-],        [ZB1399;G12,c-Pr,Br,H,-], [ZB1400;G12,OMe,Br,H,-],        [ZB1401;G12,O(i-Pr),Br,H,-], [ZB1402;G12,F,Br,H,-],        [ZB1403;G12,Cl,Br,H,-], [Z B1404;G12,Br,Br,H,-],        [ZB1405;G22,H,Bu,-,-], [ZB1406;G22,H,CH₂(i-Pr),-,-],        [ZB1407;G22,H,c-Bu,-,-], [ZB1408;G22,H,c-Pen,-,-],        [ZB1409;G22,H,c-Hex,-,-], [ZB1410;G22,H,c-hexen-1-yl,-,-],        [ZB1411;G22,H,CHF₂,-,-], [ZB1412;G22,H,CF₂CF₃,-, -], [Z        B1413;G22,H,CH═CH₂,-,-], [ZB1414;G22,H,C(Me)=CH₂,-,-], [ZB141        5;G22,H,CC(c-Pr),-,-], [ZB1416;G22,H,CC(i-Pr),-,-],        [ZB1417;G22,H,CC(Me),-,-], [ZB1418;G22,H,CH═NOMe,-,-],        [ZB1419;G22,H,C(Me)=NOMe,-,-], [ZB1420;G22,H,CH₂O(i-Pr),-,-],        [ZB1421;G22,H,CH₂OEt, -, -], [ZB1422;G22,H,CH₂OPh, -, -],        [ZB1423;G22,Me,H,-,-], [ZB1424;G22,Et,H,-,-], [ZB1425;G22,P        r,H,-,-], [ZB1426;G22,Bu,H,-,-], [ZB1427;G22,CH₂(i-Pr),H,-, -],        [ZB1428;G22,c-Bu,H, -, -], [ZB1429;G22,c-Pen,H,-,-],        [ZB1430;G22,c-Hex,H,-,-], [ZB1431;G22,c-hexen-1-yl,H,-,-],        [ZB1432;G22,CHF₂,H,-,-], [ZB1433;G22,CF₂CF₃,H, -,-],        [ZB1434;G22,CN,H,-,-], [ZB1435;G22,OMe,H,-,-], [ZB1436;G22,CH        ═CH₂,H,-, -], [ZB1437;G22,C(Me)=CH₂,H,-, -],        [ZB1438;G22,CC(c-Pr),H,-, -], [ZB1439;G22,CC(i-Pr),H,-,-],        [ZB1440;G22,CC(Me),H,-,-], [ZB1441;G22,CH═NOMe,H, -,-],        [ZB1442;G22,C(Me)=NOMe,H,-,-], [ZB1443;G22,CH₂O(i-Pr),H,-,-],        [ZB1444;G22,CH₂OEt,H,-,-], [ZB1445;G22,CH₂OPh,H,-,-],        [ZB1446;G22,Me,Me,-,-], [ZB1447;G22,Me,Et,-,-], [ZB1448;G        22,Me,i-Pr,-,-], [ZB1449;G22,Me,c-Pr,-,-],        [ZB1450;G22,Me,c-Hex,-,-], [ZB1451;G22,Me,CHF₂,-,-],        [ZB1452;G22,Me,CF₃,-,-], [ZB1453;G22,Me,F,-,-],        [ZB1454;G22,Me,Cl,-,-], [ZB1455;G22,Me, Br,-,-],        [ZB1456;G22,Cl,Me,-,-], [ZB1457;G22,Cl,Et,-,-], [ZB14        58;G22,Cl,i-Pr,-,-], [ZB1459;G22,Cl,c-Pr,-,-],        [ZB1460;G22,Cl,c-Hex,-,-], [ZB1461;G22,Cl,CHF₂,-,-],        [ZB1462;G22,Cl,CF₃,-,-], [ZB1463;G22,Cl,F,-,-],        [ZB1464;G22,Cl,Cl,-,-], [ZB1465;G22,Cl, Br,-,-],        [ZB1466;G22,F,Me,-,-], [ZB1467;G22,F,Et,-,-],        [ZB1468;G22,F,i-Pr,-,-], [ZB1469;G22,F,c-Pr,-,-],        [ZB1470;G22,F,c-Hex,-,-], [ZB1471;G22,F,CHF₂,-, -],        [ZB1472;G22,F,CF₃,-,-], [ZB 1473;G22,F,F,-,-],        [ZB1474;G22,F,Cl,-,-], [ZB1475;G22,F,Br,-,-], [ZB1476;G35,Me,H,        -, -], [ZB1477;G35,Et,H, -, -], [ZB1478;G35, Pr,H,-,-],        [ZB1479;G35,Bu,H,-,-], [ZB1480;G35,i-Pr,H,-,-],        [ZB1481;G35,C(Me)=CH₂,H,-,-], [ZB1482;G35,CHF₂,H,-,-],        [ZB1483;G35,CF₃,H,-,-], [ZB1484;G35,c-Pr,H,-,-],        [ZB1485;G35,c-Pen,H,-,-], [ZB1486;G35,c-Hex,H,-,-],        [ZB1487;G35,C(Me)=NOH,H,-,-], [ZB1488;G35,C(Me)=N OEt,H,-,-],        [ZB1489;G35,F,H,-,-], [ZB1490;G35,Cl,H,-,-], [ZB14        91;G35,Br,H,-,-], [ZB1492;G35,Me,Cl,-,-],        [ZB1493;G35,Et,Cl,-,-], [ZB1494;G35,Pr,Cl,-,-],        [ZB1495;G35,Bu,Cl,-,-], [ZB1496;G 35,i-Pr,Cl,-,-],        [ZB1497;G35,C(Me)=CH₂,Cl,-,-] [ZB1498;G35,CHF₂,Cl,-,-],        [ZB1499;G35,CF₃,Cl, -, -], [ZB1500;G35,c-Pr,Cl,-,-],        [ZB1501;G35,c-Pen,Cl,-,-], [ZB1502;G35,c-Hex,Cl,-,-],        [ZB1503;G35,C(Me)=NOH,Cl,-,-], [ZB1504;G35,C(Me)=NOEt,Cl,-,-],        [ZB1505;G35,F,Cl,-,-], [ZB1506;G35,Cl,Cl,-,-],        [ZB1507;G35,Br,Cl,-,-], [ZB1508;G35,Me,Br,-,-], [ZB1509;G35,E        t,Br,-,-], [ZB1510;G35,Pr,Br,-,-], [ZB1511;G35,Bu,Br,-,-], [ZB        1512;G35,i-Pr,Br,-,-], [ZB1513;G35,C(Me)=CH₂,Br,-,-],        [ZB1514;G35,CHF₂,B r,-,-], [ZB1515;G35,CF₃,Br,-,-],        [ZB1516;G35,c-Pr,Br,-,-], [ZB1517;G35,c-Pen,Br,-,-],        [ZB1518;G35,c-Hex,Br,-,-], [ZB1519;G35,C(Me)=NOH,Br,-,-],        [ZB1520;G35,C(Me)=NOEt,Br,-,-], [ZB1521;G35,F,Br,-,-],        [ZB1522;G35,Cl,Br,-,-], [ZB1523;G35,Br,Br,-,-],        [ZB1524;G35,Me,Me,-,-], [ZB1525;G35,E t,Me,-,-],        [ZB1526;G35,Pr,Me,-,-], [ZB1527;G35,Bu,Me,-,-], [ZB        1528;G35,i-Pr,Me,-,-], [ZB1529;G35,C(Me)=CH₂,Me,-,-],        [ZB1530;G35,CHF₂,M e,-,-], [ZB1531;G35,CF₃,Me,-,-],        [ZB1532;G35,c-Pr,Me,-,-], [ZB1533;G35,c-Pen,Me,-,-],        [ZB1534;G35,c-Hex,Me,-,-], [ZB1535;G35,C(Me)=NOH,Me,-,-],        [ZB1536;G35,C(Me)=NOEt,Me,-,-], [ZB1537;G35,F,Me,-,-],        [ZB1538;G35,Cl,Me,-,-], [ZB1539;G35,Br,Me,-,-],        [ZB1540;G22,C≡C-Me,H,-,-], [ZB1541;G22,C≡C-Et,H,-,-],        [ZB1542;G22,C≡C-n-Pr,H,-,-], [ZB1543;G23,C≡C-i-Pr,H,-,-],        [ZB1544;G22,C≡C-n-Bu,H,-,-], [ZB1545;G22,C≡C-t-Bu,H,-,-],        [ZB1546;G23,C≡C-i-Bu,H,-,-], [ZB1547;G22,C≡C-c-Bu,H,-,-].        [ZB1548;G22,C≡C-c-Pen,H,-,-], [ZB1549;G22,C≡C-c-Hex,H,-,-],        [ZB1550;G22,C≡C-Ph,H,-,-], [ZB1551;G22,H,C≡C-Me,-,-],        [ZB1552;G22,H,C≡C-Et,-,-], [ZB1553;G22,H,C≡C-n-Pr,-,-],        [ZB1554;G22,H,C≡C-i-Pr,-,-], [ZB1555;G22,H,C≡C-n-Bu,-,-],        [ZB1556;G22,H,C≡C-t-Bu,-,-], [ZB1557;G22,H,C≡C-i-Bu,-,-],        [ZB1558;G22,H,C≡C-c-Bu,-,-], [ZB1559;G22,H,C≡C-c-Pen,-,-],        [ZB1560;G22,H,C≡C-c-Hex,-,-], [ZB1561;G22,H,C≡C-Ph,-,-],        [ZB1562;G22,H,C≡CH,-,-]

A compound according to Compound (1J) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX387).

A compound according to Compound (1J) wherein R¹ represents a methylgroup, Q represents Q4, and a combination of structure of G andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G represents any combination described in Combination B (hereinafter,referred to as Compound group SX388).

A compound according to Compound (1J) wherein R¹ represents a chlorineatom, Q represents Q4, and a combination of structure of G andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G represents any combination described in Combination B (hereinafter,referred to as Compound group SX389).

A compound according to Compound (1J) wherein R¹ represents a methylgroup, Q represents Q5, and a combination of structure of G andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G represents any combination described in Combination B (hereinafter,referred to as Compound group SX390).

A compound according to Compound (1J) wherein R¹ represents a chlorineatom, Q represents Q5, and a combination of structure of G andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G represents any combination described in Combination B (hereinafter,referred to as Compound group SX391).

A compound according to Compound (1J) wherein R¹ represents a methylgroup, Q represents Q6, and a combination of structure of G andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G represents any combination described in Combination B (hereinafter,referred to as Compound group SX392).

A compound according to Compound (1J) wherein R¹ represents a chlorineatom, Q represents Q6, and a combination of structure of G andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G represents any combination described in Combination B (hereinafter,referred to as Compound group SX393).

A compound according to Compound (1J) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX394).

A compound according to Compound (1J) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX395).

A compound according to Compound (1J) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, and a combination of structureof G and substituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to thestructure of G represents any combination described in Combination B(hereinafter, referred to as Compound group SX396).

A compound according to Compound (1J) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, and a combination of structureof G and substituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to thestructure of G represents any combination described in Combination B(hereinafter, referred to as Compound group SX397).

A compound according to Compound (1J) wherein R¹ represents a methylgroup, Q represents Q8A, and a combination of structure of G andsubstituents R^(X7), Rx, R^(X9) and R^(X10) applied to the structure ofG represents any combination described in Combination B (hereinafter,referred to as Compound group SX398).

A compound according to Compound (1J) wherein R¹ represents a chlorineatom, Q represents Q8A, and a combination of structure of G andsubstituents R^(X7), Rx, R^(X9) and R^(X10) applied to the structure ofG represents any combination described in Combination B (hereinafter,referred to as Compound group SX399).

A compound according to Compound (1J) wherein R¹ represents a methylgroup, Q represents Q8D, and a combination of structure of G andsubstituents R^(X7), Rx, R^(X9) and R^(X10) applied to the structure ofG represents any combination described in Combination B (hereinafter,referred to as Compound group SX400).

A compound according to Compound (1J) wherein R¹ represents a chlorineatom, Q represents Q8D, and a combination of structure of G andsubstituents R^(X7), Rx, R^(X9) and R^(X10) applied to the structure ofG represents any combination described in Combination B (hereinafter,referred to as Compound group SX401).

A compound according to Compound (1J) wherein R¹ represents a methylgroup, Q represents Q8J, and a combination of structure of G andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G represents any combination described in Combination B (hereinafter,referred to as Compound group SX402).

A compound according to Compound (1J) wherein R¹ represents a chlorineatom, Q represents Q8J, and a combination of structure of G andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G represents any combination described in Combination B (hereinafter,referred to as Compound group SX403).

A compound represented by formula (1M) (hereinafter, referred to asCompound (1M)):

wherein R¹ represents a methyl group, Q represents Q3, R³ represents amethoxy group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX404).

A compound according to Compound (1M) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX405).

A compound according to Compound (1M) wherein R¹ represents a methylgroup, Q represents Q4, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX406).

A compound according to Compound (1M) wherein R¹ represents a chlorineatom, Q represents Q4, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX407).

A compound according to Compound (1M) wherein R¹ represents a methylgroup, Q represents Q5, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX408).

A compound according to Compound (1M) wherein R¹ represents a chlorineatom, Q represents Q5, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX409).

A compound according to Compound (1M) wherein R¹ represents a methylgroup, Q represents Q6, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX410).

A compound according to Compound (1M) wherein R¹ represents a chlorineatom, Q represents Q6, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX411).

A compound according to Compound (1M) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX412).

A compound according to Compound (1M) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX413).

A compound according to Compound (1M) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, and a combination of R^(X2),R^(X3), R^(X4), R^(X5) and R^(X6) represents any combination describedin Combination A (hereinafter, referred to as Compound group SX414).

A compound according to Compound (1M) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, and a combination of R^(X2),R^(X3), R^(X4), R^(X5) and R^(X6) represents any combination describedin Combination A (hereinafter, referred to as Compound group SX415).

A compound according to Compound (1M) wherein R¹ represents a methylgroup, Q represents Q8A, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX416).

A compound according to Compound (1M) wherein R¹ represents a chlorineatom, Q represents Q8A, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX417).

A compound according to Compound (1M) wherein R¹ represents a methylgroup, Q represents Q8D, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX418).

A compound according to Compound (1M) wherein R¹ represents a chlorineatom, Q represents Q8D, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX419).

A compound according to Compound (1M) wherein R¹ represents a methylgroup, Q represents Q8J, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX420).

A compound according to Compound (1M) wherein R¹ represents a chlorineatom, Q represents Q8J, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX421).

A compound represented by formula (1N) (hereinafter, referred to asCompound (1N)):

wherein R¹ represents a methyl group, Q represents Q3, R³ represents amethoxy group, R^(X9) represents a hydrogen atom, and a combination ofR^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX422)).

A compound according to Compound (1N) wherein R¹ represents a hydrogenatom, Q represents Q3, R³ represents a methoxy group, R^(X9) representsa methyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX423).

A compound according to Compound (1N) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R^(X9) representsa hydrogen atom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX424).

A compound according to Compound (1N) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R^(X9) representsa methyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX425).

A compound according to Compound (1N) wherein R¹ represents a methylgroup, Q represents Q4, R^(X9) represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX426).

A compound according to Compound (1N) wherein R¹ represents a hydrogenatom, Q represents Q4, R^(X9) represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX427).

A compound according to Compound (1N) wherein R¹ represents a chlorineatom, Q represents Q4, R^(X9) represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX428).

A compound according to Compound (1N) wherein R¹ represents a chlorineatom, Q represents Q4, R^(X9) represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX429).

A compound according to Compound (1N) wherein R¹ represents a methylgroup, Q represents Q5, R^(X9) represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX430).

A compound according to Compound (1N) wherein R¹ represents a hydrogenatom, Q represents Q5, R^(X9) represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX431).

A compound according to Compound (1N) wherein R¹ represents a chlorineatom, Q represents Q5, R^(X9) represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX432).

A compound according to Compound (1N) wherein R¹ represents a chlorineatom, Q represents Q5, R^(X9) represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX433).

A compound according to Compound (1N) wherein R¹ represents a methylgroup, Q represents Q6, R^(X9) represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX434).

A compound according to Compound (1N) wherein R¹ represents a hydrogenatom, Q represents Q6, R^(X9) represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX435).

A compound according to Compound (1N) wherein R¹ represents a chlorineatom, Q represents Q6, R^(X9) represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX436).

A compound according to Compound (1N) wherein R¹ represents a chlorineatom, Q represents Q6, R^(X9) represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX437).

A compound according to Compound (1N) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R^(X9) representsa hydrogen atom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX438).

A compound according to Compound (1N) wherein R¹ represents a hydrogenatom, Q represents Q7, L² represents an oxygen atom, R^(X9) represents amethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX439).

A compound according to Compound (1N) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R^(X9) represents ahydrogen atom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX440).

A compound according to Compound (1N) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R^(X9) represents amethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX441).

A compound according to Compound (1N) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R^(X9) represents a hydrogenatom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX442).

A compound according to Compound (1N) wherein R¹ represents a hydrogenatom, Q represents Q7, L² represents NH, R^(X9) represents a methylgroup, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX443).

A compound according to Compound (1N) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R^(X9) represents a hydrogenatom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX444).

A compound according to Compound (1N) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R^(X9) represents a methylgroup, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX445).

A compound according to Compound (1N) wherein R¹ represents a methylgroup, Q represents Q8A, R^(X9) represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX446).

A compound according to Compound (1N) wherein R¹ represents a hydrogenatom, Q represents Q8A, R^(X9) represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX447).

A compound according to Compound (1N) wherein R¹ represents a chlorineatom, Q represents Q8A, R^(X9) represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX448).

A compound according to Compound (1N) wherein R¹ represents a chlorineatom, Q represents Q8A, R^(X9) represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX449).

A compound according to Compound (1N) wherein R¹ represents a methylgroup, Q represents Q8D, R^(X9) represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX450).

A compound according to Compound (1N) wherein R¹ represents a hydrogenatom, Q represents Q8D, R^(X9) represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX451).

A compound according to Compound (1N) wherein R¹ represents a chlorineatom, Q represents Q8D, R^(X9) represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX452).

A compound according to Compound (1N) wherein R¹ represents a chlorineatom, Q represents Q8D, R^(X9) represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX453).

A compound according to Compound (1N) wherein R¹ represents a methylgroup, Q represents Q8J, R^(X9) represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX454).

A compound according to Compound (1N) wherein R¹ represents a hydrogenatom, Q represents Q8J, R^(X9) represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX455).

A compound according to Compound (1N) wherein R¹ represents a chlorineatom, Q represents Q8J, R^(X9) represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX456).

A compound according to Compound (1N) wherein R¹ represents a chlorineatom, Q represents Q8J, R^(X9) represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX457).

A compound represented by formula (1P) (hereinafter, referred to asCompound (1P)):

wherein R¹ represents a methyl group, Q represents Q3, R³ represents amethoxy group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX458).

A compound according to Compound (1P) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX459).

A compound according to Compound (1P) wherein R¹ represents a methylgroup, Q represents Q4, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX460).

A compound according to Compound (1P) wherein R¹ represents a chlorineatom, Q represents Q4, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX461).

A compound according to Compound (1P) wherein R¹ represents a methylgroup, Q represents Q5, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX462).

A compound according to Compound (1P) wherein R¹ represents a chlorineatom, Q represents Q5, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX463).

A compound according to Compound (1P) wherein R¹ represents a methylgroup, Q represents Q6, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX464).

A compound according to Compound (1P) wherein R¹ represents a chlorineatom, Q represents Q6, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX465).

A compound according to Compound (1P) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX466).

A compound according to Compound (1P) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX467).

A compound according to Compound (1P) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, and a combination of R^(X2),R^(X3), R^(X4), R^(X5) and R^(X6) represents any combination describedin Combination A (hereinafter, referred to as Compound group SX468).

A compound according to Compound (1P) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, and a combination of R^(X2),R^(X3), R^(X4), R^(X5) and R^(X6) represents any combination describedin Combination A (hereinafter, referred to as Compound group SX469).

A compound according to Compound (1P) wherein R¹ represents a methylgroup, Q represents Q8A, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX470).

A compound according to Compound (1P) wherein R¹ represents a chlorineatom, Q represents Q8A, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX471).

A compound according to Compound (1P) wherein R¹ represents a methylgroup, Q represents Q8D, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX472).

A compound according to Compound (1P) wherein R¹ represents a chlorineatom, Q represents Q8D, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX473).

A compound according to Compound (1P) wherein R¹ represents a methylgroup, Q represents Q8J, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX474).

A compound according to Compound (1P) wherein R¹ represents a chlorineatom, Q represents Q8J, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX475).

A compound represented by formula (1U) (hereinafter, referred to asCompound (1U)):

[wherein A represents any one of groups represented by formulae AA1 toAA4

wherein R¹ represents a methyl group, Q represents Q3, R³ represents amethoxy group, and a combination of structure of A and substituents ofR^(X11), R^(X12), R^(X13) and R^(X14) applied to the structure of Arepresents any combination described in Combination D (hereinafter,referred to as Compound group SX476).

Combination D consists of substituent numbers ZD1 to ZD334. Substituentnumbers ZD1 to ZD334 represent combinations of structure of A andsubstituents of R^(X11), R^(X12). R^(X13) and R^(X14) applied to thestructure of A according to Compound (1U), compounds represented byformula (1V), compounds represented by formula (2D), and compoundsrepresented by formula (2E). And hereinafter, they are referred to as[substituent number; A,R^(X11),R^(X12),R^(X13),R^(X14)]. For example,the substituent number ZD2 refers to a combination wherein A representsAA1, R^(X11) represents a methyl group, and each of R^(X12), R^(X13) andR^(X14) represents a hydrogen atom.

-   -   Combination D: [ZD1;AA1,H,H,H,H], [ZD2;AA1,Me,H,H,H],        [ZD3;AA1,Et,H,H,H], [ZD 4;AA1,Pr,H,H,H], [ZD5;AA1,i-Pr,H,H,H],        [ZD6;AA1,c-Pr,H,H,H], [ZD7;AA1,Ph,H,H,H], [ZD8;AA1,OMe,H,H,H],        [ZD9;AA1,O Et,H,H,H], [ZD10;AA1,OPh,H,H,H],        [ZD11;AA1,CF₃,H,H,H], [ZD12;A A1,F,H,H,H], [ZD13;AA1,Cl,H,H,H],        [ZD14;AA1,Br,H,H,H], [ZD15;A A1,CN,H,H,H], [ZD16;AA1,H,Me,H,H],        [ZD17;AA1,H,Et,H,H], [ZD18; AA1,H,Pr,H,H],        [ZD19;AA1,H,i-Pr,H,H], [ZD20;AA1,H,c-Pr,H,H],        [ZD21;AA1,H,Ph,H,H], [ZD22;AA1,H,OMe,H,H], [ZD23;AA1,        H,OEt,H,H], [ZD24;AA1,H,OPh,H,H], [ZD25;AA1,H,CF₃,H,H], [ZD26;        AA1,H,F,H,H], [ZD27;AA1,H,Cl,H,H], [ZD28;AA1,H,Br,H,H], [ZD29;        AA1,H,CN,H,H], [ZD30;AA1,H,H,Me,H], [ZD31;AA1,H,H,Et,H],        [ZD32;AA1,H,H,Pr,H], [ZD33;AA1,H,H,i-Pr,H],        [ZD34;AA1,H,H,c-Pr,H], [ZD35;AA1,H,H,Ph,H],        [ZD36;AA1,H,H,OMe,H], [ZD37;AA1,H, H,OEt,H],        [ZD38;AA1,H,H,OPh,H], [ZD39;AA1,H,H,CF₃,H], [ZD40;AA 1,H,H,F,H],        [ZD41;AA1,H,H,Cl,H], [ZD42;AA1,H,H.Br,H], [ZD43;AA 1,H,H,CN,H],        [ZD44;AA1,H,H,H,Me], [ZD45;AA1,H,H,H,Et], [ZD46;A A1,H,H,H,Pr],        [ZD47;AA1,H,H,H,i-Pr], [ZD48;AA1,H,H,H,c-Pr],        [ZD49;AA1,H,H,H,Ph], [ZD50;AA1,H,H,H,OMe], [ZD51;AA1,H,H,        H,OEt], [ZD52;AA1,H,H,H,OPh], [ZD53;AA1,H,H,H,CF₃], [ZD54;AA1,        H,H,H,F], [ZD55;AA1,H,H,H,Cl], [ZD56;AA1,H,H,H,Br], [ZD57;AA1,        H,H,H,CN], [ZD58;AA1,Me,Me,H,H], [ZD59;AA1,Me,Et,H,H], [ZD60;A        A1,Me,OMe,H,H], [ZD61;AA1,Me,OEt,H,H], [ZD62;AA1,Me,SMe,H,H],        [ZD63;AA1,Me,F,H,H], [ZD64;AA1,Me,Cl,H,H], [ZD65;AA1,Me,CN,H,        H], [ZD66;AA1,F,Me,H,H], [ZD67;AA1,F,Et,H,H], [ZD68;AA1,F,OMe,        H,H], [ZD69;AA1,F,OEt,H,H], [ZD70;AA1,F,SMe,H,H], [ZD71;AA1,F,        F,H,H], [ZD72;AA1,F,Cl,H,H], [ZD73;AA1,F,CN,H,H],        [ZD74;AA1,C1,Me,H,H], [ZD75;AA1,Cl,Et,H,H],        [ZD76;AA1,Cl,OMe,H,H], [ZD77;A A1,Cl,OEt,H,H],        [ZD78;AA1,Cl,SMe,H,H], [ZD79;AA1,Cl,F,H,H], [Z        D80;AA1,Cl,Cl,H,H], [ZD81;AA1,Cl,CN,H,H], [ZD82;AA1,OMe,Me,H,        H], [ZD83;AA1,OMe,Et,H,H], [ZD84;AA1,OMe,OMe,H,H], [ZD85;AA1,O        Me,OEt,H,H], [ZD86;AA1,OMe,SMe,H,H], [ZD87;AA1,OMe,F,H,H], [ZD        88;AA1,OMe,Cl,H,H], [ZD89;AA1,OMe,CN,H,H],        [ZD90;AA1,SMe,Me,H,H], [ZD91;AA1,SMe,Et,H,H],        [ZD92;AA1,SMe,OMe,H,H], [ZD93;AA1, SMe,OEt,H,H],        [ZD94;AA1,SMe,SMe,H,H], [ZD95;AA1,SMe,F,H,H], [Z        D96;AA1,SMe,Cl,H,H], [ZD97;AA1,SMe,CN,H,H], [ZD98;AA2,H,H,H,H],        [ZD99;AA2,Me,H,H,H], [ZD100;AA2,Et,H,H,H], [ZD101;AA2,Pr,H,        H,H], [ZD102;AA2,i-Pr,H,H,H], [ZD103;AA2,c-Pr,H,H,H],        [ZD104;AA2,Ph,H,H,H], [ZD105;AA2,OMe,H,H,H],        [ZD106;AA2,OEt,H,H,H], [ZD107;AA2,OPh,H,H,H],        [ZD108;AA2,CF₃,H,H,H], [ZD109;AA2,F,H,H,H],        [ZD110;AA2,Cl,H,H,H], [ZD111;AA2,Br,H,H,H],        [ZD112;AA2,CN,H,H,H], [ZD113;AA2,H,Me,H,H], [ZD114;AA2,H,        Et,H,H], [ZD115;AA2,H,Pr,H,H], [ZD116;AA2,H,i-Pr,H,H],        [ZD117;AA2,H,c-Pr,H,H], [ZD118;AA2,H,Ph,H,H],        [ZD119;AA2,H,OMe,H,H], [ZD120;A A2,H,OEt,H,H],        [ZD121;AA2,H,OPh,H,H], [ZD122;AA2,H,CF₃,H,H],        [ZD123;AA2,H,F,H,H], [ZD124;AA2,H,Cl,H,H], [ZD125;AA2,H,Br,H,H],        [ZD126;AA2,H,CN,H,H], [ZD127;AA2,H,H,Me,H], [ZD128;AA2,H,H,        Et,H], [ZD129;AA2,H,H,Pr,H], [ZD130;AA2,H,H,i-Pr,H],        [ZD131;AA2,H,H,c-Pr,H], [ZD132;AA2,H,H,Ph,H],        [ZD133;AA2,H,H,OMe,H], [ZD134;AA2,H,H,OEt,H],        [ZD135;AA2,H,H,OPh,H], [ZD136;AA2,H,H,CF₃,H], [ZD        137;AA2,H,H,F,H], [ZD138;AA2,H,H,Cl,H], [ZD139;AA2,H,H,Br,H],        [ZD140;AA2,H,H,CN,H], [ZD141;AA2,H,H,H,Me], [ZD142;AA2,H,H,H,        Et], [ZD143;AA2,H,H,H,Pr], [ZD144;AA2,H,H,H,i-Pr],        [ZD145;AA2,H,H,H,c-Pr], [ZD146;AA2,H,H,H,Ph],        [ZD147;AA2,H,H,H,OMe], [ZD148;AA2,H,H,H,OEt],        [ZD149;AA2,H,H,H,OPh], [ZD150;AA2,H,H,H,CF₃], [ZD15        1;AA2,H,H,H,F], [ZD152;AA2,H,H,H,Cl], [ZD153;AA2,H,H,H,Br], [Z        D154;AA2,H,H,H,CN], [ZD155;AA2,Me,Me,H,H],        [ZD156;AA2,Me,Et,H,H], [ZD157;AA2,Me,OMe,H,H],        [ZD158;AA2,Me,OEt,H,H], [ZD159;AA 2,Me,SMe,H,H],        [ZD160;AA2,Me,F,H,H], [ZD161;AA2,Me,Cl,H,H], [Z        D162;AA2,Me,CN,H,H], [ZD163;AA2,F,Me,H,H], [ZD164;AA2,F,Et,H,        H], [ZD165;AA2,F,OMe,H,H], [ZD166;AA2,F,OEt,H,H],        [ZD167;AA2,F,SMe,H,H], [ZD168;AA2,F,F,H,H],        [ZD169;AA2,F,Cl,H,H], [ZD170;A A2,F,CN,H,H],        [ZD171;AA2,Cl,Me,H,H], [ZD172;AA2,Cl,Et,H,H], [Z        D173;AA2,Cl,OMe,H,H], [ZD174;AA2,Cl,OEt,H,H], [ZD175;AA2,Cl,S        Me,H,H], [ZD176;AA2,Cl,F,H,H], [ZD177;AA2,Cl,Cl,H,H], [ZD178;A        A2,Cl,CN,H,H], [ZD179;AA2,OMe,Me,H,H], [ZD180;AA2,OMe,Et,H,H],        [ZD181;AA2,OMe,OMe,H,H], [ZD182;AA2,OMe,OEt,H,H],        [ZD183;AA2,OMe,SMe,H,H], [ZD184;AA2,OMe,F,H,H],        [ZD185;AA2,OMe,Cl,H,H], [ZD186;AA2,OMe,CN,H,H],        [ZD187;AA2,SMe,Me,H,H], [ZD188;AA2,SM e,Et,H,H],        [ZD189;AA2,SMe,OMe,H,H], [ZD190;AA2,SMe,OEt,H,H],        [ZD191;AA2,SMe,SMe,H,H], [ZD192;AA2,SMe,F,H,H],        [ZD193;AA2,SMe,Cl,H,H], [ZD194;AA2,SMe,CN,H,H],        [ZD195;AA3,H,H,H,H], [ZD196; AA3,Me,H,H,H],        [ZD197;AA3,Et,H,H,H], [ZD198;AA3,Pr,H,H,H], [ZD        199;AA3,i-Pr,H,H,H], [ZD200;AA3,c-Pr,H,H,H],        [ZD201;AA3,Ph,H,H,H], [ZD202;AA3,OMe,H,H,H],        [ZD203;AA3,OEt,H,H,H], [ZD204;AA3,OPh,H,H,H],        [ZD205;AA3,CF₃,H,H,H], [ZD206;AA3,F,H,H,H],        [ZD207;AA3,Cl,H,H,H], [ZD208;AA3,Br,H,H,H],        [ZD209;AA3,CN,H,H,H], [ZD210;AA3,H,Me,H,H], [ZD211;AA3,H,        Et,H,H], [ZD212;AA3,H,Pr,H,H], [ZD213;AA3,H,i-Pr,H,H],        [ZD214;AA3,H,c-Pr,H,H], [ZD215;AA3,H,Ph,H,H],        [ZD216;AA3,H,OMe,H,H], [ZD217;A A3, H, OEt, H, H], [ZD218;AA3,        H, OPh, H, H], [ZD219;AA3, H, CF₃, H, H], [ZD220;AA3,H,F,H,H],        [ZD221;AA3,H,Cl,H,H], [ZD222;AA3,H,Br,H,H],        [ZD223;AA3,H,CN,H,H], [ZD224;AA3,H,H,Me,H], [ZD225;AA3,H,H,        Et,H], [ZD226;AA3,H,H,Pr,H], [ZD227;AA3,H,H,i-Pr,H],        [ZD228;AA3,H,H,c-Pr,H], [ZD229;AA3,H,H,Ph,H],        [ZD230;AA3,H,H,OMe,H], [ZD231;AA3,H,H,OEt,H],        [ZD232;AA3,H,H,OPh,H], [ZD233;AA3,H,H,CF₃,H], [ZD        234;AA3,H,H,F,H], [ZD235;AA3,H,H,Cl,H], [ZD236;AA3,H,H,Br,H],        [ZD237;AA3,H,H,CN,H], [ZD238;AA3,H,H,H,Me], [ZD239;AA3,H,H,H,        Et], [ZD240;AA3,H,H,H,Pr], [ZD241;AA3,H,H,H,i-Pr],        [ZD242;AA3,H,H,H,c-Pr], [ZD243;AA3,H,H,H,Ph],        [ZD244;AA3,H,H,H,OMe], [ZD245;AA3,H,H,H,OEt],        [ZD246;AA3,H,H,H,OPh], [ZD247;AA3,H,H,H,CF₃], [ZD24        8;AA3,H,H,H,F], [ZD249;AA3,H,H,H,Cl], [ZD250;AA3,H,H,H,Br], [Z        D251;AA3,H,H,H,CN], [ZD252;AA3,Me,Me,H,H],        [ZD253;AA3,Me,Et,H,H], [ZD254;AA3,Me,OMe,H,H],        [ZD255;AA3,Me,OEt,H,H], [ZD256;AA 3,Me,SMe,H,H],        [ZD257;AA3,Me,F,H,H], [ZD258;AA3,Me,Cl,H,H], [Z        D259;AA3,Me,CN,H,H], [ZD260;AA3,F,Me,H,H], [ZD261;AA3,F,Et,H,        H], [ZD262;AA3,F,OMe,H,H], [ZD263;AA3,F,OEt,H,H],        [ZD264;AA3,F,SMe,H,H], [ZD265;AA3,F,F,H,H],        [ZD266;AA3,F,Cl,H,H], [ZD267;A A3,F,CN,H,H],        [ZD268;AA3,Cl,Me,H,H], [ZD269;AA3,Cl,Et,H,H], [Z        D270;AA3,Cl,OMe,H,H], [ZD271;AA3,Cl,OEt,H,H], [ZD272;AA3,Cl,S        Me,H,H], [ZD273;AA3,Cl,F,H,H], [ZD274;AA3,Cl,Cl,H,H], [ZD275;A        A3,Cl,CN,H,H], [ZD276;AA3,OMe,Me,H,H], [ZD277;AA3,OMe,Et,H,H],        [ZD278;AA3,OMe,OMe,H,H], [ZD279;AA3,OMe,OEt,H,H],        [ZD280;AA3,OMe,SMe,H,H], [ZD281;AA3,OMe,F,H,H],        [ZD282;AA3,OMe,Cl,H,H], [ZD283;AA3,OMe,CN,H,H],        [ZD284;AA3,SMe,Me,H,H], [ZD285;AA3,SM e,Et,H,H],        [ZD286;AA3,SMe,OMe,H,H], [ZD287;AA3,SMe,OEt,H,H],        [ZD288;AA3,SMe,SMe,H,H], [ZD289;AA3,SMe,F,H,H],        [ZD290;AA3,SMe,Cl,H,H], [ZD291;AA3,SMe,CN,H,H],        [ZD292;AA4,H,H,H,-], [ZD293; AA4,Me,H,H,-],        [ZD294;AA4,Et,H,H,-], [ZD295;AA4,Pr,H,H,-], [ZD        296;AA4,i-Pr,H,H,-], [ZD297;AA4,c-Pr,H,H,-], [ZD298;AA4, Ph,H,H,        -], [ZD299;AA4,OMe,H,H, -], [ZD300;AA4,OEt,H,H, -],        [ZD301;AA4,OPh,H,H, -], [ZD302;AA4,CF₃,H,H, -],        [ZD303;AA4,F,H,H, -], [ZD304;AA4,Cl,H,H, -], [ZD305;AA4,Br,H,H,        -], [ZD306;AA4, CN,H,H, -], [ZD307;AA4,H,Me,H, -], [ZD308;AA4,H,        Et,H,-], [ZD309;AA4,H,Pr,H,-], [ZD310;AA4,H,i-Pr,H,-],        [ZD311;AA4,H,c-Pr,H,-], [ZD312;AA4,H,Ph,H, -],        [ZD313;AA4,H,OMe,H, -], [ZD314;A A4,H,OEt,H, -],        [ZD315;AA4,H,OPh,H, -], [ZD316;AA4,H,CF₃,H, -],        [ZD317;AA4,H,F,H,-], [ZD318;AA4,H,Cl,H,-], [ZD319;AA4,H,Br,H,-],        [ZD320;AA4,H,CN,H,-], [ZD321;AA4,H,H,Me,-], [ZD322;AA4,H,H,        Et,-], [ZD323;AA4,H,H,Pr,-], [ZD324;AA4,H,H,i-Pr,-],        [ZD325;AA4,H,H,c-Pr,-], [ZD326;AA4,H,H,Ph, -],        [ZD327;AA4,H,H,OMe, -], [ZD328;AA4,H,H,OEt,-],        [ZD329;AA4,H,H,OPh, -], [ZD330;AA4,H,H,CF₃, -], [ZD        331;AA4,H,H,F,-], [ZD332;AA4,H,H,Cl,-], [ZD333;AA4,H,H,Br,-],        [ZD334;AA4,H,H,CN,-]

A compound according to Compound (1U) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, and a combinationof structure of A and substituents R^(X11), R^(X12), R^(X13) and R^(X14)applied to the structure of A represents any combination described inCombination D (hereinafter, referred to as Compound group SX477).

A compound according to Compound (1U) wherein R¹ represents a methylgroup, Q represents Q4, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX478).

A compound according to Compound (1U) wherein R¹ represents a chlorineatom, Q represents Q4, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX479).

A compound according to Compound (1U) wherein R¹ represents a methylgroup, Q represents Q5, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX480).

A compound according to Compound (1U) wherein R¹ represents a chlorineatom, Q represents Q5, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX481).

A compound according to Compound (1U) wherein R¹ represents a methylgroup, Q represents Q6, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX482).

A compound according to Compound (1U) wherein R¹ represents a chlorineatom, Q represents Q6, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX483).

A compound according to Compound (1U) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, and a combinationof structure of A and substituents R^(X11), R^(X12), R^(X13) and R^(X14)applied to the structure of A represents any combination described inCombination D (hereinafter, referred to as Compound group SX484).

A compound according to Compound (1U) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, and a combinationof structure of A and substituents R^(X11), R^(X12), R^(X13) and R^(X14)applied to the structure of A represents any combination described inCombination D (hereinafter, referred to as Compound group SX485).

A compound according to Compound (1U) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, and a combination of structureof A and substituents R^(X11), R^(X12). R^(X13) and R^(X14) applied tothe structure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX486).

A compound according to Compound (1U) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, and a combination of structureof A and substituents R^(X11), R^(X12), R^(X13) and R^(X14) applied tothe structure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX487).

A compound according to Compound (1U) wherein R¹ represents a methylgroup, Q represents Q8A, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX488).

A compound according to Compound (1U) wherein R¹ represents a chlorineatom, Q represents Q8A, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX489).

A compound according to Compound (1U) wherein R¹ represents a methylgroup, Q represents Q8D, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX490).

A compound according to Compound (1U) wherein R¹ represents a chlorineatom, Q represents Q8D, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX491).

A compound according to Compound (1U) wherein R¹ represents a methylgroup, Q represents Q8J, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX492).

A compound according to Compound (1U) wherein R¹ represents a chlorineatom, Q represents Q8J, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX493).

A compound represented by formula (1V) (hereinafter, referred to asCompound (1V)):

[wherein A represents any one of groups represented by formulae AA1 toAA4.]wherein R¹ represents a methyl group, Q represents Q3, R³ represents amethoxy group, R^(X9) represents a hydrogen atom, and a combination ofstructure of A and substituents R^(X11), R^(X12), R^(X13) and R^(X14)applied to the structure of A represents any combination described inCombination D (hereinafter, referred to as Compound group SX494).

A compound according to Compound (1V) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, R^(X9) representsa methyl group, and a combination of structure of A and substituentsR^(X11), R^(X12), R^(X13) and R^(X14) applied to the structure of Arepresents any combination described in Combination D (hereinafter,referred to as Compound group SX495).

A compound according to Compound (1V) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R^(X9) representsa hydrogen atom, and a combination of structure of A and substituentsR^(X11), R^(X12), R^(X13) and R^(X14) applied to the structure of Arepresents any combination described in Combination D (hereinafter,referred to as Compound group SX496).

A compound according to Compound (1V) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R^(X9) representsa methyl group, and a combination of structure of A and substituentsR^(X11), R^(X12), R^(X13) and R^(X14) applied to the structure of Arepresents any combination described in Combination D (hereinafter,referred to as Compound group SX497).

A compound according to Compound (1V) wherein R¹ represents a methylgroup, Q represents Q4, R^(X9) represents a hydrogen atom, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX498).

A compound according to Compound (1V) wherein R¹ represents a methylgroup, Q represents Q4, R^(X9) represents a methyl group, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX499).

A compound according to Compound (1V) wherein R¹ represents a chlorineatom, Q represents Q4, R^(X9) represents a hydrogen atom, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX500).

A compound according to Compound (1V) wherein R¹ represents a chlorineatom, Q represents Q4, R^(X9) represents a methyl group, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX501).

A compound according to Compound (1V) wherein R¹ represents a methylgroup, Q represents Q5, R^(X9) represents a hydrogen atom, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX502).

A compound according to Compound (1V) wherein R¹ represents a methylgroup, Q represents Q5, R^(X9) represents a methyl group, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX503).

A compound according to Compound (1V) wherein R¹ represents a chlorineatom, Q represents Q5, R^(X9) represents a hydrogen atom, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX504).

A compound according to Compound (1V) wherein R¹ represents a chlorineatom, Q represents Q5, R^(X9) represents a methyl group, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX505).

A compound according to Compound (1V) wherein R¹ represents a methylgroup, Q represents Q6, R^(X9) represents a hydrogen atom, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX506).

A compound according to Compound (1V) wherein R¹ represents a methylgroup, Q represents Q6, R^(X9) represents a methyl group, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX507).

A compound according to Compound (1V) wherein R¹ represents a chlorineatom, Q represents Q6, R^(X9) represents a hydrogen atom, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX508).

A compound according to Compound (1V) wherein R¹ represents a chlorineatom, Q represents Q6, R^(X9) represents a methyl group, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX509).

A compound according to Compound (1V) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R^(X9) representsa hydrogen atom, and a combination of structure of A and substituentsR^(X11), R^(X12), R^(X13) and R^(X14) applied to the structure of Arepresents any combination described in Combination D (hereinafter,referred to as Compound group SX510).

A compound according to Compound (1V) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R^(X9) representsa methyl group, and a combination of structure of A and substituentsR^(X11), R^(X12), R^(X13) and R^(X14) applied to the structure of Arepresents any combination described in Combination D (hereinafter,referred to as Compound group SX511).

A compound according to Compound (1V) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R^(X9) represents ahydrogen atom, and a combination of structure of A and substituentsR^(X11), R^(X12), R^(X13) and R^(X14) applied to the structure of Arepresents any combination described in Combination D (hereinafter,referred to as Compound group SX512).

A compound according to Compound (1V) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R^(X9) represents amethyl group, and a combination of structure of A and substituentsR^(X11), R^(X12), R^(X13) and R^(X14) applied to the structure of Arepresents any combination described in Combination D (hereinafter,referred to as Compound group SX513).

A compound according to Compound (1V) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R^(X9) represents a hydrogenatom, and a combination of structure of A and substituents R^(X11),R^(X12), R^(X13) and R^(X14) applied to the structure of A representsany combination described in Combination D (hereinafter, referred to asCompound group SX514).

A compound according to Compound (1V) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R^(X9) represents a methylgroup, and a combination of structure of A and substituents R^(X11),R^(X12), R^(X13) and R^(X14) applied to the structure of A representsany combination described in Combination D (hereinafter, referred to asCompound group SX515).

A compound according to Compound (1V) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R^(X9) represents a hydrogenatom, and a combination of structure of A and substituents R^(X11),R^(X12), R^(X13) and R^(X14) applied to the structure of A representsany combination described in Combination D (hereinafter, referred to asCompound group SX516).

A compound according to Compound (1V) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R^(X9) represents a methylgroup, and a combination of structure of A and substituents R^(X11),R^(X12), R^(X13) and R^(X14) applied to the structure of A representsany combination described in Combination D (hereinafter, referred to asCompound group SX517).

A compound according to Compound (1V) wherein R¹ represents a methylgroup, Q represents Q8A, R^(X9) represents a hydrogen atom, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX518).

A compound according to Compound (1V) wherein R¹ represents a methylgroup, Q represents Q8A, R^(X9) represents a methyl group, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX519).

A compound according to Compound (1V) wherein R¹ represents a chlorineatom, Q represents Q8A, R^(X9) represents a hydrogen atom, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX520).

A compound according to Compound (1V) wherein R¹ represents a chlorineatom, Q represents Q8A, R^(X9) represents a methyl group, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX521).

A compound according to Compound (1V) wherein R¹ represents a methylgroup, Q represents Q8D, R^(X9) represents a hydrogen atom, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX522).

A compound according to Compound (1V) wherein R¹ represents a methylgroup, Q represents Q8D, R^(X9) represents a methyl group, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX523).

A compound according to Compound (1V) wherein R¹ represents a chlorineatom, Q represents Q8D, R^(X9) represents a hydrogen atom, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX524).

A compound according to Compound (1V) wherein R¹ represents a chlorineatom, Q represents Q8D, R^(X9) represents a methyl group, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX525).

A compound according to Compound (1V) wherein R¹ represents a methylgroup, Q represents Q8J, R^(X9) represents a hydrogen atom, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX526).

A compound according to Compound (1V) wherein R¹ represents a methylgroup, Q represents Q8J, R^(X9) represents a methyl group, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX527).

A compound according to Compound (1V) wherein R¹ represents a chlorineatom, Q represents Q8J, R^(X9) represents a hydrogen atom, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX528).

A compound according to Compound (1V) wherein R¹ represents a chlorineatom, Q represents Q8J, R^(X9) represents a methyl group, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX529).

A compound represented by formula (1E) (hereinafter, referred to asCompound (1E)):

wherein R¹ represents a methyl group, Q represents Q3, R³ represents amethoxy group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX530).

A compound according to Compound (1E) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX531).

A compound according to Compound (1E) wherein R¹ represents a methylgroup, Q represents Q4, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX532).

A compound according to Compound (1E) wherein R¹ represents a chlorineatom, Q represents Q4, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX533).

A compound according to Compound (1E) wherein R¹ represents a methylgroup, Q represents Q5, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX534).

A compound according to Compound (1E) wherein R¹ represents a chlorineatom, Q represents Q5, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX535).

A compound according to Compound (1E) wherein R¹ represents a methylgroup, Q represents Q6, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX536).

A compound according to Compound (1E) wherein R¹ represents a chlorineatom, Q represents Q6, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX537).

A compound according to Compound (1E) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX538).

A compound according to Compound (1E) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX539).

A compound according to Compound (1E) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, and a combination of R^(X2),R^(X3), R^(X4), R^(X5) and R^(X6) represents any combination describedin Combination A (hereinafter, referred to as Compound group SX540).

A compound according to Compound (1E) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, and a combination of R^(X2),R^(X3), R^(X4), R^(X5) and R^(X6) represents any combination describedin Combination A (hereinafter, referred to as Compound group SX541).

A compound according to Compound (1E) wherein R¹ represents a methylgroup, Q represents Q8A, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX542).

A compound according to Compound (1E) wherein R¹ represents a chlorineatom, Q represents Q8A, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX543).

A compound according to Compound (1E) wherein R¹ represents a methylgroup, Q represents Q8D, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX544).

A compound according to Compound (1E) wherein R¹ represents a chlorineatom, Q represents Q8D, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX545).

A compound according to Compound (1E) wherein R¹ represents a methylgroup, Q represents Q8J, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX546).

A compound according to Compound (1E) wherein R¹ represents a chlorineatom, Q represents Q8J, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any referred to as Compound group SX547).

A compound according to Compound (1E) wherein R¹ represents a methylgroup, Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination H(hereinafter, referred to as Compound group SX548).

Combination H consists of substituent numbers ZH1 to ZH28. Substituentnumbers ZH1 to ZH28 represent combinations of substituents R^(X2),R^(X3), R^(X4), R^(X5) and R^(X6) according to Compound (1E). Andhereinafter, they are referred to as [substituent number; R^(X2),R^(X3), R^(X4), R^(X5), R^(X6)]. For example, the substituent number ZH2refers to a combination wherein R^(X2) represents a methyl group, andeach of R^(X3), R^(X4), R^(X5) and R^(X6) represents a hydrogen atom.

-   -   Combination H: [ZH1;H,H,H,H,H], [ZH2;Me,H,H,H,H],        [ZH3;CF₃,H,H,H,H], [ZH4;H,M e,H,H,H], [ZH5;H,OMe,H,H,H],        [ZH6;H,OCF₃,H,H,H], [ZH7;H,SMe,H, H,H], [ZH8;H,SCF₃,H,H,H],        [ZH9;H,SCHF₂,H,H,H], [ZH10;H,F,H,H,H], [ZH11;H,Br,H,H,H],        [ZH12;H,I,H,H,H], [ZH13;H,CN,H,H,H], [ZH1 4;H, t-Bu,H,H,H],        [ZH15;H,CCH,H,H,H], [ZH16;H,CCMe,H,H,H], [ZH17;HCC(t-Bu),H,H,H],        [ZH18;H,CC(c-Pr),H,H,H], [ZH19;H,CC(SiMe₃),H,H,H],        [ZH20;H,H,Me,H,H], [ZH21;H,H,OCF₃,H,H], [ZH22;H,H,SMe,H,H],        [ZH23;H,H,SCF₃,H,H], [ZH24;H;HSCHF₂,H,H], [ZH25;H,H,t-Bu,H,H],        [ZH26;H,Me,H,Me,H], [ZH27;H,CF₃,H,CF₃,H], [ZH28;H,OPh,H, H, H]

A compound according to Compound (1E) wherein R¹ represents a chlorineatom, Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination H(hereinafter, referred to as Compound group SX549).

A compound according to Compound (1E) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination H (hereinafter, referred to as Compound groupSX550).

A compound according to Compound (1E) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination H (hereinafter, referred to as Compound groupSX551).

A compound according to Compound (1E) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, and a combination of R^(X2),R^(X3), R^(X4), R^(X5) and R^(X6) represents any combination describedin Combination H (hereinafter, referred to as Compound group SX552).

A compound according to Compound (1E) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, and a combination of R^(X2),R^(X3), R^(X4), R^(X5) and R^(X6) represents any combination describedin Combination H (hereinafter, referred to as Compound group SX553).

A compound represented by formula (1F) (hereinafter, referred to asCompound (1F)):

wherein R¹ represents a methyl group, Q represents Q1, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX554).

A compound according to Compound (1F) wherein R¹ represents a chlorineatom, Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX555).

A compound according to Compound (1F) wherein R¹ represents an ethylgroup, Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX556).

A compound according to Compound (1F) wherein R¹ represents a fluorineatom, Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX557).

A compound according to Compound (1F) wherein R¹ represents acyclopropyl group, Q represents Q1, and a combination of R^(X2), R^(X3),R^(X4), R^(X5) and R^(X6) represents any combination described inCombination A (hereinafter, referred to as Compound group SX558).

A compound according to Compound (1F) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX559).

A compound according to Compound (1F) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX560).

A compound according to Compound (1F) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, and a combination of R^(X2),R^(X3), R^(X4), R^(X5) and R^(X6) represents any combination describedin Combination A (hereinafter, referred to as Compound group SX561).

A compound according to Compound (1F) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, and a combination of R^(X2),R^(X3), R^(X4), R^(X5) and R^(X6) represents any combination describedin Combination A (hereinafter, referred to as Compound group SX562).

A compound according to Compound (1F) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX563).

A compound according to Compound (1F) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX564).

A compound according to Compound (1F) wherein R¹ represents a methylgroup, Q represents Q4, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX565).

A compound according to Compound (1F) wherein R¹ represents a chlorineatom, Q represents Q4, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX566).

A compound according to Compound (1F) wherein R¹ represents a methylgroup, Q represents Q5, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX567).

A compound according to Compound (1F) wherein R¹ represents a chlorineatom, Q represents Q5, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX568).

A compound according to Compound (1F) wherein R¹ represents a methylgroup, Q represents Q6, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX569).

A compound according to Compound (1F) wherein R¹ represents a chlorineatom, Q represents Q6, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX570).

A compound according to Compound (1F) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) (hereinafter, referred toas Compound group SX571).

A compound according to Compound (1F) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX572).

A compound according to Compound (1F) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, and a combination of R^(X2),R^(X3), R^(X4), R^(X5) and R^(X6) represents any combination describedin Combination A (hereinafter, referred to as Compound group SX573).

A compound according to Compound (1F) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, and a combination of R^(X2),R^(X3), R^(X4), R^(X5) and R^(X6) represents any combination describedin Combination A (hereinafter, referred to as Compound group SX574).

A compound according to Compound (1F) wherein R¹ represents a methylgroup, Q represents Q8A, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX575).

A compound according to Compound (1F) wherein R¹ represents a chlorineatom, Q represents Q8A, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX576).

A compound according to Compound (1F) wherein R¹ represents a methylgroup, Q represents Q8D, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX577).

A compound according to Compound (1F) wherein R¹ represents a chlorineatom, Q represents Q8D, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX578).

A compound according to Compound (1F) wherein R¹ represents a methylgroup, Q represents Q8J, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX579).

A compound according to Compound (1F) wherein R¹ represents a chlorineatom, Q represents Q8J, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX580).

A compound represented by formula (1Y) (hereinafter, referred to asCompound (1Y)):

wherein R¹ represents a methyl group, Q represents Q1, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX581).

A compound according to Compound (1Y) wherein R¹ represents a chlorineatom, Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX582).

A compound according to Compound (1Y) wherein R¹ represents an ethylgroup, Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX583).

A compound according to Compound (1Y) wherein R¹ represents a fluorineatom, Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX584).

A compound according to Compound (1Y) wherein R¹ represents acyclopropyl group, Q represents Q1, and a combination of R^(X2), R^(X3),R^(X4), R^(X5) and R^(X6) represents any combination described inCombination A (hereinafter, referred to as Compound group SX585).

A compound according to Compound (1Y) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX586).

A compound according to Compound (1Y) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX587).

A compound according to Compound (1Y) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, and a combination of R^(X2),R^(X3), R^(X4), R^(X5) and R^(X6) represents any combination describedin Combination A (hereinafter, referred to as Compound group SX588).

A compound according to Compound (1Y) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, and a combination of R^(X2),R^(X3), R^(X4), R^(X5) and R^(X6) represents any combination describedin Combination A (hereinafter, referred to as Compound group SX589).

A compound according to Compound (1Y) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX590).

A compound according to Compound (1Y) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX591).

A compound according to Compound (1Y) wherein R¹ represents a methylgroup, Q represents Q4, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX592).

A compound according to Compound (1Y) wherein R¹ represents a chlorineatom, Q represents Q4, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX593).

A compound according to Compound (1Y) wherein R¹ represents a methylgroup, Q represents Q5, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX594).

A compound according to Compound (1Y) wherein R¹ represents a chlorineatom, Q represents Q5, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX595).

A compound according to Compound (1Y) wherein R¹ represents a methylgroup, Q represents Q6, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX596).

A compound according to Compound (1Y) wherein R¹ represents a chlorineatom, Q represents Q6, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX597).

A compound according to Compound (1Y) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX598).

A compound according to Compound (1Y) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX599).

A compound according to Compound (1Y) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, and a combination of R^(X2),R^(X3), R^(X4), R^(X5) and R^(X6) represents any combination describedin Combination A (hereinafter, referred to as Compound group SX600).

A compound according to Compound (1Y) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, and a combination of R^(X2),R^(X3), R^(X4), R^(X5) and R^(X6) represents any combination describedin Combination A (hereinafter, referred to as Compound group SX601).

A compound according to Compound (1Y) wherein R¹ represents a methylgroup, Q represents Q8A, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX602).

A compound according to Compound (1Y) wherein R¹ represents a chlorineatom, Q represents Q8A, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX603).

A compound according to Compound (1Y) wherein R¹ represents a methylgroup, Q represents Q8D, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX604).

A compound according to Compound (1Y) wherein R¹ represents a chlorineatom, Q represents Q8D, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX605).

A compound according to Compound (1Y) wherein R¹ represents a methylgroup, Q represents Q8J, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX606).

A compound according to Compound (1Y) wherein R¹ represents a chlorineatom, Q represents Q8J, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX607).

A compound represented by formula (1Z) (hereinafter, referred to asCompound (1Z)):

wherein R¹ represents a methyl group, Q represents Q1, R^(X9) representsa methyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX608).

A compound according to Compound (1Z) wherein R¹ represents a chlorineatom, Q represents Q1, R^(X9) represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX609).

A compound according to Compound (1Z) wherein R¹ represents an ethylgroup, Q represents Q1, R^(X9) represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX610).

A compound according to Compound (1Z) wherein R¹ represents a fluorineatom, Q represents Q1, R^(X9) represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX611).

A compound according to Compound (1Z) wherein R¹ represents acyclopropyl group, Q represents Q1, R^(X9) represents a methyl group,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX612).

A compound according to Compound (1Z) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, R^(X9) representsa methyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX613).

A compound according to Compound (1Z) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, R^(X9) represents amethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX614).

A compound according to Compound (1Z) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, R^(X9) represents a methylgroup, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX615).

A compound according to Compound (1Z) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, R^(X9) represents a methylgroup, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX616).

A compound according to Compound (1Z) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, R^(X9) representsa methyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX617).

A compound according to Compound (1Z) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R^(X9) representsa methyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX618).

A compound according to Compound (1Z) wherein R¹ represents a methylgroup, Q represents Q4, R^(X9) represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX619).

A compound according to Compound (1Z) wherein R¹ represents a chlorineatom, Q represents Q4, R^(X9) represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX620).

A compound according to Compound (1Z) wherein R¹ represents a methylgroup, Q represents Q5, R^(X9) represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX621).

A compound according to Compound (1Z) wherein R¹ represents a chlorineatom, Q represents Q5, R^(X9) represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) (hereinafter,referred to as Compound group SX622).

A compound according to Compound (1Z) wherein R¹ represents a methylgroup, Q represents Q6, R^(X9) represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX623).

A compound according to Compound (1Z) wherein R¹ represents a chlorineatom, Q represents Q6, R^(X9) represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX624).

A compound according to Compound (1Z) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R^(X9) representsa methyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX625).

A compound according to Compound (1Z) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R^(X9) represents amethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX626).

A compound according to Compound (1Z) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R^(X9) represents a methylgroup, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX627).

A compound according to Compound (1Z) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R^(X9) represents a methylgroup, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX628).

A compound according to Compound (1Z) wherein R¹ represents a methylgroup, Q represents Q8A, R^(X9) represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX629).

A compound according to Compound (1Z) wherein R¹ represents a chlorineatom, Q represents Q8A, R^(X9) represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX630).

A compound according to Compound (1Z) wherein R¹ represents a methylgroup, Q represents Q8D, R^(X9) represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX631).

A compound according to Compound (1Z) wherein R¹ represents a chlorineatom, Q represents Q8D, R^(X9) represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX632).

A compound according to Compound (1Z) wherein R¹ represents a methylgroup, Q represents Q8J, R^(X9) represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX633).

A compound according to Compound (1Z) wherein R¹ represents a chlorineatom, Q represents Q8J, R^(X9) represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX634).

A compound according to Compound (1Z) wherein R¹ represents a methylgroup, Q represents Q1, R^(X9) represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX635).

A compound according to Compound (1Z) wherein R¹ represents a chlorineatom, Q represents Q1, R^(X9) represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX636).

A compound according to Compound (1Z) wherein R¹ represents an ethylgroup, Q represents Q1, R^(X9) represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX637).

A compound according to Compound (1Z) wherein R¹ represents a fluorineatom, Q represents Q1, R^(X9) represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX638).

A compound according to Compound (1Z) wherein R¹ represents acyclopropyl group, Q represents Q1, R^(X9) represents a hydrogen atom,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX639).

A compound according to Compound (1Z) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, R^(X9) representsa hydrogen atom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX640).

A compound according to Compound (1Z) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, R^(X9) represents ahydrogen atom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX641).

A compound according to Compound (1Z) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, R^(X9) represents a hydrogenatom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX642).

A compound according to Compound (1Z) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, R^(X9) represents a hydrogenatom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX643).

A compound according to Compound (1Z) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, R^(X9) representsa hydrogen atom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX644).

A compound according to Compound (1Z) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R^(X9) representsa hydrogen atom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX645).

A compound according to Compound (1Z) wherein R¹ represents a methylgroup, Q represents Q4, R^(X9) represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX646).

A compound according to Compound (1Z) wherein R¹ represents a chlorineatom, Q represents Q4, R^(X9) represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX647).

A compound according to Compound (1Z) wherein R¹ represents a methylgroup, Q represents Q5, R^(X9) represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX648).

A compound according to Compound (1Z) wherein R¹ represents a chlorineatom, Q represents Q5, R^(X9) represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX649).

A compound according to Compound (1Z) wherein R¹ represents a methylgroup, Q represents Q6, R^(X9) represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX650).

A compound according to Compound (1Z) wherein R¹ represents a chlorineatom, Q represents Q6, R^(X9) represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX651).

A compound according to Compound (1Z) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R^(X9) representsa hydrogen atom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX652).

A compound according to Compound (1Z) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R^(X9) represents ahydrogen atom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX653).

A compound according to Compound (1Z) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R^(X9) represents a hydrogenatom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX654).

A compound according to Compound (1Z) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R^(X9) represents a hydrogenatom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX655).

A compound according to Compound (1Z) wherein R¹ represents a methylgroup, Q represents Q8A, R^(X9) represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX656).

A compound according to Compound (1Z) wherein R¹ represents a chlorineatom, Q represents Q8A, R^(X9) represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX657).

A compound according to Compound (1Z) wherein R¹ represents a methylgroup, Q represents Q8D, R^(X9) represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX658).

A compound according to Compound (1Z) wherein R¹ represents a chlorineatom, Q represents Q8D, R^(X9) represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX659).

A compound according to Compound (1Z) wherein R¹ represents a methylgroup, Q represents Q8J, R^(X9) represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX660).

A compound according to Compound (1Z) wherein R¹ represents a chlorineatom, Q represents Q8J, R^(X9) represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX661).

A compound represented by formula (1W) (hereinafter, referred to asCompound (1W)):

wherein R¹ represents a methyl group, Q represents Q1, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX662).

A compound according to Compound (1W) wherein R¹ represents a chlorineatom, Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX663).

A compound according to Compound (1W) wherein R¹ represents an ethylgroup, Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX664).

A compound according to Compound (1W) wherein R¹ represents a fluorineatom, Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX665).

A compound according to Compound (1W) wherein R¹ represents acyclopropyl group, Q represents Q1, and a combination of R^(X2), R^(X3),R^(X4), R^(X5) and R^(X6) represents any combination described inCombination A (hereinafter, referred to as Compound group SX666).

A compound according to Compound (1W) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX667).

A compound according to Compound (1W) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX668).

A compound according to Compound (1W) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, and a combination of R^(X2),R^(X3), R^(X4), R^(X5) and R^(X6) represents any combination describedin Combination A (hereinafter, referred to as Compound group SX669).

A compound according to Compound (1W) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, and a combination of R^(X2),R^(X3), R^(X4), R^(X5) and R^(X6) represents any combination describedin Combination A (hereinafter, referred to as Compound group SX670).

A compound according to Compound (1W) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX671).

A compound according to Compound (1W) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX672).

A compound according to Compound (1W) wherein R¹ represents a methylgroup, Q represents Q4, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX673).

A compound according to Compound (1W) wherein R¹ represents a chlorineatom, Q represents Q4, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX674).

A compound according to Compound (1W) wherein R¹ represents a methylgroup, Q represents Q5, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX675).

A compound according to Compound (1W) wherein R¹ represents a chlorineatom, Q represents Q5, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX676).

A compound according to Compound (1W) wherein R¹ represents a methylgroup, Q represents Q6, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX677).

A compound according to Compound (1W) wherein R¹ represents a chlorineatom, Q represents Q6, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX678).

A compound according to Compound (1W) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX679).

A compound according to Compound (1W) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX680).

A compound according to Compound (1W) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, and a combination of R^(X2),R^(X3), R^(X4), R^(X5) and R^(X6) represents any combination describedin Combination A (hereinafter, referred to as Compound group SX681).

A compound according to Compound (1W) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, and a combination of R^(X2),R^(X3), R^(X4), R^(X5) and R^(X6) represents any combination describedin Combination A (hereinafter, referred to as Compound group SX682).

A compound according to Compound (1W) wherein R¹ represents a methylgroup, Q represents Q8A, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX683).

A compound according to Compound (1W) wherein R¹ represents a chlorineatom, Q represents Q8A, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX684).

A compound according to Compound (1W) wherein R¹ represents a methylgroup, Q represents Q8D, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX685).

A compound according to Compound (1W) wherein R¹ represents a chlorineatom, Q represents Q8D, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX686).

A compound according to Compound (1W) wherein R¹ represents a methylgroup, Q represents Q8J, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX687).

A compound according to Compound (1W) wherein R¹ represents a chlorineatom, Q represents Q8J, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX688].

A compound represented by formula (1X) (hereinafter, referred to asCompound (1X)):

wherein R¹ represents a methyl group, Q represents Q1, and a combinationof R^(X7), R^(X8), R^(X9) and R^(X10) represents any combinationdescribed in Combination C (hereinafter, referred to as Compound groupSX689).

Combination C consists of substituent numbers ZC1 to ZC57. Substituentnumbers ZC1 to ZC57 represent combinations of R^(X7), R^(X8), R^(X9) andR^(X10) according to Compound (1X). And hereinafter, they are referredto as [substituent number; R^(X7), R^(X8), R^(X9), R^(X10)]. Forexample, the substituent number ZC2 refers to a combination whereinR^(X7) represents a methyl group, and each of R^(X8), R^(X9) and R^(X10)represents a hydrogen atom.

-   -   Combination C: [ZC1;H,H,H,H], [ZC2;Me,H,H,H], [ZC3;Et,H,H,H],        [ZC4;Pr,H,H,H], [ZC5;i-Pr,H,H,H], [ZC6;c-Pr,H,H,H],        [ZC7;Ph,H,H,H], [ZC8;OMe,H,H,H], [ZC9;OEt,H,H,H], [Z        C10;OPh,H,H,H], [ZC11;CF₃,H,H,H], [ZC12;F,H,H,H],        [ZC13;Cl,H,H,H], [ZC14;Br,H,H,H], [ZC15;CN,H,H,H],        [ZC16;H,Me,H,H], [ZC17;H,Et,H,H], [ZC18;H,Pr,H,H],        [ZC19;H,i-Pr,H,H], [ZC20;H,c-Pr,H,H], [ZC21;H,Ph,H,H],        [ZC22;H,OMe,H,H], [ZC23;H,OEt,H,H], [ZC24;H,OPh,H,H],        [ZC25;H,CF₃,H,H], [ZC26;H,F,H,H], [ZC27;H,Cl, H,H],        [ZC28;H,Br,H,H], [ZC29;H,CN,H,H], [ZC30;H,H,Me,H], [ZC31;        H,H,Et,H], [ZC32;H,H,Pr,H], [ZC33;H,H,i-Pr,H],        [ZC34;H,H,c-Pr,H], [ZC35;H,H,Ph,H], [ZC36;H,H,OMe,H],        [ZC37;H,H,OEt,H], [ZC 38;H,H,OPh,H], [ZC39;H,H,CF₃,H],        [ZC40;H,H,F,H], [ZC41;H,H,Cl, H], [ZC42;H,H,Br,H],        [ZC43;H,H,CN,H], [ZC44;H,H,H,Me], [ZC45;H, H,H,Et],        [ZC46;H,H,H,Pr], [ZC47;H,H,H,i-Pr], [ZC48;H,H,H,c-Pr],        [ZC49;H,H,H,Ph], [ZC50;H,H,H,OMe], [ZC51;H,H,H,OEt],        [ZC52;H,H,H,OPh], [ZC53;H,H,H,CF₃], [ZC54;H,H,H,F],        [ZC55;H,H,H,Cl], [ZC56;H,H,H,Br], [ZC57;H,H,H,CN]

A compound according to Compound (1X) wherein R¹ represents a chlorineatom, Q represents Q1, and a combination of R^(X7), R^(X8), R^(X9) andR^(X10) represents any combination described in Combination C(hereinafter, referred to as Compound group SX690).

A compound according to Compound (1X) wherein R¹ represents an ethylgroup, Q represents Q1, and a combination of R^(X7), R^(X8), R^(X9) andR^(X10) represents any combination described in Combination C(hereinafter, referred to as Compound group SX691).

A compound according to Compound (1X) wherein R¹ represents a fluorineatom, Q represents Q1, and a combination of R^(X7), R^(X8), R^(X9) andR^(X10) represents any combination described in Combination C(hereinafter, referred to as Compound group SX692).

A compound according to Compound (1X) wherein R¹ represents acyclopropyl group, Q represents Q1, and a combination of R^(X7), R^(X8),R^(X9) and R^(X10) represents any combination described in Combination C(hereinafter, referred to as Compound group SX693).

A compound according to Compound (1X) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, and a combinationof R^(X7), R^(X8), R^(X9) and R^(X10) represents any combinationdescribed in Combination C (hereinafter, referred to as Compound groupSX694).

A compound according to Compound (1X) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, and a combinationof R^(X7), R^(X8), R^(X9) and R^(X10) represents any combinationdescribed in Combination C (hereinafter, referred to as Compound groupSX695).

A compound according to Compound (1X) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, and a combination of R^(X7),R^(X8), R^(X9) and R^(X10) represents any combination described inCombination C (hereinafter, referred to as Compound group SX696).

A compound according to Compound (1X) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, and a combination of R^(X7),R^(X8), R^(X9) and R^(X10) represents any combination described inCombination C (hereinafter, referred to as Compound group SX697).

A compound according to Compound (1X) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, and a combinationof R^(X7), R^(X8), R^(X9) and R^(X10) represents any combinationdescribed in Combination C (hereinafter, referred to as Compound groupSX698).

A compound according to Compound (1X) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, and a combinationof R^(X7), R^(X8), R^(X9) and R^(X10) represents any combinationdescribed in Combination C (hereinafter, referred to as Compound groupSX699).

A compound according to Compound (1X) wherein R¹ represents a methylgroup, Q represents Q4, and a combination of R^(X7), R^(X8), R^(X9) andR^(X10) represents any combination described in Combination C(hereinafter, referred to as Compound group SX700).

A compound according to Compound (1X) wherein R¹ represents a chlorineatom, Q represents Q4, and a combination of R^(X7), R^(X8), R^(X9) andR^(X10) represents any combination described in Combination C(hereinafter, referred to as Compound group SX701).

A compound according to Compound (1X) wherein R¹ represents a methylgroup, Q represents Q5, and a combination of R^(X7), R^(X8), R^(X9) andR^(X10) represents any combination described in Combination C(hereinafter, referred to as Compound group SX702).

A compound according to Compound (1X) wherein R¹ represents a chlorineatom, Q represents Q5, and a combination of R^(X7), R^(X8), R^(X9) andR^(X10) represents any combination described in Combination C(hereinafter, referred to as Compound group SX703).

A compound according to Compound (1X) wherein R¹ represents a methylgroup, Q represents Q6, and a combination of R^(X7), R^(X8), R^(X9) andR^(X10) represents any combination described in Combination C(hereinafter, referred to as Compound group SX704).

A compound according to Compound (1X) wherein R¹ represents a chlorineatom, Q represents Q6, and a combination of R^(X7), R^(X5), R^(X9) andR^(X10) represents any combination described in Combination C(hereinafter, referred to as Compound group SX705).

A compound according to Compound (1X) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, and a combinationof R^(X7), R^(X8), R^(X9) and R^(X10) represents any combinationdescribed in Combination C (hereinafter, referred to as Compound groupSX706).

A compound according to Compound (1X) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, and a combinationof R^(X7), R^(X8), R^(X9) and R^(X10) represents any combinationdescribed in Combination C (hereinafter, referred to as Compound groupSX707).

A compound according to Compound (1X) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, and a combination of R^(X7),R^(X8), R^(X9) and R^(X10) represents any combination described inCombination C (hereinafter, referred to as Compound group SX708).

A compound according to Compound (1X) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, and a combination of R^(X7),R^(X8), R^(X9) and R^(X10) represents any combination described inCombination C (hereinafter, referred to as Compound group SX709).

A compound according to Compound (1X) wherein R¹ represents a methylgroup, Q represents Q8A, and a combination of R^(X7), R^(X8), R^(X9) andR^(X10) represents any combination described in Combination C(hereinafter, referred to as Compound group SX710).

A compound according to Compound (1X) wherein R¹ represents a chlorineatom, Q represents Q8A, and a combination of R^(X7), R^(X8), R^(X9) andR^(X10) represents any combination described in Combination C(hereinafter, referred to as Compound group SX711).

A compound according to Compound (1X) wherein R¹ represents a methylgroup, Q represents Q8D, and a combination of R^(X7), R^(X8), R^(X9) andR^(X10) represents any combination described in Combination C(hereinafter, referred to as Compound group SX712).

A compound according to Compound (1X) wherein R¹ represents a chlorineatom, Q represents Q8D, and a combination of R^(X7), R^(X8), R^(X9) andR^(X10) represents any combination described in Combination C(hereinafter, referred to as Compound group SX713).

A compound according to Compound (1X) wherein R¹ represents a methylgroup, Q represents Q8J, and a combination of R^(X7), R^(X8), R^(X9) andR^(X10) represents any combination described in Combination C(hereinafter, referred to as Compound group SX714).

A compound according to Compound (1X) wherein R¹ represents a chlorineatom, Q represents Q8J, and a combination of R^(X7), R^(X8), R^(X9) andR^(X10) represents any combination described in Combination C(hereinafter, referred to as Compound group SX715).

A compound represented by formula (2B) (hereinafter, referred to asCompound (2B)):

[wherein G represents any one of formulae G1 to G35.]wherein R¹ represents a methyl group, Q represents Q1, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX716).

A compound according to Compound (2B) wherein R¹ represents a chlorineatom, Q represents Q1, and a combination of structure of G andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G represents any combination described in Combination B (hereinafter,referred to as Compound group SX717).

A compound according to Compound (2B) wherein R¹ represents a methylgroup, Q represents Q2, L represents an oxygen atom, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX718).

A compound according to Compound (2B) wherein R¹ represents a chlorineatom, Q represents Q2, L represents an oxygen atom, and a combination ofstructure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX719).

A compound according to Compound (2B) wherein R¹ represents a methylgroup, Q represents Q2, L represents NH, and a combination of structureof G and substituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to thestructure of G represents any combination described in Combination B(hereinafter, referred to as Compound group SX720).

A compound according to Compound (2B) wherein R¹ represents a chlorineatom, Q represents Q2, L represents NH, and a combination of structureof G and substituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to thestructure of G represents any combination described in Combination B(hereinafter, referred to as Compound group SX721).

A compound according to Compound (2B) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX722).

A compound according to Compound (2B) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX723).

A compound according to Compound (2B) wherein R¹ represents a methylgroup, Q represents Q4, and a combination of structure of G andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G represents any combination described in Combination B (hereinafter,referred to as Compound group SX724).

A compound according to Compound (2B) wherein R¹ represents a chlorineatom, Q represents Q4, and a combination of structure of G andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G represents any combination described in Combination B (hereinafter,referred to as Compound group SX725).

A compound according to Compound (2B) wherein R¹ represents a methylgroup, Q represents Q5, and a combination of structure of G andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G represents any combination described in Combination B (hereinafter,referred to as Compound group SX726).

A compound according to Compound (2B) wherein R¹ represents a chlorineatom, Q represents Q5, and a combination of structure of G andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G represents any combination described in Combination B (hereinafter,referred to as Compound group SX727).

A compound according to Compound (2B) wherein R¹ represents a methylgroup, Q represents Q6, and a combination of structure of G andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G represents any combination described in Combination B (hereinafter,referred to as Compound group SX728).

A compound according to Compound (2B) wherein R¹ represents a chlorineatom, Q represents Q6, and a combination of structure of G andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G represents any combination described in Combination B (hereinafter,referred to as Compound group SX729).

A compound according to Compound (2B) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX730).

A compound according to Compound (2B) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX731).

A compound according to Compound (2B) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, and a combination of structureof G and substituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to thestructure of G represents any combination described in Combination B(hereinafter, referred to as Compound group SX732).

A compound according to Compound (2B) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, and a combination of structureof G and substituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to thestructure of G represents any combination described in Combination B(hereinafter, referred to as Compound group SX733).

A compound according to Compound (2B) wherein R¹ represents a methylgroup, Q represents Q8A, and a combination of structure of G andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G represents any combination described in Combination B (hereinafter,referred to as Compound group SX734).

A compound according to Compound (2B) wherein R¹ represents a chlorineatom, Q represents Q8A, and a combination of structure of G andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G represents any combination described in Combination B (hereinafter,referred to as Compound group SX735).

A compound according to Compound (2B) wherein R¹ represents a methylgroup, Q represents Q8D, and a combination of structure of G andsubstituents R^(X7), Rx, R^(X9) and R^(X10) applied to the structure ofG represents any combination described in Combination B (hereinafter,referred to as Compound group SX736).

A compound according to Compound (2B) wherein R¹ represents a chlorineatom, Q represents Q8D, and a combination of structure of G andsubstituents R^(X7), Rx, R^(X9) and R^(X10) applied to the structure ofG represents any combination described in Combination B (hereinafter,referred to as Compound group SX737).

A compound according to Compound (2B) wherein R¹ represents a methylgroup, Q represents Q8J, and a combination of structure of G andsubstituents R^(X7), Rx, R^(X9) and R^(X10) applied to the structure ofG represents any combination described in Combination B (hereinafter,referred to as Compound group SX738).

A compound according to Compound (2B) wherein R¹ represents a chlorineatom, Q represents Q8J, and a combination of structure of G andsubstituents R^(X7), Rx, R^(X9) and R^(X10) applied to the structure ofG represents any combination described in Combination B (hereinafter,referred to as Compound group SX739).

A compound represented by formula (2D) (hereinafter, referred to asCompound (2D)):

[wherein A represents any one of groups represented by formulae AA1 toAA4.]wherein R¹ represents a methyl group, Q represents Q1, and a combinationof structure of A and substituents R^(X11), R^(X12), R^(X13) and R^(X14)applied to the structure of A represents any combination described inCombination D (hereinafter, referred to as Compound group SX740).

A compound according to Compound (2D) wherein R¹ represents a chlorineatom, Q represents Q1, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX741).

A compound according to Compound (2D) wherein R¹ represents an ethylgroup, Q represents Q1, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX742).

A compound according to Compound (2D) wherein R¹ represents a fluorineatom, Q represents Q1, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX743).

A compound according to Compound (2D) wherein R¹ represents acyclopropyl group, Q represents Q1, and a combination of structure of Aand substituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX744).

A compound according to Compound (2D) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, and a combinationof structure of A and substituents R^(X11), R^(X12), R^(X13) and R^(X14)applied to the structure of A represents any combination described inCombination D (hereinafter, referred to as Compound group SX745).

A compound according to Compound (2D) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, and a combinationof structure of A and substituents R^(X11), R^(X12), R^(X13) and R^(X14)applied to the structure of A represents any combination described inCombination D (hereinafter, referred to as Compound group SX746).

A compound according to Compound (2D) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, and a combination of structureof A and substituents R^(X11), R^(X12), R^(X13) and R^(X14) applied tothe structure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX747).

A compound according to Compound (2D) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, and a combination of structureof A and substituents R^(X11), R^(X12), R^(X13) and R^(X14) applied tothe structure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX748).

A compound according to Compound (2D) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, and a combinationof structure of A and substituents R^(X11), R^(X12), R^(X13) and R^(X14)applied to the structure of A represents any combination described inCombination D (hereinafter, referred to as Compound group SX749).

A compound according to Compound (2D) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, and a combinationof structure of A and substituents R^(X11), R^(X12), R^(X13) and R^(X14)applied to the structure of A represents any combination described inCombination D (hereinafter, referred to as Compound group SX750).

A compound according to Compound (2D) wherein R¹ represents a methylgroup, Q represents Q4, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX751).

A compound according to Compound (2D) wherein R¹ represents a chlorineatom, Q represents Q4, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX752).

A compound according to Compound (2D) wherein R¹ represents a methylgroup, Q represents Q5, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX753).

A compound according to Compound (2D) wherein R¹ represents a chlorineatom, Q represents Q5, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX754).

A compound according to Compound (2D) wherein R¹ represents a methylgroup, Q represents Q6, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX755).

A compound according to Compound (2D) wherein R¹ represents a chlorineatom, Q represents Q6, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX756).

A compound according to Compound (2D) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, and a combinationof structure of A and substituents R^(X11), R^(X12), R^(X13) and R^(X14)applied to the structure of A represents any combination described inCombination D (hereinafter, referred to as Compound group SX757).

A compound according to Compound (2D) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, and a combinationof structure of A and substituents R^(X11), R^(X12), R^(X13) and R^(X14)applied to the structure of A represents any combination described inCombination D (hereinafter, referred to as Compound group SX758).

A compound according to Compound (2D) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, and a combination of structureof A and substituents R^(X11), R^(X12), R^(X13) and R^(X14) applied tothe structure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX759).

A compound according to Compound (2D) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, and a combination of structureof A and substituents R^(X11), R^(X12), R^(X13) and R^(X14) applied tothe structure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX760).

A compound according to Compound (2D) wherein R¹ represents a methylgroup, Q represents Q8A, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX761).

A compound according to Compound (2D) wherein R¹ represents a chlorineatom, Q represents Q8A, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX762).

A compound according to Compound (2D) wherein R¹ represents a methylgroup, Q represents Q8D, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX763).

A compound according to Compound (2D) wherein R¹ represents a chlorineatom, Q represents Q8D, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX764).

A compound according to Compound (2D) wherein R¹ represents a methylgroup, Q represents Q8J, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX765).

A compound according to Compound (2D) wherein R¹ represents a chlorineatom, Q represents Q8J, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX766).

A compound represented by formula (2E) (hereinafter, referred to asCompound (2E)):

[wherein A represents any one of groups represented by formulae AA1 toAA4.]wherein R¹ represents a methyl group, R^(X9) represents a methyl group,Q represents Q1, and a combination of structure of A and substituentsR^(X11), R^(X12), R^(X13) and R^(X14) applied to the structure of Arepresents any combination described in Combination D (hereinafter,referred to as Compound group SX767).

A compound according to Compound (2E) wherein R¹ represents a chlorineatom, R^(X9) represents a methyl group, Q represents Q1, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX768).

A compound according to Compound (2E) wherein R¹ represents a methylgroup, R^(X9) represents a methyl group, Q represents Q2, L¹ representsan oxygen atom, and a combination of structure of A and substituentsR^(X11), R^(X12), R^(X13) and R^(X14) applied to the structure of Arepresents any combination described in Combination D (hereinafter,referred to as Compound group SX769).

A compound according to Compound (2E) wherein R¹ represents a chlorineatom, R^(X9) represents a methyl group, Q represents Q2, L¹ representsan oxygen atom, and a combination of structure of A and substituentsR^(X11), R^(X12), R^(X13) and R^(X14) applied to the structure of Arepresents any combination described in Combination D (hereinafter,referred to as Compound group SX770).

A compound according to Compound (2E) wherein R¹ represents a methylgroup, R^(X9) represents a methyl group, Q represents Q2, L¹ representsNH, and a combination of structure of A and substituents R^(X11),R^(X12), R^(X13) and R^(X14) applied to the structure of A representsany combination described in Combination D (hereinafter, referred to asCompound group SX771).

A compound according to Compound (2E) wherein R¹ represents a chlorineatom, R^(X9) represents a methyl group, Q represents Q2, L¹ representsNH, and a combination of structure of A and substituents R^(X11),R^(X12), R^(X13) and R^(X14) applied to the structure of A representsany combination described in Combination D (hereinafter, referred to asCompound group SX772).

A compound according to Compound (2E) wherein R¹ represents a methylgroup, R^(X9) represents a methyl group, Q represents Q3, R³ representsa methoxy group, and a combination of structure of A and substituentsR^(X11), R^(X12), R^(X13) and R^(X14) applied to the structure of Arepresents any combination described in Combination D (hereinafter,referred to as Compound group SX773).

A compound according to Compound (2E) wherein R¹ represents a chlorineatom, R^(X9) represents a methyl group, Q represents Q3, R³ represents amethoxy group, and a combination of structure of A and substituentsR^(X11), R^(X12), R^(X13) and R^(X14) applied to the structure of Arepresents any combination described in Combination D (hereinafter,referred to as Compound group SX774).

A compound according to Compound (2E) wherein R¹ represents a methylgroup, R^(X9) represents a methyl group, Q represents Q4, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX775).

A compound according to Compound (2E) wherein R¹ represents a chlorineatom, R^(X9) represents a methyl group, Q represents Q4, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX776).

A compound according to Compound (2E) wherein R¹ represents a methylgroup, R^(X9) represents a methyl group, Q represents Q5, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX777).

A compound according to Compound (2E) wherein R¹ represents a chlorineatom, R^(X9) represents a methyl group, Q represents Q5, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX778).

A compound according to Compound (2E) wherein R¹ represents a methylgroup, R^(X9) represents a methyl group, Q represents Q6, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX779).

A compound according to Compound (2E) wherein R¹ represents a chlorineatom, R^(X9) represents a methyl group, Q represents Q6, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX780).

A compound according to Compound (2E) wherein R¹ represents a methylgroup, R^(X9) represents a methyl group, Q represents Q7, L² representsan oxygen atom, and a combination of structure of A and substituentsR^(X11), R^(X12), R^(X13) and R^(X14) applied to the structure of Arepresents any combination described in Combination D (hereinafter,referred to as Compound group SX781).

A compound according to Compound (2E) wherein R¹ represents a chlorineatom, R^(X9) represents a methyl group, Q represents Q7, L² representsan oxygen atom, and a combination of structure of A and substituentsR^(X11), R^(X12), R^(X13) and R^(X14) applied to the structure of Arepresents any combination described in Combination D (hereinafter,referred to as Compound group SX782).

A compound according to Compound (2E) wherein R¹ represents a methylgroup, R^(X9) represents a methyl group, Q represents Q7, L² representsNH, and a combination of structure of A and substituents R^(X11),R^(X12), R^(X13) and R^(X14) applied to the structure of A representsany combination described in Combination D (hereinafter, referred to asCompound group SX783).

A compound according to Compound (2E) wherein R¹ represents a chlorineatom, R^(X9) represents a methyl group, Q represents Q7, L² representsNH, and a combination of structure of A and substituents R^(X11),R^(X12), R^(X13) and R^(X14) applied to the structure of A representsany combination described in Combination D (hereinafter, referred to asCompound group SX784).

A compound according to Compound (2E) wherein R¹ represents a methylgroup, R^(X9) represents a methyl group, Q represents Q8A, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX785).

A compound according to Compound (2E) wherein R¹ represents a chlorineatom, R^(X9) represents a methyl group, Q represents Q8A, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX786).

A compound according to Compound (2E) wherein R¹ represents a methylgroup, R^(X9) represents a methyl group, Q represents Q8D, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX787).

A compound according to Compound (2E) wherein R¹ represents a chlorineatom, R^(X9) represents a methyl group, Q represents Q8D, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX788).

A compound according to Compound (2E) wherein R¹ represents a methylgroup, R^(X9) represents a methyl group, Q represents Q8J, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX789).

A compound according to Compound (2E) wherein R¹ represents a chlorineatom, R^(X9) represents a methyl group, Q represents Q8J, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX790).

A compound according to Compound (2E) wherein R¹ represents a methylgroup, R^(X9) represents a hydrogen atom, Q represents Q1, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX791).

A compound according to Compound (2E) wherein R¹ represents a chlorineatom, R^(X9) represents a hydrogen atom, Q represents Q1, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX792).

A compound according to Compound (2E) wherein R¹ represents a methylgroup, R^(X9) represents a hydrogen atom, Q represents Q2, L¹ representsan oxygen atom, and a combination of structure of A and substituentsR^(X11), R^(X12), R^(X13) and R^(X14) applied to the structure of Arepresents any combination described in Combination D (hereinafter,referred to as Compound group SX793).

A compound according to Compound (2E) wherein R¹ represents a chlorineatom, R^(X9) represents a hydrogen atom, Q represents Q2, L¹ representsan oxygen atom, and a combination of structure of A and substituentsR^(X11), R^(X2), R^(X13) and R^(X14) applied to the structure of Arepresents any combination described in Combination D (hereinafter,referred to as Compound group SX794).

A compound according to Compound (2E) wherein R¹ represents a methylgroup, R^(X9) represents a hydrogen atom, Q represents Q2, L¹ representsNH, and a combination of structure of A and substituents R^(X11),R^(X2), R^(X13) and R^(X14) applied to the structure of A represents anycombination described in Combination D (hereinafter, referred to asCompound group SX795).

A compound according to Compound (2E) wherein R¹ represents a chlorineatom, R^(X9) represents a hydrogen atom, Q represents Q2, L¹ representsNH, and a combination of structure of A and substituents R^(X11),R^(X2), R^(X13) and R^(X14) applied to the structure of A represents anycombination described in Combination D (hereinafter, referred to asCompound group SX796).

A compound according to Compound (2E) wherein R¹ represents a methylgroup, R^(X9) represents a hydrogen atom, Q represents Q3, R³ representsa methoxy group, and a combination of structure of A and substituentsR^(X11), R^(X2), R^(X13) and R^(X14) applied to the structure of Arepresents any combination described in Combination D (hereinafter,referred to as Compound group SX797).

A compound according to Compound (2E) wherein R¹ represents a chlorineatom, R^(X9) represents a hydrogen atom, Q represents Q3, R³ representsa methoxy group, and a combination of structure of A and substituentsR^(X11), R^(X12), R^(X13) and R^(X14) applied to the structure of Arepresents any combination described in Combination D (hereinafter,referred to as Compound group SX798).

A compound according to Compound (2E) wherein R¹ represents a methylgroup, R^(X9) represents a hydrogen atom, Q represents Q4, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX799).

A compound according to Compound (2E) wherein R¹ represents a chlorineatom, R^(X9) represents a hydrogen atom, Q represents Q4, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX800).

A compound according to Compound (2E) wherein R¹ represents a methylgroup, R^(X9) represents a hydrogen atom, Q represents Q5, and acombination of structure of A and substituents R^(X11), R^(X12). R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX801).

A compound according to Compound (2E) wherein R¹ represents a chlorineatom, R^(X9) represents a hydrogen atom, Q represents Q5, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX802).

A compound according to Compound (2E) wherein R¹ represents a methylgroup, R^(X9) represents a hydrogen atom, Q represents Q6, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX803).

A compound according to Compound (2E) wherein R¹ represents a chlorineatom, R^(X9) represents a hydrogen atom, Q represents Q6, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX804).

A compound according to Compound (2E) wherein R¹ represents a methylgroup, R^(X9) represents a hydrogen atom, Q represents Q7, L² representsan oxygen atom, and a combination of structure of A and substituentsR^(X11), R^(X12), R^(X13) and R^(X14) applied to the structure of Arepresents any combination described in Combination D (hereinafter,referred to as Compound group SX805).

A compound according to Compound (2E) wherein R¹ represents a chlorineatom, R^(X9) represents a hydrogen atom, Q represents Q7, L² representsan oxygen atom, and a combination of structure of A and substituentsR^(X11), R^(X12), R^(X13) and R^(X14) applied to the structure of Arepresents any combination described in Combination D (hereinafter,referred to as Compound group SX806).

A compound according to Compound (2E) wherein R¹ represents a methylgroup, R^(X9) represents a hydrogen atom, Q represents Q7, L² representsNH, and a combination of structure of A and substituents R^(X11),R^(X12), R^(X13) and R^(X14) applied to the structure of A representsany combination described in Combination D (hereinafter, referred to asCompound group SX807).

A compound according to Compound (2E) wherein R¹ represents a chlorineatom, R^(X9) represents a hydrogen atom, Q represents Q7, L² representsNH, and a combination of structure of A and substituents R^(X11),R^(X12), R^(X13) and R^(X14) applied to the structure of A representsany combination described in Combination D (hereinafter, referred to asCompound group SX808).

A compound according to Compound (2E) wherein R¹ represents a methylgroup, R^(X9) represents a hydrogen atom, Q represents Q8A, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX809).

A compound according to Compound (2E) wherein R¹ represents a chlorineatom, R^(X9) represents a hydrogen atom, Q represents Q8A, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX810).

A compound according to Compound (2E) wherein R¹ represents a methylgroup, R^(X9) represents a hydrogen atom, Q represents Q8D, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX811).

A compound according to Compound (2E) wherein R¹ represents a chlorineatom, R^(X9) represents a hydrogen atom, Q represents Q8D, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX812).

A compound according to Compound (2E) wherein R¹ represents a methylgroup, R^(X9) represents a hydrogen atom, Q represents Q8J, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX813).

A compound according to Compound (2E) wherein R¹ represents a chlorineatom, R^(X9) represents a hydrogen atom, Q represents Q8J, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX814).

A compound represented by formula (2F) (hereinafter, referred to asCompound (2F)):

wherein R¹ represents a methyl group, Q represents Q1, R⁷ represents ahydrogen atom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX815).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q1, R⁷ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, (hereinafter, referred to asCompound group SX816).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, R⁷ represents ahydrogen atom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX817).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, R⁷ represents ahydrogen atom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX818).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, R⁷ represents a hydrogen atom,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX819).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, R⁷ represents a hydrogen atom,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX820).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, R⁷ represents ahydrogen atom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX821).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R⁷ represents ahydrogen atom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX822).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q4, R⁷ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX823).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q4, R⁷ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX824).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q5, R⁷ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX825).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q5, R⁷ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX826).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q6, R⁷ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX827).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q6, R⁷ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX828).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R⁷ represents ahydrogen atom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX829).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R⁷ represents ahydrogen atom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX830).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R⁷ represents a hydrogen atom,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX831).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R⁷ represents a hydrogen atom,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX832).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q8A, R⁷ represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX833).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q8A, R⁷ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX834).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q8D, R⁷ represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX835).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q8D, R⁷ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX836).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q8J, R⁷ represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX837).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q8J, R⁷ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX838).

A compound represented by formula (2G) (hereinafter, referred to asCompound (2G)):

[wherein G² represents any one of formula G1, formula G9, formula G10and formula G22.]wherein R¹ represents a methyl group, Q represents Q1, and a combinationof structure of G² and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G² represents any combination described inCombination J (hereinafter, referred to as Compound group SX839).

Combination J consists of substituent numbers ZJ1 to ZJ50. Substituentnumbers ZJ1 to ZJ50 represent combinations of structure of G² andsubstituents of R^(X7), R^(X8), R^(X9) and R^(X10) applied to thestructure of G² according to Compound (2G). And hereinafter, they arereferred to as [substituent number; G², R^(X7), R^(X8), R^(X9),R^(X10)]. For example, the substituent number ZJ2 refers to acombination wherein G² represents G1, R^(X8) represents a methyl group,and each of R^(X7), R^(X9) and R^(X10) represents a hydrogen atom.

-   -   Combination J: [ZJ1;G1,Me,H,H,H], [ZJ2;G1,H,Me,H,H],        [ZJ3;G1,H,H,Me,H], [ZJ4; G1,CF₃,H,H,H], [ZJ5;G1,H,CF₃,H,H],        [ZJ6;G1,H,H,CF₃,H], [ZJ7;G1, Me,H,Me,H], [ZJ8;G1,Me,H,CF₃,H],        [ZJ9;G9,H,Me,H, -], [ZJ10;G9,H,H,Me,-], [ZJ11;G9,H,Me,Me,-],        [ZJ12;G9,H,t-Bu,H,-], [ZJ13;G9,H,H,t-Bu,-], [ZJ14;G9,CF₃,H,H,-],        [ZJ15;G9,C1,H,H,-], [ZJ16;G9,H,Cl, H,-], [ZJ17;G9,H,H,Cl,-],        [ZJ18;G9,H,Cl,Me,-], [ZJ19;G9,H,Br,H,-], [ZJ20;G9,H,H,Br,-],        [ZJ21;G9,H,Br,Me,-], [ZJ22;G9,H,I,H,-], [ZJ23;G9,H,H,I,-],        [ZJ24;G9,H,I,Me,-], [ZJ25;G10,H,Me,H,-], [ZJ26;G10,H,H,Me,-],        [ZJ27;G10,H,Me,Me,-], [ZJ28;G10,H,t-Bu,H,-],        [ZJ29;G10,H,H,t-Bu,-], [ZJ30;G10,Cl,H,H,-], [ZJ31;G10,H,Cl,H,-],        [ZJ32;G10,H,H,Cl,-], [ZJ33;G10,H,Cl,Me,-], [ZJ34;G10,H,Br,H,-],        [ZJ35;G10,H,H,Br,-], [ZJ36;G10,H,Br,Me,-], [ZJ37;G10,H,I,H,-],        [ZJ38;G10, H,H,I,-], [ZJ39;G10,H,I,Me, -], [ZJ40;G22,CF₃,H,        -,-], [ZJ41;G22,OCF₃,H,-,-], [ZJ42;G22,SMe,H,-,-],        [ZJ43;G22,Cl,H, -,-], [ZJ44;G22,I,H,-, -], [ZJ45;G22,CCN,H,        -,-], [ZJ46;G22,SiMe₃,H,-, -], [Z J47;G22,CF₃,Me,-,-],        [ZJ48;G22,Cl,Me,-,-], [ZJ49;G22,I,Me,-,-], [ZJ50;G22,CN,Me,-,-]

A compound according to Compound (2G) wherein R¹ represents a chlorineatom, Q represents Q1, and a combination of structure of G² andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G² represents any combination described in Combination J(hereinafter, referred to as Compound group SX840).

A compound according to Compound (2G) wherein R¹ represents a methylgroup, Q represents Q2, L represents an oxygen atom, and a combinationof structure of G² and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G² represents any combination described inCombination J (hereinafter, referred to as Compound group SX841).

A compound according to Compound (2G) wherein R¹ represents a chlorineatom, Q represents Q2, L represents an oxygen atom, and a combination ofstructure of G² and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G² represents any combination described inCombination J (hereinafter, referred to as Compound group SX842).

A compound according to Compound (2G) wherein R¹ represents a methylgroup, Q represents Q2, L represents NH, and a combination of structureof G² and substituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to thestructure of G² represents any combination described in Combination J(hereinafter, referred to as Compound group SX843).

A compound according to Compound (2G) wherein R¹ represents a chlorineatom, Q represents Q2, L represents NH, and a combination of structureof G² and substituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to thestructure of G² represents any combination described in Combination J(hereinafter, referred to as Compound group SX844).

A compound according to Compound (2G) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, and a combinationof structure of G² and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G² represents any combination described inCombination E (hereinafter, referred to as Compound group SX845).

Combination E consists of substituent numbers ZE1 to ZE196. Substituentnumbers ZE1 to ZE196 represent combinations of structure of G² andsubstituents of R^(X7), R^(X8), R^(X9) and R^(X10) applied to thestructure of G² according to Compound (2G). And hereinafter, they arereferred to as [substituent number; G2, R^(X7), R^(X8), R^(X9),R^(X10)]. For example, the substituent number ZE2 refers to acombination wherein G2 represents G1, R^(X7) represents a methyl group,and each of R^(X8), R^(X9) and R^(X10) represents a hydrogen atom.

-   -   Combination E: [ZE1;G1,H,H,H,H], [ZE2;G1,Me,H,H,H],        [ZE3;G1,Et,H,H,H], [ZE4;G1,Pr,H,H,H], [ZE5;G1,i-Pr,H,H,H],        [ZE6;G1,c-Pr,H,H,H], [ZE7;G1,Ph,H,H,H], [ZE8;G1,OMe,H,H,H],        [ZE9;G1,OEt,H,H,H], [ZE10;G1,OPh,H,H,H], [ZE11;G1,CF₃,H,H,H],        [ZE12;G1,F,H,H,H], [ZE13;G1,Cl,H,H,H], [ZE14;G1,Br,H,H,H],        [ZE15;G1,CN,H,H,H], [ZE16;G1,H,Me,H,H], [ZE17;G1,H,Et,H,H],        [ZE18;G1,H,Pr,H,H], [ZE19;G1,H,i-Pr,H,H], [ZE20;G1,H,c-Pr,H,H],        [ZE21;G1,H,Ph,H,H], [ZE22;G1,H,OMe,H,H], [ZE23;G1,H,OEt,H,H],        [ZE24;G1,H,OPh,H,H], [ZE25;G1,H,CF₃,H,H], [ZE26;G1,H,F,H,H],        [ZE27;G1,H,Cl,H,H], [ZE28;G1,H,Br,H,H], [ZE29;G1,H,CN,H,H],        [ZE30;G1,H,H,Me,H], [ZE31;G1,H,H,Et,H], [ZE32;G1,H,H,Pr,H],        [ZE33;G1,H,H,i-Pr,H], [ZE34;G1,H,H,c-Pr,H], [ZE35;G1,H,H,Ph,H],        [ZE36;G1,H,H,OMe,H], [ZE37;G1,H,H,OEt,H], [ZE38;G1,H,H,OPh,H],        [ZE39;G1,H,H,CF₃,H], [ZE40;G1,H,H,F,H], [ZE41;G1,H,H,Cl,H],        [ZE42;G1,H,H,Br,H], [ZE43;G1,H,H,CN,H], [ZE44;G1,H,H,H,Me],        [ZE45;G1,H,H,H,Et], [ZE46;G1,H,H,H,Pr], [ZE47;G1,H,H,H,i-Pr],        [ZE48;G1,H,H,H,c-Pr], [ZE49;G1,H,H,H,Ph], [ZE50;G1,H,H,H,OMe],        [ZE51;G1,H,H,H,OEt], [ZE52;G1,H,H,H,OPh], [ZE53;G1,H,H,H,CF₃],        [ZE54;G1,H,H,H,F], [ZE55;G1,H,H,H,Cl], [ZE56;G1,H,H,H,Br],        [ZE57;G1,H,H,H,CN], [ZE58;G9,H,H,H,-], [ZE59;G9,Me,H,H,-],        [ZE60;G9,Et,H,H,-], [ZE61;G9,Pr,H,H,-], [ZE62;G9,i-Pr,H,H,-],        [ZE63;G9,c-Pr,H,H,-], [ZE64;G9,Ph,H,H,-], [ZE65;G9,OMe,H,H,-],        [ZE66;G9,OEt,H,H,-], [ZE67;G9,OPh,H,H,-], [ZE68;G9,CF₃,H,H, -],        [ZE69;G9, F,H,H, -], [ZE70;G9,Cl,H,H, -], [ZE71;G9,Br,H,H,-],        [ZE72;G9,CN,H,H,-], [ZE73;G9,H,Me,H,-], [ZE74;G9,H,Et,H,-],        [ZE75;G9,H,Pr,H,-], [ZE76;G9,H,i-Pr,H,-], [ZE77;G9,H,c-Pr,H,-],        [ZE78;G9,H,Ph,H,-], [ZE79;G9,H,OMe,H,-], [ZE80;G9,H,OEt,H,-],        [ZE81;G9,H,OPh,H, -], [ZE82;G9,H,CF₃,H, -], [ZE83;G9,H, F,H, -],        [ZE84;G9,H,Cl,H,-], [ZE85;G9,H,Br,H,-], [ZE86;G9,H,CN,H,-],        [ZE87;G9,H,H,Me,-], [ZE88;G9,H,H,Et,-], [ZE89;G9,H,H,Pr,-],        [ZE90;G9,H,H,i-Pr,-], [ZE91;G9,H,H,c-Pr,-], [ZE92;G9,H,H,Ph,-],        [ZE93;G9,H,H,OMe,-], [ZE94;G9,H,H,OEt,-], [ZE95;G9,H,H,OPh,-],        [ZE96;G9,H,H,CF₃,-], [ZE97;G9,H,H,F,-], [ZE98;G9,H,H,Cl,-],        [ZE99;G9,H,H,Br,-], [ZE100;G9,H,H,CN,-], [ZE101;G10,H,H,H,-],        [ZE102;G10,Me,H,H,-], [ZE103;G10,Et,H,H,-],        [ZE104;G10,Pr,H,H,-], [ZE105;G10,i-Pr,H,H,-],        [ZE106;G10,c-Pr,H,H,-], [ZE107;G10,Ph,H,H,-],        [ZE108;G10,OMe,H,H,-], [ZE109;G10,OEt,H,H,-],        [ZE110;G10,OPh,H,H, -], [ZE111;G10,CF₃,H,H, -],        [ZE112;G10,F,H,H,-], [ZE113;G10,Cl,H,H,-], [ZE114;G10,Br,H,H,-],        [ZE115;G10,CN,H,H,-], [ZE116;G10,H,Me,H,-],        [ZE117;G10,H,Et,H,-], [ZE118;G10,H,Pr,H,-],        [ZE119;G10,H,i-Pr,H,-], [ZE120;G10,H,c-Pr,H,-],        [ZE121;G10,H,Ph,H,-], [ZE122;G10,H,OMe,H,-],        [ZE123;G10,H,OEt,H,-], [ZE124;G10,H,OPh,H,-],        [ZE125;G10,H,CF₃,H,-], [ZE126;G10,H,F,H,-],        [ZE127;G10,H,Cl,H,-], [ZE128;G10,H,Br,H,-],        [ZE129;G10,H,CN,H,-], [ZE130;G10,H,H,Me,-],        [ZE131;G10,H,H,Et,-], [ZE132;G10,H,H,Pr,-],        [ZE133;G10,H,H,i-Pr,-], [ZE134;G10,H,H,c-Pr,-],        [ZE135;G10,H,H,Ph,-], [ZE136;G10,H,H,OMe,-],        [ZE137;G10,H,H,OEt,-], [ZE138;G10,H,H,OPh, -],        [ZE139;G10,H,H,CF₃, -], [ZE140;G10,H,H,F,-],        [ZE141;G10,H,H,Cl,-], [ZE142;G10,H,H,Br,-],        [ZE143;G10,H,H,CN,-], [ZE144;G30,H,H,H,-], [ZE145;G30,Me,H,H,-],        [ZE146;G30,Et,H,H,-], [ZE147;G30,Pr,H,H,-],        [ZE148;G30,i-Pr,H,H,-], [ZE149;G30,c-Pr,H,H,-],        [ZE150;G30,Ph,H,H,-], [ZE151;G30,OMe,H,H,-],        [ZE152;G30,OEt,H,H,-], [ZE153;G30,OPh,H,H, -],        [ZE154;G30,CF₃,H,H, -], [ZE155;G30,F,H,H,-],        [ZE156;G30,Cl,H,H,-], [ZE157;G30,Br,H,H,-],        [ZE158;G30,CN,H,H,-], [ZE159;G30,H,Me,H,-],        [ZE160;G30,H,Et,H,-], [ZE161;G30,H,Pr,H,-],        [ZE162;G30,H,i-Pr,H,-], [ZE163;G30,H,c-Pr,H,-],        [ZE164;G30,H,Ph,H,-], [ZE165;G30,H,OMe,H,-],        [ZE166;G30,H,OEt,H,-], [ZE167;G30,H,OPh,H, -],        [ZE168;G30,H,CF₃,H, -], [ZE169;G30,H,F,H,-],        [ZE170;G30,H,Cl,H,-], [ZE171;G30,H,Br,H,-],        [ZE172;G30,H,CN,H,-], [ZE173;G30,H,H,Me,-],        [ZE174;G30,H,H,Et,-], [ZE175;G30,H,H,Pr,-],        [ZE176;G30,H,H,i-Pr,-], [ZE177;G30,H,H,c-Pr,-],        [ZE178;G30,H,H,Ph,-], [ZE179;G30,H,H,OMe,-],        [ZE180;G30,H,H,OEt,-], [ZE181;G30,H,H,OPh,-],        [ZE182;G30,H,H,CF₃,-], [ZE183;G30,H,H,F,-],        [ZE184;G30,H,H,Cl,-], [ZE185;G30,H,H,Br,-],        [ZE186;G30,H,H,CN,-], [ZE187;G30,H,Oi-Pr,H,-],        [ZE188;G30,H,Oc-Pr,H,-], [ZE189;G30,H,Ot-Bu,H,-],        [ZE190;G30,H,OCF₃,H,-], [ZE191;G30,H,OCHF₂,H, -],        [ZE192;G30,H,OPr,H, -], [ZE193;G30,H,OCH2Ph,H,-],        [ZE194;G30,H,OCH2-i-Pr,H,-], [ZE195;G30,H,OCH2-c-Pr,H,-],        [ZE196;G30,H,OCH2-t-Bu,H,-]

A compound according to Compound (2G) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, and a combinationof structure of G² and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G² represents any combination described inCombination E (hereinafter, referred to as Compound group SX846).

A compound according to Compound (2G) wherein R¹ represents a methylgroup, Q represents Q4, and a combination of structure of G² andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G² represents any combination described in Combination E(hereinafter, referred to as Compound group SX847).

A compound according to Compound (2G) wherein R¹ represents a chlorineatom, Q represents Q4, and a combination of structure of G² andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G² represents any combination described in Combination E(hereinafter, referred to as Compound group SX848).

A compound according to Compound (2G) wherein R¹ represents a methylgroup, Q represents Q5, and a combination of structure of G² andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G² represents any combination described in Combination E(hereinafter, referred to as Compound group SX849).

A compound according to Compound (2G) wherein R¹ represents a chlorineatom, Q represents Q5, and a combination of structure of G² andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G² represents any combination described in Combination E(hereinafter, referred to as Compound group SX850).

A compound according to Compound (2G) wherein R¹ represents a methylgroup, Q represents Q6, and a combination of structure of G² andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G² represents any combination described in Combination E(hereinafter, referred to as Compound group SX851).

A compound according to Compound (2G) wherein R¹ represents a chlorineatom, Q represents Q6, and a combination of structure of G² andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G² represents any combination described in Combination E(hereinafter, referred to as Compound group SX852).

A compound according to Compound (2G) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, and a combinationof structure of G² and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G² represents any combination described inCombination E (hereinafter, referred to as Compound group SX853).

A compound according to Compound (2G) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, and a combinationof structure of G² and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G² represents any combination described inCombination E (hereinafter, referred to as Compound group SX854).

A compound according to Compound (2G) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, and a combination of structureof G² and substituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to thestructure of G² represents any combination described in Combination E(hereinafter, referred to as Compound group SX855).

A compound according to Compound (2G) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, and a combination of structureof G² and substituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to thestructure of G² represents any combination described in Combination E(hereinafter, referred to as Compound group SX856).

A compound according to Compound (2G) wherein R¹ represents a methylgroup, Q represents Q8A, and a combination of structure of G² andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G² represents any combination described in Combination E(hereinafter, referred to as Compound group SX857).

A compound according to Compound (2G) wherein R¹ represents a chlorineatom, Q represents Q8A, and a combination of structure of G² andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G² represents any combination described in Combination E(hereinafter, referred to as Compound group SX858).

A compound according to Compound (2G) wherein R¹ represents a methylgroup, Q represents Q8D, and a combination of structure of G² andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G² represents any combination described in Combination E(hereinafter, referred to as Compound group SX859).

A compound according to Compound (2G) wherein R¹ represents a chlorineatom, Q represents Q8D, and a combination of structure of G² andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G² represents any combination described in Combination E(hereinafter, referred to as Compound group SX860).

A compound according to Compound (2G) wherein R¹ represents a methylgroup, Q represents Q8J, and a combination of structure of G² andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G² represents any combination described in Combination E(hereinafter, referred to as Compound group SX861).

A compound according to Compound (2G) wherein R¹ represents a chlorineatom, Q represents Q8J, and a combination of structure of G² andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G² represents any combination described in Combination E(hereinafter, referred to as Compound group SX862).

A compound represented by formula (1K) (hereinafter, referred to asCompound (1K)):

wherein R¹ represents a methyl group, Q represents Q1, R¹⁰ represents ahydrogen atom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX863).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q1, R¹⁰ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX864).

A compound according to Compound (1K) wherein R¹ represents an ethylgroup, Q represents Q1, R¹⁰ represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX865).

A compound according to Compound (1K) wherein R¹ represents a fluorineatom, Q represents Q1, R¹⁰ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX866).

A compound according to Compound (1K) wherein R¹ represents acyclopropyl group, Q represents Q1, R¹⁰ represents a hydrogen atom, anda combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) representsany combination described in Combination A (hereinafter, referred to asCompound group SX867).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, R¹⁰ represents ahydrogen atom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX868).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, R¹⁰ represents ahydrogen atom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX869).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, R¹⁰ represents a hydrogenatom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX870).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, R¹⁰ represents a hydrogen atom,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX871).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, R¹⁰ represents ahydrogen atom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX872).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R¹⁰ represents ahydrogen atom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX873).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q4, R¹⁰ represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX874).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q4, R¹⁰ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX875).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q5, R¹⁰ represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX876).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q5, R¹⁰ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX877).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q6, R¹⁰ represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX878).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q6, R¹⁰ represents a hydrogen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX879).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R¹⁰ represents ahydrogen atom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX880).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R¹⁰ represents ahydrogen atom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX881).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R¹⁰ represents a hydrogenatom, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX882).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R¹⁰ represents a hydrogen atom,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX883).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q8A, R¹⁰ represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX884).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q8A, R¹⁰ represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX885).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q8D, R¹⁰ represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX886).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q8D, R¹⁰ represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX887).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q8J, R¹⁰ represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX888).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q8J, R¹⁰ represents a hydrogen atom, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX889).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, R¹⁰ represents amethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX890).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R¹⁰ represents amethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX891).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q4, R¹⁰ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX892).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q4, R¹⁰ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX893).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q5, R¹⁰ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX894).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q5, R¹⁰ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX895).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q6, R¹⁰ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX896).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q6, R¹⁰ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX897).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R¹⁰ represents amethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX898).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R¹⁰ represents amethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX899).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R¹⁰ represents a methyl group,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX900).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R¹⁰ represents a methyl group,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX901).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q8A, R¹⁰ represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX902).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q8A, R¹⁰ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX903).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q8D, R¹⁰ represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX904).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q8D, R¹⁰ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX905).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q8J, R¹⁰ represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX906).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q8J, R¹⁰ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX907).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, R¹⁰ represents anethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX908).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R¹⁰ represents anethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX909).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q4, R¹⁰ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX910).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q4, R¹⁰ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX911).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q5, R¹⁰ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX912).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q5, R¹⁰ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX913).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q6, R¹⁰ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX914).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q6, R¹⁰ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX915).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R¹⁰ represents anethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX916).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R¹⁰ represents anethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX917).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R¹⁰ represents an ethyl group,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX918).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R¹⁰ represents an ethyl group,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX919).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q8A, R¹⁰ represents an ethyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX920).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q8A, R¹⁰ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX921).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q8D, R¹⁰ represents an ethyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX922).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q8D, R¹⁰ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX923).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q8J, R¹⁰ represents an ethyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX924).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q8J, R¹⁰ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX925).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, R¹⁰ represents acyclopropyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5)and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX926).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R¹⁰ represents acyclopropyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5)and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX927).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q4, R¹⁰ represents a cyclopropyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX928).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q4, R¹⁰ represents a cyclopropyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX929).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q5, R¹⁰ represents a cyclopropyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX930).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q5, R¹⁰ represents a cyclopropyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX931).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q6, R¹⁰ represents a cyclopropyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX932).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q6, R¹⁰ represents a cyclopropyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX933).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R¹⁰ represents acyclopropyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5)and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX34).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R¹⁰ represents acyclopropyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5)and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX935).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R¹⁰ represents a cyclopropylgroup, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX936).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R¹⁰ represents a cyclopropylgroup, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX937).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q8A, R¹⁰ represents a cyclopropyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX938).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q8A, R¹⁰ represents a cyclopropyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX939).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q8D, R¹⁰ represents a cyclopropyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX940).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q8D, R¹⁰ represents a cyclopropyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX941).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q8J, R¹⁰ represents a cyclopropyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX942).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q8J, R¹⁰ represents a cyclopropyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX943).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q1, R¹⁰ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX944).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q1, R¹⁰ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX945).

A compound according to Compound (1K) wherein R¹ represents an ethylgroup, Q represents Q1, R¹⁰ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX946).

A compound according to Compound (1K) wherein R¹ represents a fluorineatom, Q represents Q1, R¹⁰ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX947).

A compound according to Compound (1K) wherein R¹ represents acyclopropyl group, Q represents Q1, R¹⁰ represents a methyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX948).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, R¹⁰ represents amethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX949).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, R¹⁰ represents amethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX950).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, R¹⁰ represents a methyl group,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX951).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, R¹⁰ represents a methyl group,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX952).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q1, R¹⁰ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX953).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q1, R¹⁰ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX954).

A compound according to Compound (1K) wherein R¹ represents an ethylgroup, Q represents Q1, R¹⁰ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX955).

A compound according to Compound (1K) wherein R¹ represents a fluorineatom, Q represents Q1, R¹⁰ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX956).

A compound according to Compound (1K) wherein R¹ represents acyclopropyl group, Q represents Q1, R¹⁰ represents an ethyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX957).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, R¹⁰ represents anethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX958).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, R¹⁰ represents anethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX959).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, R¹⁰ represents an ethyl group,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX960).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, R¹⁰ represents an ethyl group,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX961).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q1, R¹⁰ represents a cyclopropyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX962).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q1, R¹⁰ represents a cyclopropyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX963).

A compound according to Compound (1K) wherein R¹ represents an ethylgroup, Q represents Q1, R¹⁰ represents a cyclopropyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX964).

A compound according to Compound (1K) wherein R¹ represents a fluorineatom, Q represents Q1, R¹⁰ represents a cyclopropyl group, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX965).

A compound according to Compound (1K) wherein R¹ represents acyclopropyl group, Q represents Q1, R¹⁰ represents a cyclopropyl group,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX966).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, R¹⁰ represents acyclopropyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5)and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX967).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, R¹⁰ represents acyclopropyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5)and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX968).

A compound according to Compound (1K) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, R¹⁰ represents a cyclopropylgroup, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX969).

A compound according to Compound (1K) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, R¹⁰ represents a cyclopropylgroup, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX970).

A compound represented by formula (1L) (hereinafter, referred to asCompound (1L)):

wherein R¹ represents a methyl group, Q represents Q1, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX971).

Combination F consists of substituent numbers ZF1 to ZF145. Substituentnumbers ZF1 to ZF145 represent combinations of R^(X3), R^(X4), R^(X5)and R^(X6) according to Compound (1L), compounds represented by formula(10), compounds represented by formula (1Q), compounds represented byformula (1R), compounds represented by formula (1S) and compoundsrepresented by formula (1T). And hereinafter, they are referred to as[substituent number; R^(X3),R^(X4),R^(X5),R^(X6)]. For example, thesubstituent number ZF2 refers to a combination wherein R^(X3) representsa methyl group, and each of R^(X4), R^(X5) and R^(X6) represents ahydrogen atom.

-   -   Combination F: [ZF1;H,H,H,H], [ZF2;Me,H,H,H], [ZF3;Et,H,H,H],        [ZF4;Pr,H,H,H], [ZF5;i-Pr,H,H,H], [ZF6;c-Pr,H,H,H],        [ZF7;OMe,H,H,H], [ZF8;OEt,H,H,H], [ZF9;CF₃,H,H,H],        [ZF10;F,H,H,H], [ZF11;Cl,H,H,H], [ZF12;Br,H,H,H], [ZF13;CN,H,H,        H], [ZF14;H,Me,H,H], [ZF15;H,Et,H,H], [ZF16;H,Pr,H,H], [ZF17;H,        i-Pr,H,H], [ZF18;H,c-Pr,H,H], [ZF19;H,OMe,H,H],        [ZF20;H,OEt,H,H], [ZF21;H,CF₃,H,H], [ZF22;H,F,H,H],        [ZF23;H,Cl,H,H], [ZF24;H,Br,H,H], [ZF25;H,CN,H,H],        [ZF26;H,H,Me,H], [ZF27;H,H,Et,H], [ZF28;H,H,Pr,H],        [ZF29;H,H,i-Pr,H], [ZF30;H,H,c-Pr,H], [ZF31;H,H,OMe,H],        [ZF32;H,H,OEt,H], [ZF33;H,H,CF₃,H], [Z F34;H,H,F,H],        [ZF35;H,H,Cl,H], [ZF36;H,H,Br,H], [ZF37;H,H,CN,H],        [ZF38;H,H,H,Me], [ZF39;H,H,H,Et], [ZF40;H,H,H,Pr],        [ZF41;H,H,H,i-Pr], [ZF42;H,H,H,c-Pr], [ZF43;H,H,H,OMe],        [ZF44;H,H,H,OEt], [ZF45;H,H,H,CF₃], [ZF4 6;H,H,H,F],        [ZF47;H,H,H,Cl], [ZF48;H,H,H,Br], [ZF49;H,H,H,CN],        [ZF50;Me,Me,H,H], [ZF51;Me,OMe,H,H], [ZF52;Me,F,H,H],        [ZF53;Me,Cl,H,H], [ZF54;Me,H,Me,H], [ZF55;Me,H,OMe,H],        [ZF56;Me,H,F,H], [ZF57;Me,H,Cl,H], [ZF58;Me,H,H,Me],        [ZF59;Me,H,H,OMe], [ZF60; Me,H,H,F], [ZF61;Me,H,H,Cl],        [ZF62;OMe,Me,H,H], [ZF63;OMe,OMe, H,H], [ZF64;OMe,F,H,H],        [ZF65;OMe,Cl,H,H], [ZF66;OMe,H,Me,H], [ZF67;OMe,H,OMe,H],        [ZF68;OMe,H,F,H], [ZF69;OMe,H,Cl,H], [ZF70; OMe,H,H,Me],        [ZF71;OMe,H,H,OMe], [ZF72;OMe,H,H,F], [ZF73;OMe,H,H,Cl],        [ZF74;F,Me,H,H], [ZF75;F,OMe,H,H], [ZF76;F,F,H,H], [ZF7        7;F,Cl,H,H], [ZF78;F,H,Me,H], [ZF79;F,H,OMe,H], [ZF80;F,H,F,H],        [ZF81;F,H,Cl,H], [ZF82;F,H,H,Me], [ZF83;F,H,H,OMe],        [ZF84;F,H,H,F], [ZF85;F,H,H,Cl], [ZF86;Cl,Me,H,H],        [ZF87;Cl,OMe,H,H], [Z F88;Cl,F,H,H], [ZF89;Cl,Cl,H,H],        [ZF90;Cl,H,Me,H], [ZF91;Cl,H, OMe,H], [ZF92;Cl,H,F,H],        [ZF93;Cl,H,Cl,H], [ZF94;Cl,H,H,Me], [Z F95;Cl,H,H,OMe],        [ZF96;Cl,H,H,F], [ZF97;Cl,H,H,Cl], [ZF98;H,Me,Me,H],        [ZF99;H,Me,OMe,H], [ZF100;H,Me,F,H], [ZF101;H,Me,Cl,H],        [ZF102;H,Me,H,Me], [ZF103;H,Me,H,OMe], [ZF104;H,Me,H,F], [ZF1        05;H,Me,H,Cl], [ZF106;H,OMe,Me,H], [ZF107;H,OMe,OMe,H],        [ZF108;H,OMe,F,H], [ZF109;H,OMe,Cl,H], [ZF110;H,OMe,H,Me],        [ZF111;H, OMe,H,OMe], [ZF112;H,OMe,H,F], [ZF113;H,OMe,H,Cl],        [ZF114;H,F, Me,H], [ZF115;H,F,OMe,H], [ZF116;H,F,F,H],        [ZF117;H,F,Cl,H], [Z F118;H,F,H,Me], [ZF119;H,F,H,OMe],        [ZF120;H,F,H,F], [ZF121;H,F,H,Cl], [ZF122;H,Cl,Me,H],        [ZF123;H,Cl,OMe,H], [ZF124;H,Cl,F,H], [ZF125;H,Cl,Cl,H],        [ZF126;H,Cl,H,Me], [ZF127;H,Cl,H,OMe], [Z F128;H,Cl,H,F],        [ZF129;H,Cl,H,Cl], [ZF130;H,H,Me,Me], [ZF131;H,H,Me,OMe],        [ZF132;H,H,Me,F], [ZF133;H,H,Me,Cl], [ZF134;H,H,OM e,Me],        [ZF135;H,H,OMe,OMe], [ZF136;H,H,OMe,F], [ZF137;H,H,OMe, Cl],        [ZF138;H,H,F,Me], [ZF139;H,H,F,OMe], [ZF140;H,H,F,F], [ZF1        41;H,H,F,Cl], [ZF142;H,H,Cl,Me], [ZF143;H,H,Cl,OMe], [ZF144;H,        H,Cl,F], [ZF145;H,H,Cl,Cl]

A compound according to Compound (1L) wherein R¹ represents a chlorineatom, Q represents Q1, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX972).

A compound according to Compound (1L) wherein R¹ represents an ethylgroup, Q represents Q1, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX973).

A compound according to Compound (1L) wherein R¹ represents a fluorineatom, Q represents Q1, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX974).

A compound according to Compound (1L) wherein R¹ represents acyclopropyl group, Q represents Q1, and a combination of R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX975).

A compound according to Compound (1L) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX976).

A compound according to Compound (1L) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX977).

A compound according to Compound (1L) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, and a combination of R^(X3),R^(X4), R^(X5) and R^(X6) represents any combination described inCombination F (hereinafter, referred to as Compound group SX978).

A compound according to Compound (1L) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, and a combination of R^(X3),R^(X4), R^(X5) and R^(X6) represents any combination described inCombination F (hereinafter, referred to as Compound group SX979).

A compound according to Compound (1L) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX980).

A compound according to Compound (1L) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX981).

A compound according to Compound (1L) wherein R¹ represents a methylgroup, Q represents Q4, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX982).

A compound according to Compound (1L) wherein R¹ represents a chlorineatom, Q represents Q4, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX983).

A compound according to Compound (1L) wherein R¹ represents a methylgroup, Q represents Q5, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX984).

A compound according to Compound (1L) wherein R¹ represents a chlorineatom, Q represents Q5, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX985).

A compound according to Compound (1L) wherein R¹ represents a methylgroup, Q represents Q6, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX986).

A compound according to Compound (1L) wherein R¹ represents a chlorineatom, Q represents Q6, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX987).

A compound according to Compound (1L) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX988).

A compound according to Compound (1L) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX989).

A compound according to Compound (1L) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, and a combination of R^(X3),R^(X4), R^(X5) and R^(X6) represents any combination described inCombination F (hereinafter, referred to as Compound group SX990).

A compound according to Compound (1L) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, and a combination of R^(X3),R^(X4), R^(X5) and R^(X6) represents any combination described inCombination F (hereinafter, referred to as Compound group SX991).

A compound according to Compound (1L) wherein R¹ represents a methylgroup, Q represents Q8A, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX992).

A compound according to Compound (1L) wherein R¹ represents a chlorineatom, Q represents Q8A, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX993).

A compound according to Compound (1L) wherein R¹ represents a methylgroup, Q represents Q8D, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX994).

A compound according to Compound (1L) wherein R¹ represents a chlorineatom, Q represents Q8D, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX995).

A compound according to Compound (1L) wherein R¹ represents a methylgroup, Q represents Q8J, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX996).

A compound according to Compound (1L) wherein R¹ represents a chlorineatom, Q represents Q8J, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX997).

A compound represented by formula (10) (hereinafter, referred to asCompound (1O)):

wherein R¹ represents a methyl group, Q represents Q1, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX998).

A compound according to Compound (1O) wherein R¹ represents a chlorineatom, Q represents Q1, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX999).

A compound according to Compound (1O) wherein R¹ represents an ethylgroup, Q represents Q1, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1000).

A compound according to Compound (1O) wherein R¹ represents a fluorineatom, Q represents Q1, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1001).

A compound according to Compound (1O) wherein R¹ represents acyclopropyl group, Q represents Q1, and a combination of R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1002).

A compound according to Compound (1O) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1003).

A compound according to Compound (1O) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1004).

A compound according to Compound (1O) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, and a combination of R^(X3),R^(X4), R^(X5) and R^(X6) represents any combination described inCombination F (hereinafter, referred to as Compound group SX1005).

A compound according to Compound (1O) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, and a combination of R^(X3),R^(X4), R^(X5) and R^(X6) represents any combination described inCombination F (hereinafter, referred to as Compound group SX1006).

A compound according to Compound (1O) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1007).

A compound according to Compound (1O) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1008).

A compound according to Compound (1O) wherein R¹ represents a methylgroup, Q represents Q4, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1009).

A compound according to Compound (1O) wherein R¹ represents a chlorineatom, Q represents Q4, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1010).

A compound according to Compound (1O) wherein R¹ represents a methylgroup, Q represents Q5, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1011).

A compound according to Compound (1O) wherein R¹ represents a chlorineatom, Q represents Q5, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1012).

A compound according to Compound (1O) wherein R¹ represents a methylgroup, Q represents Q6, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1013).

A compound according to Compound (1O) wherein R¹ represents a chlorineatom, Q represents Q6, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1014).

A compound according to Compound (1O) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1015).

A compound according to Compound (1O) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1016).

A compound according to Compound (1O) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, and a combination of R^(X3),R^(X4), R^(X5) and R^(X6) represents any combination described inCombination F (hereinafter, referred to as Compound group SX1017).

A compound according to Compound (1O) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, and a combination of R^(X3),R^(X4), R^(X5) and R^(X6) represents any combination described inCombination F (hereinafter, referred to as Compound group SX1018).

A compound according to Compound (1O) wherein R¹ represents a methylgroup, Q represents Q8A, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1019).

A compound according to Compound (1O) wherein R¹ represents a chlorineatom, Q represents Q8A, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1020).

A compound according to Compound (1O) wherein R¹ represents a methylgroup, Q represents Q8D, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1021).

A compound according to Compound (1O) wherein R¹ represents a chlorineatom, Q represents Q8D, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1022).

A compound according to Compound (1O) wherein R¹ represents a methylgroup, Q represents Q8J, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1023).

A compound according to Compound (1O) wherein R¹ represents a chlorineatom, Q represents Q8J, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1024).

A compound represented by formula (1Q) (hereinafter, referred to asCompound (1Q)):

wherein R¹ represents a methyl group, Q represents Q1, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1025).

A compound according to Compound (1Q) wherein R¹ represents a chlorineatom, Q represents Q1, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1026).

A compound according to Compound (1Q) wherein R¹ represents an ethylgroup, Q represents Q1, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1027).

A compound according to Compound (1Q) wherein R¹ represents a fluorineatom, Q represents Q1, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1028).

A compound according to Compound (1Q) wherein R¹ represents acyclopropyl group, Q represents Q1, and a combination of R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1029).

A compound according to Compound (1Q) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1030).

A compound according to Compound (1Q) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1031).

A compound according to Compound (1Q) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, and a combination of R^(X3),R^(X4), R^(X5) and R^(X6) represents any combination described inCombination F (hereinafter, referred to as Compound group SX1032).

A compound according to Compound (1Q) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, and a combination of R^(X3),R^(X4), R^(X5) and R^(X6) represents any combination described inCombination F (hereinafter, referred to as Compound group SX1033).

A compound according to Compound (1Q) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1034).

A compound according to Compound (1Q) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1035).

A compound according to Compound (1Q) wherein R¹ represents a methylgroup, Q represents Q4, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1036).

A compound according to Compound (1Q) wherein R¹ represents a chlorineatom, Q represents Q4, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1037).

A compound according to Compound (1Q) wherein R¹ represents a methylgroup, Q represents Q5, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1038).

A compound according to Compound (1Q) wherein R¹ represents a chlorineatom, Q represents Q5, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1039).

A compound according to Compound (1Q) wherein R¹ represents a methylgroup, Q represents Q6, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1040).

A compound according to Compound (1Q) wherein R¹ represents a chlorineatom, Q represents Q6, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1041).

A compound according to Compound (1Q) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1042).

A compound according to Compound (1Q) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1043).

A compound according to Compound (1Q) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, and a combination of R^(X3),R^(X4), R^(X5) and R^(X6) represents any combination described inCombination F (hereinafter, referred to as Compound group SX1044).

A compound according to Compound (1Q) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, and a combination of R^(X3),R^(X4), R^(X5) and R^(X6) represents any combination described inCombination F (hereinafter, referred to as Compound group SX1045).

A compound according to Compound (1Q) wherein R¹ represents a methylgroup, Q represents Q8A, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1046).

A compound according to Compound (1Q) wherein R¹ represents a chlorineatom, Q represents Q8A, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1047).

A compound according to Compound (1Q) wherein R¹ represents a methylgroup, Q represents Q8D, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1048).

A compound according to Compound (1Q) wherein R¹ represents a chlorineatom, Q represents Q8D, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1049).

A compound according to Compound (1Q) wherein R¹ represents a methylgroup, Q represents Q8J, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1050).

A compound according to Compound (1Q) wherein R¹ represents a chlorineatom, Q represents Q8J, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1051).

A compound represented by formula (1R) (hereinafter, referred to asCompound (1R)):

wherein R¹ represents a methyl group, Q represents Q1, R¹⁰ represents amethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1052).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q1, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1053).

A compound according to Compound (1R) wherein R¹ represents an ethylgroup, Q represents Q1, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1054).

A compound according to Compound (1R) wherein R¹ represents a fluorineatom, Q represents Q1, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1055).

A compound according to Compound (1R) wherein R¹ represents acyclopropyl group, Q represents Q1, R¹⁰ represents a methyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1056).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, R¹⁰ represents amethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1057).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, R¹⁰ represents amethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1058).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, R¹⁰ represents a methyl group,and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1059).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, R¹⁰ represents a methyl group,and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1060).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, R¹⁰ represents amethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1061).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R¹⁰ represents amethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1062).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q4, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1063).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q4, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1064).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q5, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1065).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q5, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1066).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q6, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1067).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q6, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1068).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R¹⁰ represents amethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1069).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R¹⁰ represents amethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1070).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R¹⁰ represents a methyl group,and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1071).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R¹⁰ represents a methyl group,and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1072).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q8A, R¹⁰ represents a methyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1073).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q8A, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1074).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q8D, R¹⁰ represents a methyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1075).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q8D, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1076).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q8J, R¹⁰ represents a methyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1077).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q8J, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1078).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q1, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1079).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q1, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1080).

A compound according to Compound (1R) wherein R¹ represents an ethylgroup, Q represents Q1, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1081).

A compound according to Compound (1R) wherein R¹ represents a fluorineatom, Q represents Q1, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1082).

A compound according to Compound (1R) wherein R¹ represents acyclopropyl group, Q represents Q1, R¹⁰ represents an ethyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1083).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, R¹⁰ represents anethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1084).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, R¹⁰ represents anethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1085).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, R¹⁰ represents an ethyl group,and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1086).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, R¹⁰ represents an ethyl group,and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1087).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, R¹⁰ represents anethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1088).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R¹⁰ represents anethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1089).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q4, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1090).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q4, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1091).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q5, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1092).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q5, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1093).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q6, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1094).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q6, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1095).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R¹⁰ represents anethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1096).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R¹⁰ represents anethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1097).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R¹⁰ represents an ethyl group,and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1098).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R¹⁰ represents an ethyl group,and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1099).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q8A, R¹⁰ represents an ethyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1100).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q8A, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1101).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q8D, R¹⁰ represents an ethyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1102).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q8D, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1103).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q8J, R¹⁰ represents an ethyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1104).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q8J, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1105).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q1, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1106).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q1, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1107).

A compound according to Compound (1R) wherein R¹ represents an ethylgroup, Q represents Q1, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1108).

A compound according to Compound (1R) wherein R¹ represents a fluorineatom, Q represents Q1, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1109).

A compound according to Compound (1R) wherein R¹ represents acyclopropyl group, Q represents Q1, R¹⁰ represents a cyclopropyl group,and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1110).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, R¹⁰ represents acyclopropyl group, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1111).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, R¹⁰ represents acyclopropyl group, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1112).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, R¹⁰ represents a cyclopropylgroup, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) representsany combination described in Combination F (hereinafter, referred to asCompound group SX1113).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, R¹⁰ represents a cyclopropylgroup, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) representsany combination described in Combination F (hereinafter, referred to asCompound group SX1114).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, R¹⁰ represents acyclopropyl group, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1115).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R¹⁰ represents acyclopropyl group, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1116).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q4, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1117).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q4, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1118).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q5, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1119).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q5, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1120).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q6, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1121).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q6, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1122).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R¹⁰ represents acyclopropyl group, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1123).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R¹⁰ represents acyclopropyl group, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1124).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R¹⁰ represents a cyclopropylgroup, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) representsany combination described in Combination F (hereinafter, referred to asCompound group SX1125).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R¹⁰ represents a cyclopropylgroup, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) representsany combination described in Combination F (hereinafter, referred to asCompound group SX1126).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q8A, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1127).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q8A, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1128).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q8D, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1129).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q8D, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1130).

A compound according to Compound (1R) wherein R¹ represents a methylgroup, Q represents Q8J, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1131).

A compound according to Compound (1R) wherein R¹ represents a chlorineatom, Q represents Q8J, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1132).

A compound represented by formula (1S) (hereinafter, referred to asCompound (1S)):

wherein R¹ represents a methyl group, Q represents Q1, R¹⁰ represents amethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1133).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q1, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1134).

A compound according to Compound (1S) wherein R¹ represents an ethylgroup, Q represents Q1, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1135).

A compound according to Compound (1S) wherein R¹ represents a fluorineatom, Q represents Q1, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1136).

A compound according to Compound (1S) wherein R¹ represents acyclopropyl group, Q represents Q1, R¹⁰ represents a methyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1137).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, R¹⁰ represents amethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1138).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, R¹⁰ represents amethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1139).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, R¹⁰ represents a methyl group,and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1140).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, R¹⁰ represents a methyl group,and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1141).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, R¹⁰ represents amethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1142).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R¹⁰ represents amethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1143).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q4, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1144).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q4, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1145).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q5, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1146).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q5, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1147).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q6, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1148).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q6, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1149).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R¹⁰ represents amethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1150).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R¹⁰ represents amethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1151).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R¹⁰ represents a methyl group,and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1152).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R¹⁰ represents a methyl group,and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1153).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q8A, R¹⁰ represents a methyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1154).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q8A, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1155).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q8D, R¹⁰ represents a methyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1156).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q8D, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1157).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q8J, R¹⁰ represents a methyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1158).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q8J, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1159).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q1, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1160).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q1, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1161).

A compound according to Compound (1S) wherein R¹ represents an ethylgroup, Q represents Q1, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1162).

A compound according to Compound (1S) wherein R¹ represents a fluorineatom, Q represents Q1, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1163).

A compound according to Compound (1S) wherein R¹ represents acyclopropyl group, Q represents Q1, R¹⁰ represents an ethyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1164).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, R¹⁰ represents anethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1165).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, R¹⁰ represents anethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1166).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, R¹⁰ represents an ethyl group,and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1167).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, R¹⁰ represents an ethyl group,and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1168).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, R¹⁰ represents anethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1169).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R¹⁰ represents anethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1170).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q4, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1171).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q4, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1172).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q5, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1173).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q5, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1174).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q6, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1175).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q6, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1176).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R¹⁰ represents anethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1177).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R¹⁰ represents anethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1178).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R¹⁰ represents an ethyl group,and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1179).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R¹⁰ represents an ethyl group,and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1180).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q8A, R¹⁰ represents an ethyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1181).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q8A, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1182).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q8D, R¹⁰ represents an ethyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1183).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q8D, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1184).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q8J, R¹⁰ represents an ethyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1185).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q8J, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1186).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q1, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1187).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q1, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1188).

A compound according to Compound (1S) wherein R¹ represents an ethylgroup, Q represents Q1, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1189).

A compound according to Compound (1S) wherein R¹ represents a fluorineatom, Q represents Q1, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1190).

A compound according to Compound (1S) wherein R¹ represents acyclopropyl group, Q represents Q1, R¹⁰ represents a cyclopropyl group,and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1191).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, R¹⁰ represents acyclopropyl group, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1192).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, R¹⁰ represents acyclopropyl group, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1193).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, R¹⁰ represents a cyclopropylgroup, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) representsany combination described in Combination F (hereinafter, referred to asCompound group SX1194).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, R¹⁰ represents a cyclopropylgroup, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) representsany combination described in Combination F (hereinafter, referred to asCompound group SX1195).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, R¹⁰ represents acyclopropyl group, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1196).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R¹⁰ represents acyclopropyl group, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1197).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q4, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1198).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q4, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1199).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q5, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1200).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q5, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1201).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q6, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1202).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q6, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1203).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R¹⁰ represents acyclopropyl group, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1204).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R¹⁰ represents acyclopropyl group, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1205).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R¹⁰ represents a cyclopropylgroup, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) representsany combination described in Combination F (hereinafter, referred to asCompound group SX1206).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R¹⁰ represents a cyclopropylgroup, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) representsany combination described in Combination F (hereinafter, referred to asCompound group SX1207).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q8A, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1208).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q8A, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1209).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q8D, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1210).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q8D, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1211).

A compound according to Compound (1S) wherein R¹ represents a methylgroup, Q represents Q8J, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1212).

A compound according to Compound (1S) wherein R¹ represents a chlorineatom, Q represents Q8J, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1213).

A compound represented by formula (1T) (hereinafter, referred to asCompound (1T)):

wherein R¹ represents a methyl group, Q represents Q1, R¹⁰ represents amethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1214).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q1, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1215).

A compound according to Compound (1T) wherein R¹ represents an ethylgroup, Q represents Q1, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1216).

A compound according to Compound (1T) wherein R¹ represents a fluorineatom, Q represents Q1, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1217).

A compound according to Compound (1T) wherein R¹ represents acyclopropyl group, Q represents Q1, R¹⁰ represents a methyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1218).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, R¹⁰ represents amethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1219).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, R¹⁰ represents amethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1220).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, R¹⁰ represents a methyl group,and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1221).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, R¹⁰ represents a methyl group,and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1222).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, R¹⁰ represents amethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1223).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R¹⁰ represents amethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1224).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q4, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1225).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q4, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1226).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q5, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1227).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q5, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1228).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q6, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1229).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q6, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1230).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R¹⁰ represents amethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1231).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R¹⁰ represents amethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1232).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R¹⁰ represents a methyl group,and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1233).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R¹⁰ represents a methyl group,and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1234).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q8A, R¹⁰ represents a methyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1235).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q8A, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1236).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q8D, R¹⁰ represents a methyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1237).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q8D, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1238).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q8J, R¹⁰ represents a methyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1239).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q8J, R¹⁰ represents a methyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1240).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q1, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1241).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q1, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1242).

A compound according to Compound (1T) wherein R¹ represents an ethylgroup, Q represents Q1, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1243).

A compound according to Compound (1T) wherein R¹ represents a fluorineatom, Q represents Q1, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1244).

A compound according to Compound (1T) wherein R¹ represents acyclopropyl group, Q represents Q1, R¹⁰ represents an ethyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1245).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, R¹⁰ represents anethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1246).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, R¹⁰ represents anethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1247).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, R¹⁰ represents an ethyl group,and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1248).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, R¹⁰ represents an ethyl group,and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1249).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, R¹⁰ represents anethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1250).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R¹⁰ represents anethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1251).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q4, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1252).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q4, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1253).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q5, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1254).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q5, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1255).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q6, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1256).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q6, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1257).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R¹⁰ represents anethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1258).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R¹⁰ represents anethyl group, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination F (hereinafter,referred to as Compound group SX1259).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R¹⁰ represents an ethyl group,and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1260).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R¹⁰ represents an ethyl group,and a combination of R^(X3), Rx, R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1261).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q8A, R¹⁰ represents an ethyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1262).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q8A, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1263).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q8D, R¹⁰ represents an ethyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1264).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q8D, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1265).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q8J, R¹⁰ represents an ethyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1266).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q8J, R¹⁰ represents an ethyl group, and a combinationof R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination F (hereinafter, referred to as Compound groupSX1267).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q1, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1268).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q1, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1269).

A compound according to Compound (1T) wherein R¹ represents an ethylgroup, Q represents Q1, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1270).

A compound according to Compound (1T) wherein R¹ represents a fluorineatom, Q represents Q1, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1271).

A compound according to Compound (1T) wherein R¹ represents acyclopropyl group, Q represents Q1, R¹⁰ represents a cyclopropyl group,and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1272).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, R¹⁰ represents acyclopropyl group, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1273).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, R¹⁰ represents acyclopropyl group, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1274).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, R¹⁰ represents a cyclopropylgroup, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) representsany combination described in Combination F (hereinafter, referred to asCompound group SX1275).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, R¹⁰ represents a cyclopropylgroup, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) representsany combination described in Combination F (hereinafter, referred to asCompound group SX1276).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, R¹⁰ represents acyclopropyl group, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1277).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R¹⁰ represents acyclopropyl group, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1278).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q4, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1279).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q4, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1280).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q5, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1281).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q5, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1282).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q6, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1283).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q6, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1284).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R¹⁰ represents acyclopropyl group, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1285).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R¹⁰ represents acyclopropyl group, and a combination of R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination F(hereinafter, referred to as Compound group SX1286).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R¹⁰ represents a cyclopropylgroup, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) representsany combination described in Combination F (hereinafter, referred to asCompound group SX1287).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R¹⁰ represents a cyclopropylgroup, and a combination of R^(X3), R^(X4), R^(X5) and R^(X6) representsany combination described in Combination F (hereinafter, referred to asCompound group SX1288).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q8A, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1289).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q8A, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1290).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q8D, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1291).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q8D, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1292).

A compound according to Compound (1T) wherein R¹ represents a methylgroup, Q represents Q8J, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1293).

A compound according to Compound (1T) wherein R¹ represents a chlorineatom, Q represents Q8J, R¹⁰ represents a cyclopropyl group, and acombination of R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination F (hereinafter, referred to asCompound group SX1294).

A compound represented by formula (2A) (hereinafter, referred to asCompound (2A)):

[wherein G⁴ represents any one of formulae G2 to G8, formulae G11 to G21and formulae G23 to G34.]wherein R¹ represents a methyl group, Q represents Q1, and a combinationof structure of G⁴ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G⁴ represents any combination described inCombination K (hereinafter, referred to as Compound group SX1295).

Combination K consists of substituent numbers ZK1 to ZK1148. Substituentnumbers ZK1 to ZK1148 represent combinations of structure of G⁴ andsubstituents of R^(X7), R^(X8), R^(X9) and R^(X10) applied to thestructure of G⁴ according to Compound (2A). And hereinafter, they arereferred to as [substituent number; G4, R^(X7),R^(X8),R^(X9),R^(X10)].For example, the substituent number ZK2 refers to a combination whereinG4 represents G2, R^(X7) represents a methyl group, and each of R^(X8),R^(X9) and R^(X10) represents a hydrogen atom.

-   -   Combination K: [ZK1;G2,H,H,H,H], [ZK2;G2,Me,H,H,H],        [ZK3;G2,Et,H,H,H], [ZK4;G 2,Pr,H,H,H], [ZK5;G2,i-Pr,H,H,H],        [ZK6;G2,c-Pr,H,H,H], [ZK7;G2,Ph,H,H,H], [ZK8;G2,OMe,H,H,H],        [ZK9;G2,OEt, H, H, H], [ZK10; G2, OPh, H, H, H], [ZK11; G2, CF₃,        H, H, H], [ZK12; G2, F, H,H,H], [ZK13;G2,Cl,H,H,H],        [ZK14;G2,Br,H,H,H], [ZK15;G2,CN,H,H,H], [ZK16;G2,H,Me,H,H],        [ZK17;G2,H,Et,H,H], [ZK18;G2,H,Pr,H,H], [ZK19;G2,H,i-Pr,H,H],        [ZK20;G2,H,c-Pr,H,H], [ZK21;G2,H,Ph,H,H], [ZK22;G2,H,OMe,H,H],        [ZK23;G2,H,O Et,H,H], [ZK24;G2,H,OPh,H,H], [ZK25;G2,H,CF₃,H,H],        [ZK26;G2,H, F,H,H], [ZK27;G2,H,Cl,H,H], [ZK28;G2,H,Br,H,H],        [ZK29;G2,H,CN, H,H], [ZK30;G2,H,H,Me,H], [ZK31;G2,H,H,Et,H],        [ZK32;G2,H,H,Pr, H], [ZK33;G2,H,H,i-Pr,H], [ZK34;G2,H,H,c-Pr,H],        [ZK35;G2,H,H,Ph,H], [ZK36;G2,H,H,OMe,H], [ZK37;G2,H,H,O Et,H],        [ZK38;G2,H,H,OPh,H], [ZK39;G2,H,H,CF₃,H], [ZK40;G2,H,H, F,H],        [ZK41;G2,H,H,Cl,H], [ZK42;G2,H,H,Br,H], [ZK43;G2,H,H,CN, H],        [ZK44;G2,H,H,H,Me], [ZK45;G2,H,H,H,Et], [ZK46:G2,H,H,H,Pr],        [ZK47;G2,H,H,H,i-Pr], [ZK48;G2,H,H,H,c-Pr], [ZK49;G2,H,H,H,Ph],        [ZK50;G2,H,H,H,OMe], [ZK51;G2,H,H,H,O Et], [ZK52;G2,H,H,H,OPh],        [ZK53;G2,H,H,H,CF₃], [ZK54;G2,H,H,H, F], [ZK55;G2,H,H,H,Cl],        [ZK56;G2,H,H,H,Br], [ZK57;G2,H,H,H,CN], [ZK58;G3,H,H,H,H],        [ZK59;G3,Me,H,H,H], [ZK60;G3,Et,H,H,H], [Z K61;G3,Pr,H,H,H],        [ZK62;G3,i-Pr,H,H,H], [ZK63;G3,c-Pr,H,H,H], [ZK64;G3,Ph,H,H,H],        [ZK65;G3,OMe,H,H,H], [ZK66;G3,O Et,H,H,H], [ZK67;G3,OPh,H,H,H],        [ZK68;G3,CF₃,H,H,H], [ZK69;G3, F,H,H,H], [ZK70;G3,Cl,H,H,H],        [ZK71;G3,Br,H,H,H], [ZK72;G3,CN, H,H,H], [ZK73;G3,H,Me,H,H],        [ZK74;G3,H,Et,H,H], [ZK75;G3,H,Pr, H,H], [ZK76;G3,H,i-Pr,H,H],        [ZK77;G3,H,c-Pr,H,H], [ZK78;G3,H,Ph,H,H], [ZK79;G3,H,OMe,H,H],        [ZK80;G3,H,O Et,H,H], [ZK81;G3,H,OPh,H,H], [ZK82;G3,H,CF₃,H,H],        [ZK83;G3,H, F,H,H], [ZK84;G3,H,Cl,H,H], [ZK85;G3,H,Br,H,H],        [ZK86;G3,H,CN, H,H], [ZK87;G3,H,H,Me,H], [ZK88;G3,H,H,Et,H],        [ZK89;G3,H,H,Pr, H], [ZK90;G3,H,H,i-Pr,H], [ZK91;G3,H,H,c-Pr,H],        [ZK92;G3,H,H,Ph,H], [ZK93;G3,H,H,OMe,H], [ZK94;G3,H,H,O Et,H],        [ZK95;G3,H,H,OPh,H], [ZK96;G3,H,H,CF₃,H], [ZK97;G3,H,H, F,H],        [ZK98;G3,H,H,Cl,H], [ZK99;G3,H,H,Br,H], [ZK100;G3,H,H,CN,H],        [ZK101;G3,H,H,H,Me], [ZK102;G3,H,H,H,Et], [ZK103;G3,H,H,H,Pr],        [ZK104;G3,H,H,H,i-Pr], [ZK105;G3,H,H,H,c-Pr],        [ZK106;G3,H,H,H,Ph], [ZK107;G3,H,H,H,OMe], [ZK108;G3,H,H,        H,OEt], [ZK109;G3,H,H,H,OPh], [ZK110;G3,H,H,H,CF₃], [ZK111;G3,        H,H,H,F], [ZK112;G3,H,H,H,Cl], [ZK113;G3,H,H,H,Br], [ZK114;G3,        H,H,H,CN], [ZK115;G4,H,H,H,-], [ZK116;G4,Me,H,H,-], [ZK117;G4,        Et,H,H,-], [ZK118;G4,Pr,H,H,-], [ZK119;G4,i-Pr,H,H,-],        [ZK120;G4,c-Pr,H,H,-], [ZK121;G4,Ph,H,H,-],        [ZK122;G4,OMe,H,H,-], [ZK123;G 4,OEt,H,H,-],        [ZK124;G4,OPh,H,H,-], [ZK125;G4,CF₃,H,H,-], [ZK1 26;G4,F,H,H,-],        [ZK127;G4,Cl,H,H,-], [ZK128;G4,Br,H,H,-], [ZK1 29;G4,CN,H,H,-],        [ZK130;G4,H,Me,H,-], [ZK131;G4,H,Et,H,-], [ZK 132;G4,H,Pr,H,-],        [ZK133;G4,H,i-Pr,H,-], [ZK134;G4,H,c-Pr,H,-],        [ZK135;G4,H,Ph,H,-], [ZK136;G4,H,OMe,H,-], [ZK137;G4,        H,OEt,H,-], [ZK138;G4,H,OPh,H,-], [ZK139;G4,H,CF₃,H,-],        [ZK140;G4,H,F,H,-], [ZK141;G4,H,Cl,H,-], [ZK142;G4,H,Br,H,-],        [ZK143;G4,H,CN,H,-], [ZK144;G4,H,H,Me,-], [ZK145;G4,H,H,Et,-],        [ZK14 6;G4,H,H,Pr,-], [ZK147;G4,H,H,i-Pr,-],        [ZK148;G4,H,H,c-Pr,-], [ZK149;G4,H,H,Ph,-],        [ZK150;G4,H,H,OMe,-], [ZK151;G4,H, H,OEt,-],        [ZK152;G4,H,H,OPh,-], [ZK153;G4,H,H,CF₃,-], [ZK154;G 4,H,H,F,-],        [ZK155;G4,H,H,Cl,-], [ZK156;G4,H,H,Br,-], [ZK157;G 4,H,H,CN,-],        [ZK158;G5,H,H,H,-], [ZK159;G5,Me,H,H,-], [ZK160;G 5,Et,H,H,-],        [ZK161;G5,Pr,H,H,-], [ZK162;G5,i-Pr,H,H,-],        [ZK163;G5,c-Pr,H,H,-], [ZK164;G5,Ph,H,H,-],        [ZK165;G5,OMe,H,H,-], [ZK166;G 5,OEt,H,H,-],        [ZK167;G5,OPh,H,H,-], [ZK168;G5,CF₃,H,H,-], [ZK1 69;G5,F,H,H,-],        [ZK170;G5,Cl,H,H,-], [ZK171;G5,Br,H,H,-], [ZK1 72;G5,CN,H,H,H-],        [ZK173;G5,H,Me,H,-], [ZK174;G5,H,Et,H,-], [ZK 175;G5,H,Pr,H,-],        [ZK176;G5,H,i-Pr,H,-], [ZK177;G5,H,c-Pr,H,-],        [ZK178;G5,H,Ph,H,-], [ZK179;G5,H,OMe,H,-], [ZK180;G5,        H,OEt,H,-], [ZK181;G5,H,OPh,H,-], [ZK182;G5,H,CF₃,H,-],        [ZK183;G5,H,F,H,-], [ZK184;G5,H,Cl,H,-], [ZK185;G5,H,Br,H,-],        [ZK186;G5,H,CN,H,-], [ZK187;G5,H,H,Me,-], [ZK188;G5,H,H,Et,-],        [ZK18 9;G5,H,H,Pr,-], [ZK190;G5,H,H,i-Pr,-],        [ZK191;G5,H,H,c-Pr,-], [ZK192;G5,H,H,Ph,-],        [ZK193;G5,H,H,OMe,-], [ZK194;G5,H, H,OEt,-],        [ZK195;G5,H,H,OPh,-], [ZK196;G5,H,H,CF₃,-], [ZK197;G 5,H,H,F,-],        [ZK198;G5,H,H,Cl,-], [ZK199;G5,H,H,Br,-], [ZK200;G 5,H,H,CN,-],        [ZK201;G6,H,H,H,-], [ZK202;G6,Me,H,H,-], [ZK203;G 6,Et,H,H,-],        [ZK204;G6,Pr,H,H,-], [ZK205;G6,i-Pr,H,H,-],        [ZK206;G6,c-Pr,H,H,-], [ZK207;G6,Ph,H,H,-],        [ZK208;G6,OMe,H,H,-], [ZK209;G 6,OEt,H,H,-],        [ZK210;G6,OPh,H,H,-], [ZK211;G6,CF₃,H,H,-], [ZK2 12;G6,F,H,H,-],        [ZK213;G6,Cl,H,H,-], [ZK214;G6,Br,H,H,-], [ZK2 15;G6,CN,H,H,-],        [ZK216;G6,H,Me,H,-], [ZK217;G6,H,Et,H,-], [ZK 218;G6,H,Pr,H,-],        [ZK219;G6,H,i-Pr,H,-], [ZK220;G6,H,c-Pr,H,-],        [ZK221;G6,H,Ph,H,-], [ZK222;G6,H,OMe,H,-], [ZK223;G6,        H,OEt,H,-], [ZK224;G6,H,OPh,H,-], [ZK225;G6,H,CF₃,H,-],        [ZK226;G6,H,F,H,-], [ZK227;G6,H,Cl,H,-], [ZK228;G6,H,Br,H,-],        [ZK229;G6,H,CN,H,-], [ZK230;G6,H,H,Me,-], [ZK231;G6,H,H,Et,-],        [ZK23 2;G6,H,H,Pr,-], [ZK233;G6,H,H,i-Pr,-],        [ZK234;G6,H,H,c-Pr,-], [ZK235;G6,H,H,Ph,-],        [ZK236;G6,H,H,OMe,-], [ZK237;G6,H, H,OEt,-],        [ZK238;G6,H,H,OPh,-], [ZK239;G6,H,H,CF₃,-], [ZK240;G 6,H,H,F,-],        [ZK241;G6,H,H,Cl,-], [ZK242;G6,H,H,Br,-], [ZK243;G 6,H,H,CN,-],        [ZK244;G7,H,H,H,-], [ZK245;G7,Me,H,H,-], [ZK246;G 7,Et,H,H,-],        [ZK247;G7,Pr,H,H,-], [ZK248;G7,i-Pr,H,H,-],        [ZK249;G7,c-Pr,H,H,-], [ZK250;G7,Ph,H,H,-],        [ZK251;G7,OMe,H,H,-], [ZK252;G 7,OEt,H,H,-],        [ZK253;G7,OPh,H,H,-], [ZK254;G7,CF₃,H,H,-], [ZK2 55;G7,F,H,H,-],        [ZK256;G7,Cl,H,H,-], [ZK257;G7,Br,H,H,-], [ZK2 58;G7,CN,H,H,-],        [ZK259;G7,H,Me,H,-], [ZK260;G7,H,Et,H,-], [ZK 261;G7,H,Pr,H,-],        [ZK262;G7,H,i-Pr,H,-], [ZK263;G7,H,c-Pr,H,-],        [ZK264;G7,H,Ph,H,-], [ZK265;G7,H,OMe,H,-], [ZK266;G7,        H,OEt,H,-], [ZK267;G7,H,OPh,H,-], [ZK268;G7,H,CF₃,H,-],        [ZK269;G7,H,F,H,-], [ZK270;G7,H,Cl,H,-], [ZK271;G7,H,Br,H,-],        [ZK272;G7,H,CN,H,-], [ZK273;G7,H,H,Me,-], [ZK274;G7,H,H,Et,-],        [ZK27 5;G7,H,H,Pr,-], [ZK276;G7,H,H,i-Pr,-],        [ZK277;G7,H,H,c-Pr,-], [ZK278;G7,H,H,Ph,-],        [ZK279;G7,H,H,OMe,-], [ZK280;G7,H, H,OEt,-],        [ZK281;G7,H,H,OPh,-], [ZK282;G7,H,H,CF₃,-], [ZK283;G 7,H,H,F,-],        [ZK284;G7,H,H,Cl,-], [ZK285;G7,H,H,Br,-], [ZK286;G 7,H,H,CN,-],        [ZK287;G8,H,H,H,-], [ZK288;G8,Me,H,H,-], [ZK289;G 8,Et,H,H,-],        [ZK290;G8,Pr,H,H,-], [ZK291;G8,i-Pr,H,H,-],        [ZK292;G8,c-Pr,H,H,-], [ZK293;G8,Ph,H,H,-],        [ZK294;G8,OMe,H,H,-], [ZK295;G 8,OEt,H,H,-],        [ZK296;G8,OPh,H,H,-], [ZK297;G8,CF₃,H,H,-], [ZK2 98;G8,F,H,H,-],        [ZK299;G8,Cl,H,H,-], [ZK300;G8,Br,H,H,-], [ZK3 01;G8,CN,H,H,-],        [ZK302;G8,H,Me,H,-], [ZK303;G8,H,Et,H,-], [ZK 304;G8,H,Pr,H,-],        [ZK305;G8,H,i-Pr,H,-], [ZK306;G8,H,c-Pr,H,-],        [ZK307;G8,H,Ph,H,-], [ZK308;G8,H,OMe,H,-], [ZK309;G8,        H,OEt,H,-], [ZK310;G8,H,OPh,H,-], [ZK311;G8,H,CF₃,H,-],        [ZK312;G8,H,F,H,-], [ZK313;G8,H,Cl,H,-], [ZK314;G8,H,Br,H,-],        [ZK315;G8,H,CN,H,-], [ZK316;G8,H,H,Me,-], [ZK317;G8,H,H,Et,-],        [ZK31 8;G8,H,H,Pr,-], [ZK319;G8,H,H,i-Pr,-],        [ZK320;G8,H,H,c-Pr,-], [ZK321;G8,H,H,Ph,-],        [ZK322;G8,H,H,OMe,-], [ZK323;G8,H, H,OEt,-],        [ZK324;G8,H,H,OPh,-], [ZK325;G8,H,H,CF₃,-], [ZK326;G 8,H,H,F,-],        [ZK327;G8,H,H,Cl,-], [ZK328;G8,H,H,Br,-], [ZK329;G 8,H,H,CN,-],        [ZK330;G11,H,H,H,-], [ZK331;G11,H,Me,H,-], [ZK332;G11,H,Et,H,-],        [ZK333;G11,H,Pr,H,-], [ZK334;G11,H,i-Pr,H,-],        [ZK335;G11,H,c-Pr,H,-], [ZK336;G11,H,Ph,H,-],        [ZK337;G11,H,OMe,H,-], [ZK338;G 11,H,OEt,H, -],        [ZK339;G11,H,OPh,H, -], [ZK340;G11,H,CF₃,H,-],        [ZK341;G11,HF,H,-], [ZK342;G11,H,Cl,H,-], [ZK343;G11,H,Br,H,-],        [ZK344;G11,H,CN,H,-], [ZK345;G11,H,H,Me,-], [ZK346;G11,H,H,E        t,-], [ZK347;G11,H,H,Pr,-], [ZK348;G11,H,H,i-Pr,-],        [ZK349;G11,H,H,c-Pr,-], [ZK350;G11,H,H,Ph,-],        [ZK351;G11,H,H,OMe,-], [ZK352;G11,H,H,OEt,-],        [ZK353;G11,H,H,OPh,-], [ZK354;G11,H,H,CF₃,-], [ZK        355;G11,H,H,F,-], [ZK356;G11,H,H,Cl,-], [ZK357;G11,H,H,Br,-],        [ZK358;G11,H,H,CN,-], [ZK359;G11,Me,H,H,-], [ZK360;G11,Me,Me,        H,-], [ZK361;G11,Me,Et,H,-], [ZK362;G11,Me,Pr,H,-],        [ZK363;G11,Me,i-Pr,H,-], [ZK364;G11,Me,c-Pr,H,-],        [ZK365;G11,Me,Ph,H,-], [ZK366;G11,Me,OMe,H,-],        [ZK367;G11,Me,OEt,H,-], [ZK368;G11,Me,OPh,H,-],        [ZK369;G11,Me,CF₃,H,-], [ZK370;G11,Me,F,H,-],        [ZK371;G11,Me,Cl,H,-], [ZK372;G11,M e,Br,H,-],        [ZK373;G11,Me,CN,H,-], [ZK374;G11,Me,H,Me,-], [ZK37        5;G11,Me,H,Et,-], [ZK376;G11,Me,H,Pr,-],        [ZK377;G11,Me,H,i-Pr,-], [ZK378;G11,Me,H,c-Pr,-],        [ZK379;G11,Me,H,Ph,-], [ZK380;G11,Me,H,OMe,-], [ZK381;G        11,Me,H,OEt,-], [ZK382;G11,Me,H,OPh,-], [ZK383;G11,Me,H,CF₃,-],        [ZK384;G11,Me,H,F,-], [ZK385;G11,Me,H,Cl,-], [ZK386;G11,Me,        H,Br,-], [ZK387;G11,Me,H,CN,-], [ZK388;G12,H,H,H,-], [ZK389;G1        2,Me,H,H,-], [ZK390;G12,Et,H,H,-], [ZK391;G12,Pr,H,H,-], [ZK39        2;G12,i-Pr,H,H,-], [ZK393;G12,c-Pr,H,H,-], [ZK394;G12,Ph,H,H,-],        [ZK395;G12,OMe,H,H,-], [ZK396;G12,OEt,H,H,-],        [ZK397;G12,OPh,H,H,-], [ZK398;G12,CF₃,H,H,-],        [ZK399;G12,F,H,H,-], [ZK400;G12,Cl,H,H,-], [ZK401;G12,Br,H,H,-],        [ZK402;G12,CN,H,H,-], [ZK403;G12,H,Me,H,-], [ZK404;G12,H,        Et,H,-], [ZK405;G12,H,Pr,H,-], [ZK406;G12,H,i-Pr,H,-],        [ZK407;G12,H,c-Pr,H,-], [ZK408;G12,H,Ph,H,-],        [ZK409;G12,H,OMe,H,-], [ZK410;G 12,H,OEt,H, -],        [ZK411;G12,H,OPh,H, -], [ZK412;G12,H,CF₃,H,-],        [ZK413;G12,H,F,H,-], [ZK414;G12,H,Cl,H,-], [ZK415;G12,H,Br,H,-],        [ZK416;G12,H,CN,H,-], [ZK417;G12,H,H,Me,-], [ZK418;G12,H,H,        Et,-], [ZK419;G12,H,H,Pr,-], [ZK420;G12,H,H,i-Pr,-],        [ZK421;G12,H,H,c-Pr,-], [ZK422;G12,H,H,Ph,-],        [ZK423;G12,H,H,OMe,-], [ZK424;G12,H,H,OEt,-],        [ZK425;G12,H,H,OPh,-], [ZK426;G12,H,H,CF₃,-], [ZK        427;G12,H,H,F,-], [ZK428;G12,H,H,Cl,-], [ZK429;G12,H,H,Br,-],        [ZK430;G12,H,H,CN,-], [ZK431;G13,H,H,H,-], [ZK432;G13,Me,H,H,-],        [ZK433;G13,Et,H,H,-], [ZK434;G13,Pr,H,H,-],        [ZK435;G13,i-Pr,H,H,-], [ZK436;G13,c-Pr,H,H,-],        [ZK437;G13,Ph,H,H,-], [ZK438;G13,OMe,H,H,-], [ZK439;G13,OEt,H,H,        -], [ZK440;G13,OPh,H,H, -], [ZK441;G13,CF₃,H,H,-],        [ZK442;G13,F,H,H,-], [ZK443;G13,Cl,H,H,-], [ZK444;G13,Br,H,H,-],        [ZK445;G13,CN,H,H,-], [ZK446;G13,H,H,Me,-], [ZK447;G13,H,        H,Et,-], [ZK448;G13,H,H,Pr,-], [ZK449;G13,H,H,i-Pr,-],        [ZK450;G13,H,H,c-Pr,-], [ZK451;G13,H,H,Ph,-],        [ZK452;G13,H,H,OMe,-], [ZK453;G13,H,H,OEt,-],        [ZK454;G13,H,H,OPh,-], [ZK455;G13,H,H,CF₃,-], [ZK        456;G13,H,H,F,-], [ZK457;G13,H,H,Cl,-], [ZK458;G13,H,H,Br,-],        [ZK459;G13,H,H,CN,-], [ZK460;G13,H,Me,H,-], [ZK461;G13,Me,Me,        H,-], [ZK462;G13,Et,Me,H,-], [ZK463;G13,Pr,Me,H,-],        [ZK464;G13,i-Pr,Me,H,-], [ZK465;G13,c-Pr,Me,H,-],        [ZK466;G13,Ph,Me,H,-], [ZK467;G13,OMe,Me,H,-], [ZK        468;G13,OEt,Me,H,-], [ZK469;G13,OPh,Me,H,-], [ZK470;G13,CF₃,M        e,H,-], [ZK471;G13,F,Me,H,-], [ZK472;G13,Cl,Me,H,-], [ZK473;G1        3,Br,Me,H,-], [ZK474;G13,CN,Me,H,-], [ZK475;G13,H,Me,Me,-], [Z        K476;G13,H,Me,Et,-], [ZK477;G13,H,Me,Pr,-],        [ZK478;G13,H,Me,i-Pr,-], [ZK479;G13,H,Me,c-Pr,-],        [ZK480;G13,H,Me,Ph,-], [ZK481;G13,H,Me,OMe,-], [ZK482;G        13,H,Me,OEt,-], [ZK483;G13,H,Me,OPh,-], [ZK484;G13,H,Me,CF₃,-],        [ZK485;G13,H,Me,F,-], [ZK486;G13,H,Me,Cl,-], [ZK487;G13,H,M        e,Br,-], [ZK488;G13,H,Me,CN,-], [ZK489;G14,H,H,H,-], [ZK490;G1        4,Me,H,H,-], [ZK491;G14,Et,H,H,-], [ZK492;G14,Pr,H,H,-], [ZK49        3;G14,i-Pr,H,H,-], [ZK494;G14,c-Pr,H,H,-], [ZK495;G14,Ph,H,H,-],        [ZK496;G14,OMe,H,H,-], [ZK497;G14,OEt,H,H,-],        [ZK498;G14,OPh,H,H,-],        [ZK499;G14,CF₃,H,H,-],[ZK500;G14,F,H,H,-], [ZK501;G14,Cl,H,H,-],        [ZK502;G14,Br,H,H, -], [ZK503;G14,CN,H,H, -], [ZK504;G14,H,Me,H,        -], [ZK505;G14,H, Et,H,-], [ZK506;G14,H,Pr,H,-],        [ZK507;G14,H,i-Pr,H,-], [ZK508;G14,H,c-Pr,H,-],        [ZK509;G14,H,Ph,H,-], [ZK510;G14,H,OMe,H,-], [ZK511;G        14,H,OEt,H,-], [ZK512;G14,H,OPh,H,-], [ZK513;G14,H,CF₃,H,-],        [ZK514;G14,H,F,H,-], [ZK515;G14,H,Cl,H,-], [ZK516;G14,H,Br,H,-],        [ZK517;G14,H,CN,H,-], [ZK518;G14,H,H,Me,-], [ZK519;G14,H,H,        Et,-], [ZK520;G14,H,H,Pr,-], [ZK521;G14,H,H,i-Pr,-],        [ZK522;G14,H,H,c-Pr,-], [ZK523;G14,H,H,Ph,-],        [ZK524;G14,H,H,OMe,-], [ZK525;G14,H,H,OEt,-],        [ZK526;G14,H,H,OPh,-], [ZK527;G14,H,H,CF₃,-], [ZK        528;G14,H,H,F,-], [ZK529;G14,H,H,Cl,-], [ZK530;G14,H,H,Br,-],        [ZK531;G14,H,H,CN,-], [ZK532;G15,H,H,H,-], [ZK533;G15,Me,H,H,-],        [ZK534;G15,Et,H,H,-], [ZK535;G15,Pr,H,H,-],        [ZK536;G15,i-Pr,H,H,-], [ZK537;G15,c-Pr,H,H,-],        [ZK538;G15,Ph,H,H,-], [ZK539;G15,OMe,H,H,-],        [ZK540;G15,OEt,H,H,-], [ZK541;G15,OPh,H,H,-],        [ZK542;G15,CF₃,H,H,-], [ZK543;G15,F,H,H,-],        [ZK544;G15,Cl,H,H,-], [ZK545;G15,Br,H,H,-],        [ZK546;G15,CN,H,H,-], [ZK547;G15,H,Me,H,-], [ZK548;G15,H,        Et,H,-], [ZK549;G15,H,Pr,H,-], [ZK550;G15,H,i-Pr,H,-],        [ZK551;G15,H,c-Pr,H,-], [ZK552;G15,H,Ph,H,-],        [ZK553;G15,H,OMe,H,-], [ZK554;G 15,H,OEt,H, -],        [ZK555;G15,H,OPh,H, -], [ZK556;G15,H,CF₃,H,-],        [ZK557;G15,H,F,H,-], [ZK558;G15,H,Cl,H,-],        [ZK559;G15,H,Br,H,-][ZK560;G15,H,CN,H,-], [ZK561;G15,H,H,Me,-],        [ZK562;G15,H,H, Et,-], [ZK563;G15,H,H,Pr,-],        [ZK564;G15,H,H,i-Pr,-], [ZK565;G15,H,H,C-Pr,-],        [ZK566;G15,H,H,Ph,-], [ZK567;G15,H,H,OMe,-],        [ZK568;G15,H,H,OEt,-], [ZK569;G15,H,H,OPh,-],        [ZK570;G15,H,H,CF₃,-], [ZK 571;G15,H,H,F,-],        [ZK572;G15,H,H,Cl,-], [ZK573;G15,H,H,Br,-],        [ZK574;G15,H,H,CN,-], [ZK575;G16,H,H,-,-], [ZK576;G16,Me,H,-,-],        [ZK577;G16,Et,H,-,-], [ZK578;G16,Pr,H,-,-],        [ZK579;G16,i-Pr,H,-,-], [ZK580;G16,c-Pr,H,-,-],        [ZK581;G16,Ph,H,-,-], [ZK582;G16,OMe,H,-,-], [ZK583;G16,OEt,H,        -, -], [ZK584;G16,OPh,H, -, -], [ZK585;G16,CF₃,H, -,-],        [ZK586;G16,F,H,-,-], [ZK587;G16,Cl,H,-,-], [ZK588;G16,Br,H,-,-],        [ZK589;G16,CN,H,-,-], [ZK590;G16,H,Me,-,-], [ZK591;G16,H,        Et,-,-], [ZK592;G16,H,Pr,-,-], [ZK593;G16,H,i-Pr,-,-],        [ZK594;G16,H,c-Pr,-,-], [ZK595;G16,H,Ph,-,-],        [ZK596;G16,H,OMe,-,-], [ZK597;G 16,H,OEt,-,-],        [ZK598;G16,H,OPh,-,-], 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[ZK755;G23,Ph,H,-,-], [ZK756;G23,OMe,H,-,-], [ZK757;G23,OEt,H,        -,-], [ZK758;G23,OPh,H, -,-], [ZK759;G23,CF₃,H,-,-],        [ZK760;G23,F,H,-,-], [ZK761;G23,Cl,H,-,-], [ZK762;G23,Br,H,-,-],        [ZK763;G23,CN,H,-,-], [ZK764;G23,H,Me,-,-], [ZK765;G23,H,        Et,-,-], [ZK766;G23,H,Pr,-,-], [ZK767;G23,H,i-Pr,-,-],        [ZK768;G23,H,c-Pr,-,-], [ZK769;G23,H,Ph,-,-],        [ZK770;G23,H,OMe,-,-], [ZK771;G 23,H,OEt,-,-],        [ZK772;G23,H,OPh,-,-], [ZK773;G23,H,CF₃,-,-],        [ZK774;G23,H,F,-,-], [ZK775;G23,H,Cl,-,-], [ZK776;G23,H,Br,-,-],        [ZK777;G23,H,CN,-,-], [ZK778;G24,H,H,-,-], [ZK779;G24,Me,H,        -,-], [ZK780;G24,Et,H,-,-], [ZK781;G24,Pr,H,-,-],        [ZK782;G24,i-Pr,H,-,-], [ZK783;G24,c-Pr,H,-,-],        [ZK784;G24,Ph,H,-,-], [ZK785;G24,OMe,H,-,-], [ZK786;G24,OEt,H,        -, -], [ZK787;G24,OPh,H, -, -], [ZK788;G24,CF₃,H, -,-],        [ZK789;G24,F,H,-,-], [ZK790;G24,Cl,H,-,-], [ZK791;G24,Br,H,-,-],        [ZK792;G24,CCN,H,-,-], [ZK793;G24,H,Me,-,-], 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[ZK908;G26,Me,CN,H,-], [ZK909;G26,Me,H,Me,-], [ZK91        0;G26,Me,H,Et,-], [ZK911;G26,Me,H,Pr,-],        [ZK912;G26,Me,H,i-Pr,-], [ZK913;G26,Me,H,c-Pr,-],        [ZK914;G26,Me,H,Ph,-], [ZK915;G26,Me,H,OMe,-], [ZK916;G        26,Me,H,OEt,-], [ZK917;G26,Me,H,OPh,-], [ZK918;G26,Me,H,CF₃,-],        [ZK919;G26,Me,H,F,-], [ZK920;G26,Me,H,Cl,-], [ZK921;G26,Me,        H,Br,-], [ZK922;G26,Me,H,CN,-], [ZK923;G27,H,H,H,-], [ZK924;G2        7,Me,H,H,-], [ZK925;G27,Et,H,H,-], [ZK926;G27,Pr,H,H,-], [ZK92        7;G27,i-Pr,H,H,-], [ZK928;G27,c-Pr,H,H,-], [ZK929;G27,Ph,H,H,-],        [ZK930;G27,OMe,H,H,-], [ZK931;G27,OEt,H,H, -],        [ZK932;G27,OPh,H,H, -], [ZK933;G27,CF₃,H,H,-],        [ZK934;G27,F,H,H,-], [ZK935;G27,Cl,H,H,-], [ZK936;G27,Br,H,H,-],        [ZK937;G27,CN,H,H,-], [ZK938;G27,H,Me,H,-], [ZK939;G27,H,        Et,H,-], [ZK940;G27,H,Pr,H,-], [ZK941;G27,H,i-Pr,H,-],        [ZK942;G27,H,c-Pr,H,-], [ZK943;G27,H,Ph,H,-],        [ZK944;G27,H,OMe,H,-], [ZK945;G 27,H,OEt,H, -],        [ZK946;G27,H,OPh,H, -], [ZK947;G27,H,CF₃,H,-],        [ZK948;G27,H,F,H,-], [ZK949;G27,H,Cl,H,-], [ZK950;G27,H,Br,H,-],        [ZK951;G27,H,CN,H,-], [ZK952;G27,H,H,Me,-], [ZK953;G27,H,H,        Et,-], [ZK954;G27,H,H,Pr,-], [ZK955;G27,H,H,i-Pr,-],        [ZK956;G27,H,H,c-Pr,-], [ZK957;G27,H,H,Ph,-],        [ZK958;G27,H,H,OMe,-], [ZK959;G27,H,H,OEt,-],        [ZK960;G27,H,H,OPh,-], [ZK961;G27,H,H,CF₃,-], [ZK        962;G27,H,H,F,-], [ZK963;G27,H,H,Cl,-], [ZK964;G27,H,H,Br,-],        [ZK965;G27,H,H,CN,-], [ZK966;G28,H,H,-,-], [ZK967;G28,Me,H,-,-],        [ZK968;G28,Cl,H,-,-], [ZK969;G28,CF₃,H,-,-], [ZK970;G28,H,        Me,-,-], [ZK971;G28,H,Cl,-,-], [ZK972;G28,H,CF₃,-,-], [ZK973;G        28,H,SH,-,-], [ZK974;G29,H,H,H,-], [ZK975;G29,H,Me,H,-], [ZK97        6;G29,H,Et,H,-], [ZK977;G29,H,Pr,H,-], [ZK978;G29,H,i-Pr,H,-],        [ZK979;G29,H,c-Pr,H,-], [ZK980;G29,H,Ph,H,-],        [ZK981;G29,H,OMe,H,-], [ZK982;G 29,H,OEt,H,-],        [ZK983;G29,H,OPh,H,-], [ZK984;G29,H,CF₃,H,-],        [ZK985;G29,H,F,H,-], [ZK986;G29,H,Cl,H,-], [ZK987;G29,H,Br,H,-],        [ZK988;G29,H,CN,H,-], [ZK989;G29,H,H,Me,-], [ZK990;G29,H,H,        Et,-], [ZK991;G29,H,H,Pr,-], [ZK992;G29,H,H,i-Pr,-],        [ZK993;G29,H,H,c-Pr,-], [ZK994;G29,H,H,Ph,-],        [ZK995;G29,H,H,OMe,-], [ZK996;G29,H,H,OEt,-],        [ZK997;G29,H,H,OPh,-], [ZK998;G29,H,H,CF₃,-], [ZK        999;G29,H,H,F,-], [ZK1000;G29,H,H,Cl,-], [ZK1001;G29,H,H,Br,-],        [ZK1002;G29,H,H,CN,-], [ZK1003;G29,Me,H,H,-], [ZK1004;G29,M        e,Me,H,-], [ZK1005;G29,Me,Et,H,-], [ZK1006;G29,Me,Pr,H,-], [ZK        1007;G29,Me,i-Pr,H,-], [ZK1008;G29,Me,c-Pr,H,-],        [ZK1009;G29,Me,Ph,H,-], [ZK1010;G29,Me,OMe,H,-], [ZK1        011;G29,Me,OEt,H,-], [ZK1012;G29,Me,OPh,H,-], [ZK1013;G29,Me,        CF₃,H,-], [ZK1014;G29,Me,F,H,-], [ZK1015;G29,Me,Cl,H,-], [ZK10        16;G29,Me,Br,H,-], [ZK1017;G29,Me,CN,H,-], [ZK1018;G29,Me,H,M        e,-], [ZK1019;G29,Me,H,Et,-], [ZK1020;G29,Me,H,Pr,-], [ZK1021;        G29,Me,H,i-Pr,-], [ZK1022;G29,Me,H,c-Pr,-],        [ZK1023;G29,Me,H,Ph,-], [ZK1024;G29,Me,H,OMe,-], [ZK102        5;G29,Me,H,OEt,-], [ZK1026;G29,Me,H,OPh,-], [ZK1027;G29,Me,H,        CF₃,-], [ZK1028;G29,Me,H,F,-], [ZK1029;G29,Me,H,Cl,-],        [ZK1030;G29,Me,H,Br,-], [ZK1031;G29,Me,H,CN,-],        [ZK1032;G30,H,H,H,-],[ZK1033;G30,Me,H,H,-],        [ZK1034;G30,Et,H,H,-], [ZK1035;G30,Pr,H,H,-],        [ZK1036;G30,i-Pr,H,H,-], [ZK1037;G30,c-Pr,H,H,-],        [ZK1038;G30,Ph,H,H,-], [ZK1039;G30,OMe,H,H,-], [ZK1        040;G30,OEt,H,H,-], [ZK1041;G30,OPh,H,H,-],        [ZK1042;G30,CF₃,H,H,-], [ZK1043;G30,F,H,H,-],        [ZK1044;G30,Cl,H,H,-], [ZK1045;G3 0,Br,H,H,-],        [ZK1046;G30,CN,H,H,-], [ZK1047;G30,H,Me,H,-], [ZK        1048;G30,H,Et,H,-], [ZK1049;G30,H,Pr,H,-],        [ZK1050;G30,H,i-Pr,H,-], [ZK1051;G30,H,c-Pr,H,-],        [ZK1052;G30,H,Ph,H,-], [ZK1053;G30,H,OMe,H,-], [ZK105        4;G30,H,OEt,H,-], [ZK1055;G30,H,OPh,H,-],        [ZK1056;G30,H,CF₃,H,-], [ZK1057;G30,H,F,H,-],        [ZK1058;G30,H,Cl,H,-], [ZK1059;G30, H,Br,H,-],        [ZK1060;G30,H,CN,H,-], [ZK1061;G30,H,H,Me,-], [ZK10        62;G30,H,H,Et,-], [ZK1063;G30,H,H,Pr,-],        [ZK1064;G30,H,H,i-Pr,-], [ZK1065;G30,H,H,c-Pr,-],        [ZK1066;G30,H,H,Ph,-], [ZK1067;G30,H,H,OMe,-], [ZK1068;        G30,H,H,OEt,-], [ZK1069;G30,H,H,OPh,-], [ZK1070;G30,H,H,CF₃,-],        [ZK1071;G30,H,H,F,-], [ZK1072;G30,H,H,Cl,-], [ZK1073;G30,H,        H,Br,-], [ZK1074;G30,H,H,CN,-], [ZK1075;G30,H,Oi-Pr,H,-],        [ZK1076;G30,H,Oc-Pr,H,-], [ZK1077;G30,H,Ot-Bu,H,-],        [ZK1078;G30,H,OCF₃,H,-], [ZK1079;G30,H,OCHF₂,H, -], [Z        K1080;G30,H,OPr,H,-], [ZK1081;G30,H,OCH2Ph,H,-], [ZK1082;G30,        H,OCH2-i-Pr,H,-], [ZK1083;G30,H,OCH2-c-Pr,H,-],        [ZK1084;G30,H,OCH2-t-Bu,H,-], [ZK1085;G31,H,-,-,-],        [ZK1086;G31,Me,-,-,-], [ZK1087; G31,Et,-,-,-],        [ZK1088;G31,Pr,-,-,-], [ZK1089;G31,i-Pr,-,-,-],        [ZK1090;G31,c-Pr,-,-,-], [ZK1091;G31,Ph,-,-,-],        [ZK1092;G31,OMe,-,-,-], [ZK1 093;G31,OEt,-,-,-],        [ZK1094;G31,OPh,-,-,-], [ZK1095;G31,CF₃,-,-,-],        [ZK1096;G31,F,-,-,-], [ZK1097;G31,Cl,-,-,-], [ZK1098;G3        1,Br,-,-,-], [ZK1099;G31,CN,-,-,-], [ZK1100;G31,t-Bu,-,-,-],        [ZK1101;G32,H,-,-,-], [ZK1102;G32,Me,-,-,-], [ZK110        3;G32,Et,-,-,-], [ZK1104;G32,Pr,-,-,-], [ZK1105;G32,i-Pr,-,-,-],        [ZK1106;G32,c-Pr,-,-,-], [ZK1107;G32,Ph,-,-,-],        [ZK1108;G32,OMe,-,-,-], [ZK1 109;G32,OEt,-,-,-],        [ZK1110;G32,OPh,-,-,-], [ZK1111;G32,CF₃,-,-,-],        [ZK1112;G32,F,-,-,-], [ZK1113;G32,Cl,-,-,-], [ZK1114;G3        2,Br,-,-,-], [ZK1115;G32,CN,-,-,-], [ZK1116;G32,t-Bu,-,-,-],        [ZK1117;G33,H,-,-,-], [ZK1118;G33,Me,-,-,-], [ZK111        9;G33,Et,-,-,-], [ZK1120;G33,Pr,-,-,-], [ZK1121;G33,i-Pr,-,-,-],        [ZK1122;G33,c-Pr,-,-,-], [ZK1123;G33,Ph,-,-,-],        [ZK1124;G33,OMe,-,-,-], [ZK1 125;G33,OEt,-,-,-],        [ZK1126;G33,OPh,-,-,-], [ZK1127;G33,CF₃,-,-,-],        [ZK1128;G33,F,-,-,-], [ZK1129;G33,Cl,-,-,-], [ZK1130;G3        3,Br,-,-,-], [ZK1131;G33,CN,-,-,-], [ZK1132;G33,t-Bu,-,-,-],        [ZK1133;G34,H,-,-,-], [ZK1134;G34,Me,-,-,-], [ZK113        5;G34,Et,-,-,-], [ZK1136;G34,Pr,-,-,-], [ZK1137;G34,i-Pr,-,-,-],        [ZK1138;G34,c-Pr,-,-,-], [ZK1139;G34,Ph,-,-,-],        [ZK1140;G34,OMe,-,-,-], [ZK1 141;G34,OEt,-,-,-],        [ZK1142;G34,OPh,-,-,-], [ZK1143;G34,CF₃,-,-,-],        [ZK1144;G34,F,-,-,-], [ZK1145;G34,Cl,-,-,-], [ZK1146;G3        4,Br,-,-,-], [ZK1147;G34, CN,-,-,-], [ZK1148;G34, t-Bu, -,-, -]

A compound according to Compound (2A) wherein R¹ represents a chlorineatom, Q represents Q1, and a combination of structure of G⁴ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G⁴ represents any combination described in Combination K(hereinafter, referred to as Compound group SX1296).

A compound according to Compound (2A) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, and a combinationof structure of G⁴ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G⁴ represents any combination described inCombination K (hereinafter, referred to as Compound group SX1297).

A compound according to Compound (2A) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, and a combinationof structure of G⁴ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G⁴ represents any combination described inCombination K (hereinafter, referred to as Compound group SX1298).

A compound according to Compound (2A) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, and a combination of structureof G⁴ and substituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to thestructure of G⁴ represents any combination described in Combination K(hereinafter, referred to as Compound group SX1299).

A compound according to Compound (2A) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, and a combination of structureof G⁴ and substituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to thestructure of G⁴ represents any combination described in Combination K(hereinafter, referred to as Compound group SX1300).

A compound according to Compound (2A) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, and a combinationof structure of G⁴ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G⁴ represents any combination described inCombination K (hereinafter, referred to as Compound group SX1301).

A compound according to Compound (2A) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, and a combinationof structure of G⁴ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G⁴ represents any combination described inCombination K (hereinafter, referred to as Compound group SX1302).

A compound according to Compound (2A) wherein R¹ represents a methylgroup, Q represents Q4, and a combination of structure of G⁴ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G⁴ represents any combination described in Combination K(hereinafter, referred to as Compound group SX1303).

A compound according to Compound (2A) wherein R¹ represents a chlorineatom, Q represents Q4, and a combination of structure of G⁴ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G⁴ represents any combination described in Combination K(hereinafter, referred to as Compound group SX1304).

A compound according to Compound (2A) wherein R¹ represents a methylgroup, Q represents Q5, and a combination of structure of G⁴ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G⁴ represents any combination described in Combination K(hereinafter, referred to as Compound group SX1305).

A compound according to Compound (2A) wherein R¹ represents a chlorineatom, Q represents Q5, and a combination of structure of G⁴ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G⁴ represents any combination described in Combination K(hereinafter, referred to as Compound group SX1306).

A compound according to Compound (2A) wherein R¹ represents a methylgroup, Q represents Q6, and a combination of structure of G⁴ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G⁴ represents any combination described in Combination K(hereinafter, referred to as Compound group SX1307).

A compound according to Compound (2A) wherein R¹ represents a chlorineatom, Q represents Q6, and a combination of structure of G⁴ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G⁴ represents any combination described in Combination K(hereinafter, referred to as Compound group SX1308).

A compound according to Compound (2A) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, and a combinationof structure of G⁴ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G⁴ represents any combination described inCombination K (hereinafter, referred to as Compound group SX1309).

A compound according to Compound (2A) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, and a combinationof structure of G⁴ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G⁴ represents any combination described inCombination K (hereinafter, referred to as Compound group SX1310).

A compound according to Compound (2A) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, and a combination of structureof G⁴ and substituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to thestructure of G⁴ represents any combination described in Combination K(hereinafter, referred to as Compound group SX1311).

A compound according to Compound (2A) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, and a combination of structureof G⁴ and substituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to thestructure of G⁴ represents any combination described in Combination K(hereinafter, referred to as Compound group SX1312).

A compound according to Compound (2A) wherein R¹ represents a methylgroup, Q represents Q8A, and a combination of structure of G⁴ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G⁴ represents any combination described in Combination K(hereinafter, referred to as Compound group SX1313).

A compound according to Compound (2A) wherein R¹ represents a chlorineatom, Q represents Q8A, and a combination of structure of G⁴ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G⁴ represents any combination described in Combination K(hereinafter, referred to as Compound group SX1314).

A compound according to Compound (2A) wherein R¹ represents a methylgroup, Q represents Q8D, and a combination of structure of G⁴ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G⁴ represents any combination described in Combination K(hereinafter, referred to as Compound group SX1315).

A compound according to Compound (2A) wherein R¹ represents a chlorineatom, Q represents Q8D, and a combination of structure of G⁴ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G⁴ represents any combination described in Combination K(hereinafter, referred to as Compound group SX1316).

A compound according to Compound (2A) wherein R¹ represents a methylgroup, Q represents Q8J, and a combination of structure of G⁴ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G⁴ represents any combination described in Combination K(hereinafter, referred to as Compound group SX1317).

A compound according to Compound (2A) wherein R¹ represents a chlorineatom, Q represents Q8J, and a combination of structure of G⁴ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G⁴ represents any combination described in Combination K(hereinafter, referred to as Compound group SX1318).

A compound represented by formula (2C) (hereinafter, referred to asCompound (2C)):

[wherein G represents any one of formulae G1 to G35.]wherein R¹ represents a methyl group, R¹⁰ represents a methyl group, Qrepresents Q1, and a combination of structure of G and substituentsR^(X7), R^(X8), R^(X9) and R^(X10) applied to the structure of Grepresents any combination described in Combination B (hereinafter,referred to as Compound group SX1319).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents a methyl group, Q represents Q1, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX1320).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents a methyl group, Q represents Q2, L¹ represents anoxygen atom, and a combination of structure of G and substituentsR^(X7), R^(X8), R^(X9) and R^(X10) applied to the structure of Grepresents any combination described in Combination B (hereinafter,referred to as Compound group SX1321).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents a methyl group, Q represents Q2, L¹ represents anoxygen atom, and a combination of structure of G and substituentsR^(X7), R^(X8), R^(X9) and R^(X10) applied to the structure of Grepresents any combination described in Combination B (hereinafter,referred to as Compound group SX1322).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents a methyl group, Q represents Q2, L¹ represents NH,and a combination of structure of G and substituents R^(X7), R^(X8),R^(X9) and R^(X10) applied to the structure of G represents anycombination described in Combination B (hereinafter, referred to asCompound group SX1323).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents a methyl group, Q represents Q2, L¹ represents NH,and a combination of structure of G and substituents R^(X7), R^(X8),R^(X9) and R^(X10) applied to the structure of G represents anycombination described in Combination B (hereinafter, referred to asCompound group SX1324).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents a methyl group, Q represents Q3, R³ represents amethoxy group, and a combination of structure of G and substituentsR^(X7), R^(X8), R^(X9) and R^(X10) applied to the structure of Grepresents any combination described in Combination B (hereinafter,referred to as Compound group SX1325).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents a methyl group, Q represents Q3, R³ represents amethoxy group, and a combination of structure of G and substituentsR^(X7), R^(X8), R^(X9) and R^(X10) applied to the structure of Grepresents any combination described in Combination B (hereinafter,referred to as Compound group SX1326).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents a methyl group, Q represents Q4, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX1327).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents a methyl group, Q represents Q4, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX1328).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents a methyl group, Q represents Q5, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX1329).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents a methyl group, Q represents Q5, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX1330).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents a methyl group, Q represents Q6, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX1331).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents a methyl group, Q represents Q6, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX1332).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents a methyl group, Q represents Q7, L² represents anoxygen atom, and a combination of structure of G and substituentsR^(X7), R^(X8), R^(X9) and R^(X10) applied to the structure of Grepresents any combination described in Combination B (hereinafter,referred to as Compound group SX1333).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents a methyl group, Q represents Q7, L² represents anoxygen atom, and a combination of structure of G and substituentsR^(X7), R^(X8), R^(X9) and R^(X10) applied to the structure of Grepresents any combination described in Combination B (hereinafter,referred to as Compound group SX1334).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents a methyl group, Q represents Q7, L² represents NH,and a combination of structure of G and substituents R^(X7), R^(X8),R^(X9) and R^(X10) applied to the structure of G represents anycombination described in Combination B (hereinafter, referred to asCompound group SX1335).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents a methyl group, Q represents Q7, L² represents NH,and a combination of structure of G and substituents R^(X7), R^(X8),R^(X9) and R^(X10) applied to the structure of G represents anycombination described in Combination B (hereinafter, referred to asCompound group SX1336).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents a methyl group, Q represents Q8A, and acombination of structure of G and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1337).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents a methyl group, Q represents Q8A, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX1338).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents a methyl group, Q represents Q8D, and acombination of structure of G and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1339).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents a methyl group, Q represents Q8D, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX1340).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents a methyl group, Q represents Q8J, and acombination of structure of G and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1341).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents a methyl group, Q represents Q8J, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX1342).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents an ethyl group, Q represents Q1, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX1343).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents an ethyl group, Q represents Q1, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX1344).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents an ethyl group, Q represents Q2, L¹ represents anoxygen atom, and a combination of structure of G and substituentsR^(X7), R^(X8), R^(X9) and R^(X10) applied to the structure of Grepresents any combination described in Combination B (hereinafter,referred to as Compound group SX1345).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents an ethyl group, Q represents Q2, L¹ represents anoxygen atom, and a combination of structure of G and substituentsR^(X7), R^(X8), R^(X9) and R^(X10) applied to the structure of Grepresents any combination described in Combination B (hereinafter,referred to as Compound group SX1346).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents an ethyl group, Q represents Q2, L¹ represents NH,and a combination of structure of G and substituents R^(X7), R^(X8),R^(X9) and R^(X10) applied to the structure of G represents anycombination described in Combination B (hereinafter, referred to asCompound group SX1347).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents an ethyl group, Q represents Q2, L¹ represents NH,and a combination of structure of G and substituents R^(X7), R^(X8),R^(X9) and R^(X10) applied to the structure of G represents anycombination described in Combination B (hereinafter, referred to asCompound group SX1348).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents an ethyl group, Q represents Q3, R³ represents amethoxy group, and a combination of structure of G and substituentsR^(X7), Rx, R^(X9) and R^(X10) applied to the structure of G representsany combination described in Combination B (hereinafter, referred to asCompound group SX1349).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents an ethyl group, Q represents Q3, R³ represents amethoxy group, and a combination of structure of G and substituentsR^(X7), Rx, R^(X9) and R^(X10) applied to the structure of G representsany combination described in Combination B (hereinafter, referred to asCompound group SX1350).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents an ethyl group, Q represents Q4, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX1351).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents an ethyl group, Q represents Q4, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX1352).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents an ethyl group, Q represents Q5, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX1353).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents an ethyl group, Q represents Q5, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX1354).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents an ethyl group, Q represents Q6, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX1355).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents an ethyl group, Q represents Q6, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX1356).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents an ethyl group, Q represents Q7, L² represents anoxygen atom, and a combination of structure of G and substituentsR^(X7), R^(X8), R^(X9) and R^(X10) applied to the structure of Grepresents any combination described in Combination B (hereinafter,referred to as Compound group SX1357).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents an ethyl group, Q represents Q7, L² represents anoxygen atom, and a combination of structure of G and substituentsR^(X7), R^(X8), R^(X9) and R^(X10) applied to the structure of Grepresents any combination described in Combination B (hereinafter,referred to as Compound group SX1358).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents an ethyl group, Q represents Q7, L² represents NH,and a combination of structure of G and substituents R^(X7), R^(X8),R^(X9) and R^(X10) applied to the structure of G represents anycombination described in Combination B (hereinafter, referred to asCompound group SX1359).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents an ethyl group, Q represents Q7, L² represents NH,and a combination of structure of G and substituents R^(X7), R^(X8),R^(X9) and R^(X10) applied to the structure of G represents anycombination described in Combination B (hereinafter, referred to asCompound group SX1360).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents an ethyl group, Q represents Q8A, and acombination of structure of G and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1361).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents an ethyl group, Q represents Q8A, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX1362).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents an ethyl group, Q represents Q8D, and acombination of structure of G and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1363).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents an ethyl group, Q represents Q8D, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX1364).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents an ethyl group, Q represents Q8J, and acombination of structure of G and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1365).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents an ethyl group, Q represents Q8J, and a combinationof structure of G and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G represents any combination described inCombination B (hereinafter, referred to as Compound group SX1366).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents a cyclopropyl group, Q represents Q1, and acombination of structure of G and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1367).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents a cyclopropyl group, Q represents Q1, and acombination of structure of G and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1368).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents a cyclopropyl group, Q represents Q2, L¹represents an oxygen atom, and a combination of structure of G andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G represents any combination described in Combination B (hereinafter,referred to as Compound group SX1369).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents a cyclopropyl group, Q represents Q2, L¹ representsan oxygen atom, and a combination of structure of G and substituentsR^(X7), R^(X8), R^(X9) and R^(X10) applied to the structure of Grepresents any combination described in Combination B (hereinafter,referred to as Compound group SX1370).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents a cyclopropyl group, Q represents Q2, L¹represents NH, and a combination of structure of G and substituentsR^(X7), R^(X8), R^(X9) and R^(X10) applied to the structure of Grepresents any combination described in Combination B (hereinafter,referred to as Compound group SX1371).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents a cyclopropyl group, Q represents Q2, L¹ representsNH, and a combination of structure of G and substituents R^(X7), R^(X8),R^(X9) and R^(X10) applied to the structure of G represents anycombination described in Combination B (hereinafter, referred to asCompound group SX1372).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents a cyclopropyl group, Q represents Q3, R³represents a methoxy group, and a combination of structure of G andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G represents any combination described in Combination B (hereinafter,referred to as Compound group SX1373).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents a cyclopropyl group, Q represents Q3, R³ representsa methoxy group, and a combination of structure of G and substituentsR^(X7), R^(X8), R^(X9) and R^(X10) applied to the structure of Grepresents any combination described in Combination B (hereinafter,referred to as Compound group SX1374).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents a cyclopropyl group, Q represents Q4, and acombination of structure of G and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1375).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents a cyclopropyl group, Q represents Q4, and acombination of structure of G and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1376).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents a cyclopropyl group, Q represents Q5, and acombination of structure of G and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1377).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents a cyclopropyl group, Q represents Q5, and acombination of structure of G and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1378).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents a cyclopropyl group, Q represents Q6, and acombination of structure of G and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1379).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents a cyclopropyl group, Q represents Q6, and acombination of structure of G and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1380).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents a cyclopropyl group, Q represents Q7, L²represents an oxygen atom, and a combination of structure of G andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G represents any combination described in Combination B (hereinafter,referred to as compound group SX1381).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents a cyclopropyl group, Q represents Q7, L² representsan oxygen atom, and a combination of structure of G and substituentsR^(X7), R^(X8), R^(X9) and R^(X10) applied to the structure of Grepresents any combination described in Combination B (hereinafter,referred to as Compound group SX1382).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents a cyclopropyl group, Q represents Q7, L²represents NH, and a combination of structure of G and substituentsR^(X7), R^(X8), R^(X9) and R^(X10) applied to the structure of Grepresents any combination described in Combination B (hereinafter,referred to as Compound group SX1383).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents a cyclopropyl group, Q represents Q7, L² representsNH, and a combination of structure of G and substituents R^(X7), R^(X8),R^(X9) and R^(X10) applied to the structure of G represents anycombination described in Combination B (hereinafter, referred to asCompound group SX1384).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents a cyclopropyl group, Q represents Q8A, and acombination of structure of G and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1385).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents a cyclopropyl group, Q represents Q8A, and acombination of structure of G and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1386).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents a cyclopropyl group, Q represents Q8D, and acombination of structure of G and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1387).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents a cyclopropyl group, Q represents Q8D, and acombination of structure of G and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1388).

A compound according to Compound (2C) wherein R¹ represents a methylgroup, R¹⁰ represents a cyclopropyl group, Q represents Q8J, and acombination of structure of G and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1389).

A compound according to Compound (2C) wherein R¹ represents a chlorineatom, R¹⁰ represents a cyclopropyl group, Q represents Q8J, and acombination of structure of G and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1390).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q1, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1391).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q1, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1392).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, R⁷ represents amethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1393).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, R⁷ represents amethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1394).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, R⁷ represents a methyl group,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX1395).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, R⁷ represents a methyl group,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX1396).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, R⁷ represents amethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1397).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R⁷ represents amethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1398).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q4, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1399).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q4, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1400).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q5, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1401).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q5, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1402).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q6, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1403).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q6, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1404).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R⁷ represents amethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1405).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R⁷ represents amethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1406).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R⁷ represents a methyl group,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX1407).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R⁷ represents a methyl group,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX1408).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q8A, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1409).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q8A, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1410).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q8D, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1411).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q8D, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1412).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q8J, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1413).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q8J, R⁷ represents a methyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1414).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q1, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1415).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q1, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1416).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, R⁷ represents anethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1417).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, R⁷ represents anethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1418).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, R⁷ represents an ethyl group,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX1419).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, R⁷ represents an ethyl group,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX1420).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q3, R³ represents a methoxy group, R⁷ represents anethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1421).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, R⁷ represents anethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1422).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q4, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1423).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q4, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1424).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q5, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1425).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q5, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1426).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q6, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1427).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q6, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1428).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q7, L² represents an oxygen atom, R⁷ represents anethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1429).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents an oxygen atom, R⁷ represents anethyl group, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1430).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q7, L² represents NH, R⁷ represents an ethyl group,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX1431).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q7, L² represents NH, R⁷ represents an ethyl group,and a combination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6)represents any combination described in Combination A (hereinafter,referred to as Compound group SX1432).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q8A, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1433).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q8A, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1434).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q8D, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1435).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q8D, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1436).

A compound according to Compound (2F) wherein R¹ represents a methylgroup, Q represents Q8J, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1437).

A compound according to Compound (2F) wherein R¹ represents a chlorineatom, Q represents Q8J, R⁷ represents an ethyl group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1438).

A compound according to Compound (1E) wherein R¹ represents an ethylgroup, Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1439).

A compound according to Compound (1E) wherein R¹ represents a fluorineatom, Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1440).

A compound according to Compound (1E) wherein R¹ represents acyclopropyl group, Q represents Q1, and a combination of R^(X2), R^(X3),R^(X4), R^(X5) and R^(X6) represents any combination described inCombination A (hereinafter, referred to as Compound group SX1441).

A compound according to Compound (1E) wherein R¹ represents a methylgroup, Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination G(hereinafter, referred to as Compound group SX1442).

Combination G consists of substituent numbers ZG1 to ZG170. Substituentnumbers ZG1 to ZG170 represent combinations of substituents R^(X2),R^(X3), R^(X4), R^(X5) and R^(X6) according to Compound (1E). Andhereinafter, they are referred to as [substituent number; R^(X2),R^(X3), R^(X4), R^(X5), R^(X6)]. For example, the substituent number ZG2refers to a combination wherein R^(X2) represents a trifluoromethoxygroup, and each of R^(X3), R^(X4), R^(X5) and R^(X6) represents ahydrogen atom.

-   -   Combination G: [ZG1; OMe, H, H, H, H], [ZG2; OCF₃, H, H, H, H],        [ZG3; OCHF₂, H, H, H, H], [Z G4;SMe,H,H,H,H],        [ZG5;SCF₃,H,H,H,H], [ZG6;SCHF₂,H,H,H,H], [ZG7;F,H,H,H,H],        [ZG8;Cl,H,H,H,H], [ZG9;Br,H,H,H,H], [ZG10;I,H,H,H,H],        [ZG11;CN,H,H,H,H], [ZG12;Et,H,H,H,H], [ZG13;Pr,H,H,H,H],        [ZG14;i-Pr,H,H,H,H], [ZG15;t-Bu,H,H,H,H], [ZG16;Ph,H,H,H,H],        [ZG17;HCl,H,H,H], [ZG18;H,CHF₂,H,H,H], [ZG19;H,CF₃,H,H,H],        [ZG20;H,Et,H,H,H], [ZG21;H,Pr,H,H,H], [ZG22;H,i-Pr,H,H,H],        [ZG23;H,Ph,H,H,H], [ZG24;H,H,OMe,H,H], [ZG25;H,H,OC HF₂,H,H],        [ZG26;H,H,F,H,H], [ZG27;H,H,Cl,H,H], [ZG28;H,H,Br,H, H],        [ZG29;H,H, I,H,H], [ZG30;H,H,CN,H,H], [ZG31;H,H,CHF₂,H,H],        [ZG32;H,H,CF₃,H,H], [ZG33;H,H,Me,H,H], [ZG34;H,H,Et,H,H],        [ZG35;H,H,Pr,H,H], [ZG36;H,H,i-Pr,H,H], [ZG37;H,H,Ph,H,H],        [ZG38;F,F,H,H,H], [ZG39;F,H,F,H,H], [ZG40;F,H,H,F,H],        [ZG41;F,H,H,H,F], [ZG42;H,F,F,H,H], [ZG43;H,F,H,F,H],        [ZG44;H,F,F,F,H], [ZG45;F,F,H,F,F], [ZG46;F,F,F,F,F],        [ZG47;Cl,Cl,H,H,H], [ZG48;Cl,H,Cl,H,H], [ZG49;Cl,H,H,Cl,H],        [ZG50; Cl,H, H,H, Cl], [ZG51;H, Cl, Cl, H,H], [ZG52;H, Cl,H,        Cl,H], [Z G53;CF₃,CF₃,H,H,H], [ZG54;CF₃,H,CF₃,H,H],        [ZG55;CF₃,H,H,CF₃,H], [ZG56;CF₃,H,H,H,CF₃],        [ZG57;H,CF₃,CF₃,H,H], [ZG58;Me,Me,H,H,H], [ZG59;Me,H,Me,H,H],        [ZG60;Me,H,H,Me,H], [ZG61;Me,H,H,H,Me], [ZG62;H,Me,Me,H,H],        [ZG63;OMe,OMe,H,H,H], [ZG64;OMe,H,OMe,H,H],        [ZG65;OMe,H,H,OMe,H], [ZG66;OMe,H,H,H,OMe], [ZG67;H,OMe,OMe,        H,H], [ZG68;H,OMe,H,OMe,H], [ZG69;F,Cl,H,H,H], [ZG70;Cl,F,H,H,        H], [ZG71;F,H,Cl,H,H], [ZG72;Cl,H,F,H,H], [ZG73;F,H,H,Cl,H], [Z        G74;Cl,H,H,F,H], [ZG75;F,H,H,H,Cl], [ZG76;H,F,Cl,H,H],        [ZG77;H,Cl,F,H,H], [ZG78;H,F,H,Cl,H], [ZG79;F,Me,H,H,H],        [ZG80;Me,F,H,H,H], [ZG81;F,H,Me,H,H], [ZG82;Me,H,F,H,H],        [ZG83;F,H,H,Me,H], [ZG84;Me,H,H,F,H], [ZG85;F,H,H,H,Me],        [ZG86;H,F,Me,H,H], [ZG8 7;H,Me,F,H,H], [ZG88;H,F,H,Me,H],        [ZG89;F,OMe,H,H,H], [ZG90;OM e,F,H,H,H], [ZG91;F,H,OMe,H,H],        [ZG92;OMe,H,F,H,H], [ZG93;F,H, H,OMe,H], [ZG94;OMe,H,H,F,H],        [ZG95;F,H,H,H,OMe], [ZG96;H,F,OM e,H,H], [ZG97;H,OMe,F,H,H],        [ZG98;H,F,H,OMe,H], [ZG99;F,CF₃,H, H,H], [ZG100;CF₃,F,H,H,H],        [ZG101;F,H,CF₃,H,H], [ZG102;CF₃,H,F, H,H], [ZG103;F,H,H,CF₃,H],        [ZG104;CF₃,H,H,F,H], [ZG105;F,H,H,H,CF₃], [ZG106;H,F,CF₃,H,H],        [ZG107;H,CF₃,F,H,H], [ZG108;H,F,H,C F₃,H], [ZG109;Cl,OMe,H,H,H],        [ZG110;OMe,Cl,H,H,H], [ZG111;Cl,H,OMe,H,H],        [ZG112;OMe,H,Cl,H,H], [ZG113;Cl,H,H,OMe,H], [ZG114;        OMe,H,H,Cl,H], [ZG115;Cl,H,H,H,OMe], [ZG116;H,Cl,OMe,H,H], [ZG        117;H,OMe,Cl,H,H], [ZG118;H,Cl,H,OMe,H], [ZG119;Cl,Me,H,H,H],        [ZG120;Me,Cl,H,H,H], [ZG121;Cl,H,Me,H,H], [ZG122;Me,H,Cl,H,H],        [ZG123;Cl,H,H,Me,H], [ZG124;Me,H,H,Cl,H], [ZG125;Cl,H,H,H,Me],        [ZG126;H,Cl,Me,H,H], [ZG127;H,Me,Cl,H,H], [ZG128;H,Cl,H,Me, H],        [ZG129;Cl,CF₃,H,H,H], [ZG130;CF₃,Cl,H,H,H],        [ZG131;Cl,H,CF₃,H,H], [ZG132;CF₃,H,Cl,H,H],        [ZG133;Cl,H,H,CF₃,H], [ZG134;CF₃,H,H,Cl,H],        [ZG135;Cl,H,H,H,CF₃], [ZG136;H,Cl,CF₃,H,H],        [ZG137;H,CF₃,Cl,H,H], [ZG138;H,Cl,H,CF₃,H],        [ZG139;Me,CF₃,H,H,H], [ZG14 0;CF₃,Me,H,H,H],        [ZG141;Me,H,CF₃,H,H], [ZG142;CF₃,H,Me,H,H], [Z        G143;Me,H,H,CF₃,H], [ZG144;CF₃,H,H,Me,H],        [ZG145;Me,H,H,H,CF₃][ZG146;H,Me,CF₃,H,H], [ZG147;H,CF₃,Me,H,H],        [ZG148;H,Me,H,CF₃,H], [ZG149;Me,OMe,H,H,H],        [ZG150;OMe,Me,H,H,H], [ZG151;Me,H,O Me,H,H],        [ZG152;OMe,H,Me,H,H], [ZG153;Me,H,H,OMe,H], [ZG154;OM        e,H,H,Me,H], [ZG155;Me,H,H,H,OMe], [ZG156;H,Me,OMe,H,H], [ZG15        7;H,OMe,Me,H,H], [ZG158;H,Me,H,OMe,H], [ZG159;OMe,CF₃,H,H,H],        [ZG160;CF₃,OMe,H,H,H], [ZG161;OMe,H,CF₃,H,H],        [ZG162;CF₃,H,OMe,H,H], [ZG163;OMe,H,H,CF₃,H],        [ZG164;CF₃,H,H,OMe,H], [ZG165;OM e,H,H,H,CF₃],        [ZG166;H,OMe,CF₃,H,H], [ZG167;H,CF₃,OMe,H,H], [ZG        168;H,OMe,H,CF₃,H], [ZG169;OPh,H,H,H,H], [ZG170; H,H,OPh,H,H]

A compound according to Compound (1E) wherein R¹ represents a chlorineatom, Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination G(hereinafter, referred to as Compound group SX1443).

A compound according to Compound (1E) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination G (hereinafter, referred to as Compound groupSX1444).

A compound according to Compound (1E) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination G (hereinafter, referred to as Compound groupSX1445).

A compound according to Compound (1E) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, and a combination of R^(X2),R^(X3), R^(X4), R^(X5) and R^(X6) represents any combination describedin Combination G (hereinafter, referred to as Compound group SX1446).

A compound according to Compound (1E) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, and a combination of R^(X2),R^(X3), R^(X4), R^(X5) and R^(X6) represents any combination describedin Combination G (hereinafter, referred to as Compound group SX1447).

A compound according to Compound (2G) wherein R¹ represents a methylgroup, Q represents Q1, and a combination of structure of G² andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G² represents any combination described in Combination I(hereinafter, referred to as Compound group SX1448).

Combination I consists of substituent numbers ZI1 to ZI1327. Substituentnumbers ZI1 to ZI1327 represent combinations of structure of G² andsubstituents of R^(X7), R^(X8), R^(X9) and R^(X10) applied to thestructure of G² according to Compound (2G). And hereinafter, they arereferred to as [substituent number; G², R^(X7), R^(X8), R^(X9), R^(Xl)].For example, the substituent number ZI2 refers to a combination whereinG² represents G1, R^(X7) represents an ethyl group, and each of R^(X8),R^(X9) and R^(X10) represents a hydrogen atom.

-   -   Combination I: [ZI1;G1,H,H,H,H], [ZI2;G1,Et,H,H,H],        [ZI3;G1,Pr,H,H,H], [ZI4;G 1,i-Pr,H,H,H], [ZI5;G1,c-Pr,H,H,H],        [ZI6;G1,Ph,H,H,H], [ZI7;G1,OMe,H,H,H], [ZI8;G1,OEt, H,H,H],        [ZI9;G1,OPh,H,H,H], [ZI10;G1,F,H,H,H], [ZI11;G1,C1,H,H,H],        [ZI12;G1,Br,H,H,H], [ZI13;G1,I,H,H,H], [ZI14;G1,CN,H,H,H],        [ZI15;G1,OCF₃,H,H,H], [ZI16;G1,OCHF₂,H,H,H], [ZI17;G1,CHF₂,H,        H,H], [ZI18;G1,H,Et,H,H], [ZI19;G1,H,Pr,H,H],        [ZI20;G1,H,i-Pr,H,H], [ZI21;G1,H,c-Pr,H,H], [ZI22;G1,H,Ph,H,H],        [ZI23;G1,H,OMe,H,H], [ZI24;G1,H,O Et,H,H], [ZI25;G1,H,OPh,H,H],        [ZI26;G1,H,F,H,H], [ZI27;G1,H,Cl,H,H], [ZI28;G1,H,Br,H,H],        [ZI29;G1,H,I,H,H], [ZI30;G1,H,CN,H, H], [ZI31;G1,H,OCF₃,H,H],        [ZI32;G1,H,OCHF₂,H,H], [ZI33;G1,H,CH F₂,H,H],        [ZI34;G1,H,H,Et,H], [ZI35;G1,H,H,Pr,H], [ZI36;G1,H,H, i-Pr,H],        [ZI37;G1,H,H,c-Pr,H], [ZI38;G1,H,H,Ph,H], [ZI39;G1,H,H,OMe,H],        [ZI40;G1,H,H,O Et,H], [ZI41;G1,H,H,OPh,H], [ZI42;G1,H,H,F,H],        [ZI43;G1,H,H,Cl,H], [ZI44;G1,H,H,Br,H], [ZI45;G1,H,H,I,H],        [ZI46;G,H,H,CN,H], [ZI47;G1,H,H,OCF₃,H], [ZI48;G1,H,H,OCHF₂,H],        [ZI49;G1,H,H,CH F₂,H], [ZI50;G1,H,H,H,Me], [ZI51;G1,H,H,H,Et],        [ZI52;G1,H,H,H, Pr], [ZI53;G1,H,H,H,i-Pr], [ZI54;G1,H,H,H,c-Pr],        [ZI55;G1,H,H,H,Ph], [ZI56;G1,H,H,H,OMe], [ZI57;G1,H,H,H,O Et],        [ZI58;G1,H,H,H,OPh], [ZI59;G1,H,H,H,CF₃], [ZI60;G1,H,H,H, F],        [ZI61;G1,H,H,H,Cl], [ZI62;G1,H,H,H,Br], [ZI63;G1,H,H,HI],        [ZI64;G1,H,H,H,CN], [ZI65;G1,H,H,H,OCF₃], [ZI66;G1,H,H,H,OCHF₂],        [ZI67;G1,H,H,H,CHF₂], [ZI68;G1,Me,Me,H,H], [ZI69;G1,Me,Et,H,H],        [ZI70;G1,Me,OMe,H,H], [ZI71;G1,Me,OEt,H,H], [ZI72;G1,Me,S        Me,H,H], [ZI73;G1,Me,F,H,H], [ZI74;G1,Me,Cl,H,H], [ZI75;G1,Me,        CN,H,H], [ZI75;G1,Me,CF₃,H,H], [ZI76;G1,F,Me,H,H], [ZI77;G1,F,        Et,H,H], [ZI78;G1,F,OMe,H,H], [ZI79;G1,F,OEt,H,H], [ZI80;G1,F,        SMe,H,H], [ZI81;G1,F,F,H,H], [ZI82;G1,F,Cl,H,H],        [ZI83;G1,F,CN,H,H], [ZI84;G1,F,CF₃,H,H], [ZI85;G1,Cl,Me,H,H],        [ZI86;G1,Cl,E t,H,H], [ZI87;G1,Cl,OMe,H,H],        [ZI88;G1,Cl,OEt,H,H], [ZI89;G1,Cl,SMe,H,H], [ZI90;G1,Cl,F,H,H],        [ZI91;G1,Cl,Cl,H,H], [ZI92;G1, Cl,CN,H,H], [ZI93;G1ClCF₃,H,H],        [ZI94;G1,OMe,Me,H,H], [ZI95;G1,OMe,Et,H,H],        [ZI96;G1,OMe,OMe,H,H], [ZI97;G1,OMe,OEt,H,H], [Z        I98;G1,OMe,SMe,H,H], [ZI99;G1,OMe,F,H,H], [ZI100;G1,OMe,Cl,H,        H], [ZI101;G1,OMe,CN,H,H], [ZI102;G1OMeCF₃,H,H],        [ZI103;G1,SMe,Me,H,H], [ZI104;G1,SMe,Et,H,H],        [ZI105;G1,SMe,OMe,H,H], [ZI10 6;G1,SMe,OEt,H,H],        [ZI107;G1,SMe,SMe,H,H], [ZI108;G1,SMe,F,H, H],        [ZI109;G1,SMe,Cl,H,H], [ZI110;G1,SMe,CN,H,H], [ZI111;G1SMe        CF₃,H,H], [ZI112;G1,CF₃,Me,H,H], [ZI113;G1,CF₃,Et,H,H], [ZI114;        G1,CF₃,OMe,H,H], [ZI115;G1,CF₃,OEt,H,H], [ZI116;G1,CF₃,SMe,H,H],        [ZI117;G1,CF₃,F,H,H], [ZI118;G1,CF₃,Cl,H,H], [ZI119;G1,CF₃,C        N,H,H], [ZI120;G1,Me,H,Et,H], [ZI121;G1,Me,H,OMe,H],        [ZI122;G1,Me,H,OEt,H], [ZI123;G1,Me,H,SMe,H],        [ZI124;G1,Me,H,F,H], [ZI1 25;G1,Me,H,Cl,H],        [ZI126;G1,Me,H,CN,H], [ZI127;G1,F,H,Me,H], [ZI128;G1,F,H,Et,H],        [ZI129;G1,F,H,OMe,H], [ZI130;G1,F,H,OEt,H],        [ZI131;G1,F,H,SMe,H], [ZI132;G1,F,H,F,H], [ZI133;G1,F,H,Cl, H],        [ZI134;G1,F,H,CN,H], [ZI135;G1,F,H,CF₃,H], [ZI136;G1,Cl,H,        Me,H], [ZI137;G1,Cl,H,Et,H], [ZI138;G1,Cl,H,OMe,H], [ZI139;G1,        Cl,H,OEt,H], [ZI140;G1,Cl,H,SMe,H], [ZI141;G1,Cl,H,F,H], [ZI14        2;G1,Cl,H,Cl,H], [ZI143;G1,Cl,H,CN,H], [ZI144;G1ClH,CF₃,H], [Z        I145;G1,OMe,H,Me,H], [ZI146;G1,OMe,H,Et,H], [ZI147;G1,OMe,H,O        Me,H], [ZI148;G1,OMe,H,OEt,H], [ZI149;G1,OMe,H,SMe,H], [ZI150;        G1,OMe,H,F,H], [ZI151;G1,OMe,H,Cl,H], [ZI152;G1,OMe,H,CN,H],        [ZI153;GlOMeH,CF₃,H], [ZI154;G1,SMe,H,Me,H], [ZI155;G1,SMe,H,E        t,H], [ZI156;G1,SMe,H,OMe,H], [ZI157;G1,SMe,H,OEt,H], [ZI158;G        1,SMe,H,SMe,H], [ZI159;G1,SMe,H,F,H], [ZI160;G1,SMe,H,Cl,H],        [ZI61;G1,SMe,H,CN,H], [ZI162;G1SMeH,CF₃,H], [ZI163;G1,CF₃,H,M        e,H], [ZI164;G1,CF₃,H,Et,H], [ZI165;G1,CF₃,H,OMe,H],        [ZI166;G1,CF₃,H,OEt,H], [ZI167;G1,CF₃,H,SMe,H],        [ZI168;G1,CF₃,H,F,H], [Z I169;G1,CF₃,H,Cl,H],        [Z170;G1,CF₃,H,CN,H], [ZI171;G1,Me,H,H, Me],        [ZI172;G1,Me,H,H,Et], [ZI173;G1,Me,H,H,OMe],        [ZI174;G1,Me,H,H,OEt], [ZI175;G1,Me,H,H,SMe],        [ZI176;G1,Me,H,H,F], [ZI177; G1,Me,H,H,Cl],        [ZI178;G1,Me,H,H,CN], [ZI179;G1,Me,H,H,CF₃], [Z        I180;G1,F,H,H,Me], [ZI181;G1,F,H,H,Et], [ZI182;G1,F,H,H,OMe],        [ZI183;G1,F,H,H,OEt], [ZI184;G1,F,H,H,SMe], [ZI185;G1,F,H,H,F],        [ZI186;G1,F,H,H,Cl], [ZI187;G1,F,H,H,CN], [ZI188;G1,F,H,H,C F₃],        [ZI189;G1,Cl,H,H,Me], [ZI190;G1,Cl,H,H,Et], [ZI191;G1,Cl,        H,H,OMe], [ZI192;G1,Cl,H,H,OEt], [ZI193;G1,Cl,H,H,SMe],        [ZI194;G1,Cl,H,H,F], [ZI195;G1,Cl,H,H,Cl], [ZI196;G1,Cl,H,H,CN],        [ZI 197;G1ClH,H,CF₃], [ZI198;G1,OMe,H,H,Me],        [ZI199;G1,OMe,H,H,Et], [ZI200;G1,OMe,H,H,OMe],        [ZI201;G1,OMe,H,H,OEt], [ZI202;G1,0 Me,H,H,SMe],        [ZI203;G1,OMe,H,H,F], [ZI204;G1,OMe,H,H,Cl], [ZI2        05;G1,OMe,H,H,CN], [ZI206;GlOMeH,H,CF₃], [ZI207;G1,SMe,H,H,Me],        [ZI208;G1,SMe,H,H,Et], [ZI209;G1,SMe,H,H,OMe], [ZI210;G1,SM        e,H,H,OEt], [ZI211;G1,SMe,H,H,SMe], [ZI212;G1,SMe,H,H,F], [ZI2        13;G1,SMe,H,H,Cl], [ZI214;G1,SMe,H,H,CN], [ZI215;G1SMeH,H,CF₃],        [ZI216;G1,CF₃,H,H,Me], [ZI217;G1,CF₃,H,H,Et], [ZI218;G1,CF₃,        H,H,OMe], [ZI219;G1,CF₃,H,H,OEt], [ZI220;G1,CF₃,H,H,SMe], [ZI2        21;G1,CF₃,H,H,F], [ZI222;G1,CF₃,H,H,Cl], [ZI223;G1,CF₃,H,H,CN],        [ZI224;G9,H,H,H,-], [ZI225;G9,Me,H,H,-], [ZI226;G9,Et,H,H,-],        [ZI227;G9,Pr,H,H,-], [ZI228;G9,i-Pr,H,H,-],        [ZI229;G9,c-Pr,H,H,-], [ZI230;G9,Ph,H,H,-],        [ZI231;G9,OMe,H,H,-], [ZI232;G 9,OEt,H,H,-],        [ZI233;G9,OPh,H,H,-], [ZI234;G9,F,H,H,-], [ZI235;G9,Br,H,H,-],        [ZI236;G9,CN,H,H,-], [ZI237;G9,H,Et,H,-], [ZI23 8;G9,H,Pr,H,-],        [ZI239;G9,H,i-Pr,H,-], [ZI240;G9,H,c-Pr,H,-],        [ZI241;G9,H,Ph,H,-], [ZI242;G9,H,OMe,H,-], [ZI243;G9,        H,OEt,H,-], [ZI244;G9,H,OPh,H,-], [ZI245;G9,H,CF₃,H,-],        [ZI246;G9,H,F,H,-], [ZI247;G9,H,CN,H,-], [ZI248;G9,H,H,Et,-],        [ZI249;G9,H,H,Pr,-], [ZI250;G9,H,H,i-Pr,-],        [ZI251;G9,H,H,c-Pr,-], [ZI252;G9,H,H,Ph,-],        [ZI253;G9,H,H,OMe,-], [ZI254;G9,H, H,OEt,-],        [ZI255;G9,H,H,OPh,-], [ZI256;G9,H,H,CF₃,-], [ZI257;G 9,H,H,F,-],        [ZI258;G9,H,H,CN,-], [ZI259;G10,H,H,H,-], [ZI260;G 10,Me,H,H,-],        [ZI261;G10,Et,H,H,-], [ZI262;G10,Pr,H,H,-], [ZI2        63;G10,i-Pr,H,H,-], [ZI264;G10,c-Pr,H,H,-],        [ZI265;G10,Ph,H,H,-], [ZI266;G10,OMe,H,H,-], [ZI267;G10,OEt,H,H,        -], [ZI268;G10,OPh,H,H, -], [ZI269;G10,CF₃,H,H,-],        [ZI270;G10,F,H,H,-], [ZI271;G10,Br,H,H,-], [ZI272;G10,CN,H,H,-],        [ZI273;G10,H,Et,H,-], [ZI274;G10,H,Pr,H,-], [ZI275;G10,H,        i-Pr,H,-], [ZI276;G10,H,c-Pr,H,-], [ZI277;G10,H,Ph,H,-],        [ZI278;G10,H,OMe,H,-], [ZI279;G 10,H,OEt,H, -],        [ZI280;G10,H,OPh,H, -], [ZI281;G10,H,CF₃,H,-],        [ZI282;G10,H,F,H,-], [ZI283;G10,H,CN,H,-], [ZI284;G10,H,H,Et,-],        [ZI285;G10,H,H,Pr,-], [ZI286;G10,H,H,i-Pr,-],        [ZI287;G10,H,H,c-Pr,-], [ZI288;G10,H,H,Ph,-],        [ZI289;G10,H,H,OMe,-], [ZI290;G10,H,H,OEt,-],        [ZI291;G10,H,H,OPh,-], [ZI292;G10,H,H,CF₃,-], [ZI        293;G10,H,H,F,-], [ZI294;G10,H,H,CN,-], [ZI295;G22,H,H,-,-],        [ZI296;G22,Me,H,-,-], [ZI297;G22,Et,H,-,-],        [ZI298;G22,Pr,H,-,-], [ZI299;G22,i-Pr,H,-,-],        [ZI300;G22,t-Bu,H,-,-], [ZI301;G22,c-Pr,H,-,-],        [ZI302;G22,Ph,H,-,-], [ZI303;G22,OMe,H,-,-],        [ZI304;G22,OEt,H,-,-], [ZI305;G22,OPh,H,-,-],        [ZI306;G22,CHF₂,H,-,-], [ZI307;G22,F,H,-,-],        [ZI308;G22,Br,H,-,-], [ZI309;G22,H,Me, -,-],        [ZI310;G22,H,Et,-,-], [ZI311;G22,H,Pr,-,-],        [ZI312;G22,H,i-Pr,-,-], [ZI313;G22,H,t-Bu,-,-],        [ZI314;G22,H,c-Pr,-,-], [ZI315;G22,H,Ph,-,-],        [ZI316;G22,H,OMe,-,-], [ZI317;G 22,H,OEt,-,-],        [ZI318;G22,H,OPh,-,-], [ZI319;G22,H,OCF₃,-,-],        [ZI320;G22,H,CN,-,-], [ZI321;G22,HCF₃,-,-], [ZI322;G22,HCHF₂,        -,-], [ZI323;G22,H,F,-,-], [ZI324;G22,H,Cl,-,-], [ZI325;G22,H,        Br,-,-], [ZI326;G22,H,I,-,-], [ZI327;G22,H,SMe,-,-]

A compound according to Compound (2G) wherein R¹ represents a chlorineatom, Q represents Q1, and a combination of structure of G² andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G² represents any combination described in Combination I(hereinafter, referred to as Compound group SX1449).

A compound according to Compound (2G) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, and a combinationof structure of G² and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G² represents any combination described inCombination I (hereinafter, referred to as Compound group SX1450).

A compound according to Compound (2G) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, and a combinationof structure of G² and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G² represents any combination described inCombination I (hereinafter, referred to as Compound group SX1451).

A compound according to Compound (2G) wherein R¹ represents a methylgroup, Q represents Q2, L¹ represents NH, and a combination of structureof G² and substituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to thestructure of G² represents any combination described in Combination I(hereinafter, referred to as Compound group SX1452).

A compound according to Compound (2G) wherein R¹ represents a chlorineatom, Q represents Q2, L¹ represents NH, and a combination of structureof G² and substituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to thestructure of G² represents any combination described in Combination I(hereinafter, referred to as Compound group SX1453).

A compound represented by formula (2H) (hereinafter, referred to asCompound (2H)):

wherein Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1454).

A compound according to Compound (2H) wherein Q represents Q2, L¹represents an oxygen atom, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1455).

A compound according to Compound (2H) wherein Q represents Q2, L¹represents NH, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1456).

A compound according to Compound (2H) wherein Q represents Q3, R³represents a methoxy group, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1457).

A compound according to Compound (2H) wherein Q represents Q4, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX1458).

A compound according to Compound (2H) wherein Q represents Q5, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX1459).

A compound according to Compound (2H) wherein Q represents Q6, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX1460).

A compound represented by formula (2I) (hereinafter, referred to asCompound (2I)):

[wherein A represents any one of groups represented by formulae AA1 toAA4.]wherein Q represents Q1, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX1461).

A compound according to Compound (2I) wherein Q represents Q2, L¹represents an oxygen atom, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX1462).

A compound according to Compound (2I) wherein Q represents Q2, L¹represents NH, and a combination of structure of A and substituentsR^(X11), R^(X12), R^(X13) and R^(X14) applied to the structure of Arepresents any combination described in Combination D (hereinafter,referred to as Compound group SX1463).

A compound according to Compound (2I) wherein Q represents Q3, R³represents a methoxy group, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX1464).

A compound according to Compound (2I) wherein Q represents Q4, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX1465).

A compound according to Compound (2I) wherein Q represents Q5, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX1466).

A compound according to Compound (2I) wherein Q represents Q6, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX1467).

A compound represented by formula (2J) (hereinafter, referred to asCompound (2J)):

wherein Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1468)

A compound according to Compound (2J) wherein Q represents Q2, L¹represents an oxygen atom, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1469).

A compound according to Compound (2J) wherein Q represents Q2, L¹represents NH, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1470).

A compound according to Compound (2J) wherein Q represents Q3, R³represents a methoxy group, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1471).

A compound according to Compound (2J) wherein Q represents Q4, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX1472).

A compound according to Compound (2J) wherein Q represents Q5, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX1473).

A compound according to Compound (2J) wherein Q represents Q6, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX1474).

A compound represented by formula (2K) (hereinafter, referred to asCompound (2K)):

[wherein G³ represents any one of formulae G1 to G34.]wherein R² represents a methyl group, Q represents Q1, and a combinationof structure of G³ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G³ represents any combination described inCombination B (hereinafter, referred to as Compound group SX1475).

A compound according to Compound (2K) wherein R² represents a chlorineatom, Q represents Q1, and a combination of structure of G³ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G³ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1476).

A compound according to Compound (2K) wherein R² represents an ethylgroup, Q represents Q1, and a combination of structure of G³ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G³ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1477).

A compound according to Compound (2K) wherein R² represents a methoxygroup, Q represents Q1, and a combination of structure of G³ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G³ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1478).

A compound according to Compound (2K) wherein R² represents a fluorineatom, Q represents Q1, and a combination of structure of G³ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G³ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1479).

A compound according to Compound (2K) wherein R² represents acyclopropyl group, Q represents Q1, and a combination of structure of G³and substituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to thestructure of G³ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1480).

A compound according to Compound (2K) wherein R² represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, and a combinationof structure of G³ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G³ represents any combination described inCombination B (hereinafter, referred to as Compound group SX1481).

A compound according to Compound (2K) wherein R² represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, and a combinationof structure of G³ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G³ represents any combination described inCombination B (hereinafter, referred to as Compound group SX1482).

A compound according to Compound (2K) wherein R² represents a methylgroup, Q represents Q2, L¹ represents NH, and a combination of structureof G³ and substituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to thestructure of G³ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1483).

A compound according to Compound (2K) wherein R² represents a chlorineatom, Q represents Q2, L¹ represents NH, and a combination of structureof G³ and substituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to thestructure of G³ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1484).

A compound according to Compound (2K) wherein R² represents a methylgroup, Q represents Q3, R³ represents a methoxy group, and a combinationof structure of G³ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G³ represents any combination described inCombination B (hereinafter, referred to as Compound group SX1485).

A compound according to Compound (2K) wherein R² represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, and a combinationof structure of G³ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G³ represents any combination described inCombination B (hereinafter, referred to as Compound group SX1486).

A compound according to Compound (2K) wherein R² represents a methylgroup, Q represents Q4, and a combination of structure of G³ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G³ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1487).

A compound according to Compound (2K) wherein R² represents a chlorineatom, Q represents Q4, and a combination of structure of G³ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G³ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1488).

A compound according to Compound (2K) wherein R² represents a methylgroup, Q represents Q5, and a combination of structure of G³ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G³ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1489).

A compound according to Compound (2K) wherein R² represents a chlorineatom, Q represents Q5, and a combination of structure of G³ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G³ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1490).

A compound according to Compound (2K) wherein R² represents a methylgroup, Q represents Q6, and a combination of structure of G³ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G³ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1491).

A compound according to Compound (2K) wherein R² represents a chlorineatom, Q represents Q6, and a combination of structure of G³ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G³ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1492).

A compound represented by formula (2L) (hereinafter, referred to asCompound (2L)):

wherein R² represents a methyl group, Q represents Q1, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1493).

A compound according to Compound (2L) wherein R² represents a chlorineatom, Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1494).

A compound according to Compound (2L) wherein R² represents a fluorineatom, Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1495).

A compound according to Compound (2L) wherein R² represents an ethylgroup, Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1496).

A compound according to Compound (2L) wherein R² represents a methoxygroup, Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1497).

A compound according to Compound (2L) wherein R² represents acyclopropyl group, Q represents Q1, and a combination of R^(X2), R^(X3),R^(X4), R^(X5) and R^(X6) represents any combination described inCombination A (hereinafter, referred to as Compound group SX1498).

A compound according to Compound (2L) wherein R² represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1499).

A compound according to Compound (2L) wherein R² represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1500).

A compound according to Compound (2L) wherein R² represents a methylgroup, Q represents Q2, L¹ represents NH, and a combination of R^(X2),R^(X3), R^(X4), R^(X5) and R^(X6) represents any combination describedin Combination A (hereinafter, referred to as Compound group SX1501).

A compound according to Compound (2L) wherein R² represents a chlorineatom, Q represents Q2, L¹ represents NH, and a combination of R^(X2),R^(X3), R^(X4), R^(X5) and R^(X6) represents any combination describedin Combination A (hereinafter, referred to as Compound group SX1502).

A compound according to Compound (2L) wherein R² represents a methylgroup, Q represents Q3, R³ represents a methoxy group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1503).

A compound according to Compound (2L) wherein R² represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1504).

A compound according to Compound (2L) wherein R² represents a methylgroup, Q represents Q4, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1505).

A compound according to Compound (2L) wherein R² represents a chlorineatom, Q represents Q4, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1506).

A compound according to Compound (2L) wherein R² represents a methylgroup, Q represents Q5, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1507).

A compound according to Compound (2L) wherein R² represents a chlorineatom, Q represents Q5, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1508).

A compound according to Compound (2L) wherein R² represents a methylgroup, Q represents Q6, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1509).

A compound according to Compound (2L) wherein R² represents a chlorineatom, Q represents Q6, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1510).

A compound represented by formula (2M) (hereinafter, referred to asCompound (2M)):

[wherein G³ represents any one of formulae G1 to G34.]wherein R² represents a methyl group, Q represents Q1, and a combinationof structure of G³ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G³ represents any combination described inCombination B (hereinafter, referred to as Compound group SX1511).

A compound according to Compound (2M) wherein R² represents a chlorineatom, Q represents Q1, and a combination of structure of G³ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G³ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1512).

A compound according to Compound (2M) wherein R² represents an ethylgroup, Q represents Q1, and a combination of structure of G³ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G³ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1513).

A compound according to Compound (2M) wherein R² represents a methoxygroup, Q represents Q1, and a combination of structure of G³ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G³ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1514).

A compound according to Compound (2M) wherein R² represents a fluorineatom, Q represents Q1, and a combination of structure of G³ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G³ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1515).

A compound according to Compound (2M) wherein R² represents acyclopropyl group, Q represents Q1, and a combination of structure of G³and substituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to thestructure of G³ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1516).

A compound according to Compound (2M) wherein R² represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, and a combinationof structure of G³ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G³ represents any combination described inCombination B (hereinafter, referred to as Compound group SX1517).

A compound according to Compound (2M) wherein R² represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, and a combinationof structure of G³ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G³ represents any combination described inCombination B (hereinafter, referred to as Compound group SX1518).

A compound according to Compound (2M) wherein R² represents a methylgroup, Q represents Q2, L¹ represents NH, and a combination of structureof G³ and substituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to thestructure of G³ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1519).

A compound according to Compound (2M) wherein R² represents a chlorineatom, Q represents Q2, L¹ represents NH, and a combination of structureof G³ and substituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to thestructure of G³ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1520).

A compound according to Compound (2M) wherein R² represents a methylgroup, Q represents Q3, R³ represents a methoxy group, and a combinationof structure of G³ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G³ represents any combination described inCombination B (hereinafter, referred to as Compound group SX1521).

A compound according to Compound (2M) wherein R² represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, and a combinationof structure of G³ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G³ represents any combination described inCombination B (hereinafter, referred to as Compound group SX1522).

A compound according to Compound (2M) wherein R² represents a methylgroup, Q represents Q4, and a combination of structure of G³ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G³ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1523).

A compound according to Compound (2M) wherein R² represents a chlorineatom, Q represents Q4, and a combination of structure of G³ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G³ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1524).

A compound according to Compound (2M) wherein R² represents a methylgroup, Q represents Q5, and a combination of structure of G³ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G³ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1525).

A compound according to Compound (2M) wherein R² represents a chlorineatom, Q represents Q5, and a combination of structure of G³ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G³ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1526).

A compound according to Compound (2M) wherein R² represents a methylgroup, Q represents Q6, and a combination of structure of G³ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G³ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1527).

A compound according to Compound (2M) wherein R² represents a chlorineatom, Q represents Q6, and a combination of structure of G³ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G³ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1528).

A compound represented by formula (2N) (hereinafter, referred to asCompound (2N)):

wherein R² represents a methyl group, Q represents Q1, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1529).

A compound according to Compound (2N) wherein R² represents a chlorineatom, Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1530).

A compound according to Compound (2N) wherein R² represents a fluorineatom, Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1531).

A compound according to Compound (2N) wherein R² represents an ethylgroup, Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1532).

A compound according to Compound (2N) wherein R² represents a methoxygroup, Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1533).

A compound according to Compound (2N) wherein R² represents acyclopropyl group, Q represents Q1, and a combination of R^(X2), R^(X3),R^(X4), R^(X5) and R^(X6) represents any combination described inCombination A (hereinafter, referred to as Compound group SX1534).

A compound according to Compound (2N) wherein R² represents a methylgroup, Q represents Q2, L¹ represents an oxygen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1535).

A compound according to Compound (2N) wherein R² represents a chlorineatom, Q represents Q2, L¹ represents an oxygen atom, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1536).

A compound according to Compound (2N) wherein R² represents a methylgroup, Q represents Q2, L¹ represents NH, and a combination of R^(X2),R^(X3), R^(X4), R^(X5) and R^(X6) represents any combination describedin Combination A (hereinafter, referred to as Compound group SX1537).

A compound according to Compound (2N) wherein R² represents a chlorineatom, Q represents Q2, L¹ represents NH, and a combination of R^(X2),R^(X3), R^(X4), R^(X5) and R^(X6) represents any combination describedin Combination A (hereinafter, referred to as Compound group SX1538).

A compound according to Compound (2N) wherein R² represents a methylgroup, Q represents Q3, R³ represents a methoxy group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1539).

A compound according to Compound (2N) wherein R² represents a chlorineatom, Q represents Q3, R³ represents a methoxy group, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1540).

A compound according to Compound (2N) wherein R² represents a methylgroup, Q represents Q4, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1541).

A compound according to Compound (2N) wherein R² represents a chlorineatom, Q represents Q4, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1542).

A compound according to Compound (2N) wherein R² represents a methylgroup, Q represents Q5, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1543).

A compound according to Compound (2N) wherein R² represents a chlorineatom, Q represents Q5, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1544).

A compound according to Compound (2N) wherein R² represents a methylgroup, Q represents Q6, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1545).

A compound according to Compound (2N) wherein R² represents a chlorineatom, Q represents Q6, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1546).

A compound represented by formula (20) (hereinafter, referred to asCompound (20)):

[wherein G³ represents any one of formulae G1 to G34.]wherein R¹ represents a methyl group, R² represents a methyl group, Qrepresents Q1, and a combination of structure of G³ and substituentsR^(X7), R^(X8), R^(X9) and R^(X10) applied to the structure of G³represents any combination described in Combination B (hereinafter,referred to as Compound group SX1547).

A compound according to Compound (20) wherein R¹ represents a methylgroup, R² represents a chlorine atom, Q represents Q1, and a combinationof structure of G³ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G³ represents any combination described inCombination B (hereinafter, referred to as Compound group SX1548).

A compound according to Compound (20) wherein R¹ represents a methylgroup, R² represents an ethyl group, Q represents Q1, and a combinationof structure of G³ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G³ represents any combination described inCombination B (hereinafter, referred to as Compound group SX1549).

A compound according to Compound (20) wherein R¹ represents a methylgroup, R² represents a methoxy group, Q represents Q1, and a combinationof structure of G³ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G³ represents any combination described inCombination B (hereinafter, referred to as Compound group SX1550).

A compound according to Compound (20) wherein R¹ represents a methylgroup, R² represents a fluorine atom, Q represents Q1, and a combinationof structure of G³ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G³ represents any combination described inCombination B (hereinafter, referred to as Compound group SX1551).

A compound according to Compound (20) wherein R¹ represents a methylgroup, R² represents a cyclopropyl group, Q represents Q1, and acombination of structure of G³ and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G³ represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1552).

A compound according to Compound (20) wherein R¹ represents a fluorineatom, R² represents a methyl group, Q represents Q1, and a combinationof structure of G³ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G³ represents any combination described inCombination B (hereinafter, referred to as Compound group SX1553).

A compound according to Compound (20) wherein R¹ represents a fluorineatom, R² represents a chlorine atom, Q represents Q1, and a combinationof structure of G³ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G³ represents any combination described inCombination B (hereinafter, referred to as Compound group SX1554).

A compound according to Compound (20) wherein R¹ represents a fluorineatom, R² represents an ethyl group, Q represents Q1, and a combinationof structure of G³ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G³ represents any combination described inCombination B (hereinafter, referred to as Compound group SX1555).

A compound according to Compound (20) wherein R¹ represents a fluorineatom, R² represents a methoxy group, Q represents Q1, and a combinationof structure of G³ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G³ represents any combination described inCombination B (hereinafter, referred to as Compound group SX1556).

A compound according to Compound (20) wherein R¹ represents a fluorineatom, R² represents a fluorine atom, Q represents Q1, and a combinationof structure of G³ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G³ represents any combination described inCombination B (hereinafter, referred to as Compound group SX1557).

A compound according to Compound (20) wherein R¹ represents a fluorineatom, R² represents a cyclopropyl group, Q represents Q1, and acombination of structure of G³ and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G³ represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1558).

A compound according to Compound (20) wherein R¹ represents a chlorineatom, R² represents a methyl group, Q represents Q1, and a combinationof structure of G³ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G³ represents any combination described inCombination B (hereinafter, referred to as Compound group SX1559).

A compound according to Compound (20) wherein R¹ represents a chlorineatom, R² represents a chlorine atom, Q represents Q1, and a combinationof structure of G³ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G³ represents any combination described inCombination B (hereinafter, referred to as Compound group SX1560).

A compound according to Compound (20) wherein R¹ represents a chlorineatom, R² represents an ethyl group, Q represents Q1, and a combinationof structure of G³ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G³ represents any combination described inCombination B (hereinafter, referred to as Compound group SX1561).

A compound according to Compound (20) wherein R¹ represents a chlorineatom, R² represents a methoxy group, Q represents Q1, and a combinationof structure of G³ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G³ represents any combination described inCombination B (hereinafter, referred to as Compound group SX1562).

A compound according to Compound (20) wherein R¹ represents a chlorineatom, R² represents a fluorine atom, Q represents Q1, and a combinationof structure of G³ and substituents R^(X7), R^(X8), R^(X9) and R^(X10)applied to the structure of G³ represents any combination described inCombination B (hereinafter, referred to as Compound group SX1563).

A compound according to Compound (20) wherein R¹ represents a chlorineatom, R² represents a cyclopropyl group, Q represents Q1, and acombination of structure of G³ and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G³ represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1564).

A compound represented by formula (2P) (hereinafter, referred to asCompound (2P)):

wherein R¹ represents a methyl group, R² represents a methyl group, Qrepresents Q1, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1565).

A compound according to Compound (2P) wherein R¹ represents a methylgroup, R² represents a chlorine atom, Q represents Q1, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1566).

A compound according to Compound (2P) wherein R¹ represents a methylgroup, R² represents a fluorine atom, Q represents Q1, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1567).

A compound according to Compound (2P) wherein R¹ represents a methylgroup, R² represents an ethyl group, Q represents Q1, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1568).

A compound according to Compound (2P) wherein R¹ represents a methylgroup, R² represents a methoxy group, Q represents Q1, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1569).

A compound according to Compound (2P) wherein R¹ represents a methylgroup, R² represents a cyclopropyl group, Q represents Q1, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX1570).

A compound according to Compound (2P) wherein R¹ represents a fluorineatom, R² represents a methyl group, Q represents Q1, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1571).

A compound according to Compound (2P) wherein R¹ represents a fluorineatom, R² represents a chlorine atom, Q represents Q1, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1572).

A compound according to Compound (2P) wherein R¹ represents a fluorineatom, R² represents a fluorine atom, Q represents Q1, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1573).

A compound according to Compound (2P) wherein R¹ represents a fluorineatom, R² represents an ethyl group, Q represents Q1, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1574).

A compound according to Compound (2P) wherein R¹ represents a fluorineatom, R² represents a methoxy group, Q represents Q1, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1575).

A compound according to Compound (2P) wherein R¹ represents a fluorineatom, R² represents a cyclopropyl group, Q represents Q1, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX1576).

A compound according to Compound (2P) wherein R¹ represents a chlorineatom, R² represents a methyl group, Q represents Q1, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1577).

A compound according to Compound (2P) wherein R¹ represents a chlorineatom, R² represents a chlorine atom, Q represents Q1, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1578).

A compound according to Compound (2P) wherein R¹ represents a chlorineatom, R² represents a fluorine atom, Q represents Q1, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1579).

A compound according to Compound (2P) wherein R¹ represents a chlorineatom, R² represents an ethyl group, Q represents Q1, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1580).

A compound according to Compound (2P) wherein R¹ represents a chlorineatom, R² represents a methoxy group, Q represents Q1, and a combinationof R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents any combinationdescribed in Combination A (hereinafter, referred to as Compound groupSX1581).

A compound according to Compound (2P) wherein R¹ represents a chlorineatom, R² represents a cyclopropyl group, Q represents Q1, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX1582).

A compound represented by formula (3A) (hereinafter, referred to asCompound (3A)):

wherein Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1583).

A compound according to Compound (3A) wherein Q represents Q2, L¹represents an oxygen atom, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1584).

A compound according to Compound (3A) wherein Q represents Q2, L¹represents NH, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1585).

A compound according to Compound (3A) wherein Q represents Q3, R³represents a methoxy group, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1586).

A compound according to Compound (3A) wherein Q represents Q4, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX1587).

A compound according to Compound (3A) wherein Q represents Q5, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX1588).

A compound according to Compound (3A) wherein Q represents Q6, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX1589).

A compound represented by formula (3B) (hereinafter, referred to asCompound (3B)):

[wherein A represents any one of groups represented by formulae AA1 toAA4.]wherein Q represents Q1, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX1590).

A compound according to Compound (3B) wherein Q represents Q2, L¹represents an oxygen atom, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX1591).

A compound according to Compound (3B) wherein Q represents Q2, L¹represents NH, and a combination of structure of A and substituentsR^(X11), R^(X12), R^(X13) and R^(X14) applied to the structure of Arepresents any combination described in Combination D (hereinafter,referred to as Compound group SX1592).

A compound according to Compound (3B) wherein Q represents Q3, R³represents a methoxy group, and a combination of structure of A andsubstituents R^(X11), R^(X12), R^(X13) and R^(X14) applied to thestructure of A represents any combination described in Combination D(hereinafter, referred to as Compound group SX1593).

A compound according to Compound (3B) wherein Q represents Q4, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX1594).

A compound according to Compound (3B) wherein Q represents Q5, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX1595).

A compound according to Compound (3B) wherein Q represents Q6, and acombination of structure of A and substituents R^(X11), R^(X12), R^(X13)and R^(X14) applied to the structure of A represents any combinationdescribed in Combination D (hereinafter, referred to as Compound groupSX1596).

A compound represented by formula (3C) (hereinafter, referred to asCompound (3C)):

[wherein G⁵ represents any one of formulae G1 to G35.]wherein Q represents Q1, and a combination of structure of G⁵ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G⁵ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1597).

A compound according to Compound (3C) wherein Q represents Q2, L¹represents an oxygen atom, and a combination of structure of G⁵ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G⁵ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1598).

A compound according to Compound (3C) wherein Q represents Q2, L¹represents NH, and a combination of structure of G⁵ and substituentsR^(X7), R^(X8), R^(X9) and R^(X10) applied to the structure of G⁵represents any combination described in Combination B (hereinafter,referred to as Compound group SX1599).

A compound according to Compound (3C) wherein Q represents Q3, R³represents a methoxy group, and a combination of structure of G⁵ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G⁵ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1600).

A compound according to Compound (3C) wherein Q represents Q4, and acombination of structure of G⁵ and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G⁵ represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1601).

A compound according to Compound (3C) wherein Q represents Q5, and acombination of structure of G⁵ and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G⁵ represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1602).

A compound according to Compound (3C) wherein Q represents Q6, and acombination of structure of G⁵ and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G⁵ represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1603).

A compound represented by formula (3D) (hereinafter, referred to asCompound (3D)):

wherein Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1604).

A compound according to Compound (3D) wherein Q represents Q2, L¹represents an oxygen atom, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1605).

A compound according to Compound (3D) wherein Q represents Q2, L¹represents NH, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1606).

A compound according to Compound (3D) wherein Q represents Q3, R³represents a methoxy group, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1607).

A compound according to Compound (3D) wherein Q represents Q4, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX1608).

A compound according to Compound (3D) wherein Q represents Q5, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX1609).

A compound according to Compound (3D) wherein Q represents Q6, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX1610).

A compound represented by formula (3E) (hereinafter, referred to asCompound (3E)):

[wherein G⁵ represents any one of formulae G1 to G34.]wherein Q represents Q1, and a combination of structure of G⁵ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G⁵ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1611).

A compound according to Compound (3E) wherein Q represents Q2, L¹represents an oxygen atom, and a combination of structure of G⁵ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G⁵ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1612).

A compound according to Compound (3E) wherein Q represents Q2, L¹represents NH, and a combination of structure of G⁵ and substituentsR^(X7), R^(X8), R^(X9) and R^(X10) applied to the structure of G⁵represents any combination described in Combination B (hereinafter,referred to as Compound group SX1613).

A compound according to Compound (3E) wherein Q represents Q3, R³represents a methoxy group, and a combination of structure of G⁵ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G⁵ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1614).

A compound according to Compound (3E) wherein Q represents Q4, and acombination of structure of G⁵ and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G⁵ represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1615).

A compound according to Compound (3E) wherein Q represents Q5, and acombination of structure of G⁵ and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G⁵ represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1616).

A compound according to Compound (3E) wherein Q represents Q6, and acombination of structure of G⁵ and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G⁵ represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1617).

A compound represented by formula (3F) (hereinafter, referred to asCompound (3F)):

wherein Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX161).

A compound according to Compound (3F) wherein Q represents Q2, L¹represents an oxygen atom, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1619).

A compound according to Compound (3F) wherein Q represents Q2, L¹represents NH, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1620).

A compound according to Compound (3F) wherein Q represents Q3, R³represents a methoxy group, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1621).

A compound according to Compound (3F) wherein Q represents Q4, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX1622).

A compound according to Compound (3F) wherein Q represents Q5, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX1623).

A compound according to Compound (3F) wherein Q represents Q6, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX1624).

A compound represented by formula (3G) (hereinafter, referred to asCompound (3G)):

wherein Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1625).

A compound according to Compound (3G) wherein Q represents Q2, L¹represents an oxygen atom, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1626).

A compound according to Compound (3G) wherein Q represents Q2, L¹represents NH, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1627).

A compound according to Compound (3G) wherein Q represents Q3, R³represents a methoxy group, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1628).

A compound according to Compound (3G) wherein Q represents Q4, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX1629).

A compound according to Compound (3G) wherein Q represents Q5, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX1630).

A compound according to Compound (3G) wherein Q represents Q6, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX1631).

A compound represented by formula (3H) (hereinafter, referred to asCompound (3H)):

wherein Q represents Q1, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1632).

A compound according to Compound (3H) wherein Q represents Q2, L¹represents an oxygen atom, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1633).

A compound according to Compound (3H) wherein Q represents Q2, L¹represents NH, and a combination of R^(X2), R^(X3), R^(X4), R^(X5) andR^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1634).

A compound according to Compound (3H) wherein Q represents Q3, R³represents a methoxy group, and a combination of R^(X2), R^(X3), R^(X4),R^(X5) and R^(X6) represents any combination described in Combination A(hereinafter, referred to as Compound group SX1635).

A compound according to Compound (3H) wherein Q represents Q4, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX1636).

A compound according to Compound (3H) wherein Q represents Q5, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX1637).

A compound according to Compound (3H) wherein Q represents Q6, and acombination of R^(X2), R^(X3), R^(X4), R^(X5) and R^(X6) represents anycombination described in Combination A (hereinafter, referred to asCompound group SX1638).

A compound represented by formula (3I) (hereinafter, referred to asCompound (3I)):

wherein Q represents Q1, and R⁴¹ represents any substituent selectedfrom Group Y (hereinafter, referred to as Compound group SX1639).

A compound according to Compound (3I) wherein Q represents Q2, L¹represents an oxygen atom, and R⁴¹ represents any substituent selectedfrom Group Y (hereinafter, referred to as Compound group SX1640).

A compound according to Compound (3I) wherein Q represents Q2, L¹represents NH, and R⁴¹ represents any substituent selected from Group Y(hereinafter, referred to as Compound group SX1641).

A compound according to Compound (3I) wherein Q represents Q3, R³represents a methoxy group, and R⁴¹ represents any substituent selectedfrom Group Y (hereinafter, referred to as Compound group SX1642).

A compound according to Compound (3I) wherein Q represents Q4, and R⁴¹represents any substituent selected from Group Y (hereinafter, referredto as Compound group SX1643).

A compound according to Compound (3I) wherein Q represents Q5, and R⁴¹represents any substituent selected from Group Y (hereinafter, referredto as Compound group SX1644).

A compound according to Compound (3I) wherein Q represents Q6, and R⁴¹represents any substituent selected from Group Y (hereinafter, referredto as Compound group SX1645).

A compound according to Compound (3I) wherein Q represents Q1, and R⁴¹represents any substituent selected from group Y2 (hereinafter, referredto as Compound group SX1646).

Group Y2: a group consisting of c-Pen, c-Hex, and2-cyclopropylcyclopropyl.

A compound according to Compound (3I) wherein Q represents Q2, L¹represents NH, and R⁴¹ represents any substituent selected from group Y2(hereinafter, referred to as Compound group SX1647).

A compound according to Compound (3I) wherein Q represents Q2, L¹represents an oxygen atom, and R⁴¹ represents any substituent selectedfrom group Y2 (hereinafter, referred to as Compound group SX1648).

A compound according to Compound (3I) wherein Q represents Q3, R³represents a methoxy group, and R⁴¹ represents any substituent selectedfrom group Y2 (hereinafter, referred to as Compound group SX1649).

A compound according to Compound (3I) wherein Q represents Q4, and R⁴¹represents any substituent selected from group Y2 (hereinafter, referredto as Compound group SX1650).

A compound according to Compound (3I) wherein Q represents Q5, and R⁴¹represents any substituent selected from group Y2 (hereinafter, referredto as Compound group SX1651).

A compound according to Compound (3I) wherein Q represents Q6, and R⁴¹represents any substituent selected from group Y2 (hereinafter, referredto as Compound group SX1652).

A compound according to Compound (3I) wherein Q represents Q7, L²represents an oxygen atom, and R⁴¹ represents any substituent selectedfrom group Y2 (hereinafter, referred to as Compound group SX1653).

A compound according to Compound (3I) wherein Q represents Q7, L²represents NH, and R⁴¹ represents any substituent selected from group Y2(hereinafter, referred to as Compound group SX1654).

A compound according to Compound (3I) wherein Q represents Q8A, and R⁴¹represents any substituent selected from group Y2 (hereinafter, referredto as Compound group SX1655).

A compound represented by formula (3J) (hereinafter, referred to asCompound (3J)):

wherein Q represents Q1, and R⁴⁶ represents any substituent selectedfrom group Y2 (hereinafter, referred to as Compound group SX1656).

A compound according to Compound (3J) wherein Q represents Q2, L¹represents NH, and R⁴⁶ represents any substituent selected from group Y2(hereinafter, referred to as Compound group SX1657).

A compound according to Compound (3J) wherein Q represents Q2, L¹represents an oxygen atom, and R⁴⁶ represents any substituent selectedfrom group Y2 (hereinafter, referred to as Compound group SX1658).

A compound according to Compound (3J) wherein Q represents Q3, R³represents a methoxy group, and R⁴⁶ represents any substituent selectedfrom group Y2 (hereinafter, referred to as Compound group SX1659).

A compound according to Compound (3J) wherein Q represents Q4, and R⁴⁶represents any substituent selected from group Y2 (hereinafter, referredto as Compound group SX1660).

A compound according to Compound (3J) wherein Q represents Q5, and R⁴⁶represents any substituent selected from group Y2 (hereinafter, referredto as Compound group SX1661).

A compound according to Compound (3J) wherein Q represents Q6, and R⁴⁶represents any substituent selected from group Y2 (hereinafter, referredto as Compound group SX1662).

A compound according to Compound (3J) wherein Q represents Q7, L²represents an oxygen atom, and R⁴⁶ represents any substituent selectedfrom group Y2 (hereinafter, referred to as Compound group SX1663).

A compound according to Compound (3J) wherein Q represents Q7, L²represents NH, and R⁴⁶ represents any substituent selected from group Y2(hereinafter, referred to as Compound group SX1664).

A compound according to Compound (3J) wherein Q represents Q8A, and R⁴⁶represents any substituent selected from group Y2 (hereinafter, referredto as Compound group SX1665).

A compound represented by formula (2Q) (hereinafter, referred to asCompound (2Q)):

wherein Q represents Q3, R³ represents a methoxy group, R¹ represents amethyl group, and a combination of R^(X21), R^(X22), R^(X23), R^(X24),R^(X25), R^(X26), R^(X27), R^(X28) and R^(X29) represents anycombination described in Combination L (hereinafter, referred to asCompound group SX1666).

Combination L consists of substituent numbers ZL1 to ZL30. Substituentnumbers ZL1 to ZL30 represent combinations of R^(X21), R^(X22), R^(X23),R^(X24), R^(X25), R^(X26), R^(X27), R^(X28) and R^(X29) according toCompound (2Q). And hereinafter, they are referred to as [substituentnumber; R^(X21), R^(X22), R^(X23), R^(X24), R^(X25), R^(X26), R^(X27),R^(X23), R^(X29)]. For example, the substituent number ZL2 refers to acombination wherein R^(X21) represents a methyl group, and each ofR^(X22), R^(X23), R^(X24), R^(X25), R^(X26), R^(X27), R^(X25) andR^(X29) represents a hydrogen atom.

-   -   Combination L: [ZL1;H,H,H,H,H,H,H,H,H],        [ZL2;Me,H,H,H,H,H,H,H,H], [ZL3;F,H,H,H,H,H,H,H,H],        [ZL4;Cl,H,H,H,H,H,H,H,H], [ZL5;H,F,F,H,H,H,H,H,H],        [ZL6;Me,F,F,H,H,H,H,H,H], [ZL7;F,F,F,H,H,H,H,H,H],        [ZL8;Cl,F,F,H,H,H,H,H,H], [ZL9;H,H,H,H,H,H,H,F,F],        [ZL10;Me,H,H,H,H,H,H,F,F], [ZL11;F,H,H,H,H,H,H,F,F],        [ZL12;Cl,H,H,H,H,H,H,F,F], [ZL13;H,Cl,Cl,H,H,H,H,H,H],        [ZL14;Me,Cl,Cl,H,H,H,H,H,H], [ZL15;F,Cl,Cl,H,H,H,H,H,H],        [ZL16;Cl,Cl,Cl,H,H,H,H,H,H], [ZL17; H,H,H,H,H,H,H,Cl,Cl],        [ZL18;Me,H,H,H,H,H,H,Cl,Cl], [ZL19;F,H, H,H,H,H,H,Cl,Cl],        [ZL20;Cl,H,H,H,H,H,H,Cl,Cl], [ZL21;H,H,H,F, F,H,H,H,H],        [ZL22;H,H,H,Me,Me,H,H,H,H], [ZL23;H,H,H,Cl,Cl,H,H,H,H],        [ZL24;H,H,H,i-Pr, H, H, H, H, H], [ZL25; H, H, H, CHF₂, H, H, H,        H, H], [ZL26; H, H, H, CF₃, H,H,H,H,H],        [ZL27;H,H,H,CN,H,H,H,H,H], [ZL28;H,H,H,OH,H,H,H,H, H],        [ZL29;H,H,H,OMe,H,H,H,H,H], [ZL30;H,H,H,OCHF₂,H,H,H,H,H]

A compound according to Compound (2Q) wherein Q represents Q3, R³represents a methoxy group, R¹ represents a chlorine atom, and acombination of R^(X21), R^(X22), R^(X23), R^(X24), R^(X25), R^(X26),R^(X27), R^(X28) and R^(X29) represents any combination described inCombination L (hereinafter, referred to as Compound group SX1667).

A compound according to Compound (2Q) wherein Q represents Q4, R¹represents a methyl group, and a combination of R^(X21), R^(X22),R^(X23), R^(X24), R^(X25), R^(X26), R^(X27), R^(X28) and R^(X29)represents any combination described in Combination L (hereinafter,referred to as Compound group SX1668).

A compound according to Compound (2Q) wherein Q represents Q4, R¹represents a chlorine atom, and a combination of R^(X21), R^(X22),R^(X23), R^(X24), R^(X25), R^(X26), R^(X27), R^(X28) and R^(X29)represents any combination described in Combination L (hereinafter,referred to as Compound group SX1669).

A compound according to Compound (2Q) wherein Q represents Q5, R¹represents a methyl group, and a combination of R^(X21), R^(X22),R^(X23), R^(X24), R^(X25), R^(X26), R^(X27), R^(X28) and R^(X29)represents any combination described in Combination L (hereinafter,referred to as Compound group SX1670).

A compound according to Compound (2Q) wherein Q represents Q5, R¹represents a chlorine atom, and a combination of R^(X21), R^(X22),R^(X23), R^(X24), R^(X25), R^(X26), R^(X27), R^(X28) and R^(X29)represents any combination described in Combination L (hereinafter,referred to as Compound group SX1671).

A compound according to Compound (2Q) wherein Q represents Q6, R¹represents a methyl group, and a combination of R^(X21), R^(X22),R^(X23), R^(X24), R^(X25), R^(X26), R^(X27), R^(X28) and R^(X29)represents any combination described in Combination L (hereinafter,referred to as Compound group SX1672).

A compound according to Compound (2Q) wherein Q represents Q6, R¹represents a chlorine atom, and a combination of R^(X2)1, R^(X22),R^(X23), R^(X24), R^(X25), R^(X26), R^(X27), R^(X28) and R^(X29)represents any combination described in Combination L (hereinafter,referred to as Compound group SX1673).

A compound according to Compound (2Q) wherein Q represents Q7, L²represents an oxygen atom, R¹ represents a methyl group, and acombination of R^(X21), R^(X22), R^(X23), R^(X24), R^(X25), R^(X26),R^(X27), R^(X28) and R^(X29) represents any combination described inCombination L (hereinafter, referred to as Compound group SX1674).

A compound according to Compound (2Q) wherein Q represents Q7, L²represents an oxygen atom, R¹ represents a chlorine atom, and acombination of R^(X21), R^(X22), R^(X23), R^(X24), R^(X25), R^(X26),R^(X27), R^(X28) and R^(X29) represents any combination described inCombination L (hereinafter, referred to as Compound group SX1675).

A compound according to Compound (2Q) wherein Q represents Q7, L²represents NH, R¹ represents a methyl group, and a combination ofR^(X21), R^(X22), R^(X23), R^(X24), R^(X25), R^(X26), R^(X27), R^(X28)and R^(X29) represents any combination described in Combination L(hereinafter, referred to as Compound group SX1676).

A compound according to Compound (2Q) wherein Q represents Q7, L²represents NH, R¹ represents a chlorine atom, and a combination ofR^(X21), R^(X22), R^(X23), R^(X24), R^(X25), R^(X26), R^(X27), R^(X28)and R^(X29) represents any combination described in Combination L(hereinafter, referred to as Compound group SX1677).

A compound according to Compound (2Q) wherein Q represents Q8A, R¹represents a methyl group, and a combination of R^(X21), R^(X22),R^(X23), R^(X24), R^(X25), R^(X26), R^(X27), R^(X28) and R^(X29)represents any combination described in Combination L (hereinafter,referred to as Compound group SX1678).

A compound according to Compound (2Q) wherein Q represents Q8A, R¹represents a chlorine atom, and a combination of R^(X21), R^(X22),R^(X23), R^(X24), R^(X25), R^(X26), R^(X27), R^(X28) and R^(X29)represents any combination described in Combination L (hereinafter,referred to as Compound group SX1679).

A compound represented by formula (2R) (hereinafter, referred to asCompound (2R)):

wherein Q represents Q3, R¹ represents a methyl group, R³ represents amethoxy group, and a combination of R^(X31), R^(X32), R^(X33), R^(X34),R^(X35), R^(X36) and R^(X37) represents any combination described inCombination M (hereinafter, referred to as Compound group SX1680).

Combination M consists of substituent numbers ZM1 to ZM20. Substituentnumbers ZM1 to ZM20 represent combinations of R^(X31), R^(X32), R^(X33),R^(X34), R^(X35), R^(X36) and R^(X37) according to Compound (2R). Andhereinafter, they are referred to as [substituent number; R^(X31),R^(X32), R^(X33), R^(X34), R^(X35), R^(X36), R^(X37)]. For example, thesubstituent number ZM2 refers to a combination wherein R^(X31)represents a methyl group, and each of R^(X32), R^(X33), R^(X34),R^(X35), R^(X36) and R^(X37) represents a hydrogen atom.

-   -   Combination M: [ZM1;H,H,H,H,H,H,H], [ZM2;Me,H,H,H,H,H,H],        [ZM3;F,H,H,H,H,H,H], [ZM4;Cl,H,H,H,H,H,H], [ZM5;H,F,F,H,H,H,H],        [ZM6;Me,F,F,H,H, H,H], [ZM7;F,F,F,H,H,H,H],        [ZM8;Cl,F,F,H,H,H,H], [ZM9;H,H,H,H, H,F,F],        [ZM10;Me,H,H,H,H,F,F], [ZM11;F,H,H,H,H,F,F], [ZM12;Cl,        H,H,H,H,F,F], [ZM13;H,Cl,Cl,H,H,H,H], [ZM14;Me,Cl,Cl,H,H,H,H],        [ZM15;F,Cl,Cl,H,H,H,H], [ZM16;Cl,Cl,Cl,H,H,H,H],        [ZM17;H,H,H,H,H,Cl,Cl], [ZM18;Me,H,H,H,H,Cl,Cl],        [ZM19;F,H,H,H,H,Cl,Cl], [ZM20;Cl,H,H,H,H,Cl,Cl]

A compound according to Compound (2R) wherein Q represents Q3, R¹represents a chlorine atom, R³ represents a methoxy group, and acombination of R^(X31), R^(X32), P^(X33), R^(X34), R^(X35), R^(X36) andR^(X37) represents any combination described in Combination M(hereinafter, referred to as Compound group SX1681).

A compound according to Compound (2R) wherein Q represents Q4, R¹represents a methyl group, and a combination of R^(X31), R^(X32),R^(X33), R^(X34), R^(X35), R^(X36) and R^(X37) represents anycombination described in Combination M (hereinafter, referred to asCompound group SX1682).

A compound according to Compound (2R) wherein Q represents Q4, R¹represents a chlorine atom, and a combination of R^(X31), R^(X32),R^(X33), R^(X34), R^(X35), R^(X36) and R^(X37) represents anycombination described in Combination M (hereinafter, referred to asCompound group SX1683).

A compound according to Compound (2R) wherein Q represents Q5, R¹represents a methyl group, and a combination of R^(X31), R^(X32),R^(X33), R^(X34), R^(X35), R^(X36) and R^(X37) represents anycombination described in Combination M (hereinafter, referred to asCompound group SX1684).

A compound according to Compound (2R) wherein Q represents Q5, R¹represents a chlorine atom, and a combination of R^(X31), R^(X32),R^(X33), R^(X34), R^(X35), R^(X36) and R^(X37) represents anycombination described in Combination M (hereinafter, referred to asCompound group SX1685).

A compound according to Compound (2R) wherein Q represents Q6, R¹represents a methyl group, and a combination of R^(X31), R^(X32),R^(X33), R^(X34), R^(X35), R^(X36) and R^(X37) represents anycombination described in Combination M (hereinafter, referred to asCompound group SX1686).

A compound according to Compound (2R) wherein Q represents Q6, R¹represents a chlorine atom, and a combination of R^(X31), R^(X32),R^(X33), R^(X34), R^(X35), R^(X36) and R^(X37) represents anycombination described in Combination M (hereinafter, referred to asCompound group SX1687).

A compound according to Compound (2R) wherein Q represents Q7, L²represents an oxygen atom, R¹ represents a methyl group, and acombination of R^(X31), R^(X32), R^(X33), R^(X34), R^(X35), R^(X36) andR^(X37) represents any combination described in Combination M(hereinafter, referred to as Compound group SX1688).

A compound according to Compound (2R) wherein Q represents Q7, L²represents an oxygen atom, R¹ represents a chlorine atom, and acombination of R^(X31), R^(X32), R^(X33), R^(X34), R^(X35), R^(X36) andR^(X37) represents any combination described in Combination M(hereinafter, referred to as Compound group SX1689).

A compound according to Compound (2R) wherein Q represents Q7, L²represents NH, R¹ represents a methyl group, and a combination ofR^(X31), R^(X32), R^(X33), R^(X34), R^(X35), R^(X36) and R^(X37)represents any combination described in Combination M (hereinafter,referred to as Compound group SX1690).

A compound according to Compound (2R) wherein Q represents Q7, L²represents NH, R¹ represents a chlorine atom, and a combination ofR^(X31), R^(X32), R^(X33), R^(X34), R^(X35), R^(X36) and R^(X37)represents any combination described in Combination M (hereinafter,referred to as Compound group SX1691).

A compound according to Compound (2R) wherein Q represents Q8A, R¹represents a methyl group, and a combination of R^(X31), R^(X32),R^(X33), R^(X34), R^(X35), R^(X36) and R^(X37) represents anycombination described in Combination M (hereinafter, referred to asCompound group SX1692).

A compound according to Compound (2R) wherein Q represents Q8A, R¹represents a chlorine atom, and a combination of R^(X31), R^(X32),R^(X33), R^(X34), R^(X35), R^(X36) and R^(X37) represents anycombination described in Combination M (hereinafter, referred to asCompound group SX1693).

A compound represented by formula (2S) (hereinafter, referred to asCompound (2S)):

[wherein G⁸ represents any one of formulae G36 to G42

wherein Q represents Q1, R¹ represents a methyl group, and a combinationof structure of G⁸ and substituents R^(Y1), R^(Y2) and R^(Y3) applied tothe structure of G⁸ represents any combination described in CombinationN (hereinafter, referred to as Compound group SX1694).

Combination N consists of substituent numbers ZN1 to ZN26. Substituentnumbers ZN1 to ZN26 represent combinations of structure of G⁸ andsubstituents of R^(Y1), R^(Y2) and R^(Y3) applied to the structure of G⁸according to compounds represented by Compound (2S). And hereinafter,they are referred to as [substituent number; G⁸, R^(Y1), R^(Y2),R^(Y3)]. For example, the substituent number ZN2 refers to a combinationwherein G⁸ represents G36, and each of R^(Y1) and R^(Y2) represents afluorine atom.

-   -   Combination N: [ZN1;G36,H,H,-], [ZN2;G36,F,F,-],        [ZN3;G36,Me,Me,-], [ZN4;G36, CHF₂,H, -], [ZN5;G36, CF₃,H, -],        [ZN6;G36, i-Pr,H,-], [ZN7;G36,CN,H, -], [ZN8;G36,OMe,H, -],        [ZN9;G36,OCHF₂,H,-], [ZN10;G37,Me,-,-], [ZN11;G37,Et,-,-],        [ZN12;G37,n-Pr,-,-], [ZN13;G38,Me,Me,NOMe], [ZN14;G38,Me,Me,O],        [ZN15;G38, H,H,NOMe], [ZN16;G38,H,H,O], [ZN17;G39,H,H,-],        [ZN18;G39,c-Pr,H,-], [ZN19;G39,Me,H,-], [ZN20;G39,Et,H,-],        [ZN21;G39,n-Pr,H,-], [ZN22;G39,i-Pr,H,-], [ZN23;G39,Ph,H,-],        [ZN24;G40,-,-,-], [ZN25;G41,-,-,-], [ZN26;G42,-,-,-]

A compound according to Compound (2S) wherein Q represents Q1, R¹represents a chlorine atom, and a combination of structure of G⁸ andsubstituents R^(Y1), R^(Y2) and R^(Y3) applied to the structure of G⁸represents any combination described in Combination N (hereinafter,referred to as Compound group SX1695).

A compound according to Compound (2S) wherein Q represents Q2, L¹represents an oxygen atom, R¹ represents a methyl group, and acombination of structure of G⁸ and substituents R^(Y1), R^(Y2) andR^(Y3) applied to the structure of G⁸ represents any combinationdescribed in Combination N (hereinafter, referred to as Compound groupSX1696).

A compound according to Compound (2S) wherein Q represents Q2, L¹represents an oxygen atom, R¹ represents a chlorine atom, and acombination of structure of G⁸ and substituents R^(Y1), R^(Y2) andR^(Y3) applied to the structure of G⁸ represents any combinationdescribed in Combination N (hereinafter, referred to as Compound groupSX1697).

A compound according to Compound (2S) wherein Q represents Q2, L¹represents NH, R¹ represents a methyl group, and a combination ofstructure of G⁸ and substituents R^(Y1), R^(Y2) and R^(Y3) applied tothe structure of G⁸ represents any combination described in CombinationN (hereinafter, referred to as Compound group SX1698).

A compound according to Compound (2S) wherein Q represents Q2, L¹represents NH, R¹ represents a chlorine atom, and a combination ofstructure of G⁸ and substituents R^(Y1), R^(Y2) and R^(Y3) applied tothe structure of G⁸ represents any combination described in CombinationN (hereinafter, referred to as Compound group SX1699).

A compound according to Compound (2S) wherein Q represents Q3, R¹represents a methyl group, R³ represents a methoxy group, and acombination of structure of G⁸ and substituents R^(Y1), R^(Y2) andR^(Y3) applied to the structure of G⁸ represents any combinationdescribed in Combination N (hereinafter, referred to as Compound groupSX1700).

A compound according to Compound (2S) wherein Q represents Q3, R¹represents a chlorine atom, R³ represents a methoxy group, and acombination of structure of G⁸ and substituents R^(Y1), R^(Y2) andR^(Y3) applied to the structure of G⁸ represents any combinationdescribed in Combination N (hereinafter, referred to as Compound groupSX1701).

A compound according to Compound (2S) wherein Q represents Q4, R¹represents a methyl group, and a combination of structure of G⁸ andsubstituents R^(Y1), R^(Y2) and R^(Y3) applied to the structure of G⁸represents any combination described in Combination N (hereinafter,referred to as Compound group SX1702).

A compound according to Compound (2S) wherein Q represents Q4, R¹represents a chlorine atom, and a combination of structure of G⁸ andsubstituents R^(Y1), R^(Y2) and R^(Y3) applied to the structure of G⁸represents any combination described in Combination N (hereinafter,referred to as Compound group SX1703).

A compound according to Compound (2S) wherein Q represents Q5, R¹represents a methyl group, and a combination of structure of G⁸ andsubstituents R^(Y1), R^(Y2) and R^(Y3) applied to the structure of G⁸represents any combination described in Combination N (hereinafter,referred to as Compound group SX1704).

A compound according to Compound (2S) wherein Q represents Q5, R¹represents a chlorine atom, and a combination of structure of G⁸ andsubstituents R^(Y1), R^(Y2) and R^(Y3) applied to the structure of G⁸represents any combination described in Combination N (hereinafter,referred to as Compound group SX1705).

A compound according to Compound (2S) wherein Q represents Q6, R¹represents a methyl group, and a combination of structure of G⁸ andsubstituents R^(Y1), R^(Y2) and R^(Y3) applied to the structure of G⁸represents any combination described in Combination N (hereinafter,referred to as Compound group SX1706).

A compound according to Compound (2S) wherein Q represents Q6, R¹represents a chlorine atom, and a combination of structure of G⁸ andsubstituents R^(Y1), R^(Y2) and R^(Y3) applied to the structure of G⁸represents any combination described in Combination N (hereinafter,referred to as Compound group SX1707).

A compound according to Compound (2S) wherein Q represents Q7, L²represents an oxygen atom, R¹ represents a methyl group, and acombination of structure of G⁸ and substituents R^(Y1), R^(Y2) andR^(Y3) applied to the structure of G⁸ represents any combinationdescribed in Combination N (hereinafter, referred to as Compound groupSX1708).

A compound according to Compound (2S) wherein Q represents Q7, L²represents an oxygen atom, R¹ represents a chlorine atom, and acombination of structure of G⁸ and substituents R^(Y1), R^(Y2) andR^(Y3) applied to the structure of G⁸ represents any combinationdescribed in Combination N (hereinafter, referred to as Compound groupSX1709).

A compound according to Compound (2S) wherein Q represents Q7, L²represents NH, R¹ represents a methyl group, and a combination ofstructure of G⁸ and substituents R^(Y1), R^(Y2) and R^(Y3) applied tothe structure of G⁸ represents any combination described in CombinationN (hereinafter, referred to as Compound group SX1710).

A compound according to Compound (2S) wherein Q represents Q7, L²represents NH, R¹ represents a chlorine atom, and a combination ofstructure of G⁸ and substituents R^(Y1), R^(Y2) and R^(Y3) applied tothe structure of G⁸ represents any combination described in CombinationN (hereinafter, referred to as Compound group SX1711).

A compound according to Compound (2S) wherein Q represents Q8A, R¹represents a methyl group, and a combination of structure of G⁸ andsubstituents R^(Y1), R^(Y2) and R^(Y3) applied to the structure of G⁸represents any combination described in Combination N (hereinafter,referred to as Compound group SX1712).

A compound according to Compound (2S) wherein Q represents Q8A, R¹represents a chlorine atom, and a combination of structure of G⁸ andsubstituents R^(Y1), R^(Y2) and R^(Y3) applied to the structure of G⁸represents any combination described in Combination N (hereinafter,referred to as Compound group SX1713).

A compound represented by formula (2T) (hereinafter, referred to asCompound (2T)):

[wherein G⁵ represents any one of formulae G1 to G35.]wherein Q represents Q1, and a combination of structure of G⁵ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G⁵ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1714).

A compound according to Compound (2T) wherein Q represents Q2, L¹represents an oxygen atom, and a combination of structure of G⁵ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G⁵ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1715).

A compound according to Compound (2T) wherein Q represents Q2, L¹represents NH, and a combination of structure of G⁵ and substituentsR^(X7), R^(X8), R^(X9) and R^(X10) applied to the structure of G⁵represents any combination described in Combination B (hereinafter,referred to as Compound group SX1716).

A compound according to Compound (2T) wherein Q represents Q3, R³represents a methoxy group, and a combination of structure of G⁵ andsubstituents R^(X7), R^(X8), R^(X9) and R^(X10) applied to the structureof G⁵ represents any combination described in Combination B(hereinafter, referred to as Compound group SX1717).

A compound according to Compound (2T) wherein Q represents Q4, and acombination of structure of G⁵ and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G⁵ represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1718).

A compound according to Compound (2T) wherein Q represents Q5, and acombination of structure of G⁵ and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G⁵ represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1719).

A compound according to Compound (2T) wherein Q represents Q6, and acombination of structure of G⁵ and substituents R^(X7), R^(X8), R^(X9)and R^(X10) applied to the structure of G⁵ represents any combinationdescribed in Combination B (hereinafter, referred to as Compound groupSX1720).

Next, specific examples of the Composition of the present invention areshown below. The present compound T refers to the present compound 4-1,4-6, 4-9, 4-12, 4-13, 4-14, 4-15, 4-17, 4-36, 4-38, 4-40, 4-54, 4-55,4-56, 4-57, 4-58, 4-74, 14-4, 14-6, 14-7, 14-8, 14-9, 14-10, 14-12,14-14, 14-35, 14-36, 14-37, 14-38, 14-39, 14-40, 14-41, 14-42 and 14-43.

-   -   Composition group MX1: a composition for controlling plant        diseases comprising any one of the present compound T and        picoxystrobin at a ratio of 0.1:1;    -   Composition group MX2: a composition for controlling plant        diseases comprising any one of the present compound T and        picoxystrobin at a ratio of 1:1;    -   Composition group MX3: a composition for controlling plant        diseases comprising any one of the present compound T and        picoxystrobin at a ratio of 10:1;    -   Composition group MX4: a composition for controlling plant        diseases comprising any one of the present compound T and        pyraclostrobin at a ratio of 0.1:1;    -   Composition group MX5: a composition for controlling plant        diseases comprising any one of the present compound T and        pyraclostrobin at a ratio of 1:1;    -   Composition group MX6: a composition for controlling plant        diseases comprising any one of the present compound T and        pyraclostrobin at a ratio of 10:1;    -   Composition group MX7: a composition for controlling plant        diseases comprising any one of the present compound T and        metyltetraprole at a ratio of 0.1:1;    -   Composition group MX8: a composition for controlling plant        diseases comprising any one of the present compound T and        metyltetraprole at a ratio of 1:1;    -   Composition group MX9: a composition for controlling plant        diseases comprising any one of the present compound T and        metyltetraprole at a ratio of 10:1;    -   Composition group MX10: a composition for controlling plant        diseases comprising any one of the present compound T and        fenpicoxamid at a ratio of 0.1:1;    -   Composition group MX11: a composition for controlling plant        diseases comprising any one of the present compound T and        fenpicoxamid at a ratio of 1:1;    -   Composition group MX12: a composition for controlling plant        diseases comprising any one of the present compound T and        fenpicoxamid at a ratio of 10:1;    -   Composition group MX13: a composition for controlling plant        diseases comprising any one of the present compound T and        florylpicoxamid at a ratio of 0.1:1;    -   Composition group MX14: a composition for controlling plant        diseases comprising any one of the present compound T and        florylpicoxamid at a ratio of 1:1;    -   Composition group MX15: a composition for controlling plant        diseases comprising any one of the present compound T and        florylpicoxamid at a ratio of 10:1;    -   Composition group MX16: a composition for controlling plant        diseases comprising any one of the present compound T and        fluxapyroxad at a ratio of 0.1:1;    -   Composition group MX17: a composition for controlling plant        diseases comprising any one of the present compound T and        fluxapyroxad at a ratio of 1:1;    -   Composition group MX18: a composition for controlling plant        diseases comprising any one of the present compound T and        fluxapyroxad at a ratio of 10:1;    -   Composition group MX19: a composition for controlling plant        diseases comprising any one of the present compound T and        benzovindiflupyr at a ratio of 0.1:1;    -   Composition group MX20: a composition for controlling plant        diseases comprising any one of the present compound T and        benzovindiflupyr at a ratio of 1:1;    -   Composition group MX21: a composition for controlling plant        diseases comprising any one of the present compound T and        benzovindiflupyr at a ratio of 10:1;    -   Composition group MX22: a composition for controlling plant        diseases comprising any one of the present compound T and        fluindapyr at a ratio of 0.1:1;    -   Composition group MX23: a composition for controlling plant        diseases comprising any one of the present compound T and        fluindapyr at a ratio of 1:1;    -   Composition group MX24: a composition for controlling plant        diseases comprising any one of the present compound T and        fluindapyr at a ratio of 10:1;    -   Composition group MX25: a composition for controlling plant        diseases comprising any one of the present compound T and        pydiflumetofen at a ratio of 0.1:1;    -   Composition group MX26: a composition for controlling plant        diseases comprising any one of the present compound T and        pydiflumetofen at a ratio of 1:1;    -   Composition group MX27: a composition for controlling plant        diseases comprising any one of the present compound T and        pydiflumetofen at a ratio of 10:1;    -   Composition group MX28: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazol-4-carboxamide        at a ratio of 0.1:1;    -   Composition group MX29: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazol-4-carboxamide        at a ratio of 1:1;    -   Composition group MX30: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazol-4-carboxamide        at a ratio of 10:1;    -   Composition group MX31: a composition for controlling plant        diseases comprising any one of the present compound T and the        compound represented by formula (1) at a ratio of 0.1:1;    -   Composition group MX32: a composition for controlling plant        diseases comprising any one of the present compound T and the        compound represented by formula (1) at a ratio of 1:1;    -   Composition group MX33: a composition for controlling plant        diseases comprising any one of the present compound T and the        compound represented by formula (1) at a ratio of 10:1;    -   Composition group MX34: a composition for controlling plant        diseases comprising any one of the present compound T and the        compound represented by formula (2) at a ratio of 0.1:1;    -   Composition group MX35: a composition for controlling plant        diseases comprising any one of the present compound T and the        compound represented by formula (2) at a ratio of 1:1;    -   Composition group MX36: a composition for controlling plant        diseases comprising any one of the present compound T and the        compound represented by formula (2) at a ratio of 10:1;    -   Composition group MX37: a composition for controlling plant        diseases comprising any one of the present compound T and the        compound represented by formula (3) at a ratio of 0.1:1;    -   Composition group MX38: a composition for controlling plant        diseases comprising any one of the present compound T and the        compound represented by formula (3) at a ratio of 1:1;    -   Composition group MX39: a composition for controlling plant        diseases comprising any one of the present compound T and the        compound represented by formula (3) at a ratio of 10:1;    -   Composition group MX40: a composition for controlling plant        diseases comprising any one of the present compound T and        mefentrifluconazole at a ratio of 0.1:1;    -   Composition group MX41: a composition for controlling plant        diseases comprising any one of the present compound T and        mefentrifluconazole at a ratio of 1:1;    -   Composition group MX42: a composition for controlling plant        diseases comprising any one of the present compound T and        mefentrifluconazole at a ratio of 10:1;    -   Composition group MX43: a composition for controlling plant        diseases comprising any one of the present compound T and        prothioconazole at a ratio of 0.1:1;    -   Composition group MX44: a composition for controlling plant        diseases comprising any one of the present compound T and        prothioconazole at a ratio of 1:1;    -   Composition group MX45: a composition for controlling plant        diseases comprising any one of the present compound T and        prothioconazole at a ratio of 10:1.    -   Composition group MX46: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(2-methylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate at a        ratio of 0.1:1.    -   Composition group MX47: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(2-methylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate at a        ratio of 1:1.    -   Composition group MX48: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(2-methylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate at a        ratio of 10:1.    -   Composition group MX49: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(4-fluoro-2-methylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate at a        ratio of 0.1:1.    -   Composition group MX50: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(4-fluoro-2-methylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate at a        ratio of 1:1.    -   Composition group MX51: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(4-fluoro-2-methylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate at a        ratio of 10:1.    -   Composition group MX52: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(4-methoxy-2-methylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate at a        ratio of 0.1:1.    -   Composition group MX53: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(4-methoxy-2-methylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate at a        ratio of 1:1.    -   Composition group MX54: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(4-methoxy-2-methylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate at a        ratio of 10:1.    -   Composition group MX55: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(2,4-dimethylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate at a        ratio of 0.1:1.    -   Composition group MX56: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(2,4-dimethylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate at a        ratio of 1:1.    -   Composition group MX57: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(2,4-dimethylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate at a        ratio of 10:1.    -   Composition group MX58: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(2-methylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate        at a ratio of 0.1:1.    -   Composition group MX59: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(2-methylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate        at a ratio of 1:1.    -   Composition group MX60: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(2-methylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate        at a ratio of 10:1.    -   Composition group MX61: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(4-fluoro-2-methylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate        at a ratio of 0.1:1.    -   Composition group MX62: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(4-fluoro-2-methylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate        at a ratio of 1:1.    -   Composition group MX63: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(4-fluoro-2-methylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate        at a ratio of 10:1.    -   Composition group MX64: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(4-methoxy-2-methylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate        at a ratio of 0.1:1.    -   Composition group MX65: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(4-methoxy-2-methylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate        at a ratio of 1:1.    -   Composition group MX66: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(4-methoxy-2-methylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate        at a ratio of 10:1.    -   Composition group MX67: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(2,4-dimethylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate        at a ratio of 0.1:1.    -   Composition group MX68: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(2,4-dimethylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate        at a ratio of 1:1.    -   Composition group MX69: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(2,4-dimethylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate        at a ratio of 10:1.    -   Composition group MX70: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(2-methylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate at a        ratio of 0.1:1.    -   Composition group MX71: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(2-methylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate at a        ratio of 1:1.    -   Composition group MX72: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(2-methylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate at a        ratio of 10:1.    -   Composition group MX73: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(4-fluoro-2-methylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate at a        ratio of 0.1:1.    -   Composition group MX74: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(4-fluoro-2-methylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate at a        ratio of 1:1.    -   Composition group MX75: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(4-fluoro-2-methylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate at a        ratio of 10:1.    -   Composition group MX76: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(4-methoxy-2-methylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate at a        ratio of 0.1:1.    -   Composition group MX77: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(4-methoxy-2-methylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate at a        ratio of 1:1.    -   Composition group MX78: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(4-methoxy-2-methylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate at a        ratio of 10:1.    -   Composition group MX79: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(2,4-dimethylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate at a        ratio of 0.1:1.    -   Composition group MX80: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(2,4-dimethylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate at a        ratio of 1:1.    -   Composition group MX81: a composition for controlling plant        diseases comprising any one of the present compound T and        3-(2,4-dimethylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate at a        ratio of 10:1.    -   Composition group MX82: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(2-methylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate at a        ratio of 0.1:1.    -   Composition group MX83: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(2-methylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate at a        ratio of 1:1.    -   Composition group MX84: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(2-methylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate at a        ratio of 10:1.    -   Composition group MX85: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(4-fluoro-2-methylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate at a        ratio of 0.1:1.    -   Composition group MX86: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(4-fluoro-2-methylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate at a        ratio of 1:1.    -   Composition group MX87: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(4-fluoro-2-methylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate at a        ratio of 10:1.    -   Composition group MX88: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(4-methoxy-2-methylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate at a        ratio of 0.1:1.    -   Composition group MX89: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(4-methoxy-2-methylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate at a        ratio of 1:1.    -   Composition group MX90: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(4-methoxy-2-methylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate at a        ratio of 10:1.    -   Composition group MX91: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(2,4-dimethylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate at a        ratio of 0.1:1.    -   Composition group MX92: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(2,4-dimethylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate at a        ratio of 1:1.    -   Composition group MX93: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(2,4-dimethylphenyl)butan-2-yl        N-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate at a        ratio of 10:1.    -   Composition group MX94: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(2-methylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)-L-alaninate        at a ratio of 0.1:1.    -   Composition group MX95: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(2-methylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)-L-alaninate        at a ratio of 1:1.    -   Composition group MX96: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(2-methylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)-L-alaninate        at a ratio of 10:1.    -   Composition group MX97: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(4-fluoro-2-methylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)-L-alaninate        at a ratio of 0.1:1.    -   Composition group MX98: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(4-fluoro-2-methylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)-L-alaninate        at a ratio of 1:1.    -   Composition group MX99: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(4-fluoro-2-methylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)-L-alaninate        at a ratio of 10:1.    -   Composition group MX100: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(4-methoxy-2-methylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)-L-alaninate        at a ratio of 0.1:1.    -   Composition group MX101: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(4-methoxy-2-methylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)-L-alaninate        at a ratio of 1:1.    -   Composition group MX102: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(4-methoxy-2-methylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)-L-alaninate        at a ratio of 10:1.    -   Composition group MX103: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(2,4-dimethylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)-L-alaninate        at a ratio of 0.1:1.    -   Composition group MX104: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(2,4-dimethylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)-L-alaninate        at a ratio of 1:1.    -   Composition group MX105: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(2,4-dimethylphenyl)butan-2-yl        N-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)-L-alaninate        at a ratio of 10:1.    -   Composition group MX106: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(2-methylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate at a        ratio of 0.1:1.    -   Composition group MX107: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(2-methylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate at a        ratio of 1:1.    -   Composition group MX108: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(2-methylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate at a        ratio of 10:1.    -   Composition group MX109: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(4-fluoro-2-methylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate at a        ratio of 0.1:1.    -   Composition group MX110: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(4-fluoro-2-methylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate at a        ratio of 1:1.    -   Composition group MX111: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(4-fluoro-2-methylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate at a        ratio of 10:1.    -   Composition group MX112: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(4-methoxy-2-methylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate at a        ratio of 0.1:1.    -   Composition group MX113: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(4-methoxy-2-methylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate at a        ratio of 1:1.    -   Composition group MX114: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(4-methoxy-2-methylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate at a        ratio of 10:1.    -   Composition group MX115: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(2,4-dimethylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate at a        ratio of 0.1:1.    -   Composition group MX116: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(2,4-dimethylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate at a        ratio of 1:1.    -   Composition group MX117: a composition for controlling plant        diseases comprising any one of the present compound T and        (2S,3S)-3-(2,4-dimethylphenyl)butan-2-yl        N-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]-L-alaninate at a        ratio of 10:1.

Next, the formulation examples of the compounds described herein areshown below. In the formulation examples, the “parts” represents “partby weight” unless otherwise specified. The present compound S representsthe compounds described in the Compound Classes SX1 to SX1720.

Formulation Example 1

Fifty (50) parts of any one of the present compound S, 3 parts ofcalcium lignin sulfonate, 2 parts of sodium lauryl sulfate, and 45 partsof wet silica are well mixed-grinding to obtain a formulation.

Formulation Exmaple 2

Twenty (20) parts of any one of the present compound S, 1.5 parts ofsorbitan trioleate are mixed with 28.5 parts of an aqueous solutioncontaining 2 parts of polyvinyl alcohol, and the mixture is thenfinely-ground by a wet grinding method. To the mixture is then added 40parts of an aqueous solution containing 0.05 parts of xanthan gum and0.1 parts of magnesium aluminum silicate, and 10 parts of propyleneglycol is further added thereto. The mixture is stirred to obtain aformulation.

Formulation Example 3

Two (2) parts of any one of the present compound S, 88 parts of kaolinclay and 10 parts of talc are mixed-grinding to obtain a formulation.

Formulation Example 4

Five (5) parts of any one of the present compound S, 14 parts ofpolyoxyethylene styryl phenyl ether, 6 parts of calcium dodecylbenzenesulfonate and 75 parts of xylene are well mixed to obtain a formulation.

Formulation Example 5

Five (5) parts of any one of the present compound S, 1 part of wetsilica, 2 parts of calcium lignosulfonate, 30 parts of bentonite and 65parts of kaolin clay are mixed-grinding, and thereto is added water, andthe mixture is well kneaded and is then granulated and dried to obtain aformulation.

Formulation Example 6

Thirty five (35) parts of a mixture of ammonium polyoxyethylene alkylether sulfate and wet silica (weight ratio: 1:1), 20 parts of any one ofthe present compound S, and 45 parts of water are well mixed to obtain aformulation.

Next, the formulation examples of the comositions of the presentinvention are shown below. In the formulation examples, the “parts”represents “part by weight” unless otherwise specified. The compound MXrepresents the compositions described in the Composition Classes MX1 toMX45.

Formulation Example A1

Fifty (50) parts of any one of the composition MX, 3 parts of calciumlignin sulfonate, 2 parts of sodium lauryl sulfate, and 45 parts of wetsilica are well mixed-grinding to obtain a formulation.

Formulation Exmaple A2

Twenty (20) parts of any one of the composition MX, 1.5 parts ofsorbitan trioleate are mixed with 28.5 parts of an aqueous solutioncontaining 2 parts of polyvinyl alcohol, and the mixture is thenfinely-ground by a wet grinding method. To the mixture is then added 40parts of an aqueous solution containing 0.05 parts of xanthan gum and0.1 parts of magnesium aluminum silicate, and 10 parts of propyleneglycol is further added thereto. The mixture is stirred to obtain aformulation.

Formulation Example A3

Two (2) parts of any one of the composition MX, 88 parts of kaolin clayand 10 parts of talc are mixed-grinding to obtain a formulation.

Formulation Example A4

Five (5) parts of any one of the composition MX, 14 parts ofpolyoxyethylene styryl phenyl ether, 6 parts of calcium dodecylbenzenesulfonate and 75 parts of xylene are well mixed to obtain a formulation.

Formulation Example A5

Five (5) parts of any one of the composition MX, 1 part of wet silica, 2parts of calcium lignosulfonate, 30 parts of bentonite and 65 parts ofkaolin clay are mixed-grinding, and thereto is added water, and themixture is well kneaded and is then granulated and dried to obtain aformulation.

Formulation Example A6

Thirty five (35) parts of a mixture of ammonium polyoxyethylene alkylether sulfate and wet silica (weight ratio: 1:1), 20 parts of any one ofthe composition MX, and 45 parts of water are well mixed to obtain aformulation.

Next, Test Examples of the compounds described herein are described.

Test Example 1

Soybean leaf (cv; Kurosengoku) was punched out to 1 cm diameter toprepare a leaf disk. Each 1 mL of an agar medium (agar concentration1.2%) was dispensed in 24 well microplate. A piece of the leaf disk wasplaced on each well. To a mixture of 0.5 μL of Sorpol (registeredtrademark) 1200KX, 4.5 μL of DMSO, and 5 μL of xylene was added 20 μL ofa solution containing 10000 ppm of the test compound in DMSO. Theresulting mixture was diluted with ion exchange water to prepare a spraysolution containing a predetermined concentration of the test compound.The spray solution was sprayed in 10 μL per one leaf disk. After 1 day,an aqueous suspension of spores of soybean rust fungus (Phakopsorapachyrhizi) having an amino acid substitution of F129L on mitochondrialcytochrome b protein (1.0×10⁵/mL) was inoculated onto the leaf disks.After the inoculation, the microplate was placed in a growth chamber(light on for 6 hours, light off for 18 hours, 23° C. temperature, 60%humidity). After 1 day, the leaf disks were air-dried to disappear waterdroplets on the surface of the leaf disk, and the microplate was placedagain in the growth chamber for 12 days. Thereafter, a lesion area ofsoybean rust disease was assessed. As a result, in all cases, the lesionareas of the leaf disk on which any one of the present compounds 1-1,1-2, 2-2, 2-4, 2-7, 2-8, 2-9, 2-10, 4-1, 4-2, 4-3, 4-4, 4-6, 4-8, 4-9,4-10, 9-4, 9-6, 2-3, 2-5, 3-1, 3-2, 4-12, 4-13, 4-14, 4-15, 4-17, 4-27,4-36, 4-37, 4-38, 4-39, 4-40, 4-41, 4-43, 4-44, 4-45, 4-46, 4-47, 4-48,5-1, 10-1, 10-2, 11-2, 11-18, 12-1, 12-2, 13-1, 13-2, 13-3, 13-4, 14-1,14-3, 1A-1, 1A-2, 1A-3, 2A-1, 1-3, 1-4, 1-5, 1-6, 1-8, 1-9, 1-10, 2-12,2-14, 4-21, 4-22, 4-24, 4-28, 4-29, 4-42, 4-59, 4-60, 4-61, 4-62, 4-63,4-64, 4-65, 4-66, 4-67, 4-68, 4-69, 4-70, 4-73, 4-74, 4-76, 4-78, 4-79,4-80, 4-81, 5-2, 9-5, 10-4, 12-3, 14-4, 14-5, 14-6, 14-7, 14-8, 14-9,14-10, 14-11, 14-12, 14-13, 14-14, 14-17, 14-25, 14-26, 14-27, 14-28,14-29, 14-30, 14-31, 14-32, 14-33, 14-34, 14-44, 2A-4, 3A-1 or 4A-1 wasapplied as a test compound at 50 ppm was shown to 30% or less of thelesion area of the untreated leaf disk. Here the untreated means thatthe spray solution containing the test compound was not sprayed onto theleaf disk.

Comparative Test Example 1

The test was conducted by using as a test compound the present compound1-1, 1-2, 2-2, 2-4, 2-8, 4-2, 4-3, 14-6, or 14-8, or pyraclostrobin,azoxystrobin, picoxystrobin, orysastrobin, dimoxystrobin,metominostrobin, or pyribencarb at 12.55 ppm or 3.1 ppm according to amethod described in the Test Example 1. The results are indicated in[Table A], and [Table B].

TABLE A Lesion Area at each of Compound concentrations (%) No.Structural formula 12.5 ppm 3.1 ppm 1-1

0 10 1-2

0 10 2-2

10 30 2-4

0 10 2-8

0 10 4-2

0 0 4-3

0 0 14-6 

0 10 14-8 

0 10

TABLE B Lesion Area at each of concentrations (%) Compound 12.5 ppm 3.1ppm

100 100

100 100

100 100

100 100

100 100

100 100

100 100

The above-indicated results suggests that the present compound hassuperior efficacies for soybean rust fungus having an amino acidsubstitution of F129L in comparison with various commercially availableQoI fungicides.

Next, the below-described test examples shows that the composition ofthe present invention is useful for controlling plant diseases.

Test Example B1

Control Test Against Soybean Rust Disease (Phakopsora pachyrhizi)

Soybean leaf (cv; Kurosengoku) was punched out to 1 cm diameter toprepare a leaf disk. Each 1 mL of an agar medium (agar concentration1.2%) was dispensed in 24 well microplate. A piece of the leaf disk wasplaced on each well. To a mixture of 1.0 μL of Sorpol (registeredtrademark) 1200KX, 4.5 μL of DMSO, and 5 μL of xylene was added 20 μL ofa solution containing a predetermined concentration of a compoundselected from the present compound T or 20 μL of a solution containing apredetermined concentration of the present compound B. The resultingmixture was diluted with ion exchange water to prepare a spray solutioncontaining a predetermined concentration of the test compound. The agentsolution was sprayed in 10 μL per one leaf disk. After 1 day, an aqueoussuspension of spores of soybean rust fungus (Phakopsora pachyrhizi)(1.0×10⁵/mL) was inoculated onto the leaf disks. After the inoculation,the microplate was placed in a growth chamber (light on for 6 hours,light off for 18 hours, 23° C. temperature, 60% humidity). After 1 day,the leaf disks were air-dried to disappear water droplets on the surfaceof the leaf disk, and the microplate was placed again in the growthchamber for 12 days (which was “treated area”). Thereafter, a lesionarea of soybean rust disease was assessed.

Control effect was calculated by the following “Equation 4” from theratio of the lesion area of the incidence of disease in the treated areaand the ratio of the lesion area of the incidence of disease in thenon-treated area.

Control effect=100×(X−Y)/X  “Equation 4”

-   -   X: Ratio of the lesion area of the incidence of disease in the        non-treated area    -   Y: Ratio of the lesion area of the incidence of disease in the        treated area

Here the non-treated area represents an area wherein the same proceduresare taken except for using the present compound T and the presentcompound B.

The results are shown in [Table B1] to [Table B19].

TABLE B1 Conc. Control Present composition (ppm) Effect Present compound4-40 + benzovindiflupyr 10 + 10 100 Present compound 4-40 +benzovindiflupyr  3 + 30 100 Present compound 4-40 + benzovindiflupyr10 + 1  100 Present compound 4-40 +3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 10 100trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4- carboxamide Presentcompound 4-40 + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-  3 + 30 100trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4- carboxamide Presentcompound 4-40 + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 1  100trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4- carboxamide Presentcompound 4-40 + fluindapyr 10 + 10 100 Present compound 4-40 +fluindapyr  3 + 30 100 Present compound 4-40 + fluindapyr 10 + 1  100Present compound 4-40 + fluxapyroxad 10 + 10 100 Present compound 4-40 +fluxapyroxad  3 + 30 100 Present compound 4-40 + fluxapyroxad 10 + 1 100 Present compound 4-40 + Compound of formula (1) 10 + 10 100 Presentcompound 4-40 + Compound of formula (1)  3 + 30 100 Present compound4-40 + Compound of formula (1) 10 + 1  100 Present compound 4-40 +Compound of formula (2) 10 + 10 100 Present compound 4-40 + Compound offormula (2)  3 + 30 100 Present compound 4-40 + Compound of formula (2)10 + 1  100 Present compound 4-40 + Compound of formula (3) 10 + 10 100Present compound 4-40 + Compound of formula (3)  3 + 30 100 Presentcompound 4-40 + Compound of formula (3) 10 + 1  100 Present compound4-40 + pyraclostrobin 10 + 10 100 Present compound 4-40 + pyraclostrobin 5 + 50 100 Present compound 4-40 + pyraclostrobin 10 + 1  100 Presentcompound 4-40 + picoxystrobin 10 + 10 100 Present compound 4-40 +picoxystrobin  5 + 50 100 Present compound 4-40 + picoxystrobin 10 + 1 100 Present compound 4-40 + prothioconazole 10 + 10 100 Present compound4-40 prothioconazole  5 + 50 100 Present compound 4-40 prothioconazole30 + 10 100 Present compound 4-40 + fenpicoxamid 10 + 10 100 Presentcompound 4-40 + fenpicoxamid  5 + 50 100 Present compound 4-40 +fenpicoxamid 30 + 10 100 Present compound 4-40 + florylpicoxamid 10 + 10100 Present compound 4-40 + florylpicoxamid  5 + 50 100 Present compound4-40 + florylpicoxamid 30 + 10 100 Present compound 4-40 +3-(2-methylphenyl)butan-2-yl N-[(3-hydroxy-4- 10 + 10 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-40 +3-(2-methylphenyl)butan-2-yl N-[(3-hydroxy-4-  5 + 50 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-40 +3-(2-methylphenyl)butan-2-yl N-[(3-hydroxy-4- 10 + 1  100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-40 +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4- 10 + 10 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-40 +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4-  5 + 50 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-40 +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4- 10 + 1  100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-40 +3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2- 10 + 10 100methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninate Presentcompound 4-40 + 3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2-  5 + 50100 methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninatePresent compound 4-40 + 3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2-10 + 1  100 methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate Present compound 4-40 +3-(4-methoxy-2-methylphenyl)butan-2-yl N-[(3- 10 + 10 100hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-40 +3-(4-methoxy-2-methylphenyl)butan-2-yl N-[(3-  5 + 50 100hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-40 +3-(4-methoxy-2-methylphenyl)butan-2-yl N-[(3- 10 + 1  100hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate

TABLE B2 Conc. Control Present composition (ppm) Effect Present compound4-17 + benzovindiflupyr 10 + 10 100 Present compound 4-17 +benzovindiflupyr  3 + 30 100 Present compound 4-17 + benzovindiflupyr10 + 1  100 Present compound 4-17 +3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 10 100trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4- carboxamide Presentcompound 4-17 + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-  3 + 30 100trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4- carboxamide Presentcompound 4-17 + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 1  100trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4- carboxamide Presentcompound 4-17 + fluindapyr 10 + 10 100 Present compound 4-17 +fluindapyr  3 + 30 100 Present compound 4-17 + fluindapyr 10 + 1  100Present compound 4-17 + fluxapyroxad 10 + 10 100 Present compound 4-17 +fluxapyroxad  3 + 30 100 Present compound 4-17 + fluxapyroxad 10 + 1 100 Present compound 4-17 + Compound of formula(1) 10 + 10 100 Presentcompound 4-17 + Compound of formula(1)  3 + 30 100 Present compound4-17 + Compound of formula(1) 10 + 1  100 Present compound 4-17 +Compound of formula(2) 10 + 10 100 Present compound 4-17 + Compound offormula(2)  3 + 30 100 Present compound 4-17 + Compound of formula(2)10 + 1  100 Present compound 4-17 + Compound of formula(3) 10 + 10 100Present compound 4-17 + Compound of formula(3)  3 + 30 100 Presentcompound 4-17 + Compound of formula(3) 10 + 1  100 Present compound4-17 + pyraclostrobin 10 + 10 100 Present compound 4-17 + pyraclostrobin 5 + 50 100 Present compound 4-17 + pyraclostrobin 10 + 1  100 Presentcompound 4-17 + picoxystrobin 10 + 10 100 Present compound 4-17 +picoxystrobin  5 + 50 100 Present compound 4-17 + picoxystrobin 10 + 1 100 Present compound 4-17 + prothioconazole 10 + 10 100 Present compound4-17 + prothioconazole  5 + 50 100 Present compound 4-17 +prothioconazole 30 + 10 100 Present compound 4-17 + fenpicoxamid 10 + 10100 Present compound 4-17 + fenpicoxamid  5 + 50 100 Present compound4-17 + fenpicoxamid 30 + 10 100 Present compound 4-17 + florylpicoxamid10 + 10 100 Present compound 4-17 + florylpicoxamid  5 + 50 100 Presentcompound 4-17 + florylpicoxamid 30 + 10 100 Present compound 4-17 +3-(2-methylphenyl)butan-2-yl N-[(3-hydroxy-4- 10 + 10 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-17 +3-(2-methylphenyl)butan-2-yl N-[(3-hydroxy-4-  5 + 50 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-17 +3-(2-methylphenyl)butan-2-yl N-[(3-hydroxy-4- 10 + 1  100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-17 +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4- 10 + 10 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-17 +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4-  5 + 50 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-17 +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4- 10 + 1  100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-17 +3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2- 10 + 10 100methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninate Presentcompound 4-17 + 3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2-  5 + 50100 methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninatePresent compound 4-17 + 3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2-10 + 1  100 methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate Present compound 4-17 +3-(4-methoxy-2-methylphenyl)butan-2-yl N-[(3- 10 + 10 100hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-17 +3-(4-methoxy-2-methylphenyl)butan-2-yl N-[(3-  5 + 50 100hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-17 +3-(4-methoxy-2-methylphenyl)butan-2-yl N-[(3- 10 + 1  100hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate

TABLE B3 Conc. Control Present composition (ppm) Effect Present compound4-1 + benzovindiflupyr 10 + 10 100 Present compound 4-1 +benzovindiflupyr  3 + 30 100 Present compound 4-1 + benzovindiflupyr10 + 1  100 Present compound 4-1 +3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 10 100trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4- carboxamide Presentcompound 4-1 + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-  3 + 30 100trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4- carboxamide Presentcompound 4-1 + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 1  100trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4- carboxamide Presentcompound 4-1 + fluindapyr 10 + 10 100 Present compound 4-1 + fluindapyr 3 + 30 100 Present compound 4-1 + fluindapyr 10 + 1  100 Presentcompound 4-1 + fluxapyroxad 10 + 10 100 Present compound 4-1 +fluxapyroxad  3 + 30 100 Present compound 4-1 + fluxapyroxad 10 + 1  100Present compound 4-1 + Compound of formula(1) 10 + 10 100 Presentcompound 4-1 + Compound of formula(1)  3 + 30 100 Present compound 4-1 +Compound of formula(1) 10 + 1  100 Present compound 4-1 + Compound offormula(2) 10 + 10 100 Present compound 4-1 + Compound of formula(2) 3 + 30 100 Present compound 4-1 + Compound of formula(2) 10 + 1  100Present compound 4-1 + Compound of formula(3) 10 + 10 100 Presentcompound 4-1 + Compound of formula(3)  3 + 30 100 Present compound 4-1 +Compound of formula(3) 10 + 1  100 Present compound 4-1 + pyraclostrobin10 + 10 100 Present compound 4-1 + pyraclostrobin  5 + 50 100 Presentcompound 4-1 + pyraclostrobin 10 + 1  100 Present compound 4-1 +picoxystrobin 10 + 10 100 Present compound 4-1 + picoxystrobin  5 + 50100 Present compound 4-1 + picoxystrobin 10 + 1  100 Present compound4-1 + prothioconazole 10 + 10 100 Present compound 4-1 + prothioconazole 5 + 50 100 Present compound 4-1 + prothioconazole 30 + 10 100 Presentcompound 4-1 + fenpicoxamid 10 + 10 100 Present compound 4-1 +fenpicoxamid  5 + 50 100 Present compound 4-1 + fenpicoxamid 30 + 10 100Present compound 4-1 + florylpicoxamid 10 + 10 100 Present compound4-1 + florylpicoxamid  5 + 50 100 Present compound 4-1 + florylpicoxamid30 + 10 100 Present compound 4-1 + 3-(2-methylphenyl)butan-2-ylN-[(3-hydroxy-4- 10 + 10 100 methoxypyridin-2-yl)carbonyl]alaninatePresent compound 4-1 + 3-(2-methylphenyl)butan-2-yl N-[(3-hydroxy-4- 5 + 50 100 methoxypyridin-2-yl)carbonyl]alaninate Present compound4-1 + 3-(2-methylphenyl)butan-2-yl N-[(3-hydroxy-4- 10 + 1  100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-1 +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4- 10 + 10 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-1 +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4-  5 + 50 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-1 +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4- 10 + 1  100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-1 +3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2- 10 + 10 100methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninate Presentcompound 4-1 + 3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2-  5 + 50100 methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninatePresent compound 4-1 + 3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2-10 + 1  100 methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate Present compound 4-1 +3-(4-methoxy-2-methylphenyl)butan-2-yl N-[(3- 10 + 10 100hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-1 +3-(4-methoxy-2-methylphenyl)butan-2-yl N-[(3-  5 + 50 100hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-1 +3-(4-methoxy-2-methylphenyl)butan-2-yl N-[(3- 10 + 1  100hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate

TABLE B4 Conc. Control Present composition (ppm) Effect Present compound4-36 + benzovindiflupyr 10 + 10 100 Present compound 4-36 +benzovindiflupyr  3 + 30 100 Present compound 4-36 + benzovindiflupyr10 + 1  100 Present compound 4-36 +3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 10 100trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4- carboxamide Presentcompound 4-36 + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-  3 + 30 100trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4- carboxamide Presentcompound 4-36 + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 1  100trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4- carboxamide Presentcompound 4-36 + fluindapyr 10 + 10 100 Present compound 4-36 +fluindapyr  3 + 30 100 Present compound 4-36 + fluindapyr 10 + 1  100Present compound 4-36 + fluxapyroxad 10 + 10 100 Present compound 4-36 +fluxapyroxad  3 + 30 100 Present compound 4-36 + fluxapyroxad 10 + 1 100 Present compound 4-36 + Compound of formula(1) 10 + 10 100 Presentcompound 4-36 + Compound of formula(1)  3 + 30 100 Present compound4-36 + Compound of formula(1) 10 + 1  100 Present compound 4-36 +Compound of formula(2) 10 + 10 100 Present compound 4-36 + Compound offormula(2)  3 + 30 100 Present compound 4-36 + Compound of formula(2)10 + 1  100 Present compound 4-36 + Compound of formula(3) 10 + 10 100Present compound 4-36 + Compound of formula(3)  3 + 30 100 Presentcompound 4-36 + Compound of formula(3) 10 + 1  100 Present compound4-36 + pyraclostrobin 10 + 10 100 Present compound 4-36 + pyraclostrobin 5 + 50 100 Present compound 4-36 + pyraclostrobin 10 + 1  100 Presentcompound 4-36 + picoxystrobin 10 + 10 100 Present compound 4-36 +picoxystrobin  5 + 50 100 Present compound 4-36 + picoxystrobin 10 + 1 100 Present compound 4-36 + prothioconazole 10 + 10 100 Present compound4-36 + prothioconazole  5 + 50 100 Present compound 4-36 +prothioconazole 30 + 10 100 Present compound 4-36 + fenpicoxamid 10 + 10100 Present compound 4-36 + fenpicoxamid  5 + 50 100 Present compound4-36 + fenpicoxamid 30 + 10 100 Present compound 4-36 + florylpicoxamid10 + 10 100 Present compound 4-36 + florylpicoxamid  5 + 50 100 Presentcompound 4-36 + florylpicoxamid 30 + 10 100 Present compound 4-36 +3-(2-methylphenyl)butan-2-yl N-[(3-hydroxy-4- 10 + 10 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-36 +3-(2-methylphenyl)butan-2-yl N-[(3-hydroxy-4-  5 + 50 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-36 +3-(2-methylphenyl)butan-2-yl N-[(3-hydroxy-4- 10 + 1  100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-36 +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4- 10 + 10 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-36 +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4-  5 + 50 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-36 +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4- 10 + 1  100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-36 +3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2- 10 + 10 100methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninate Presentcompound 4-36 + 3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2-  5 + 50100 methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninatePresent compound 4-36 + 3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2-10 + 1  100 methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate Present compound 4-36 +3-(4-methoxy-2-methylphenyl)butan-2-yl N-[(3- 10 + 10 100hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-36 +3-(4-methoxy-2-methylphenyl)butan-2-yl N-[(3-  5 + 50 100hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-36 +3-(4-methoxy-2-methylphenyl)butan-2-yl N-[(3- 10 + 1  100hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate

TABLE B5 Conc. Control Present composition (ppm) Effect Present compound4-6 + benzovindiflupyr 10 + 10 100 Present compound 4-6 +benzovindiflupyr  3 + 30 100 Present compound 4-6 + benzovindiflupyr10 + 1  100 Present compound 4-6 +3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 10 100trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4- carboxamide Presentcompound 4-6 + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-  3 + 30 100trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4- carboxamide Presentcompound 4-6 + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 1  100trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4- carboxamide Presentcompound 4-6 + fluindapyr 10 + 10 100 Present compound 4-6 + fluindapyr 3 + 30 100 Present compound 4-6 + fluindapyr 10 + 1  100 Presentcompound 4-6 + fluxapyroxad 10 + 10 100 Present compound 4-6 +fluxapyroxad  3 + 30 100 Present compound 4-6 + fluxapyroxad 10 + 1  100Present compound 4-6 + Compound of formula(1) 10 + 10 100 Presentcompound 4-6 + Compound of formula(1)  3 + 30 100 Present compound 4-6 +Compound of formula(1) 10 + 1  100 Present compound 4-6 + Compound offormula(2) 10 + 10 100 Present compound 4-6 + Compound of formula(2) 3 + 30 100 Present compound 4-6 + Compound of formula(2) 10 + 1  100Present compound 4-6 + Compound of formula(3) 10 + 10 100 Presentcompound 4-6 + Compound of formula(3)  3 + 30 100 Present compound 4-6 +Compound of formula(3) 10 + 1  100 Present compound 4-6 + pyraclostrobin10 + 10 100 Present compound 4-6 + pyraclostrobin  5 + 50 100 Presentcompound 4-6 + pyraclostrobin 10 + 1  100 Present compound 4-6 +picoxystrobin 10 + 10 100 Present compound 4-6 + picoxystrobin  5 + 50100 Present compound 4-6 + picoxystrobin 10 + 1  100 Present compound4-6 + prothioconazole 10 + 10 100 Present compound 4-6 prothioconazole 5 + 50 100 Present compound 4-6 prothioconazole 30 + 10 100 Presentcompound 4-6 + fenpicoxamid 10 + 10 100 Present compound 4-6 +fenpicoxamid  5 + 50 100 Present compound 4-6 + fenpicoxamid 30 + 10 100Present compound 4-6 + florylpicoxamid 10 + 10 100 Present compound4-6 + florylpicoxamid  5 + 50 100 Present compound 4-6 + florylpicoxamid30 + 10 100 Present compound 4-6 + 3-(2-methylphenyl)butan-2-ylN-[(3-hydroxy-4- 10 + 10 100 methoxypyridin-2-yl)carbonyl]alaninatePresent compound 4-6 + 3-(2-methylphenyl)butan-2-yl N-[(3-hydroxy-4- 5 + 50 100 methoxypyridin-2-yl)carbonyl]alaninate Present compound4-6 + 3-(2-methylphenyl)butan-2-yl N-[(3-hydroxy-4- 10 + 1  100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-6 +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4- 10 + 10 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-6 +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4-  5 + 50 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-6 +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4- 10 + 1  100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-6 +3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2- 10 + 10 100methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninate Presentcompound 4-6 + 3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2-  5 + 50100 methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninatePresent compound 4-6 + 3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2-10 + 1  100 methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate Present compound 4-6 +3-(4-methoxy-2-methylphenyl)butan-2-yl N-[(3- 10 + 10 100hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-6 +3-(4-methoxy-2-methylphenyl)butan-2-yl N-[(3-  5 + 50 100hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-6 +3-(4-methoxy-2-methylphenyl)butan-2-yl N-[(3- 10 + 1  100hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate

TABLE B6 Conc. Control Present composition (ppm) Effect Present compound4-38 + benzovindiflupyr 10 + 10 100 Present compound 4-38 +benzovindiflupyr  3 + 30 100 Present compound 4-38 + benzovindiflupyr10 + 1  100 Present compound 4-38 +3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 10 100trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4- carboxamide Presentcompound 4-38 + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-  3 + 30 100trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4- carboxamide Presentcompound 4-38 + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 1  100trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4- carboxamide Presentcompound 4-38 + fluindapyr 10 + 10 100 Present compound 4-38 +fluindapyr  3 + 30 100 Present compound 4-38 + fluindapyr 10 + 1  100Present compound 4-38 + fluxapyroxad 10 + 10 100 Present compound 4-38 +fluxapyroxad  3 + 30 100 Present compound 4-38 + fluxapyroxad 10 + 1 100 Present compound 4-38 + Compound of formula(1) 10 + 10 100 Presentcompound 4-38 + Compound of formula(1)  3 + 30 100 Present compound4-38 + Compound of formula(1) 10 + 1  100 Present compound 4-38 +Compound of formula(2) 10 + 10 100 Present compound 4-38 + Compound offormula(2)  3 + 30 100 Present compound 4-38 + Compound of formula(2)10 + 1  100 Present compound 4-38 + Compound of formula(3) 10 + 10 100Present compound 4-38 + Compound of formula(3)  3 + 30 100 Presentcompound 4-38 + Compound of formula(3) 10 + 1  100 Present compound4-38 + pyraclostrobin 10 + 10 100 Present compound 4-38 + pyraclostrobin 5 + 50 100 Present compound 4-38 + pyraclostrobin 10 + 1  100 Presentcompound 4-38 + picoxystrobin 10 + 10 100 Present compound 4-38 +picoxystrobin  5 + 50 100 Present compound 4-38 + picoxystrobin 10 + 1 100 Present compound 4-38 + prothioconazole 10 + 10 100 Present compound4-38 + prothioconazole  5 + 50 100 Present compound 4-38 +prothioconazole 30 + 10 100 Present compound 4-38 + fenpicoxamid 10 + 10100 Present compound 4-38 + fenpicoxamid  5 + 50 100 Present compound4-38 + fenpicoxamid 30 + 10 100 Present compound 4-38 + florylpicoxamid10 + 10 100 Present compound 4-38 + florylpicoxamid  5 + 50 100 Presentcompound 4-38 + florylpicoxamid 30 + 10 100 Present compound 4-38 +3-(2-methylphenyl)butan-2-yl N-[(3-hydroxy-4- 10 + 10 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-38 +3-(2-methylphenyl)butan-2-yl N-[(3-hydroxy-4-  5 + 50 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-38 +3-(2-methylphenyl)butan-2-yl N-[(3-hydroxy-4- 10 + 1  100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-38 +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4- 10 + 10 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-38 +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4-  5 + 50 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-38 +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4- 10 + 1  100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-38 +3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2- 10 + 10 100methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninate Presentcompound 4-38 + 3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2-  5 + 50100 methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninatePresent compound 4-38 + 3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2-10 + 1  100 methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate Present compound 4-38 +3-(4-methoxy-2-methylphenyl)butan-2-yl N-[(3- 10 + 10 100hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-38 +3-(4-methoxy-2-methylphenyl)butan-2-yl N-[(3-  5 + 50 100hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-38 +3-(4-methoxy-2-methylphenyl)butan-2-yl N-[(3- 10 + 1  100hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate

TABLE B7 Conc. Control Present composition (ppm) Effect Present compound4-12 + benzovindiflupyr 10 + 10 100 Present compound 4-12 +benzovindiflupyr  3 + 30 100 Present compound 4-12 + benzovindiflupyr10 + 1  100 Present compound 4-12 +3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 10 100trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4- carboxamide Presentcompound 4-12 + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-  3 + 30 100trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4- carboxamide Presentcompound 4-12 + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 1  100trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4- carboxamide Presentcompound 4-12 + fluindapyr 10 + 10 100 Present compound 4-12 +fluindapyr  3 + 30 100 Present compound 4-12 + fluindapyr 10 + 1  100Present compound 4-12 + fluxapyroxad 10 + 10 100 Present compound 4-12 +fluxapyroxad  3 + 30 100 Present compound 4-12 + fluxapyroxad 10 + 1 100 Present compound 4-12 + Compound of formula(1) 10 + 10 100 Presentcompound 4-12 + Compound of formula(1)  3 + 30 100 Present compound4-12 + Compound of formula(1) 10 + 1  100 Present compound 4-12 +Compound of formula(2) 10 + 10 100 Present compound 4-12 + Compound offormula(2)  3 + 30 100 Present compound 4-12 + Compound of formula(2)10 + 1  100 Present compound 4-12 + Compound of formula(3) 10 + 10 100Present compound 4-12 + Compound of formula(3)  3 + 30 100 Presentcompound 4-12 + Compound of formula(3) 10 + 1  100 Present compound4-12 + pyraclostrobin 10 + 10 100 Present compound 4-12 + pyraclostrobin 5 + 50 100 Present compound 4-12 + pyraclostrobin 10 + 1  100 Presentcompound 4-12 + picoxystrobin 10 + 10 100 Present compound 4-12 +picoxystrobin  5 + 50 100 Present compound 4-12 + picoxystrobin 10 + 1 100 Present compound 4-12 + prothioconazole 10 + 10 100 Present compound4-12 + prothioconazole  5 + 50 100 Present compound 4-12 +prothioconazole 30 + 10 100 Present compound 4-12 + fenpicoxamid 10 + 10100 Present compound 4-12 + fenpicoxamid  5 + 50 100 Present compound4-12 + fenpicoxamid 30 + 10 100 Present compound 4-12 + florylpicoxamid10 + 10 100 Present compound 4-12 + florylpicoxamid  5 + 50 100 Presentcompound 4-12 + florylpicoxamid 30 + 10 100 Present compound 4-12 +3-(2-methylphenyl)butan-2-yl N-[(3-hydroxy-4- 10 + 10 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-12 +3-(2-methylphenyl)butan-2-yl N-[(3-hydroxy-4-  5 + 50 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-12 +3-(2-methylphenyl)butan-2-yl N-[(3-hydroxy-4- 10 + 1  100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-12 +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4- 10 + 10 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-12 +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4-  5 + 50 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-12 +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4- 10 + 1  100methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-12 +3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2- 10 + 10 100methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninate Presentcompound 4-12 + 3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2-  5 + 50100 methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninatePresent compound 4-12 + 3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2-10 + 1  100 methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate Present compound 4-12 +3-(4-methoxy-2-methylphenyl)butan-2-yl N-[(3- 10 + 10 100hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-12 +3-(4-methoxy-2-methylphenyl)butan-2-yl N-[(3-  5 + 50 100hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present compound 4-12 +3-(4-methoxy-2-methylphenyl)butan-2-yl N-[(3- 10 + 1  100hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate

TABLE B8 Conc. Control Present composition (ppm) Effect Present +benzovindiflupyr 10 + 10 100 compound 4-14 Present + benzovindiflupyr 3 + 30 100 compound 4-14 Present + benzovindiflupyr 10 + 1  100compound 4-14 Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 10100 compound 4-14 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-  3 + 30100 compound 4-14 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 1 100 compound 4-14 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + fluindapyr 10 + 10 100 compound 4-14 Present +fluindapyr  3 + 30 100 compound 4-14 Present + fluindapyr 10 + 1  100compound 4-14 Present + fluxapyroxad 10 + 10 100 compound 4-14 Present +fluxapyroxad  3 + 30 100 compound 4-14 Present + fluxapyroxad 10 + 1 100 compound 4-14 Present + Compound of formula (1) 10 + 10 100 compound4-14 Present + Compound of formula (1)  3 + 30 100 compound 4-14Present + Compound of formula (1) 10 + 1  100 compound 4-14 Present +Compound of formula (2) 10 + 10 100 compound 4-14 Present + Compound offormula (2)  3 + 30 100 compound 4-14 Present + Compound of formula (2)10 + 1  100 compound 4-14 Present + Compound of formula (3) 10 + 10 100compound 4-14 Present + Compound of formula (3)  3 + 30 100 compound4-14 Present + Compound of formula (3) 10 + 1  100 compound 4-14Present + pyraclostrobin 10 + 10 100 compound 4-14 Present +pyraclostrobin  5 + 50 100 compound 4-14 Present + pyraclostrobin 10 +1  100 compound 4-14 Present + picoxystrobin 10 + 10 100 compound 4-14Present + picoxystrobin  5 + 50 100 compound 4-14 Present +picoxystrobin 10 + 1  100 compound 4-14 Present + prothioconazole 10 +10 100 compound 4-14 Present prothioconazole  5 + 50 100 compound 4-14Present prothioconazole 30 + 10 100 compound 4-14 Present + fenpicoxamid10 + 10 100 compound 4-14 Present + fenpicoxamid  5 + 50 100 compound4-14 Present + fenpicoxamid 30 + 10 100 compound 4-14 Present +florylpicoxamid 10 + 10 100 compound 4-14 Present + florylpicoxamid  5 +50 100 compound 4-14 Present + florylpicoxamid 30 + 10 100 compound 4-14Present + 3-(2-methylpheny])butan-2-yl N-[(3-hydroxy-4- 10 + 10 100compound 4-14 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2-methylpheny])butan-2-yl N-[(3-hydroxy-4-  5 + 50 100 compound 4-14methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2-methylpheny])butan-2-yl N-[(3-hydroxy-4- 10 + 1  100 compound 4-14methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylpheny])butan-2-yl N-[(3-acetoxy-4- 10 + 10 100 compound4-14 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylpheny])butan-2-yl N-[(3-acetoxy-4-  5 + 50 100 compound4-14 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylpheny])butan-2-yl N-[(3-acetoxy-4- 10 + 1  100 compound4-14 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2- 10 + 10 100 compound4-14 methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninatePresent + 3-(4-fluoro-2-methylpheny])butan-2-yl N-({3-[(2-  5 + 50 100compound 4-14 methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate Present + 3-(4-fluoro-2-methylpheny])butan-2-ylN-({3-[(2- 10 + 1  100 compound 4-14methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninate Present +3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3- 10 + 10 100 compound 4-14hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present +3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3-  5 + 50 100 compound 4-14hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present +3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3- 10 + 1  100 compound 4-14hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate

TABLE B9 Conc. Control Present composition (ppm) Effect Present +benzovindiflupyr 10 + 10 100 compound 4-13 Present + benzovindiflupyr 3 + 30 100 compound 4-13 Present + benzovindiflupyr 10 + 1  100compound 4-13 Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 10100 compound 4-13 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-  3 + 30100 compound 4-13 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 1 100 compound 4-13 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + fluindapyr 10 + 10 100 compound 4-13 Present +fluindapyr  3 + 30 100 compound 4-13 Present + fluindapyr 10 + 1  100compound 4-13 Present + fluxapyroxad 10 + 10 100 compound 4-13 Present +fluxapyroxad  3 + 30 100 compound 4-13 Present + fluxapyroxad 10 + 1 100 compound 4-13 Present + Compound of formula (1) 10 + 10 100 compound4-13 Present + Compound of formula (1)  3 + 30 100 compound 4-13Present + Compound of formula (1) 10 + 1  100 compound 4-13 Present +Compound of formula (2) 10 + 10 100 compound 4-13 Present + Compound offormula (2)  3 + 30 100 compound 4-13 Present + Compound of formula (2)10 + 1  100 compound 4-13 Present + Compound of formula (3) 10 + 10 100compound 4-13 Present + Compound of formula (3)  3 + 30 100 compound4-13 Present + Compound of formula (3) 10 + 1  100 compound 4-13Present + pyraclostrobin 10 + 10 100 compound 4-13 Present +pyraclostrobin  5 + 50 100 compound 4-13 Present + pyraclostrobin 10 +1  100 compound 4-13 Present + picoxystrobin 10 + 10 100 compound 4-13Present + picoxystrobin  5 + 50 100 compound 4-13 Present +picoxystrobin 10 + 1  100 compound 4-13 Present + prothioconazole 10 +10 100 compound 4-13 Present prothioconazole  5 + 50 100 compound 4-13Present prothioconazole 30 + 10 100 compound 4-13 Present + fenpicoxamid10 + 10 100 compound 4-13 Present + fenpicoxamid  5 + 50 100 compound4-13 Present + fenpicoxamid 30 + 10 100 compound 4-13 Present +florylpicoxamid 10 + 10 100 compound 4-13 Present + florylpicoxamid  5 +50 100 compound 4-13 Present + florylpicoxamid 30 + 10 100 compound 4-13Present + 3-(2-methylpheny])butan-2-yl N-[(3-hydroxy-4- 10 + 10 100compound 4-13 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2-methylpheny])butan-2-yl N-[(3-hydroxy-4-  5 + 50 100 compound 4-13methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2-methylpheny])butan-2-yl N-[(3-hydroxy-4- 10 + 1  100 compound 4-13methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylpheny])butan-2-yl N-[(3-acetoxy-4- 10 + 10 100 compound4-13 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylpheny])butan-2-yl N-[(3-acetoxy-4-  5 + 50 100 compound4-13 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylpheny])butan-2-yl N-[(3-acetoxy-4- 10 + 1  100 compound4-13 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2- 10 + 10 100 compound4-13 methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninatePresent + 3-(4-fluoro-2-methylpheny])butan-2-yl N-({3-[(2-  5 + 50 100compound 4-13 methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate Present + 3-(4-fluoro-2-methylphenyl)butan-2-ylN-({3-[(2- 10 + 1  100 compound 4-13methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninate Present +3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3- 10 + 10 100 compound 4-13hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present +3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3-  5 + 50 100 compound 4-13hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present +3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3- 10 + 1  100 compound 4-13hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate

TABLE B10 Conc. Control Present composition (ppm) Effect Present +benzovindiflupyr 10 + 10 100 compound 4-15 Present + benzovindiflupyr 3 + 30 100 compound 4-15 Present + benzovindiflupyr 10 + 1  100compound 4-15 Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 10100 compound 4-15 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-  3 + 30100 compound 4-15 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 1 100 compound 4-15 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + fluindapyr 10 + 10 100 compound 4-15 Present +fluindapyr  3 + 30 100 compound 4-15 Present + fluindapyr 10 + 1  100compound 4-15 Present + fluxapyroxad 10 + 10 100 compound 4-15 Present +fluxapyroxad  3 + 30 100 compound 4-15 Present + fluxapyroxad 10 + 1 100 compound 4-15 Present + Compound of formula (1) 10 + 10 100 compound4-15 Present + Compound of formula (1)  3 + 30 100 compound 4-15Present + Compound of formula (1) 10 + 1  100 compound 4-15 Present +Compound of formula (2) 10 + 10 100 compound 4-15 Present + Compound offormula (2)  3 + 30 100 compound 4-15 Present + Compound of formula (2)10 + 1  100 compound 4-15 Present + Compound of formula (3) 10 + 10 100compound 4-15 Present + Compound of formula (3)  3 + 30 100 compound4-15 Present + Compound of formula (3) 10 + 1  100 compound 4-15Present + pyraclostrobin 10 + 10 100 compound 4-15 Present +pyraclostrobin  5 + 50 100 compound 4-15 Present + pyraclostrobin 10 +1  100 compound 4-15 Present + picoxystrobin 10 + 10 100 compound 4-15Present + picoxystrobin  5 + 50 100 compound 4-15 Present +picoxystrobin 10 + 1  100 compound 4-15 Present + prothioconazole 10 +10 100 compound 4-15 Present prothioconazole  5 + 50 100 compound 4-15Present prothioconazole 30 + 10 100 compound 4-15 Present + fenpicoxamid10 + 10 100 compound 4-15 Present + fenpicoxamid  5 + 50 100 compound4-15 Present + fenpicoxamid 30 + 10 100 compound 4-15 Present +florylpicoxamid 10 + 10 100 compound 4-15 Present + florylpicoxamid  5 +50 100 compound 4-15 Present + florylpicoxamid 30 + 10 100 compound 4-15Present + 3-(2-methylpheny])butan-2-yl N-[(3-hydroxy-4- 10 + 10 100compound 4-15 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2-methylpheny])butan-2-yl N-[(3-hydroxy-4-  5 + 50 100 compound 4-15methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2-methylphenyl)butan-2-yl N-[(3-hydroxy-4- 10 + 1  100 compound 4-15methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4- 10 + 10 100 compound4-15 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4-  5 + 50 100 compound4-15 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylpheny])butan-2-yl N-[(3-acetoxy-4- 10 + 1  100 compound4-15 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2- 10 + 10 100 compound4-15 methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninatePresent + 3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2-  5 + 50 100compound 4-15 methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate Present + 3-(4-fluoro-2-methylphenyl)butan-2-ylN-({3-[(2- 10 + 1  100 compound 4-15methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninate Present +3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3- 10 + 10 100 compound 4-15hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present +3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3-  5 + 50 100 compound 4-15hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present +3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3- 10 + 1  100 compound 4-15hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate

TABLE B11 Conc. Control Present composition (ppm) Effect Present +benzovindiflupyr 10 + 10 100 compound 14-4 Present + benzovindiflupyr 3 + 30 100 compound 14-4 Present + benzovindiflupyr 10 + 1  100compound 14-4 Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 10100 compound 14-4 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-  3 + 30100 compound 14-4 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 1 100 compound 14-4 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + fluindapyr 10 + 10 100 compound 14-4 Present +fluindapyr  3 + 30 100 compound 14-4 Present + fluindapyr 10 + 1  100compound 14-4 Present + fluxapyroxad 10 + 10 100 compound 14-4 Present +fluxapyroxad  3 + 30 100 compound 14-4 Present + fluxapyroxad 10 + 1 100 compound 14-4 Present + Compound of formula (1) 10 + 10 100 compound14-4 Present + Compound of formula (1)  3 + 30 100 compound 14-4Present + Compound of formula (1) 10 + 1  100 compound 14-4 Present +Compound of formula (2) 10 + 10 100 compound 14-4 Present + Compound offormula (2)  3 + 30 100 compound 14-4 Present + Compound of formula (2)10 + 1  100 compound 14-4 Present + Compound of formula (3) 10 + 10 100compound 14-4 Present Compound of formula (3)  3 + 30 100 compound 14-4Present + Compound of formula (3) 10 + 1  100 compound 14-4 Present +pyraclostrobin 10 + 10 100 compound 14-4 Present + pyraclostrobin  5 +50 100 compound 14-4 Present + pyraclostrobin 10 + 1  100 compound 14-4Present + picoxystrobin 10 + 10 100 compound 14-4 Present +picoxystrobin  5 + 50 100 compound 14-4 Present + picoxystrobin 10 + 1 100 compound 14-4 Present + prothioconazole 10 + 10 100 compound 14-4Present prothioconazole  5 + 50 100 compound 14-4 Presentprothioconazole 30 + 10 100 compound 14-4 Present + fenpicoxamid 10 + 10100 compound 14-4 Present + fenpicoxamid  5 + 50 100 compound 14-4Present + fenpicoxamid 30 + 10 100 compound 14-4 Present +florylpicoxamid 10 + 10 100 compound 14-4 Present + florylpicoxamid  5 +50 100 compound 14-4 Present + florylpicoxamid 30 + 10 100 compound 14-4Present + 3-(2-methylpheny])butan-2-yl N-[(3-hydroxy-4- 10 + 10 100compound 14-4 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2-methylpheny])butan-2-yl N-[(3-hydroxy-4-  5 + 50 100 compound 14-4methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2-methylpheny])butan-2-yl N-[(3-hydroxy-4- 10 + 1  100 compound 14-4methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylpheny])butan-2-yl N-[(3-acetoxy-4- 10 + 10 100 compound14-4 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylpheny])butan-2-yl N-[(3-acetoxy-4-  5 + 50 100 compound14-4 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylpheny])butan-2-yl N-[(3-acetoxy-4- 10 + 1  100 compound14-4 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2- 10 + 10 100 compound14-4 methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninatePresent + 3-(4-fluoro-2-methylpheny])butan-2-yl N-({3-[(2-  5 + 50 100compound 14-4 methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate Present + 3-(4-fluoro-2-methylphenyl)butan-2-ylN-({3-[(2- 10 + 1  100 compound 14-4methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninate Present +3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3- 10 + 10 100 compound 14-4hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present +3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3-  5 + 50 100 compound 14-4hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present +3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3- 10 + 1  100 compound 14-4hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate

TABLE B12 Conc. Control Present composition (ppm) Effect Present +benzovindiflupyr 10 + 10 100 compound 14-7 Present + benzovindiflupyr 3 + 30 100 compound 14-7 Present + benzovindiflupyr 10 + 1  100compound 14-7 Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 10100 compound 14-7 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-  3 + 30100 compound 14-7 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 1 100 compound 14-7 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + fluindapyr 10 + 10 100 compound 14-7 Present +fluindapyr  3 + 30 100 compound 14-7 Present + fluindapyr 10 + 1  100compound 14-7 Present + fluxapyroxad 10 + 10 100 compound 14-7 Present +fluxapyroxad  3 + 30 100 compound 14-7 Present + fluxapyroxad 10 + 1 100 compound 14-7 Present + Compound of formula (1) 10 + 10 100 compound14-7 Present + Compound of formula (1)  3 + 30 100 compound 14-7Present + Compound of formula (1) 10 + 1  100 compound 14-7 Present +Compound of formula (2) 10 + 10 100 compound 14-7 Present + Compound offormula (2)  3 + 30 100 compound 14-7 Present + Compound of formula (2)10 + 1  100 compound 14-7 Present + Compound of formula (3) 10 + 10 100compound 14-7 Present + Compound of formula (3)  3 + 30 100 compound14-7 Present + Compound of formula (3) 10 + 1  100 compound 14-7Present + pyraclostrobin 10 + 10 100 compound 14-7 Present +pyraclostrobin  5 + 50 100 compound 14-7 Present + pyraclostrobin 10 +1  100 compound 14-7 Present + picoxystrobin 10 + 10 100 compound 14-7Present + picoxystrobin  5 + 50 100 compound 14-7 Present +picoxystrobin 10 + 1  100 compound 14-7 Present + prothioconazole 10 +10 100 compound 14-7 Present prothioconazole  5 + 50 100 compound 14-7Present prothioconazole 30 + 10 100 compound 14-7 Present + fenpicoxamid10 + 10 100 compound 14-7 Present + fenpicoxamid  5 + 50 100 compound14-7 Present + fenpicoxamid 30 + 10 100 compound 14-7 Present +florylpicoxamid 10 + 10 100 compound 14-7 Present + florylpicoxamid  5 +50 100 compound 14-7 Present + florylpicoxamid 30 + 10 100 compound 14-7Present + 3-(2-methylphenyl)butan-2-yl N-[(3-hydroxy-4- 10 + 10 100compound 14-7 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2-methylpheny])butan-2-yl N-[(3-hydroxy-4-  5 + 50 100 compound 14-7methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2-methylpheny])butan-2-yl N-[(3-hydroxy-4- 10 + 1  100 compound 14-7methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylpheny])butan-2-yl N-[(3-acetoxy-4- 10 + 10 100 compound14-7 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylpheny])butan-2-yl N-[(3-acetoxy-4-  5 + 50 100 compound14-7 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylpheny])butan-2-yl N-[(3-acetoxy-4- 10 + 1  100 compound14-7 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(4-fluoro-2-methylpheny])butan-2-yl N-({3-[(2- 10 + 10 100 compound14-7 methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninatePresent + 3-(4-fluoro-2-methylpheny])butan-2-yl N-({3-[(2-  5 + 50 100compound 14-7 methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate Present + 3-(4-fluoro-2-methylpheny])butan-2-ylN-({3-[(2- 10 + 1  100 compound 14-7methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninate Present +3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3- 10 + 10 100 compound 14-7hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present +3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3-  5 + 50 100 compound 14-7hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present +3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3- 10 + 1  100 compound 14-7hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate

TABLE B13 Conc. Control Present composition (ppm) Effect Present +benzovindiflupyr 10 + 10 100 compound 14-6 Present + benzovindiflupyr 3 + 30 100 compound 14-6 Present + benzovindiflupyr 10 + 1  100compound 14-6 Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 10100 compound 14-6 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-  3 + 30100 compound 14-6 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 1 100 compound 14-6 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + fluindapyr 10 + 10 100 compound 14-6 Present +fluindapyr  3 + 30 100 compound 14-6 Present + fluindapyr 10 + 1  100compound 14-6 Present + fluxapyroxad 10 + 10 100 compound 14-6 Present +fluxapyroxad  3 + 30 100 compound 14-6 Present + fluxapyroxad 10 + 1 100 compound 14-6 Present + Compound of formula (1) 10 + 10 100 compound14-6 Present + Compound of formula (1)  3 + 30 100 compound 14-6Present + Compound of formula (1) 10 + 1  100 compound 14-6 Present +Compound of formula (2) 10 + 10 100 compound 14-6 Present + Compound offormula (2)  3 + 30 100 compound 14-6 Present + Compound of formula (2)10 + 1  100 compound 14-6 Present + Compound of formula (3) 10 + 10 100compound 14-6 Present + Compound of formula (3)  3 + 30 100 compound14-6 Present + Compound of formula (3) 10 + 1  100 compound 14-6Present + pyraclostrobin 10 + 10 100 compound 14-6 Present +pyraclostrobin  5 + 50 100 compound 14-6 Present + pyraclostrobin 10 +1  100 compound 14-6 Present + picoxystrobin 10 + 10 100 compound 14-6Present + picoxystrobin  5 + 50 100 compound 14-6 Present +picoxystrobin 10 + 1  100 compound 14-6 Present + prothioconazole 10 +10 100 compound 14-6 Present prothioconazole  5 + 50 100 compound 14-6Present prothioconazole 30 + 10 100 compound 14-6 Present + fenpicoxamid10 + 10 100 compound 14-6 Present + fenpicoxamid  5 + 50 100 compound14-6 Present + fenpicoxamid 30 + 10 100 compound 14-6 Present +florylpicoxamid 10 + 10 100 compound 14-6 Present + florylpicoxamid  5 +50 100 compound 14-6 Present + florylpicoxamid 30 + 10 100 compound 14-6Present + 3-(2-methylpheny])butan-2-yl N-[(3-hydroxy-4- 10 + 10 100compound 14-6 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2-methylpheny])butan-2-yl N-[(3-hydroxy-4-  5 + 50 100 compound 14-6methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2-methylpheny])butan-2-yl N-[(3-hydroxy-4- 10 + 1  100 compound 14-6methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylpheny])butan-2-yl N-[(3-acetoxy-4- 10 + 10 100 compound14-6 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylpheny])butan-2-yl N-[(3-acetoxy-4-  5 + 50 100 compound14-6 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylpheny])butan-2-yl N-[(3-acetoxy-4- 10 + 1  100 compound14-6 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(4-fluoro-2-methylpheny])butan-2-yl N-({3-[(2- 10 + 10 100 compound14-6 methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninatePresent + 3-(4-fluoro-2-methylpheny])butan-2-yl N-({3-[(2-  5 + 50 100compound 14-6 methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate Present + 3-(4-fluoro-2-methylpheny])butan-2-ylN-({3-[(2- 10 + 1  100 compound 14-6methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninate Present +3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3- 10 + 10 100 compound 14-6hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present +3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3-  5 + 50 100 compound 14-6hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present +3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3- 10 + 1  100 compound 14-6hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate

TABLE B14 Conc. Control Present composition (ppm) Effect Present +benzovindiflupyr 10 + 10 100 compound 14-2 Present + benzovindiflupyr 3 + 30 100 compound 14-2 Present + benzovindiflupyr 10 + 1  100compound 14-2 Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 10100 compound 14-2 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-  3 + 30100 compound 14-2 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 1 100 compound 14-2 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + fluindapyr 10 + 10 100 compound 14-2 Present +fluindapyr  3 + 30 100 compound 14-2 Present + fluindapyr 10 + 1  100compound 14-2 Present + fluxapyroxad 10 + 10 100 compound 14-2 Present +fluxapyroxad  3 + 30 100 compound 14-2 Present + fluxapyroxad 10 + 1 100 compound 14-2 Present + Compound of formula (1) 10 + 10 100 compound14-2 Present + Compound of formula (1)  3 + 30 100 compound 14-2Present + Compound of formula (1) 10 + 1  100 compound 14-2 Present +Compound of formula (2) 10 + 10 100 compound 14-2 Present + Compound offormula (2)  3 + 30 100 compound 14-2 Present + Compound of formula (2)10 + 1  100 compound 14-2 Present + Compound of formula (3) 10 + 10 100compound 14-2 Present + Compound of formula (3)  3 + 30 100 compound14-2 Present + Compound of formula (3) 10 + 1  100 compound 14-2Present + pyraclostrobin 10 + 10 100 compound 14-2 Present +pyraclostrobin  5 + 50 100 compound 14-2 Present + pyraclostrobin 10 +1  100 compound 14-2 Present + picoxystrobin 10 + 10 100 compound 14-2Present + picoxystrobin  5 + 50 100 compound 14-2 Present +picoxystrobin 10 + 1  100 compound 14-2 Present + prothioconazole 10 +10 100 compound 14-2 Present prothioconazole  5 + 50 100 compound 14-2Present prothioconazole 30 + 10 100 compound 14-2 Present + fenpicoxamid10 + 10 100 compound 14-2 Present + fenpicoxamid  5 + 50 100 compound14-2 Present + fenpicoxamid 30 + 10 100 compound 14-2 Present +florylpicoxamid 10 + 10 100 compound 14-2 Present + florylpicoxamid  5 +50 100 compound 14-2 Present + florylpicoxamid 30 + 10 100 compound 14-2Present + 3-(2-methylpheny])butan-2-yl N-[(3-hydroxy-4- 10 + 10 100compound 14-2 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2-methylpheny])butan-2-yl N-[(3-hydroxy-4-  5 + 50 100 compound 14-2methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2-methylpheny])butan-2-yl N-[(3-hydroxy-4- 10 + 1  100 compound 14-2methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylpheny])butan-2-yl N-[(3-acetoxy-4- 10 + 10 100 compound14-2 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylpheny])butan-2-yl N-[(3-acetoxy-4-  5 + 50 100 compound14-2 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylpheny])butan-2-yl N-[(3-acetoxy-4- 10 + 1  100 compound14-2 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2- 10 + 10 100 compound14-2 methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninatePresent + 3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2-  5 + 50 100compound 14-2 methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate Present + 3-(4-fluoro-2-methylphenyl)butan-2-ylN-({3-[(2- 10 + 1  100 compound 14-2methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninate Present +3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3- 10 + 10 100 compound 14-2hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present +3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3-  5 + 50 100 compound 14-2hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present +3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3- 10 + 1  100 compound 14-2hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate

TABLE B15 Conc. Control Present composition (ppm) Effect Present +benzovindiflupyr 10 + 10 100 compound 14-74 Present + benzovindiflupyr 3 + 30 100 compound 14-74 Present + benzovindiflupyr 10 + 1  100compound 14-74 Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 +10 100 compound 14-74 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-  3 + 30100 compound 14-74 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 1 100 compound 14-74 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present fluindapyr 10 + 10 100 compound 14-74 Present +fluindapyr  3 + 30 100 compound 14-74 Present fluindapyr 10 + 1  100compound 14-74 Present t fluxapyroxad 10 + 10 100 compound 14-74 Presentfluxapyroxad  3 + 30 100 compound 14-74 Present + fluxapyroxad 10 + 1 100 compound 14-74 Present + Compound of formula (1) 10 + 10 100compound 14-74 Present + Compound of formula (1)  3 + 30 100 compound14-74 Present + Compound of formula (1) 10 + 1  100 compound 14-74Present + Compound of formula (2) 10 + 10 100 compound 14-74 Present +Compound of formula (2)  3 + 30 100 compound 14-74 Present + Compound offormula (2) 10 + 1  100 compound 14-74 Present + Compound of formula (3)10 + 10 100 compound 14-74 Present Compound of formula (3)  3 + 30 100compound 14-74 Present Compound of formula (3) 10 + 1  100 compound14-74 Present pyraclostrobin 10 + 10 100 compound 14-74 Present +pyraclostrobin  5 + 50 100 compound 14-74 Present + pyraclostrobin 10 +1  100 compound 14-74 Present picoxystrobin 10 + 10 100 compound 14-74Present + picoxystrobin  5 + 50 100 compound 14-74 Present +picoxystrobin 10 + 1  100 compound 14-74 Present + prothioconazole 10 +10 100 compound 14-74 Present prothioconazole  5 + 50 100 compound 14-74Present prothioconazole 30 + 10 100 compound 14-74 Present +fenpicoxamid 10 + 10 100 compound 14-74 Present + fenpicoxamid  5 + 50100 compound 14-74 Present + fenpicoxamid 30 + 10 100 compound 14-74Present + florylpicoxamid 10 + 10 100 compound 14-74 Present +florylpicoxamid  5 + 50 100 compound 14-74 Present + florylpicoxamid30 + 10 100 compound 14-74 Present + 3-(2-methylpheny])butan-2-ylN-[(3-hydroxy-4- 10 + 10 100 compound 14-74methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2-methylpheny])butan-2-yl N-[(3-hydroxy-4-  5 + 50 100 compound 14-74methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2-methylpheny])butan-2-yl N-[(3-hydroxy-4- 10 + 1  100 compound 14-74methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylpheny])butan-2-yl N-[(3-acetoxy-4- 10 + 10 100 compound14-74 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylpheny])butan-2-yl N-[(3-acetoxy-4-  5 + 50 100 compound14-74 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylpheny])butan-2-yl N-[(3-acetoxy-4- 10 + 1  100 compound14-74 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2- 10 + 10 100 compound14-74 methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninatePresent + 3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2-  5 + 50 100compound 14-74 methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate Present + 3-(4-fluoro-2-methylpheny])butan-2-ylN-({3-[(2- 10 + 1  100 compound 14-74methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninate Present +3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3- 10 + 10 100 compound 14-74hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present +3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3-  5 + 50 100 compound 14-74hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present +3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3- 10 + 1  100 compound 14-74hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate

TABLE B16 Conc. Control Present composition (ppm) Effect Present +benzovindiflupyr 10 + 10 100 compound 14-10 Present + benzovindiflupyr 3 + 30 100 compound 14-10 Present + benzovindiflupyr 10 + 1  100compound 14-10 Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 +10 100 compound 14-10 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-  3 + 30100 compound 14-10 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 1 100 compound 14-10 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + fluindapyr 10 + 10 100 compound 14-10 Present +fluindapyr  3 + 30 100 compound 14-10 Present + fluindapyr 10 + 1  100compound 14-10 Present + fluxapyroxad 10 + 10 100 compound 14-10Present + fluxapyroxad  3 + 30 100 compound 14-10 Present + fluxapyroxad10 + 1  100 compound 14-10 Present + Compound of formula (1) 10 + 10 100compound 14-10 Present + Compound of formula (1)  3 + 30 100 compound14-10 Present + Compound of formula (1) 10 + 1  100 compound 14-10Present + Compound of formula (2) 10 + 10 100 compound 14-10 Present +Compound of formula (2)  3 + 30 100 compound 14-10 Present + Compound offormula (2) 10 + 1  100 compound 14-10 Present + Compound of formula (3)10 + 10 100 compound 14-10 Present + Compound of formula (3)  3 + 30 100compound 14-10 Present + Compound of formula (3) 10 + 1  100 compound14-10 Present + pyraclostrobin 10 + 10 100 compound 14-10 Present +pyraclostrobin  5 + 50 100 compound 14-10 Present + pyraclostrobin 10 +1  100 compound 14-10 Present + picoxystrobin 10 + 10 100 compound 14-10Present + picoxystrobin  5 + 50 100 compound 14-10 Present +picoxystrobin 10 + 1  100 compound 14-10 Present + prothioconazole 10 +10 100 compound 14-10 Present prothioconazole  5 + 50 100 compound 14-10Present prothioconazole 30 + 10 100 compound 14-10 Present +fenpicoxamid 10 + 10 100 compound 14-10 Present + fenpicoxamid  5 + 50100 compound 14-10 Present + fenpicoxamid 30 + 10 100 compound 14-10Present + florylpicoxamid 10 + 10 100 compound 14-10 Present +florylpicoxamid  5 + 50 100 compound 14-10 Present + florylpicoxamid30 + 10 100 compound 14-10 Present + 3-(2-methylpheny])butan-2-ylN-[(3-hydroxy-4- 10 + 10 100 compound 14-10methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2-methylpheny])butan-2-yl N-[(3-hydroxy-4-  5 + 50 100 compound 14-10methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2-methylpheny])butan-2-yl N-[(3-hydroxy-4- 10 + 1  100 compound 14-10methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylpheny])butan-2-yl N-[(3-acetoxy-4- 10 + 10 100 compound14-10 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylpheny])butan-2-yl N-[(3-acetoxy-4-  5 + 50 100 compound14-10 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylpheny])butan-2-yl N-[(3-acetoxy-4- 10 + 1  100 compound14-10 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(4-fluoro-2-methylpheny])butan-2-yl N-({3-[(2- 10 + 10 100 compound14-10 methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninatePresent + 3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2-  5 + 50 100compound 14-10 methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate Present + 3-(4-fluoro-2-methylphenyl)butan-2-ylN-({3-[(2- 10 + 1  100 compound 14-10methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninate Present3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3- 10 + 10 100 compound 14-10hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3-  5 + 50 100 compound 14-10hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present +3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3- 10 + 1  100 compound 14-10hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate

TABLE B17 Conc. Control Present composition (ppm) Effect Present +benzovindiflupyr 10 + 10 100 compound 14-9 Present + benzovindiflupyr 3 + 30 100 compound 14-9 Present + benzovindiflupyr 10 + 1  100compound 14-9 Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 10100 compound 14-9 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-  3 + 30100 compound 14-9 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 1 100 compound 14-9 trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide Present + fluindapyr 10 + 10 100 compound 14-9 Present +fluindapyr  3 + 30 100 compound 14-9 Present + fluindapyr 10 + 1  100compound 14-9 Present + fluxapyroxad 10 + 10 100 compound 14-9 Present +fluxapyroxad  3 + 30 100 compound 14-9 Present + fluxapyroxad 10 + 1 100 compound 14-9 Present + Compound of formula (1) 10 + 10 100 compound14-9 Present + Compound of formula (1)  3 + 30 100 compound 14-9Present + Compound of formula (1) 10 + 1  100 compound 14-9 Present +Compound of formula (2) 10 + 10 100 compound 14-9 Present + Compound offormula (2)  3 + 30 100 compound 14-9 Present + Compound of formula (2)10 + 1  100 compound 14-9 Present + Compound of formula (3) 10 + 10 100compound 14-9 Present + Compound of formula (3)  3 + 30 100 compound14-9 Present Compound of formula (3) 10 + 1  100 compound 14-9 Present +pyraclostrobin 10 + 10 100 compound 14-9 Present + pyraclostrobin  5 +50 100 compound 14-9 Present + pyraclostrobin 10 + 1  100 compound 14-9Present + picoxystrobin 10 + 10 100 compound 14-9 Present +picoxystrobin  5 + 50 100 compound 14-9 Present + picoxystrobin 10 + 1 100 compound 14-9 Present + prothioconazole 10 + 10 100 compound 14-9Present prothioconazole  5 + 50 100 compound 14-9 Presentprothioconazole 30 + 10 100 compound 14-9 Present + fenpicoxamid 10 + 10100 compound 14-9 Present + fenpicoxamid  5 + 50 100 compound 14-9Present + fenpicoxamid 30 + 10 100 compound 14-9 Present +florylpicoxamid 10 + 10 100 compound 14-9 Present + florylpicoxamid  5 +50 100 compound 14-9 Present + florylpicoxamid 30 + 10 100 compound 14-9Present + 3-(2-methylpheny])butan-2-yl N-[(3-hydroxy-4- 10 + 10 100compound 14-9 methoxypyridin-2-yl)carbonyl]alaninate Present3-(2-methylpheny])butan-2-yl N-[(3-hydroxy-4-  5 + 50 100 compound 14-9methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2-methylpheny])butan-2-yl N-[(3-hydroxy-4- 10 + 1  100 compound 14-9methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylpheny])butan-2-yl N-[(3-acetoxy-4- 10 + 10 100 compound14-9 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylpheny])butan-2-yl N-[(3-acetoxy-4-  5 + 50 100 compound14-9 methoxypyridin-2-yl)carbonyl]alaninate Present +3-(2,4-dimethylpheny])butan-2-yl N-[(3-acetoxy-4- 10 + 1  100 compound14-9 methoxypyridin-2-yl)carbonyl]alaninate Present3-(4-fluoro-2-methylpheny])butan-2-yl N-({3-[(2- 10 + 10 100 compound14-9 methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninatePresent 3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2-  5 + 50 100compound 14-9 methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate Present + 3-(4-fluoro-2-methylphenyl)butan-2-ylN-({3-[(2- 10 + 1  100 compound 14-9methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninate Present +3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3- 10 + 10 100 compound 14-9hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3-  5 + 50 100 compound 14-9hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present +3-(4-methoxy-2-methylpheny])butan-2-yl N-[(3- 10 + 1  100 compound 14-9hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate

TABLE B18 Conc. Control Present composition (ppm) Effect Presentcompound 14-14 + benzovindiflupyr 10 + 10 100 Present compound 14-14 +benzovindiflupyr  3 + 30 100 Present compound 14-14 + benzovindiflupyr10 + 1  100 Present compound 14-14 +3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 10 100trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4- carboxamide Presentcompound 14-14 + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-  3 + 30 100trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4- carboxamide Presentcompound 14-14 + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 1  100trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4- carboxamide Presentcompound 14-14 + fluindapyr 10 + 10 100 Present compound 14-14 +fluindapyr  3 + 30 100 Present compound 14-14 + fluindapyr 10 + 1  100Present compound 14-14 + fluxapyroxad 10 + 10 100 Present compound14-14 + fluxapyroxad  3 + 30 100 Present compound 14-14 + fluxapyroxad10 + 1  100 Present compound 14-14 + Compound of formula (1) 10 + 10 100Present compound 14-14 + Compound of formula (1)  3 + 30 100 Presentcompound 14-14 + Compound of formula (1) 10 + 1  100 Present compound14-14 + Compound of formula (2) 10 + 10 100 Present compound 14-14 +Compound of formula (2)  3 + 30 100 Present compound 14-14 + Compound offormula (2) 10 + 1  100 Present compound 14-14 + Compound of formula (3)10 + 10 100 Present compound 14-14 + Compound of formula (3)  3 + 30 100Present compound 14-14 + Compound of formula (3) 10 + 1  100 Presentcompound 14-14 + pyraclostrobin 10 + 10 100 Present compound 14-14 +pyraclostrobin  5 + 50 100 Present compound 14-14 + pyraclostrobin 10 +1  100 Present compound 14-14 + picoxystrobin 10 + 10 100 Presentcompound 14-14 + picoxystrobin  5 + 50 100 Present compound 14-14 +picoxystrobin 10 + 1  100 Present compound 14-14 + prothioconazole 10 +10 100 Present compound 14-14 + prothioconazole  5 + 50 100 Presentcompound 14-14 + prothioconazole 30 + 10 100 Present compound 14-14 +fenpicoxamid 10 + 10 100 Present compound 14-14 + fenpicoxamid  5 + 50100 Present compound 14-14 + fenpicoxamid 30 + 10 100 Present compound14-14 + florylpicoxamid 10 + 10 100 Present compound 14-14 +florylpicoxamid  5 + 50 100 Present compound 14-14 + florylpicoxamid30 + 10 100 Present compound 14-14 + 3-(2-methylphenyl)butan-2-ylN-[(3-hydroxy-4- 10 + 10 100 methoxypyridin-2-yl)carbonyl]alaninatePresent compound 14-14 + 3-(2-methylphenyl)butan-2-yl N-[(3-hydroxy-4- 5 + 50 100 methoxypyridin-2-yl)carbonyl]alaninate Present compound14-14 + 3-(2-methylphenyl)butan-2-yl N-[(3-hydroxy-4- 10 + 1  100methoxypyridin-2-yl)carbonyl]alaninate Present compound 14-14 +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4- 10 + 10 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 14-14 +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4-  5 + 50 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 14-14 +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4- 10 + 1  100methoxypyridin-2-yl)carbonyl]alaninate Present compound 14-14 +3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2- 10 + 10 100methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninate Presentcompound 14-14 + 3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2-  5 +50 100 methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninatePresent compound 14-14 + 3-(4-fluoro-2-methylphenyl)butan-2-ylN-({3-[(2- 10 + 1  100 methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate Present compound 14-14 +3-(4-methoxy-2-methylphenyl)butan-2-yl N-[(3- 10 + 10 100hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present compound14-14 + 3-(4-methoxy-2-methylphenyl)butan-2-yl N-[(3-  5 + 50 100hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present compound14-14 + 3-(4-methoxy-2-methylphenyl)butan-2-yl N-[(3- 10 + 1  100hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate

TABLE B19 Conc. Control Present composition (ppm) Effect Presentcompound 14-8 + benzovindiflupyr 10 + 10 100 Present compound 14-8 +benzovindiflupyr  3 + 30 100 Present compound 14-8 + benzovindiflupyr10 + 1  100 Present compound 14-8 +3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 10 100trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4- carboxamide Presentcompound 14-8 + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-  3 + 30 100trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4- carboxamide Presentcompound 14-8 + 3-(difluoromethyl)-N-(2,3-dihydro-1,1,3- 10 + 1  100trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4- carboxamide Presentcompound 14-8 + fluindapyr 10 + 10 100 Present compound 14-8 +fluindapyr  3 + 30 100 Present compound 14-8 + fluindapyr 10 + 1  100Present compound 14-8 + fluxapyroxad 10 + 10 100 Present compound 14-8 +fluxapyroxad  3 + 30 100 Present compound 14-8 + fluxapyroxad 10 + 1 100 Present compound 14-8 + Compound of formula (1) 10 + 10 100 Presentcompound 14-8 + Compound of formula (1)  3 + 30 100 Present compound14-8 + Compound of formula (1) 10 + 1  100 Present compound 14-8 +Compound of formula (2) 10 + 10 100 Present compound 14-8 + Compound offormula (2)  3 + 30 100 Present compound 14-8 + Compound of formula (2)10 + 1  100 Present compound 14-8 + Compound of formula (3) 10 + 10 100Present compound 14-8 + Compound of formula (3)  3 + 30 100 Presentcompound 14-8 + Compound of formula (3) 10 + 1  100 Present compound14-8 + pyraclostrobin 10 + 10 100 Present compound 14-8 + pyraclostrobin 5 + 50 100 Present compound 14-8 + pyraclostrobin 10 + 1  100 Presentcompound 14-8 + picoxystrobin 10 + 10 100 Present compound 14-8 +picoxystrobin  5 + 50 100 Present compound 14-8 + picoxystrobin 10 + 1 100 Present compound 14-8 + prothioconazole 10 + 10 100 Present compound14-8 prothioconazole  5 + 50 100 Present compound 14-8 prothioconazole30 + 10 100 Present compound 14-8 + fenpicoxamid 10 + 10 100 Presentcompound 14-8 + fenpicoxamid  5 + 50 100 Present compound 14-8 +fenpicoxamid 30 + 10 100 Present compound 14-8 + florylpicoxamid 10 + 10100 Present compound 14-8 + florylpicoxamid  5 + 50 100 Present compound14-8 + florylpicoxamid 30 + 10 100 Present compound 14-8 +3-(2-methylphenyl)butan-2-yl N-[(3-hydroxy-4- 10 + 10 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 14-8 +3-(2-methylphenyl)butan-2-yl N-[(3-hydroxy-4-  5 + 50 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 14-8 +3-(2-methylphenyl)butan-2-yl N-[(3-hydroxy-4- 10 + 1  100methoxypyridin-2-yl)carbonyl]alaninate Present compound 14-8 +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4- 10 + 10 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 14-8 +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4-  5 + 50 100methoxypyridin-2-yl)carbonyl]alaninate Present compound 14-8 +3-(2,4-dimethylphenyl)butan-2-yl N-[(3-acetoxy-4- 10 + 1  100methoxypyridin-2-yl)carbonyl]alaninate Present compound 14-8 +3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2- 10 + 10 100methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninate Presentcompound 14-8 + 3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2-  5 + 50100 methylpropanoyl)oxy]-4-methoxypyridin-2- yl}carbonyl)alaninatePresent compound 14-8 + 3-(4-fluoro-2-methylphenyl)butan-2-yl N-({3-[(2-10 + 1  100 methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate Present compound 14-8 +3-(4-methoxy-2-methylphenyl)butan-2-yl N-[(3- 10 + 10 100hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present compound 14-8 +3-(4-methoxy-2-methylphenyl)butan-2-yl N-[(3-  5 + 50 100hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate Present compound 14-8 +3-(4-methoxy-2-methylphenyl)butan-2-yl N-[(3- 10 + 1  100hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate

Test Example 2: Control Test Against Wheat Septoria Leaf Blotch Fungus(Septoria tritici)

Each of any one of the compound selected from the present compound T andthe present compound B were diluted with DMSO so as to contain apredetermined concentration thereof, and 1 μL of the dilution mixtureswere dispensed into titer plate (96 well), and thereafter, thereto wasthen dispensed 150 μL of a potato dextrose broth (PDB broth) to whichconidia of Septoria tritici were inoculated in advance. This plate wascultured at 18° C. for 4 days, thereby allowing Septoria tritici toundergo proliferation, and the absorbance at 550 nm of each well of thetiter plate was then measured to determine a degree of growth ofSeptoria tritici (which was “treated area”).

Control effect was calculated by the following “Equation 5” from thedegree of growth.

Control effect=100×(X−Y)/X  “Equation 5”

-   -   X: Degree of growth of fungus in the non-treated area    -   Y: Degree of growth of fungus in the treated area

Here the non-treated area represents an area wherein the same proceduresare taken except for using the present compound T and the presentcompound B.

The results are shown in Table C1 to Table C6.

TABLE C1 Conc. Control Present composition (ppm) Effect Present compound4-40 + pydiflumetofen 0.04 + 0.04 100 Present compound 4-40 +pydiflumetofen 0.008 + 0.04  100 Present compound 4-40 + pydiflumetofen 0.04 + 0.008 100 Present compound 4-40 + mefentrifluconazole 0.04 +0.04 100 Present compound 4-40 + mefentrifluconazole 0.008 + 0.04  100Present compound 4-40 + mefentrifluconazole  0.04 + 0.008 100 Presentcompound 4-40 + metyltetraprole 0.04 + 0.04 100 Present compound 4-40 +metyltetraprole 0.008 + 0.04  100 Present compound 4-40 +metyltetraprole  0.04 + 0.008 100 Present compound 4-17 + pydiflumetofen0.04 + 0.04 100 Present compound 4-17 + pydiflumetofen 0.008 + 0.04  100Present compound 4-17 + pydiflumetofen  0.04 + 0.008 100 Presentcompound 4-17 + mefentrifluconazole 0.04 + 0.04 100 Present compound4-17 + mefentrifluconazole 0.008 + 0.04  100 Present compound 4-17 +mefentrifluconazole  0.04 + 0.008 100 Present compound 4-17 +metyltetraprole 0.04 + 0.04 100 Present compound 4-17 + metyltetraprole0.008 + 0.04  100 Present compound 4-17 + metyltetraprole  0.04 + 0.008100 Present compound 4-1 + pydiflumetofen 0.04 + 0.04 100 Presentcompound 4-1 + pydiflumetofen 0.008 + 0.04  100 Present compound 4-1 +pydiflumetofen  0.04 + 0.008 100 Present compound 4-1 +mefentrifluconazole 0.04 + 0.04 100 Present compound 4-1 +mefentrifluconazole 0.008 + 0.04  100 Present compound 4-1 +mefentrifluconazole  0.04 + 0.008 100 Present compound 4-1 +metyltetraprole 0.04 + 0.04 100 Present compound 4-1 + metyltetraprole0.008 + 0.04  100 Present compound 4-1 + metyltetraprole  0.04 + 0.008100 Present compound 4-36 + pydiflumetofen 0.04 + 0.04 100 Presentcompound 4-36 + pydiflumetofen 0.008 + 0.04  100 Present compound 4-36 +pydiflumetofen  0.04 + 0.008 100 Present compound 4-36 +mefentrifluconazole 0.04 + 0.04 100 Present compound 4-36 +mefentrifluconazole 0.008 + 0.04  100 Present compound 4-36 +mefentrifluconazole  0.04 + 0.008 100 Present compound 4-36 +metyltetraprole 0.04 + 0.04 100 Present compound 4-36 + metyltetraprole0.008 + 0.04  100 Present compound 4-36 + metyltetraprole  0.04 + 0.008100

TABLE C2 Conc. Control Present composition (ppm) Effect Present compound4-6 + pydiflumetofen 0.04 + 0.04 100 Present compound 4-6 +pydiflumetofen 0.008 + 0.04  100 Present compound 4-6 + pydiflumetofen 0.04 + 0.008 100 Present compound 4-6 + mefentrifluconazole 0.04 + 0.04100 Present compound 4-6 + mefentrifluconazole 0.008 + 0.04  100 Presentcompound 4-6 + mefentrifluconazole  0.04 + 0.008 100 Present compound4-6 + metyltetraprole 0.04 + 0.04 100 Present compound 4-6 +metyltetraprole 0.008 + 0.04  100 Present compound 4-6 + metyltetraprole 0.04 + 0.008 100 Present compound 4-38 + pydiflumetofen 0.04 + 0.04 100Present compound 4-38 + pydiflumetofen 0.008 + 0.04  100 Presentcompound 4-38 + pydiflumetofen  0.04 + 0.008 100 Present compound 4-38 +mefentrifluconazole 0.04 + 0.04 100 Present compound 4-38 +mefentrifluconazole 0.008 + 0.04  100 Present compound 4-38 +mefentrifluconazole  0.04 + 0.008 100 Present compound 4-38 +metyltetraprole 0.04 + 0.04 100 Present compound 4-38 + metyltetraprole0.008 + 0.04  100 Present compound 4-38 + metyltetraprole  0.04 + 0.008100 Present compound 4-12 + pydiflumetofen 0.04 + 0.04 100 Presentcompound 4-12 + pydiflumetofen 0.008 + 0.04  100 Present compound 4-12 +pydiflumetofen  0.04 + 0.008 100 Present compound 4-12 +mefentrifluconazole 0.04 + 0.04 100 Present compound 4-12 +mefentrifluconazole 0.008 + 0.04  100 Present compound 4-12 +mefentrifluconazole  0.04 + 0.008 100 Present compound 4-12 +metyltetraprole 0.04 + 0.04 100 Present compound 4-12 + metyltetraprole0.008 + 0.04  100 Present compound 4-12 + metyltetraprole  0.04 + 0.008100

TABLE C3 Conc. Control Present composition (ppm) Effect Present compound4-14 + pydiflumetofen 0.04 + 0.04 100 Present compound 4-14 +pydiflumetofen 0.008 + 0.04  100 Present compound 4-14 + pydiflumetofen 0.04 + 0.008 100 Present compound 4-14 + mefentrifluconazole 0.04 +0.04 100 Present compound 4-14 + mefentrifluconazole 0.008 + 0.04  100Present compound 4-14 + mefentrifluconazole  0.04 + 0.008 100 Presentcompound 4-14 + metyltetraprole 0.04 + 0.04 100 Present compound 4-14 +metyltetraprole 0.008 + 0.04  100 Present compound 4-14 +metyltetraprole  0.04 + 0.008 100 Present compound 4-13 + pydiflumetofen0.04 + 0.04 100 Present compound 4-13 + pydiflumetofen 0.008 + 0.04  100Present compound 4-13 + pydiflumetofen  0.04 + 0.008 100 Presentcompound 4-13 + mefentrifluconazole 0.04 + 0.04 100 Present compound4-13 + mefentrifluconazole 0.008 + 0.04  100 Present compound 4-13 +mefentrifluconazole  0.04 + 0.008 100 Present compound 4-13 +metyltetraprole 0.04 + 0.04 100 Present compound 4-13 + metyltetraprole0.008 + 0.04  100 Present compound 4-13 + metyltetraprole  0.04 + 0.008100 Present compound 4-15 + pydiflumetofen 0.04 + 0.04 100 Presentcompound 4-15 + pydiflumetofen 0.008 + 0.04  100 Present compound 4-15 +pydiflumetofen  0.04 + 0.008 100 Present compound 4-15 +mefentrifluconazole 0.04 + 0.04 100 Present compound 4-15 +mefentrifluconazole 0.008 + 0.04  100 Present compound 4-15 +mefentrifluconazole  0.04 + 0.008 100 Present compound 4-15 +metyltetraprole 0.04 + 0.04 100 Present compound 4-15 + metyltetraprole0.008 + 0.04  100 Present compound 4-15 + metyltetraprole  0.04 + 0.008100

TABLE C4 Conc. Control Present composition (ppm) Effect Present compound14-4 + pydiflumetofen 0.04 + 0.04 100 Present compound 14-4 +pydiflumetofen 0.008 + 0.04  100 Present compound 14-4 + pydiflumetofen 0.04 + 0.008 100 Present compound 14-4 + mefentrifluconazole 0.04 +0.04 100 Present compound 14-4 + mefentrifluconazole 0.008 + 0.04  100Present compound 14-4 + mefentrifluconazole  0.04 + 0.008 100 Presentcompound 14-4 + metyltetraprole 0.04 + 0.04 100 Present compound 14-4 +metyltetraprole 0.008 + 0.04  100 Present compound 14-4 +metyltetraprole  0.04 + 0.008 100 Present compound 14-7 + pydiflumetofen0.04 + 0.04 100 Present compound 14-7 + pydiflumetofen 0.008 + 0.04  100Present compound 14-7 + pydiflumetofen  0.04 + 0.008 100 Presentcompound 14-7 + mefentrifluconazole 0.04 + 0.04 100 Present compound14-7 + mefentrifluconazole 0.008 + 0.04  100 Present compound 14-7 +mefentrifluconazole  0.04 + 0.008 100 Present compound 14-7 +metyltetraprole 0.04 + 0.04 100 Present compound 14-7 + metyltetraprole0.008 + 0.04  100 Present compound 14-7 + metyltetraprole  0.04 + 0.008100 Present compound 14-6 + pydiflumetofen 0.04 + 0.04 100 Presentcompound 14-6 + pydiflumetofen 0.008 + 0.04  100 Present compound 14-6 +pydiflumetofen  0.04 + 0.008 100 Present compound 14-6 +mefentrifluconazole 0.04 + 0.04 100 Present compound 14-6 +mefentrifluconazole 0.008 + 0.04  100 Present compound 14-6 +mefentrifluconazole  0.04 + 0.008 100 Present compound 14-6 +metyltetraprole 0.04 + 0.04 100 Present compound 14-6 + metyltetraprole0.008 + 0.04  100 Present compound 14-6 + metyltetraprole  0.04 + 0.008100 Present compound 14-2 + pydiflumetofen 0.04 + 0.04 100 Presentcompound 14-2 + pydiflumetofen 0.008 + 0.04  100 Present compound 14-2 +pydiflumetofen  0.04 + 0.008 100 Present compound 14-2 +mefentrifluconazole 0.04 + 0.04 100 Present compound 14-2 +mefentrifluconazole 0.008 + 0.04  100 Present compound 14-2 +mefentrifluconazole  0.04 + 0.008 100 Present compound 14-2 +metyltetraprole 0.04 + 0.04 100 Present compound 14-2 + metyltetraprole0.008 + 0.04  100 Present compound 14-2 + metyltetraprole  0.04 + 0.008100

TABLE C5 Conc. Control Present composition (ppm) Effect Present compound14-74 + pydiflumetofen 0.04 + 0.04 100 Present compound 14-74 +pydiflumetofen 0.008 + 0.04  100 Present compound 14-74 + pydiflumetofen 0.04 + 0.008 100 Present compound 14-74 + mefentrifluconazole 0.04 +0.04 100 Present compound 14-74 + mefentrifluconazole 0.008 + 0.04  100Present compound 14-74 + mefentrifluconazole  0.04 + 0.008 100 Presentcompound 14-74 + metyltetraprole 0.04 + 0.04 100 Present compound14-74 + metyltetraprole 0.008 + 0.04  100 Present compound 14-74 +metyltetraprole  0.04 + 0.008 100 Present compound 14-10 +pydiflumetofen 0.04 + 0.04 100 Present compound 14-10 + pydiflumetofen0.008 + 0.04  100 Present compound 14-10 + pydiflumetofen  0.04 + 0.008100 Present compound 14-10 + mefentrifluconazole 0.04 + 0.04 100 Presentcompound 14-10 + mefentrifluconazole 0.008 + 0.04  100 Present compound14-10 + mefentrifluconazole  0.04 + 0.008 100 Present compound 14-10 +metyltetraprole 0.04 + 0.04 100 Present compound 14-10 + metyltetraprole0.008 + 0.04  100 Present compound 14-10 + metyltetraprole  0.04 + 0.008100 Present compound 14-9 + pydiflumetofen 0.04 + 0.04 100 Presentcompound 14-9 + pydiflumetofen 0.008 + 0.04  100 Present compound 14-9 +pydiflumetofen  0.04 + 0.008 100 Present compound 14-9 +mefentrifluconazole 0.04 + 0.04 100 Present compound 14-9 +mefentrifluconazole 0.008 + 0.04  100 Present compound 14-9 +mefentrifluconazole  0.04 + 0.008 100 Present compound 14-9 +metyltetraprole 0.04 + 0.04 100 Present compound 14-9 + metyltetraprole0.008 + 0.04  100 Present compound 14-9 + metyltetraprole  0.04 + 0.008100 Present compound 14-14 + pydiflumetofen 0.04 + 0.04 100 Presentcompound 14-14 + pydiflumetofen 0.008 + 0.04  100 Present compound14-14 + pydiflumetofen  0.04 + 0.008 100 Present compound 14-14 +mefentrifluconazole 0.04 + 0.04 100 Present compound 14-14 +mefentrifluconazole 0.008 + 0.04  100 Present compound 14-14 +mefentrifluconazole  0.04 + 0.008 100 Present compound 14-14 +metyltetraprole 0.04 + 0.04 100 Present compound 14-14 + metyltetraprole0.008 + 0.04  100 Present compound 14-14 + metyltetraprole  0.04 + 0.008100

TABLE C6 Conc. Control Present composition (ppm) Effect Present compound14-8 + pydiflumetofen 0.04 + 0.04 100 Present compound 14-8 +pydiflumetofen 0.008 + 0.04  100 Present compound 14-8 + pydiflumetofen 0.04 + 0.008 100 Present compound 14-8 + mefentrifluconazole 0.04 +0.04 100 Present compound 14-8 + mefentrifluconazole 0.008 + 0.04  100Present compound 14-8 + mefentrifluconazole  0.04 + 0.008 100 Presentcompound 14-8 + metyltetraprole 0.04 + 0.04 100 Present compound 14-8 +metyltetraprole 0.008 + 0.04  100 Present compound 14-8 +metyltetraprole  0.04 + 0.008 100

INDUSTRIAL APPLICABILITY

The present compound or the composition A shows a control effect againsta soybean rust fungus having an amino acid substitution of F129L onmitochondrial cytochrome b protein.

Also the composition for controlling plant diseases of the presentinvention can control plant diseases.

1. A method for controlling a soybean rust fungus having an amino acidsubstitution of F129L on mitochondrial cytochrome b protein, whichcomprises applying an effective amount of a compound represented byformula (I):

[wherein, a combination of Q and E represents a combination wherein Qrepresents a group represented by Q1, or a group represented by Q2, Erepresents a C1-C6 chain hydrocarbon group which may be optionallysubstituted with one or more substituents selected from Group A, a C3-C6cycloalkyl group which may be optionally substituted with one or moresubstituents selected from Group B, R⁴R⁵C═C(R⁶)—,R¹⁵—CR¹⁶R³⁶—O—N═C(R⁷)—, R⁸R⁹C═NO—CH₂—, R¹²O—N═C(R⁷)—C(R⁹)═N—O—CH₂—,R¹²C(O)—C(R⁹)═NO—CH₂—, R¹²C(═N—O—R⁷)—C(R⁹)═N—O—CH₂—,R³⁴R³⁵C═N—N═C(R¹⁰)—R¹²R⁹N—N═C(R⁷)—, R¹²SC(R⁷)═N—, R¹²SC(SR⁷)═N—,R¹²N═C(R⁷)—S—CH₂—, R¹²N═C(SR⁷)—S—CH₂—, R¹²O—N═C(R⁷)—S—CH₂—,R¹²O—N═C(SR⁷)—S—CH₂—, R¹²R⁹N—C(S)—O—CH₂—, or R¹⁴O—; or a combinationwherein Q represents a group represented by Q3, a group represented byQ4, a group represented by Q5, a group represented by Q6, a grouprepresented by Q7, or a group represented by Q8, E represents a C1-C6chain hydrocarbon group which may be optionally substituted with one ormore substituents selected from Group A, a C3-C6 cycloalkyl group, aC5-C6 cycloalkenyl group {the C3-C6 cycloalkyl group, and the C5-C6cycloalkenyl group may be optionally substituted with one or moresubstituents selected from Group B}, a C6-C10 aryl group, a five- toten-membered aromatic heterocyclic group {the C6-C10 aryl group and thefive- to ten-membered aromatic heterocyclic group may be optionallysubstituted with one or more substituents selected from Group D},R⁴R⁵C═C(R⁶)—, R¹³O—N═C(R⁷)—, R⁸R⁹C═N—O—CH₂—,R¹²O—N═C(R⁷)—C(R⁹)═N—O—CH₂—, R¹²C(O)—C(R⁹)═NO—CH₂—,R¹²C(═N—O—R⁷)—C(R⁹)═NO—CH₂—, R³⁴R³⁵C═N—N═C(R¹⁰)—, R¹²R⁹N—N═C(R⁷)—,R¹²SC(R⁷)═N—, R¹²SC(SR⁷)═N—, R¹²N═C(R⁷)—S—CH₂—, R¹²N═C(SR⁷)—S—CH₂—,R¹²O—N═C(R⁷)—S—CH₂—, R¹²O—N═C(SR⁷)—S—CH₂—, R¹²R⁹N—C(S)—O—CH₂—, R¹⁹O—,R²⁰—C≡C—, or R¹⁸—N═C(R⁷)—, each of the group represented by Q1, thegroup represented by Q2, the group represented by Q3, the grouprepresented by Q4, the group represented by Q5, the group represented byQ6, the group represented by Q7, and the group represented by Q8represents the following group respectively (where • represents abinding site to a benzene ring),

L¹, L² and L³ are identical to or different from each other andrepresent an oxygen atom or NH, Z¹ represents a single bond, CH₂, anoxygen atom or NCH₃, Z² represents a methyl group which is substitutedwith one or more fluorine atoms, Z³ represents CH or a nitrogen atom, R¹represents a C1-C3 chain hydrocarbon group, a C1-C3 alkoxy group {theC1-C3 chain hydrocarbon group, and the C1-C3 alkoxy group may beoptionally substituted with one or more halogen atoms}, a cyclopropylgroup, a halogen atom, or a hydrogen atom, n is 0, 1, 2 or 3, when n is2 or 3, a plural of R² may be identical to or different from each other,R² represents a C1-C3 chain hydrocarbon group which may be optionallysubstituted with one or more halogen atoms, or a C1-C3 alkoxy group {theC1-C3 chain hydrocarbon group, and the C1-C3 alkoxy group may beoptionally substituted with one or more halogen atoms}, a cyclopropylgroup, or a halogen atom, R³ represents a C1-C3 alkoxy group which maybe optionally substituted with one or more halogen atoms, or a C1-C3chain hydrocarbon group which may be optionally substituted with one ormore halogen atoms, R⁴ and R⁶ are identical to or different from eachother and represent a C1-C3 chain hydrocarbon group which may beoptionally substituted with one or more halogen atoms, a cyclopropylgroup, a halogen atom, a cyano group, or a hydrogen atom, R⁵ representsa C1-C6 chain hydrocarbon group which may be optionally substituted withone or more substituents selected from Group A, a C3-C6 cycloalkyl groupwhich may be optionally substituted with one or more substituentsselected from Group B, a C6-C10 aryl group, a five- to ten-memberedaromatic heterocyclic group {the C6-C10 aryl group and the five- toten-membered aromatic heterocyclic group may be optionally substitutedwith one or more substituents selected from Group D}, a halogen atom, acyano group, or a hydrogen atom, R⁸, R¹², R¹³, R¹⁵, R¹⁸, R²⁰, and R³⁴are identical to or different from each other and represent a C1-C6chain hydrocarbon group which may be optionally substituted with one ormore substituents selected from Group A, a C3-C10 alicyclic hydrocarbongroup which may be optionally substituted with one or more substituentsselected from Group E, a C6-C10 aryl group, or a five- to ten-memberedaromatic heterocyclic group {the C6-C10 aryl group and the five- toten-membered aromatic heterocyclic group may be optionally substitutedwith one or more substituents selected from Group D}, R⁷, R⁹, R¹⁰ andR³⁵ are identical to or different from each other and represent a C1-C3chain hydrocarbon group which may be optionally substituted with one ormore halogen atoms, a cyclopropyl group, or a hydrogen atom, R⁴ and R⁵may combine together with a carbon atom to which they are attached toform a C3-C10 alicyclic hydrocarbon group or a three- to ten-memberednon-aromatic heterocyclic group {the C3-C10 alicyclic hydrocarbon groupand the three- to ten-membered non-aromatic heterocyclic group may beoptionally substituted with one or more substituents selected from GroupE}, R⁸ and R⁹ may combine together with a carbon atom to which they areattached to form a C3-C10 alicyclic hydrocarbon group or a three- toten-membered non-aromatic heterocyclic group {the C3-C10 alicyclichydrocarbon group and the three- to ten-membered non-aromaticheterocyclic group may be optionally substituted with one or moresubstituents selected from Group E}, R³⁴ and R³⁵ may combine togetherwith a carbon atom to which they are attached to form a C3-C10 alicyclichydrocarbon group or a three- to ten-membered non-aromatic heterocyclicgroup {the C3-C10 alicyclic hydrocarbon group and the three- toten-membered non-aromatic heterocyclic group may be optionallysubstituted with one or more substituents selected from Group E}, R¹⁴represents a C6-C10 aryl group, a five- to ten-membered aromaticheterocyclic group {the C6-C10 aryl group and the five- to ten-memberedaromatic heterocyclic group may be optionally substituted with one ormore substituents selected from Group D}, R¹⁷R⁷NC(S)—, R¹⁷O—C(O)—, orR¹⁷C(O)—, R¹⁵ represents a C6-C10 aryl group, or a five- to ten-memberedaromatic heterocyclic group {the C6-C10 aryl group and the five- toten-membered aromatic heterocyclic group may be optionally substitutedwith one or more substituents selected from Group C}, R¹⁶ represents aC1-C3 chain hydrocarbon group which may be optionally substituted withone or more halogen atoms, or a cyclopropyl group, R¹⁷ represents aC1-C6 chain hydrocarbon group which may be optionally substituted withone or more substituents selected from Group A, a C3-C6 cycloalkyl groupwhich may be optionally substituted with one or more substituentsselected from Group B, a C6-C10 aryl group, or a five- to ten-memberedaromatic heterocyclic group {the C6-C10 aryl group and the five- toten-membered aromatic heterocyclic group may be optionally substitutedwith one or more substituents selected from Group C}, R¹⁹ represents aC6-C10 aryl group, a five- to ten-membered aromatic heterocyclic group{the C6-C10 aryl group and the five- to ten-membered aromaticheterocyclic group may be optionally substituted with one or moresubstituents selected from Group D}, a methyl group which is substitutedwith one or more substituents selected from Group F, a C2-C6 chainhydrocarbon group which may be optionally substituted with one or moresubstituents selected from Group F, a C3-C4 cycloalkyl group which maybe optionally substituted with one or more substituents selected fromGroup B, R¹⁷R⁷NC(S)—, R¹⁷O—C(O)—, R¹⁷C(O)—, or R¹⁷R⁷NC(O)—, R³⁶represents a C1-C3 chain hydrocarbon group which may be optionallysubstituted with one or more halogen atoms, a cyclopropyl group, or ahydrogen atom. Group A is a group consisting of a C3-C6 cycloalkyl group{the C3-C6 cycloalkyl group may be optionally substituted with one ormore substituents selected from Group B}, a C1-C4 alkoxy group, a C1-C4alkylthio group {the C1-C4 alkoxy group and the C1-C4 alkylthio groupmay be optionally substituted with one or more substituents selectedfrom Group F}, a halogen atom, a cyano group, a nitro group, a hydroxygroup, an oxo group, a thioxo group, a phenoxy group, a C6-C10 arylgroup, and a five- to ten-membered aromatic heterocyclic group {thephenoxy group, the C6-C10 aryl group and the five- to ten-memberedaromatic heterocyclic group may be optionally substituted with one ormore substituents selected from Group D}. Group B is a group consistingof a C1-C3 chain hydrocarbon group which may be optionally substitutedwith one or more halogen atoms, a halogen atom, and a cyano group. GroupC is a group consisting of a C1-C6 chain hydrocarbon group, a C1-C6alkoxy group, a C1-C6 alkylthio group {the C1-C6 chain hydrocarbongroup, the C1-C6 alkoxy group and the C1-C6 alkylthio group may beoptionally substituted with one or more substituents selected from GroupF}, a C3-C6 cycloalkyl group {the C3-C6 cycloalkyl group may beoptionally substituted with one or more substituents selected from GroupB}, a halogen atom, a cyano group, a nitro group, and a hydroxy group.Group D is a group consisting of a C1-C6 chain hydrocarbon group whichmay be optionally substituted with one or more substituents selectedfrom Group F, a C3-C6 cycloalkyl group which may be optionallysubstituted with one or more substituents selected from Group B, a C1-C6alkylthio group which may be optionally substituted with one or moresubstituents selected from Group F, OR¹¹, C(O)R¹¹, C(O)OR¹¹, NR¹¹R⁷,C(R⁷)═N—OR¹¹, a phenyl group, a naphthyl group, a five- to six-memberedaromatic heterocyclic group {the phenyl group, the naphthyl group, andthe five- to six-membered aromatic heterocyclic group may be optionallysubstituted with one or more substituents selected from Group C}, ahalogen atom, a cyano group, and a nitro group. R¹¹ represents a C1-C6chain hydrocarbon group which may be optionally substituted with one ormore substituents selected from Group A, a C3-C6 cycloalkyl group whichmay be optionally substituted with one or more substituents selectedfrom Group B, a phenyl group, a naphthyl group, a five- to six-memberedaromatic heterocyclic group {the phenyl group, the naphthyl group, andthe five- to six-membered aromatic heterocyclic group may be optionallysubstituted with one or more substituents selected from Group C}, or ahydrogen atom. Group E is a group consisting of an oxo group, a thioxogroup, a C1-C3 chain hydrocarbon group, a C1-C3 alkoxy group {the C1-C3chain hydrocarbon group and the C1-C3 alkoxy group may be optionallysubstituted with one or more halogen atoms}, a halogen atom, and a cyanogroup. Group F is a group consisting of a C3-C4 cycloalkyl group, ahalogen atom, and a C1-C3 alkoxy group], or its N oxide or anagriculturally acceptable salt thereof.
 2. The method according to claim1 wherein the compound represented by formula (I), or its N oxide or anagriculturally acceptable salt thereof represents a compound wherein Qrepresents a group represented by Q1, a group represented by Q2, a grouprepresented by Q3, a group represented by Q4, a group represented by Q5,a group represented by Q6, a group represented by Q7, or a grouprepresented by Q8, E represents R⁴R⁵C═C(R⁶)—, R¹⁵—CR¹⁶R³⁶—O—N═C(R⁷)—,R⁸R⁹C═NO—CH₂—, R³⁴R³⁵C═N—N═C(R¹⁰)—, or R¹⁴O—, R⁴ and R⁶ are identical toor different from each other and represent a C1-C3 alkyl group, ahalogen atom, or a hydrogen atom, R⁵ represents a C1-C6 chainhydrocarbon group which may be optionally substituted with one or moresubstituents selected from Group J, a C3-C6 cycloalkyl group which maybe optionally substituted with one or more halogen atoms, or a phenylgroup which may be optionally substituted with one or more substituentsselected from Group G, R⁷, R⁹ and R³⁵ are identical to or different fromeach other and represent a C1-C3 alkyl group, or a hydrogen atom, R⁸ andR³⁴ are identical to or different from each other and represent a phenylgroup, an indanyl group, a tetrahydronaphthyl group, or a five- tosix-aromatic heterocyclic group {the phenyl group, the indanyl group,the tetrahydronaphthyl group, and the five- to six-aromatic heterocyclicgroup may be optionally substituted with one or more substituentsselected from Group G}, R⁴ and R⁵ may combine together with a carbonatom to which they are attached to form a C3-C10 alicyclic hydrocarbongroup, or a three- to ten-membered non-aromatic heterocyclic group {theC3-C10 alicyclic hydrocarbon group and the three- to ten-memberednon-aromatic heterocyclic group may be optionally substituted with oneor more substituents selected from Group E}, R⁸ and R⁹ may combinetogether with a carbon atom to which they are attached to form a C3-C10alicyclic hydrocarbon group or a three- to ten-membered non-aromaticheterocyclic group {the C3-C10 alicyclic hydrocarbon group and thethree- to ten-membered non-aromatic heterocyclic group may be optionallysubstituted with one or more substituents selected from Group E}, R³⁴and R³⁵ may combine together with a carbon atom to which they areattached to form a C3-C10 alicyclic hydrocarbon group or a three- toten-membered non-aromatic heterocyclic group {the C3-C10 alicyclichydrocarbon group and the three- to ten-membered non-aromaticheterocyclic group may be optionally substituted with one or moresubstituents selected from Group E}, R¹⁴ and R¹⁵ are identical to ordifferent from each other and represent a phenyl group, or a five- tosix-membered aromatic heterocyclic group {the a phenyl group and thefive- to six-membered aromatic heterocyclic group may be optionallysubstituted with one or more substituents selected from Group G}, R¹⁶represents a C1-C3 alkyl group, and R³⁶ represents a hydrogen atom,Group G is a group consisting of a C1-C3 chain hydrocarbon group, aC1-C3 alkoxy group {the C1-C3 chain hydrocarbon group and the C1-C3alkoxy group may be optionally substituted with one or more halogenatoms}, a halogen atom, and a cyano group. Group J is a group consistingof a halogen atom and a cyclopropyl group, or its N oxide oragriculturally acceptable salt thereof.
 3. The method according to claim2 wherein the compound represented by formula (I), or its N oxide or anagriculturally acceptable salt thereof represents a compound wherein Erepresents R¹⁵—CR¹⁶R³⁶—O—N═C(R⁷)—, R⁸R⁹C═N—O—CH₂—, or R¹⁴O—, R⁷ and R⁸are identical to or different from each other and represent a C1-C3alkyl group or a hydrogen atom, R⁸, R¹⁴ and R¹⁵ are identical to ordifferent from each other and represent a phenyl group which may beoptionally substituted with one or more substituents selected from GroupG, R¹⁶ represents a C1-C3 alkyl group, and R³⁶ represents a hydrogenatom, or its N oxide or agriculturally acceptable salt thereof.
 4. Themethod according to claim 1 wherein the compound respected by formula(I) is a compound wherein E represents R¹⁴O—, R¹⁴ represents a thiazolylgroup which may be optionally substituted with one or more substituentsselected from Group H, or a thienyl group which may be optionallysubstituted with one or more halogen atoms, Group H is a groupconsisting of a C1-C3 chain hydrocarbon group which may be optionallysubstituted with one or more substituents selected from Group F, a C3-C6cycloalkyl group, a phenyl group {the C3-C6 cycloalkyl group and thephenyl group may be optionally substituted with one or more halogenatoms}, and a halogen atom.
 5. The method according to claim 1 whereinthe compound represented by formula (I), or its N oxide or anagriculturally acceptable salt thereof represents a compound wherein Qrepresents a group represented by Q1 or a group represented by Q2, R¹represents a methyl group, or a halogen atom, and n is 0, or its N oxideor agriculturally acceptable salt thereof.
 6. The method according toclaim 1 wherein the compound represented by formula (I), or its N oxideor an agriculturally acceptable salt thereof represents a compoundwherein Q represents a group represented by Q1, R¹ represents a methylgroup, and n is 0, or its N oxide or agriculturally acceptable saltthereof.
 7. (canceled)
 8. A compound represented by formula (II):

[wherein R¹ represents a methyl group, Q represents a group representedby Q1 or a group represented by Q2 (where • represents a binding site toa benzene ring),

L¹ represents an oxygen atom or NH, E represents R³⁴R³⁵C═N—N═C(R¹⁰)—,R⁸R⁹C═N—O—CH₂—, R¹⁵—CH(R¹⁶)—O—N═C(R⁷)—, or R¹⁹O—, R³⁴ represents a C1-C6chain hydrocarbon group which may be optionally substituted with one ormore substituents selected from Group J, a C3-C10 alicyclic hydrocarbongroup which may be optionally substituted with one or more substituentsselected from Group E, a phenyl group, or a five- to six-memberedaromatic heterocyclic group {the phenyl group and the five- tosix-membered aromatic heterocyclic group may be optionally substitutedwith one or more substituents selected from Group G}, R⁹ and R³⁵ areidentical to or different from each other and represent a C1-C3 alkylgroup, or a hydrogen atom, R⁷, R¹⁰ and R¹⁶ are identical to or differentfrom each other and represent a C1-C3 alkyl group, R⁸ represents anindanyl group, a tetrahydronaphthyl group, a dihydrobenzofuranyl group,or a dihydrobenzopyranyl group {the indanyl group, thetetrahydronaphthyl group, the dihydrobenzofuranyl group, and thedihydrobenzopyranyl group may be optionally substituted with one or moresubstituents selected from Group G}, R⁸ and R⁹ may combine together witha carbon atom to which they are attached to form a C3-C10 alicyclichydrocarbon group or a three- to ten-membered non-aromatic heterocyclicgroup {the C3-C10 alicyclic hydrocarbon group and the three- toten-membered non-aromatic heterocyclic group may be optionallysubstituted with one or more substituents selected from Group E}, R³⁴and R³⁵ may combine together with a carbon atom to which they areattached to form a C3-C10 alicyclic hydrocarbon group or a three- toten-membered non-aromatic heterocyclic group {the C3-C10 alicyclichydrocarbon group and the three- to ten-membered non-aromaticheterocyclic group may be optionally substituted with one or moresubstituents selected from Group E}, R¹⁵ represents a phenyl group, or afive- to six-membered aromatic heterocyclic group {the phenyl group andthe five- to six-membered aromatic heterocyclic group may be optionallysubstituted with one or more substituents selected from Group G}, R¹⁹represents a phenyl group which is substituted at its 2-position withsubstituent(s) selected from Group L, a phenyl group which issubstituted at its 3-position with substituent(s) selected from Group M,a phenyl group which is substituted at its 4-position withsubstituent(s) selected from Group N, a phenyl group which issubstituted with two or more substituents selected from Group P (wherethe two or more substituents selected from Group P may be identical toor different from each other), a pyridyl group which may be optionallysubstituted with substituent(s) selected from Group P, a pyrazolyl groupwhich may be optionally substituted with substituent(s) selected fromGroup G, or a pyrimidinyl group which may be optionally substituted withsubstituent(s) selected from Group Q. Group E is a group consisting ofan oxo group, a thioxo group, a C1-C3 chain hydrocarbon group, a C1-C3alkoxy group {the C1-C3 chain hydrocarbon group and the C1-C3 alkoxygroup may be optionally substituted with one or more halogen atoms}, ahalogen atom, and a cyano group. Group G is a group consisting of aC1-C3 chain hydrocarbon group, a C1-C3 alkoxy group {the C1-C3 chainhydrocarbon group and the C1-C3 alkoxy group may be optionallysubstituted with one or more halogen atoms}, a halogen atom, and a cyanogroup. Group J is a group consisting of a halogen atom and a cyclopropylgroup. Group L is a group consisting of a C2-C4 chain hydrocarbon group,a C1-C4 alkoxy group {the C2-C4 chain hydrocarbon group and the C1-C4alkoxy group may be optionally substituted with one or more halogenatoms}, a cyclopropyl group, a halogen atom, and a cyano group. Group Mis a group consisting of a C2-C3 chain hydrocarbon group, a C2-C3 alkoxygroup {the C2-C3 chain hydrocarbon group and the C2-C3 alkoxy group maybe optionally substituted with one or more halogen atoms}, atrifluoromethyl group, a cyclopropyl group, and a chlorine atom. Group Nis a group consisting of a C1-C3 alkyl group which is substituted withone or more fluorine atoms, a methoxy group, a cyclopropyl group, ahalogen atom, and a cyano group. Group P is a group consisting of aC2-C3 chain hydrocarbon group, a C1-C3 alkoxy group {the C2-C3 chainhydrocarbon group and the C1-C3 alkoxy group may be optionallysubstituted with one or more halogen atoms}, a halogen atom, and a cyanogroup. Group Q is a group consisting of a C1-C3 chain hydrocarbon groupwhich may be optionally substituted with one or more halogen atoms, aC1-C3 alkoxy group, a halogen atom, and a cyano group], or its N oxideor agriculturally acceptable salt thereof.
 9. The compound according toclaim 8 wherein E represents R¹⁹O—, R¹⁹ represents a phenyl group whichis substituted at its 2-position with substituent(s) selected from GroupV, a phenyl group which is substituted at its 4-position withsubstituent(s) selected from Group V, a 3-chlorophenyl group, a phenylgroup which is substituted with two or more halogen atoms, or a pyridylgroup which may be optionally substituted with one or more halogenatoms, Group V is a group consisting of a halogen atom and a methoxygroup, or its N oxide or agriculturally acceptable salt thereof.
 10. Anagricultural composition which comprises the compound according to claim8 or its N-oxide compound or an agriculturally acceptable salt thereofand an inert carrier.
 11. The agricultural composition according toclaim 10 which comprises one or more ingredients selected from the groupconsisting of the following Groups (a), (b), (c) and (d): Group (a): agroup consisting of insecticidal ingredients, miticidal ingredients, andnematicidal ingredients; Group (b): fungicidal ingredients: Group (c):plant growth modulating ingredients; and Group (d): repellentingredients.
 12. A method for controlling a soybean rust fungus havingan amino acid substitution of F129L on mitochondrial cytochrome bprotein, which comprises applying an effective amount of a compoundrepresented by formula (III):

[wherein E³ represents R³⁹OCH₂—, R⁴⁰CH₂O—, R⁴¹S—, R⁴²SCH₂—, R⁴³CH₂S—, orR⁴⁶O—, Q represents a group represented by Q1, a group represented byQ2, a group represented by Q3, a group represented by Q4, a grouprepresented by Q5, a group represented by Q6, a group represented by Q7,or a group represented by Q8, each of the group represented by Q1, thegroup represented by Q2, the group represented by Q3, the grouprepresented by Q4, the group represented by Q5, the group represented byQ6, the group represented by Q7, and the group represented by Q8represents the following group respectively (where • represents abinding site to a benzene ring),

L¹, L² and L³ are identical to or different from each other andrepresent an oxygen atom, or NH, Z¹ represents a single bond, CH₂, anoxygen atom or NCH₃, Z² represents a methyl group which is substitutedwith one or more fluorine atoms, Z³ represents CH or a nitrogen atom, R¹represents a C1-C3 chain hydrocarbon group, a C1-C3 alkoxy group {theC1-C3 chain hydrocarbon group, and the C1-C3 alkoxy group may beoptionally substituted with one or more halogen atoms}, a cyclopropylgroup, a halogen atom, or a hydrogen atom, n is 0, 1, 2, or 3, when n is2 or 3, a plural of R² may be identical to or different from each other,R² represents a C1-C3 chain hydrocarbon group, a C1-C3 alkoxy group {theC1-C3 chain hydrocarbon group, and the C1-C3 alkoxy group may beoptionally substituted with one or more halogen atoms}, a cyclopropylgroup, or a halogen atom, R³⁹ represents a five- to ten-memberedaromatic heterocyclic group which may be optionally substituted with oneor more substituents selected from Group R, R⁴⁰ represents a C6-C10 arylgroup, or a five- to ten-membered aromatic heterocyclic group {theC6-C10 aryl group, and the five- to ten-membered aromatic heterocyclicgroup may be optionally substituted with one or more substituentsselected from Group R}, R⁴¹ represents a C1-C6 chain hydrocarbon groupwhich may be optionally substituted with one or more substituentsselected from Group S, a C6-C10 aryl group, a five- to ten-memberedaromatic heterocyclic group {the C6-C10 aryl group, and the five- toten-membered aromatic heterocyclic group may be optionally substitutedwith one or more substituents selected from Group R}, or a C3-C6cycloalkyl group which may be optionally substituted with one or moresubstituents selected from Group T, R⁴² represents a C6-C10 aryl group,or a five- to ten-membered aromatic heterocyclic group {the C6-C10 arylgroup, and the five- to ten-membered aromatic heterocyclic group may beoptionally substituted with one or more substituents selected from GroupR}, R⁴³ represents a C6-C10 aryl group, or a five- to ten-memberedaromatic heterocyclic group {the C6-C10 aryl group, and the five- toten-membered aromatic heterocyclic group may be optionally substitutedwith one or more substituents selected from Group R}, R⁴⁶ represents aC5-C6 cycloalkyl group which may be optionally substituted with one ormore substituents selected from Group T. Group R is a group consistingof a C1-C6 chain hydrocarbon group, a C1-C6 alkoxy group, a C1-C6alkylthio group {the C1-C6 chain hydrocarbon group, the C1-C6 alkoxygroup, and the C1-C6 alkylthio group may be optionally substituted withone or more substituents selected from Group S}, a C3-C6 cycloalkylgroup which may be optionally substituted with one or more substituentsselected from Group T, a phenyl group, a five- to six-membered aromaticheterocyclic group {the phenyl group, and the five- to six-memberedaromatic heterocyclic group may be optionally substituted with one ormore substituents selected from Group U}, a halogen atom, a cyano group,and a nitro group. Group S is a group consisting of a C3-C4 cycloalkylgroup, a halogen atom, and a C1-C3 alkoxy group. Group T is a groupconsisting of a C1-C3 chain hydrocarbon group which may be optionallysubstituted with one or more halogen atoms, a halogen atom, and a cyanogroup. Group U is a group consisting of a C1-C6 chain hydrocarbon group,a C1-C6 alkoxy group, a C1-C6 alkylthio group {the C1-C6 chainhydrocarbon group, the C1-C6 alkoxy group, and the C1-C6 alkylthio groupmay be optionally substituted with one or more substituents selectedfrom Group S}, a C3-C6 cycloalkyl group which may be optionallysubstituted with one or more substituents selected from Group T, ahalogen atom, a cyano group, and a nitro group.], or its N oxide oragriculturally acceptable salt thereof.
 13. The method according toclaim 12 wherein the compound represented by formula (III) is a compoundwherein E³ represents R³⁹OCH₂—, R⁴⁰CH₂O—, R⁴¹S—, R⁴²SCH₂—, or R⁴³CH₂S—,R⁴¹ represents a C1-C6 chain hydrocarbon group which may be optionallysubstituted with one or more substituents selected from Group S, aC6-C10 aryl group, or a five- to ten-membered aromatic heterocyclicgroup {the C6-C10 aryl group, and the five- to ten-membered aromaticheterocyclic group may be optionally substituted with one or moresubstituents selected from Group R.}.
 14. (canceled)
 15. A compositionfor controlling a plant disease, which comprises a compound representedby the following formula (IV) and one or more of compounds selected fromGroup (B), a compound represented by formula (IV):

[wherein E⁴ represents a phenyl group, a 2-methylphenyl group, a3-methylphenyl group, a 4-methylphenyl group, a 3-fluorophenyl group, a3-methoxyphenyl group, a 3-(trifluoromethoxy)phenyl group, a3-phenoxyphenyl group, a 3-thienyl group, a 2-thiazolyl group, a4-(trifluoromethyl)thizol-2-yl group, a 5-chlorothiazol-2-yl group, a5-bromothiazol-2-yl group, a 5-(trifluoromethyl)thiazol-2-yl group, a5-cyclopropylthiazol-2-yl group, a 5-ethynylthiazol-2-yl group, or a(5-cyclopropylethynyl)thiazol-2-yl group, a combination of A⁴ and L⁴represents a combination wherein A⁴ represents CH, and L⁴ represents anoxygen atom; or a combination wherein A⁴ represents a nitrogen atom, andL⁴ represents NH.], Group (B) is a group consisting of the followingsub-groups (B-1), (B-2), (B-3) and (B-4). Sub-group (B-1) is amitochondrial electron transport chain complex III inhibitor, whichconsists of coumoxystrobin, enoxastrobin, flufenoxystrobin,picoxystrobin, pyraoxystrobin, pyraclostrobin, mandestrobin,pyrametostrobin, triclopyricab, trifloxystrobin, dimoxystrobin,fenaminstrobin, metominostrobin, orysastrobin, fluoxastrobin,fenamidone, pyribencarb, metyltetraprole, cyazofamid, amisulbrom,fenpicoxamid, and florylpicoxamid. Sub-group (B-2) is a mitochondrialelectron transport chain complex II inhibitor, which consists ofbixafen, fluxapyroxad, benzovindiflupyr, fluindapyr, pydiflumetofen,3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide,a compound represented by the following formula (1), a compoundrepresented by the following formula (2), and a compound represented bythe following formula (3).

Sub-group (B-3) is a sterol biosynthesis inhibitor, which consists ofprothioconazole and mefentrifluconazole. Sub-group (B-4) is a groupconsisting of 3-(2-methylphenyl)butan-2-ylN-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate,3-(4-fluoro-2-methylphenyl)butan-2-ylN-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate,3-(4-methoxy-2-methylphenyl)butan-2-ylN-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate,3-(2,4-dimethylphenyl)butan-2-ylN-[(3-acetoxy-4-methoxypyridin-2-yl)carbonyl]alaninate,3-(2-methylphenyl)butan-2-ylN-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate,3-(4-fluoro-2-methylphenyl)butan-2-ylN-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate,3-(4-methoxy-2-methylphenyl)butan-2-ylN-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate,3-(2,4-dimethylphenyl)butan-2-ylN-({3-[(2-methylpropanoyl)oxy]-4-methoxypyridin-2-yl}carbonyl)alaninate,3-(2-methylphenyl)butan-2-ylN-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate,3-(4-fluoro-2-methylphenyl)butan-2-ylN-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate,3-(4-methoxy-2-methylphenyl)butan-2-ylN-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate, and3-(2,4-dimethylphenyl)butan-2-ylN-[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]alaninate.
 16. Thecomposition for controlling a plant disease according to claim 15,wherein the compound represented by formula (IV) is a compound whereinE⁴ represents a phenyl group, a 2-methylphenyl group, a 3-methylphenylgroup, a 4-methylphenyl group, a 3-fluorophenyl group, a 3-methoxyphenylgroup, a 3-(trifluoromethoxy)phenyl group, or a 3-phenoxyphenyl group,and Group (B) is a group consisting of the sub-group (B-1), thesub-group (B-2), and the sub-group (B-3).
 17. The composition forcontrolling a plant disease according to claim 16 wherein the compoundrepresented by formula (IV) is a compound wherein A⁴ represents CH, L⁴represents an oxygen atom, E⁴ represents a phenyl group, a2-methylphenyl group, a 3-methylphenyl group, a 4-methylphenyl group, a3-fluorophenyl group, a 3-methoxyphenyl group, a3-(trifluoromethoxy)phenyl group, or a 3-phenoxyphenyl group, or acompound wherein A⁴ represents a nitrogen atom, L⁴ represents NH, and E⁴represents a 2-methylphenyl group, or a 3-fluorophenyl group.
 18. Thecomposition for controlling a plant disease according to claim 16wherein in the Group (B), the sub-group (B-1) is a group consisting ofpyraclostrobin, picoxystrobin, metyltetraprole, fenpicoxamid, andflorylpicoxamid, and the sub-group (B-2) is a group consisting offluxapyroxad, benzovindiflupyr, fluindapyr, pydiflumetofen,3-(difluoromethyl)-N-(2,3-dihydro-1,1,3-trimethyl-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide,the compound represented by formula (1), the compound represented byformula (2), and the compound represented by formula (3),

the sub-group (3) is a group consisting of prothioconazole andmefentrifluconazole.
 19. The composition for controlling a plant diseaseaccording to claim 15 wherein the weight ratio of the compoundrepresented by formula (TV) to one or more compounds selected from Group(B) is within a range of 1:0.01 to 1:100.
 20. The composition forcontrolling a plant disease according to claim 15 wherein a weight ratioof the compound represented by formula (IV) to one of more compoundsselected from Group (B) is within a range of 1:0.1 to 1:10.
 21. A methodfor controlling a plant disease which comprises applying an effectiveamount of the composition for controlling a plant disease according toclaim 15 to a plant or soil where a plant is cultivated.
 22. (canceled)